Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome P450 2C40

Gene

Cyp2c40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Metabolizes arachidonic acid to produce an unidentified metabolite that coelutes with 16-,17-, and 18-hydroxyeicosatetraenoic acid (HETE).

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Chemistry databases

SwissLipidsiSLP:000001672.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C40 (EC:1.14.14.1)
Alternative name(s):
CYPIIC40
Gene namesi
Name:Cyp2c40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1306815. Cyp2c40.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517231 – 491Cytochrome P450 2C40Add BLAST491

Proteomic databases

MaxQBiP56657.
PaxDbiP56657.
PRIDEiP56657.

PTM databases

iPTMnetiP56657.
PhosphoSitePlusiP56657.

Expressioni

Tissue specificityi

Liver, brain, kidney, and intestine, with trace amounts in lung and heart.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

IntActiP56657. 2 interactors.
MINTiMINT-1863844.
STRINGi10090.ENSMUSP00000125217.

Structurei

3D structure databases

ProteinModelPortaliP56657.
SMRiP56657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP56657.
KOiK07413.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P56657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFVVLVLC LSFLLVLSLW RQRSARGNLP PGPTPLPIIG NYHLIDMKDI
60 70 80 90 100
GQCLTNFSKT YGPVFTLYFG SQPIVVLHGY EAIKEALIDH GEEFSGRGRI
110 120 130 140 150
PVFDKVSTGK GIGFSHGNVW KATRVFTVNT LRNLGMGKRT IENKVQEEAQ
160 170 180 190 200
WLMKELKKTN GSPCDPQFII GCAPCNVICS IVFQNRFDYK DKDFLSLIGK
210 220 230 240 250
VNECTEILSS PGCQIFNAVP ILIDYCPGSH NKLFKNHTWI KSYLLGKIKE
260 270 280 290 300
HEESLDVTNP RDFIDYFLIQ RRQKNGIEHM DYTIEHLATL VTDLVFGGTE
310 320 330 340 350
TLSSTMRFAL LLLMKHTHIT AKVQEEIDNV IGRHRSPCMQ DRNHMPYTNA
360 370 380 390 400
MVHEVQRYID LGPNGVVHEV TCDTKFRNYF IPKGTQVMTS LTSVLHDSTE
410 420 430 440 450
FPNPEVFDPG HFLDDNGNFK KSDYFVPFSA GKRICVGESL ARMELFLFLT
460 470 480 490
TILQNFKLKP LVDPKDIDMT PKHSGFSKIP PNFQMCFIPV E
Length:491
Mass (Da):55,763
Last modified:July 27, 2011 - v2
Checksum:i2F4CCEC2F219EA4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti382P → L in AAD13722 (PubMed:9721182).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047727 mRNA. Translation: AAD13722.1.
BC139471 mRNA. Translation: AAI39472.1.
BC139472 mRNA. Translation: AAI39473.1.
RefSeqiNP_034134.2. NM_010004.2.
UniGeneiMm.353875.

Genome annotation databases

GeneIDi13099.
KEGGimmu:13099.

Similar proteinsi

Entry informationi

Entry nameiCP240_MOUSE
AccessioniPrimary (citable) accession number: P56657
Secondary accession number(s): B2RTP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families