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P56657 (CP240_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C40

EC=1.14.14.1
Alternative name(s):
CYPIIC40
Gene names
Name:Cyp2c40
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Metabolizes arachidonic acid to produce an unidentified metabolite that coelutes with 16-,17-, and 18-hydroxyeicosatetraenoic acid (HETE).

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Liver, brain, kidney, and intestine, with trace amounts in lung and heart.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Cytochrome P450 2C40
PRO_0000051723

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict3821P → L in AAD13722. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P56657 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 2F4CCEC2F219EA4F

FASTA49155,763
        10         20         30         40         50         60 
MDPFVVLVLC LSFLLVLSLW RQRSARGNLP PGPTPLPIIG NYHLIDMKDI GQCLTNFSKT 

        70         80         90        100        110        120 
YGPVFTLYFG SQPIVVLHGY EAIKEALIDH GEEFSGRGRI PVFDKVSTGK GIGFSHGNVW 

       130        140        150        160        170        180 
KATRVFTVNT LRNLGMGKRT IENKVQEEAQ WLMKELKKTN GSPCDPQFII GCAPCNVICS 

       190        200        210        220        230        240 
IVFQNRFDYK DKDFLSLIGK VNECTEILSS PGCQIFNAVP ILIDYCPGSH NKLFKNHTWI 

       250        260        270        280        290        300 
KSYLLGKIKE HEESLDVTNP RDFIDYFLIQ RRQKNGIEHM DYTIEHLATL VTDLVFGGTE 

       310        320        330        340        350        360 
TLSSTMRFAL LLLMKHTHIT AKVQEEIDNV IGRHRSPCMQ DRNHMPYTNA MVHEVQRYID 

       370        380        390        400        410        420 
LGPNGVVHEV TCDTKFRNYF IPKGTQVMTS LTSVLHDSTE FPNPEVFDPG HFLDDNGNFK 

       430        440        450        460        470        480 
KSDYFVPFSA GKRICVGESL ARMELFLFLT TILQNFKLKP LVDPKDIDMT PKHSGFSKIP 

       490 
PNFQMCFIPV E 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF047727 mRNA. Translation: AAD13722.1.
BC139471 mRNA. Translation: AAI39472.1.
BC139472 mRNA. Translation: AAI39473.1.
RefSeqNP_034134.2. NM_010004.2.
UniGeneMm.353875.

3D structure databases

ProteinModelPortalP56657.
SMRP56657. Positions 30-490.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP56657. 2 interactions.
MINTMINT-1863844.
STRING10090.ENSMUSP00000025969.

PTM databases

PhosphoSiteP56657.

Proteomic databases

MaxQBP56657.
PaxDbP56657.
PRIDEP56657.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID13099.
KEGGmmu:13099.

Organism-specific databases

CTD13099.
MGIMGI:1306815. Cyp2c40.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidB2RTP3.
KOK07413.

Gene expression databases

BgeeP56657.
GenevestigatorP56657.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283090.
PROP56657.
SOURCESearch...

Entry information

Entry nameCP240_MOUSE
AccessionPrimary (citable) accession number: P56657
Secondary accession number(s): B2RTP3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: May 14, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot