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Protein

Cytochrome P450 2C39

Gene

Cyp2c39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET).

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.
REACT_295859. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_300263. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP56656.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C39 (EC:1.14.14.1)
Alternative name(s):
CYPIIC39
Gene namesi
Name:Cyp2c39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1306818. Cyp2c39.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C39PRO_0000051722Add
BLAST

Proteomic databases

PaxDbiP56656.
PRIDEiP56656.

PTM databases

PhosphoSiteiP56656.

Expressioni

Tissue specificityi

Liver.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

GenevestigatoriP56656.

Interactioni

Protein-protein interaction databases

IntActiP56656. 2 interactions.
MINTiMINT-1865726.

Structurei

3D structure databases

ProteinModelPortaliP56656.
SMRiP56656. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOVERGENiHBG015789.
InParanoidiP56656.
KOiK07413.
OMAiSHENLAC.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVTFLVLT LSSLILLSLW RQSCGRGSLP PGPTPFPIIG NFLQIDIKNV
60 70 80 90 100
SQSLTNFSKA YGPVFTLYLG SRPTVVLHGY EAVKEALIDH GEEFSDRGSI
110 120 130 140 150
PMVEKINNGL GIVFSNGNRW KEIRRFTLTT LRNLGMGKRN IEDRVQEEAQ
160 170 180 190 200
CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQDRFDYK DKDFLMLMEK
210 220 230 240 250
LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNVKYI RSYLLEKIKE
260 270 280 290 300
HQESLDVTNP RDFIDYYLIK QKQANHIQQA EFSLENLACT INNLFAAGTE
310 320 330 340 350
TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV IGRHRSPCMQ DRNHMPYTDA
360 370 380 390 400
MIHEVQRFIN LVPNNIPRAV TCDIKFRNYL IPKGTTVVTS LTSVLHDSKE
410 420 430 440 450
FPNPELFDPG HFLDANGNFK KSDHFMPFSA GKRVCAGEGL ARMELFLFLT
460 470 480 490
TILQNFKLKS LVHPKDIDMI PFVNGLIALP PHYQVCIIPR
Length:490
Mass (Da):55,827
Last modified:October 3, 2012 - v2
Checksum:iEE583A2B53CFC410
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471I → M in AAD13721 (PubMed:9721182).Curated
Sequence conflicti47 – 471I → M in AAI39291 (PubMed:15489334).Curated
Sequence conflicti47 – 471I → M in AAI39292 (PubMed:15489334).Curated
Sequence conflicti50 – 501V → F in AAD13721 (PubMed:9721182).Curated
Sequence conflicti50 – 501V → F in AAI39291 (PubMed:15489334).Curated
Sequence conflicti50 – 501V → F in AAI39292 (PubMed:15489334).Curated
Sequence conflicti460 – 4601S → P in AAD13721 (PubMed:9721182).Curated
Sequence conflicti460 – 4601S → P in AAI39291 (PubMed:15489334).Curated
Sequence conflicti460 – 4601S → P in AAI39292 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047726 mRNA. Translation: AAD13721.1.
AC117790 Genomic DNA. No translation available.
AC139233 Genomic DNA. No translation available.
CH466534 Genomic DNA. Translation: EDL41819.1.
BC139290 mRNA. Translation: AAI39291.1.
BC139291 mRNA. Translation: AAI39292.1.
CCDSiCCDS29795.1.
RefSeqiNP_034133.2. NM_010003.2.
UniGeneiMm.42101.

Genome annotation databases

EnsembliENSMUST00000025968; ENSMUSP00000025968; ENSMUSG00000025003.
GeneIDi13098.
KEGGimmu:13098.
UCSCiuc008hkb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047726 mRNA. Translation: AAD13721.1.
AC117790 Genomic DNA. No translation available.
AC139233 Genomic DNA. No translation available.
CH466534 Genomic DNA. Translation: EDL41819.1.
BC139290 mRNA. Translation: AAI39291.1.
BC139291 mRNA. Translation: AAI39292.1.
CCDSiCCDS29795.1.
RefSeqiNP_034133.2. NM_010003.2.
UniGeneiMm.42101.

3D structure databases

ProteinModelPortaliP56656.
SMRiP56656. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56656. 2 interactions.
MINTiMINT-1865726.

PTM databases

PhosphoSiteiP56656.

Proteomic databases

PaxDbiP56656.
PRIDEiP56656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025968; ENSMUSP00000025968; ENSMUSG00000025003.
GeneIDi13098.
KEGGimmu:13098.
UCSCiuc008hkb.2. mouse.

Organism-specific databases

CTDi13098.
MGIiMGI:1306818. Cyp2c39.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOVERGENiHBG015789.
InParanoidiP56656.
KOiK07413.
OMAiSHENLAC.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.
REACT_295859. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_300263. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP56656.

Miscellaneous databases

NextBioi283086.
PROiP56656.
SOURCEiSearch...

Gene expression databases

GenevestigatoriP56656.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
    Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
    Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCP239_MOUSE
AccessioniPrimary (citable) accession number: P56656
Secondary accession number(s): B9EIA6, G5E854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2012
Last modified: April 1, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.