##gff-version 3
P56693	UniProtKB	Chain	1	466	.	.	.	ID=PRO_0000048746;Note=Transcription factor SOX-10	
P56693	UniProtKB	DNA binding	104	172	.	.	.	Note=HMG box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267	
P56693	UniProtKB	Region	1	67	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P56693	UniProtKB	Region	62	102	.	.	.	Note=Dimerization (DIM);Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:31194875;Dbxref=PMID:31194875	
P56693	UniProtKB	Region	160	199	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P56693	UniProtKB	Region	212	274	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P56693	UniProtKB	Region	228	310	.	.	.	Note=Transactivation domain (TAM);Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:31194875;Dbxref=PMID:31194875	
P56693	UniProtKB	Region	353	466	.	.	.	Note=Transactivation domain (TAC);Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:31194875;Dbxref=PMID:31194875	
P56693	UniProtKB	Region	354	375	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P56693	UniProtKB	Region	433	466	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P56693	UniProtKB	Motif	134	145	.	.	.	Note=Nuclear export signal	
P56693	UniProtKB	Compositional bias	53	67	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P56693	UniProtKB	Compositional bias	160	184	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P56693	UniProtKB	Compositional bias	251	266	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P56693	UniProtKB	Compositional bias	436	466	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P56693	UniProtKB	Modified residue	24	24	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19369195;Dbxref=PMID:19369195	
P56693	UniProtKB	Alternative sequence	262	441	.	.	.	ID=VSP_053874;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
P56693	UniProtKB	Natural variant	106	106	.	.	.	ID=VAR_066747;Note=In WS4C%3B loss of DNA binding and transactivation capacity. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898658;Dbxref=PMID:21898658	
P56693	UniProtKB	Natural variant	108	108	.	.	.	ID=VAR_072981;Note=Found in a patient with Kallmann syndrome. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25077900;Dbxref=PMID:25077900	
P56693	UniProtKB	Natural variant	111	111	.	.	.	ID=VAR_072982;Note=Found in a patient with Kallmann syndrome. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25077900;Dbxref=PMID:25077900	
P56693	UniProtKB	Natural variant	112	112	.	.	.	ID=VAR_066748;Note=In WS2E and PCWH%3B increased DNA binding capacity. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898658;Dbxref=PMID:21898658	
P56693	UniProtKB	Natural variant	131	131	.	.	.	ID=VAR_066749;Note=In PCWH%3B reduced DNA binding capacity. N->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898658;Dbxref=PMID:21898658	
P56693	UniProtKB	Natural variant	135	135	.	.	.	ID=VAR_072983;Note=Found in a patient with Kallmann syndrome. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25077900;Dbxref=PMID:25077900	
P56693	UniProtKB	Natural variant	135	135	.	.	.	ID=VAR_021386;Note=In WS2E%3B without neurologic involvement. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10441344;Dbxref=dbSNP:rs74315515,PMID:10441344	
P56693	UniProtKB	Natural variant	145	145	.	.	.	ID=VAR_066750;Note=In WS4C%3B loss of DNA binding and transactivation capacity. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898658;Dbxref=PMID:21898658	
P56693	UniProtKB	Natural variant	150	150	.	.	.	ID=VAR_066751;Note=In PCWH%3B loss of DNA binding and transactivation capacity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898658;Dbxref=PMID:21898658	
P56693	UniProtKB	Natural variant	151	151	.	.	.	ID=VAR_072984;Note=Found in a patient with Kallmann syndrome. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25077900;Dbxref=dbSNP:rs1463736052,PMID:25077900	
P56693	UniProtKB	Natural variant	157	157	.	.	.	ID=VAR_066752;Note=In WS4C%3B loss of DNA binding and transactivation capacity. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18348274,ECO:0000269|PubMed:21898658;Dbxref=dbSNP:rs121909117,PMID:18348274,PMID:21898658	
P56693	UniProtKB	Natural variant	161	161	.	.	.	ID=VAR_072985;Note=Found in a patient with Kallmann syndrome. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25077900;Dbxref=PMID:25077900	
P56693	UniProtKB	Natural variant	161	161	.	.	.	ID=VAR_066753;Note=In WS2E%3B reduced DNA binding capacity. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898658;Dbxref=dbSNP:rs750566714,PMID:21898658	
P56693	UniProtKB	Natural variant	161	161	.	.	.	ID=VAR_003743;Note=In WS4C. R->RLR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9462749;Dbxref=PMID:9462749	
P56693	UniProtKB	Natural variant	174	174	.	.	.	ID=VAR_066754;Note=In PCWH%3B without Hirschsprung disease%3B reduced DNA binding capacity. Q->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19208381,ECO:0000269|PubMed:21898658;Dbxref=dbSNP:rs267607081,PMID:19208381,PMID:21898658	
P56693	UniProtKB	Natural variant	175	175	.	.	.	ID=VAR_066755;Note=In PCWH%3B reduced DNA binding capacity. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898658;Dbxref=PMID:21898658	
P56693	UniProtKB	Natural variant	175	175	.	.	.	ID=VAR_066756;Note=In PCWH%3B reduced DNA binding capacity. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898658;Dbxref=PMID:21898658	
P56693	UniProtKB	Natural variant	175	175	.	.	.	ID=VAR_066757;Note=In PCWH%3B reduced DNA binding capacity. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898658;Dbxref=PMID:21898658	
P56693	UniProtKB	Natural variant	321	321	.	.	.	ID=VAR_066758;Note=In PCWH. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21898658;Dbxref=PMID:21898658	
P56693	UniProtKB	Sequence conflict	222	222	.	.	.	Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P56693	UniProtKB	Sequence conflict	461	461	.	.	.	Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305