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Protein

Xylose isomerase

Gene

xylA

Organism
Thermus caldophilus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53By similarity1
Active sitei56By similarity1
Metal bindingi180Magnesium 1By similarity1
Metal bindingi216Magnesium 1By similarity1
Metal bindingi216Magnesium 2By similarity1
Metal bindingi219Magnesium 2By similarity1
Metal bindingi244Magnesium 1By similarity1
Metal bindingi254Magnesium 2By similarity1
Metal bindingi256Magnesium 2By similarity1
Metal bindingi286Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiThermus caldophilus
Taxonomic identifieri272 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958111 – 387Xylose isomeraseAdd BLAST387

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1387
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Beta strandi10 – 13Combined sources4
Helixi14 – 17Combined sources4
Helixi35 – 45Combined sources11
Beta strandi48 – 53Combined sources6
Helixi54 – 57Combined sources4
Helixi64 – 81Combined sources18
Beta strandi87 – 89Combined sources3
Beta strandi93 – 95Combined sources3
Helixi96 – 98Combined sources3
Helixi108 – 127Combined sources20
Beta strandi132 – 135Combined sources4
Beta strandi141 – 143Combined sources3
Helixi145 – 147Combined sources3
Helixi149 – 151Combined sources3
Helixi153 – 171Combined sources19
Beta strandi176 – 179Combined sources4
Beta strandi183 – 192Combined sources10
Helixi195 – 202Combined sources8
Beta strandi205 – 207Combined sources3
Helixi208 – 210Combined sources3
Beta strandi211 – 213Combined sources3
Helixi217 – 221Combined sources5
Turni222 – 224Combined sources3
Helixi227 – 237Combined sources11
Beta strandi243 – 245Combined sources3
Beta strandi250 – 253Combined sources4
Helixi264 – 276Combined sources13
Beta strandi283 – 285Combined sources3
Helixi295 – 321Combined sources27
Helixi323 – 332Combined sources10
Turni337 – 339Combined sources3
Helixi340 – 342Combined sources3
Beta strandi343 – 345Combined sources3
Helixi348 – 356Combined sources9
Helixi361 – 365Combined sources5
Helixi371 – 382Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXCX-ray2.30A/B/C/D1-387[»]
ProteinModelPortaliP56681.
SMRiP56681.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56681.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEPKPEHRF TFGLWTVGNV GRDPFGDAVR ERLDPVYVGH KLAELGVHGV
60 70 80 90 100
NLHDEDLIPR GTPPAERDQI VRRFKRALDE TGLKVPMVTG NLFSDPGFKD
110 120 130 140 150
GGFTSRDPWV RAYAFRKSLE TMDLGAELGA EIYVVWPGRE GAEVEATGKA
160 170 180 190 200
RKVWDWVREP LNFMAAYAED QGYGYRFALE PKPNEPRGDI YFATVGSMLA
210 220 230 240 250
LIHTLERPER FGLNPEFAHE TMAGLNFVHA VAQALDAGKL LHIDLNGQRM
260 270 280 290 300
NRFDQDLRFG SENLKAAFLL VDLLESSGYQ GPRHFDAHAL RTEDEEGVWA
310 320 330 340 350
FARGCMRTYL ILKERAEAFR EDPEVKELLA AYYQEDPAAL PLMDPYSHEK
360 370 380
AEALKRAELP LEAKRHRGYA LERLDQLAVE YLLGVRG
Length:387
Mass (Da):43,860
Last modified:July 15, 1999 - v1
Checksum:i28FB6568BA758065
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXCX-ray2.30A/B/C/D1-387[»]
ProteinModelPortaliP56681.
SMRiP56681.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP56681.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_THECA
AccessioniPrimary (citable) accession number: P56681
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.