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Protein

Myc-associated zinc finger protein

Gene

Maz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds to purine-rich GAGA sites found in the promoter of many genes including insulin I and II and islet amyloid polypeptide.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri190 – 21223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 36024C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41322C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: MGI
  • RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myc-associated zinc finger protein
Short name:
MAZI
Alternative name(s):
Pur-1
Purine-binding transcription factor
Gene namesi
Name:Maz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1338823. Maz.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Myc-associated zinc finger proteinPRO_0000047217Add
BLAST

Proteomic databases

EPDiP56671.
MaxQBiP56671.
PaxDbiP56671.
PRIDEiP56671.

PTM databases

iPTMnetiP56671.
PhosphoSiteiP56671.

Interactioni

Subunit structurei

Interacts with BPTF.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DccP702113EBI-1809712,EBI-1798863
FOSP011002EBI-1809712,EBI-852851From a different organism.
JUNP054122EBI-1809712,EBI-852823From a different organism.

Protein-protein interaction databases

IntActiP56671. 4 interactions.
MINTiMINT-4101319.
STRINGi10090.ENSMUSP00000032916.

Structurei

3D structure databases

ProteinModelPortaliP56671.
SMRiP56671. Positions 180-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi96 – 10813Poly-AlaAdd
BLAST
Compositional biasi130 – 1389Poly-Pro
Compositional biasi151 – 1544Poly-Ala
Compositional biasi157 – 1637Poly-Ala
Compositional biasi246 – 2494Poly-Gly
Compositional biasi435 – 44713Poly-AlaAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri190 – 21223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 36024C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41322C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000294183.
HOVERGENiHBG018163.
InParanoidiP56671.
PhylomeDBiP56671.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPVFPCTLL APPFPVLGLD SRGVGGLMNS FPPPQGHAQN PLQVGAELQS
60 70 80 90 100
RFFASQGCAQ SPFQAAPAPP PTPQAPAAEP LQVDLLPVLA AAQESAAAAA
110 120 130 140 150
AAAAAAAAVV TAPPAPAAAS TVDTAALKQP PAPPPPPPAV SAPAAEAAPP
160 170 180 190 200
AAAATIAAAA ATAVVAPTST VAVAPVASVL EKKTKSKGPY ICALCAKEFK
210 220 230 240 250
NGYNLRRHEA IHTGAKAGRV PSGAMKMPTM VPLSLLSVPQ LSGASGGGGE
260 270 280 290 300
AGAGGGTTAV AAGGVVTTTA SGKRIRKNHA CEMCGKAFRD VYHLNRHKLS
310 320 330 340 350
HSDEKPYQCP VCQQRFKRKD RMSYHVRSHD GAVHKPYNCS HCGKSFSRPD
360 370 380 390 400
HLNSHVRQVH STERPFKCEK CEAAFATKDR LRAHTVRHEE KVPCHVCGKM
410 420 430 440 450
LSSAYISDHM KVHSQGPHHV CELCNKGTGE VCPMAAAAAA AAAAAAAVVA
460 470
APPTAVGSLS GAEGVPVSSQ PLPSQPW
Length:477
Mass (Da):48,770
Last modified:July 15, 1999 - v1
Checksum:iF2276C4C7538D2EF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641Q → QQ in BAA76280 (PubMed:10092852).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04649 mRNA. No translation available.
AB006360 Genomic DNA. Translation: BAA76280.1.
CCDSiCCDS40137.1.
PIRiA47236.
UniGeneiMm.378964.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04649 mRNA. No translation available.
AB006360 Genomic DNA. Translation: BAA76280.1.
CCDSiCCDS40137.1.
PIRiA47236.
UniGeneiMm.378964.

3D structure databases

ProteinModelPortaliP56671.
SMRiP56671. Positions 180-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56671. 4 interactions.
MINTiMINT-4101319.
STRINGi10090.ENSMUSP00000032916.

PTM databases

iPTMnetiP56671.
PhosphoSiteiP56671.

Proteomic databases

EPDiP56671.
MaxQBiP56671.
PaxDbiP56671.
PRIDEiP56671.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1338823. Maz.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000294183.
HOVERGENiHBG018163.
InParanoidiP56671.
PhylomeDBiP56671.

Miscellaneous databases

ChiTaRSiMaz. mouse.
PROiP56671.
SOURCEiSearch...

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pur-1, a zinc-finger protein which binds to purine-rich sequences, activates an insulin promoter in heterologous cells."
    Kennedy G.C., Rutter W.J.
    Proc. Natl. Acad. Sci. U.S.A. 89:11498-11502(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreatic tumor.
  2. "Structural organization and expression of the mouse gene for Pur-1, a highly conserved homolog of the human MAZ gene."
    Song J., Murakami H., Tsutsui H., Ugai H., Geltinger C., Murata T., Matsumura M., Itakura K., Kanazawa I., Sun K., Yokoyama K.K.
    Eur. J. Biochem. 259:676-683(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
    Tissue: Liver.

Entry informationi

Entry nameiMAZ_MOUSE
AccessioniPrimary (citable) accession number: P56671
Secondary accession number(s): Q9R1W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: March 16, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.