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P56657

- CP240_MOUSE

UniProt

P56657 - CP240_MOUSE

Protein

Cytochrome P450 2C40

Gene

Cyp2c40

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Metabolizes arachidonic acid to produce an unidentified metabolite that coelutes with 16-,17-, and 18-hydroxyeicosatetraenoic acid (HETE).

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C40 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC40
    Gene namesi
    Name:Cyp2c40
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1306815. Cyp2c40.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Cytochrome P450 2C40PRO_0000051723Add
    BLAST

    Proteomic databases

    MaxQBiP56657.
    PaxDbiP56657.
    PRIDEiP56657.

    PTM databases

    PhosphoSiteiP56657.

    Expressioni

    Tissue specificityi

    Liver, brain, kidney, and intestine, with trace amounts in lung and heart.

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    BgeeiP56657.
    GenevestigatoriP56657.

    Interactioni

    Protein-protein interaction databases

    IntActiP56657. 2 interactions.
    MINTiMINT-1863844.
    STRINGi10090.ENSMUSP00000025969.

    Structurei

    3D structure databases

    ProteinModelPortaliP56657.
    SMRiP56657. Positions 30-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiB2RTP3.
    KOiK07413.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56657-1 [UniParc]FASTAAdd to Basket

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    MDPFVVLVLC LSFLLVLSLW RQRSARGNLP PGPTPLPIIG NYHLIDMKDI    50
    GQCLTNFSKT YGPVFTLYFG SQPIVVLHGY EAIKEALIDH GEEFSGRGRI 100
    PVFDKVSTGK GIGFSHGNVW KATRVFTVNT LRNLGMGKRT IENKVQEEAQ 150
    WLMKELKKTN GSPCDPQFII GCAPCNVICS IVFQNRFDYK DKDFLSLIGK 200
    VNECTEILSS PGCQIFNAVP ILIDYCPGSH NKLFKNHTWI KSYLLGKIKE 250
    HEESLDVTNP RDFIDYFLIQ RRQKNGIEHM DYTIEHLATL VTDLVFGGTE 300
    TLSSTMRFAL LLLMKHTHIT AKVQEEIDNV IGRHRSPCMQ DRNHMPYTNA 350
    MVHEVQRYID LGPNGVVHEV TCDTKFRNYF IPKGTQVMTS LTSVLHDSTE 400
    FPNPEVFDPG HFLDDNGNFK KSDYFVPFSA GKRICVGESL ARMELFLFLT 450
    TILQNFKLKP LVDPKDIDMT PKHSGFSKIP PNFQMCFIPV E 491
    Length:491
    Mass (Da):55,763
    Last modified:July 27, 2011 - v2
    Checksum:i2F4CCEC2F219EA4F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti382 – 3821P → L in AAD13722. (PubMed:9721182)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047727 mRNA. Translation: AAD13722.1.
    BC139471 mRNA. Translation: AAI39472.1.
    BC139472 mRNA. Translation: AAI39473.1.
    RefSeqiNP_034134.2. NM_010004.2.
    UniGeneiMm.353875.

    Genome annotation databases

    GeneIDi13099.
    KEGGimmu:13099.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047727 mRNA. Translation: AAD13722.1 .
    BC139471 mRNA. Translation: AAI39472.1 .
    BC139472 mRNA. Translation: AAI39473.1 .
    RefSeqi NP_034134.2. NM_010004.2.
    UniGenei Mm.353875.

    3D structure databases

    ProteinModelPortali P56657.
    SMRi P56657. Positions 30-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P56657. 2 interactions.
    MINTi MINT-1863844.
    STRINGi 10090.ENSMUSP00000025969.

    PTM databases

    PhosphoSitei P56657.

    Proteomic databases

    MaxQBi P56657.
    PaxDbi P56657.
    PRIDEi P56657.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 13099.
    KEGGi mmu:13099.

    Organism-specific databases

    CTDi 13099.
    MGIi MGI:1306815. Cyp2c40.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi B2RTP3.
    KOi K07413.

    Enzyme and pathway databases

    Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Miscellaneous databases

    NextBioi 283090.
    PROi P56657.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56657.
    Genevestigatori P56657.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
      Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
      Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCP240_MOUSE
    AccessioniPrimary (citable) accession number: P56657
    Secondary accession number(s): B2RTP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3