P56671 (MAZ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myc-associated zinc finger protein
Short name=MAZI

Alternative name(s):
Pur-1
Purine-binding transcription factor

Gene names

Name:

Maz

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator that binds to purine-rich GAGA sites found in the promoter of many genes including insulin I and II and islet amyloid polypeptide.
Subunit structure	Interacts with BPTF By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 6 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Dcc	P70211	3	EBI-1809712,EBI-1798863

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 477	477	Myc-associated zinc finger protein		PRO_0000047217
Regions
	Zinc finger	190 – 212	23	C2H2-type 1
	Zinc finger	279 – 301	23	C2H2-type 2
	Zinc finger	307 – 329	23	C2H2-type 3
	Zinc finger	337 – 360	24	C2H2-type 4
	Zinc finger	366 – 388	23	C2H2-type 5
	Zinc finger	392 – 413	22	C2H2-type 6; atypical
	Compositional bias	96 – 108	13	Poly-Ala
	Compositional bias	130 – 138	9	Poly-Pro
	Compositional bias	151 – 154	4	Poly-Ala
	Compositional bias	157 – 163	7	Poly-Ala
	Compositional bias	246 – 249	4	Poly-Gly
	Compositional bias	435 – 447	13	Poly-Ala
Experimental info
	Sequence conflict	64	1	Q → QQ in BAA76280. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P56671 [UniParc]. Last modified July 15, 1999. Version 1. Checksum: F2276C4C7538D2EF	FASTA	477	48,770
	10 20 30 40 50 60 MFPVFPCTLL APPFPVLGLD SRGVGGLMNS FPPPQGHAQN PLQVGAELQS RFFASQGCAQ 70 80 90 100 110 120 SPFQAAPAPP PTPQAPAAEP LQVDLLPVLA AAQESAAAAA AAAAAAAAVV TAPPAPAAAS 130 140 150 160 170 180 TVDTAALKQP PAPPPPPPAV SAPAAEAAPP AAAATIAAAA ATAVVAPTST VAVAPVASVL 190 200 210 220 230 240 EKKTKSKGPY ICALCAKEFK NGYNLRRHEA IHTGAKAGRV PSGAMKMPTM VPLSLLSVPQ 250 260 270 280 290 300 LSGASGGGGE AGAGGGTTAV AAGGVVTTTA SGKRIRKNHA CEMCGKAFRD VYHLNRHKLS 310 320 330 340 350 360 HSDEKPYQCP VCQQRFKRKD RMSYHVRSHD GAVHKPYNCS HCGKSFSRPD HLNSHVRQVH 370 380 390 400 410 420 STERPFKCEK CEAAFATKDR LRAHTVRHEE KVPCHVCGKM LSSAYISDHM KVHSQGPHHV 430 440 450 460 470 CELCNKGTGE VCPMAAAAAA AAAAAAAVVA APPTAVGSLS GAEGVPVSSQ PLPSQPW

References

[1]	"Pur-1, a zinc-finger protein which binds to purine-rich sequences, activates an insulin promoter in heterologous cells." Kennedy G.C., Rutter W.J. Proc. Natl. Acad. Sci. U.S.A. 89:11498-11502(1992) [PubMed: 1454839] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreatic tumor.
[2]	"Structural organization and expression of the mouse gene for Pur-1, a highly conserved homolog of the human MAZ gene." Song J., Murakami H., Tsutsui H., Ugai H., Geltinger C., Murata T., Matsumura M., Itakura K., Kanazawa I., Sun K., Yokoyama K.K. Eur. J. Biochem. 259:676-683(1999) [PubMed: 10092852] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L04649 mRNA. No translation available. AB006360 Genomic DNA. Translation: BAA76280.1.
IPI	IPI00114809.
PIR	A47236.
UniGene	Mm.378964.
3D structure databases
ProteinModelPortal	P56671.
SMR	P56671. Positions 185-439.
ModBase	Search...
Protein-protein interaction databases
IntAct	P56671. 1 interaction.
STRING	P56671.
PTM databases
PhosphoSite	P56671.
Proteomic databases
PRIDE	P56671.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc009jub.1. mouse.
Organism-specific databases
MGI	MGI:1338823. Maz.
Phylogenomic databases
eggNOG	maNOG06104.
HOGENOM	HBG717200.
HOVERGEN	HBG018163.
InParanoid	P56671.
OrthoDB	EOG4S7JRR.
Gene expression databases
ArrayExpress	P56671.
Bgee	P56671.
Genevestigator	P56671.
GermOnline	ENSMUSG00000030678. Mus musculus.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 5 hits.
Pfam	PF00096. zf-C2H2. 5 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 6 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

MAZ_MOUSE

Accession

Primary (citable) accession number: P56671
Secondary accession number(s): Q9R1W0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	September 21, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program