Reviewed, UniProtKB/Swiss-Prot P56657 (CP240_MOUSE)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 2C40
    EC=1.14.14.1
Alternative name(s):
    CYPIIC40

Gene names

Name:

Cyp2c40

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Metabolizes arachidonic acid to produce an unidentified metabolite that coelutes with 16-,17-, and 18-hydroxyeicosatetraenoic acid (HETE).
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue specificity	Liver, brain, kidney, and intestine, with trace amounts in lung and heart.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Cytochrome P450 2C40		PRO_0000051723
Sites
	Metal binding	435	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56657-1 [UniParc]. Last modified July 15, 1999. Version 1. Checksum: 8F4CCED7A7432BF9	FASTA	491	55,780
	10 20 30 40 50 60 MDPFVVLVLC LSFLLVLSLW RQRSARGNLP PGPTPLPIIG NYHLIDMKDI GQCLTNFSKT 70 80 90 100 110 120 YGPVFTLYFG SQPIVVLHGY EAIKEALIDH GEEFSGRGRI PVFDKVSTGK GIGFSHGNVW 130 140 150 160 170 180 KATRVFTVNT LRNLGMGKRT IENKVQEEAQ WLMKELKKTN GSPCDPQFII GCAPCNVICS 190 200 210 220 230 240 IVFQNRFDYK DKDFLSLIGK VNECTEILSS PGCQIFNAVP ILIDYCPGSH NKLFKNHTWI 250 260 270 280 290 300 KSYLLGKIKE HEESLDVTNP RDFIDYFLIQ RRQKNGIEHM DYTIEHLATL VTDLVFGGTE 310 320 330 340 350 360 TLSSTMRFAL LLLMKHTHIT AKVQEEIDNV IGRHRSPCMQ DRNHMPYTNA MVHEVQRYID 370 380 390 400 410 420 LGPNGVVHEV TCDTKFRNYF ILKGTQVMTS LTSVLHDSTE FPNPEVFDPG HFLDDNGNFK 430 440 450 460 470 480 KSDYFVPFSA GKRICVGESL ARMELFLFLT TILQNFKLKP LVDPKDIDMT PKHSGFSKIP 490 PNFQMCFIPV E

References

[1]	"Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid." Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A. Arch. Biochem. Biophys. 357:45-57(1998) [PubMed: 9721182] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF047727 mRNA. Translation: AAD13722.1.
IPI	IPI00114781.
UniGene	Mm.358585
3D structure databases
HSSP	HSSP built from PDB template 1OG2 based on UniProtKB P11712.
ModBase	Search...
Protein-protein interaction databases
STRING	P56657.
Proteomic databases
PRIDE	P56657.
Genome annotation databases
Ensembl	ENSMUST00000025969; ENSMUSP00000025969; ENSMUSG00000025004; Mus musculus. [Genome view]
KEGG	mmu:13099.
UCSC	uc008hke.1. mouse.
Organism-specific databases
CTD	13099.
MGI	MGI:1306815. Cyp2c40.
Phylogenomic databases
HOGENOM	P56657.
HOVERGEN	P56657.
Enzyme and pathway databases
BRENDA	1.14.14.1. 244.
Gene expression databases
Bgee	P56657.
Genevestigator	P56657.
GermOnline	ENSMUSG00000025004. Mus musculus.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	283090.
SOURCE	Search...

Entry information

Entry name

CP240_MOUSE

Accession

Primary (citable) accession number: P56657

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	October 13, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)