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Protein

Xylose isomerase

Gene

xylA

Organism
Thermus caldophilus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53By similarity1
Active sitei56By similarity1
Metal bindingi180Magnesium 1By similarity1
Metal bindingi216Magnesium 1By similarity1
Metal bindingi216Magnesium 2By similarity1
Metal bindingi219Magnesium 2By similarity1
Metal bindingi244Magnesium 1By similarity1
Metal bindingi254Magnesium 2By similarity1
Metal bindingi256Magnesium 2By similarity1
Metal bindingi286Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiThermus caldophilus
Taxonomic identifieri272 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958111 – 387Xylose isomeraseAdd BLAST387

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1387
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Beta strandi10 – 13Combined sources4
Helixi14 – 17Combined sources4
Helixi35 – 45Combined sources11
Beta strandi48 – 53Combined sources6
Helixi54 – 57Combined sources4
Helixi64 – 81Combined sources18
Beta strandi87 – 89Combined sources3
Beta strandi93 – 95Combined sources3
Helixi96 – 98Combined sources3
Helixi108 – 127Combined sources20
Beta strandi132 – 135Combined sources4
Beta strandi141 – 143Combined sources3
Helixi145 – 147Combined sources3
Helixi149 – 151Combined sources3
Helixi153 – 171Combined sources19
Beta strandi176 – 179Combined sources4
Beta strandi183 – 192Combined sources10
Helixi195 – 202Combined sources8
Beta strandi205 – 207Combined sources3
Helixi208 – 210Combined sources3
Beta strandi211 – 213Combined sources3
Helixi217 – 221Combined sources5
Turni222 – 224Combined sources3
Helixi227 – 237Combined sources11
Beta strandi243 – 245Combined sources3
Beta strandi250 – 253Combined sources4
Helixi264 – 276Combined sources13
Beta strandi283 – 285Combined sources3
Helixi295 – 321Combined sources27
Helixi323 – 332Combined sources10
Turni337 – 339Combined sources3
Helixi340 – 342Combined sources3
Beta strandi343 – 345Combined sources3
Helixi348 – 356Combined sources9
Helixi361 – 365Combined sources5
Helixi371 – 382Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXCX-ray2.30A/B/C/D1-387[»]
ProteinModelPortaliP56681
SMRiP56681
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56681

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Family and domain databases

HAMAPiMF_00455 Xylose_isom_A, 1 hit
InterProiView protein in InterPro
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
IPR013453 XylA_actinobac
IPR001998 Xylose_isomerase
PANTHERiPTHR32176:SF0 PTHR32176:SF0, 1 hit
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PRINTSiPR00688 XYLOSISMRASE
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR02631 xylA_Arthro, 1 hit
PROSITEiView protein in PROSITE
PS51415 XYLOSE_ISOMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

P56681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEPKPEHRF TFGLWTVGNV GRDPFGDAVR ERLDPVYVGH KLAELGVHGV
60 70 80 90 100
NLHDEDLIPR GTPPAERDQI VRRFKRALDE TGLKVPMVTG NLFSDPGFKD
110 120 130 140 150
GGFTSRDPWV RAYAFRKSLE TMDLGAELGA EIYVVWPGRE GAEVEATGKA
160 170 180 190 200
RKVWDWVREP LNFMAAYAED QGYGYRFALE PKPNEPRGDI YFATVGSMLA
210 220 230 240 250
LIHTLERPER FGLNPEFAHE TMAGLNFVHA VAQALDAGKL LHIDLNGQRM
260 270 280 290 300
NRFDQDLRFG SENLKAAFLL VDLLESSGYQ GPRHFDAHAL RTEDEEGVWA
310 320 330 340 350
FARGCMRTYL ILKERAEAFR EDPEVKELLA AYYQEDPAAL PLMDPYSHEK
360 370 380
AEALKRAELP LEAKRHRGYA LERLDQLAVE YLLGVRG
Length:387
Mass (Da):43,860
Last modified:July 15, 1999 - v1
Checksum:i28FB6568BA758065
GO

Similar proteinsi

Entry informationi

Entry nameiXYLA_THECA
AccessioniPrimary (citable) accession number: P56681
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: April 25, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure
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Main funding by: National Institutes of Health