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P56656

- CP239_MOUSE

UniProt

P56656 - CP239_MOUSE

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Protein

Cytochrome P450 2C39

Gene
Cyp2c39
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET).

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP56656.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C39 (EC:1.14.14.1)
Alternative name(s):
CYPIIC39
Gene namesi
Name:Cyp2c39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1306818. Cyp2c39.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C39PRO_0000051722Add
BLAST

Proteomic databases

PaxDbiP56656.
PRIDEiP56656.

PTM databases

PhosphoSiteiP56656.

Expressioni

Tissue specificityi

Liver.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

GenevestigatoriP56656.

Interactioni

Protein-protein interaction databases

IntActiP56656. 2 interactions.
MINTiMINT-1865726.

Structurei

3D structure databases

ProteinModelPortaliP56656.
SMRiP56656. Positions 30-489.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00680000099783.
HOVERGENiHBG015789.
InParanoidiP56656.
KOiK07413.
OMAiNLACTIN.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56656-1 [UniParc]FASTAAdd to Basket

« Hide

MDLVTFLVLT LSSLILLSLW RQSCGRGSLP PGPTPFPIIG NFLQIDIKNV    50
SQSLTNFSKA YGPVFTLYLG SRPTVVLHGY EAVKEALIDH GEEFSDRGSI 100
PMVEKINNGL GIVFSNGNRW KEIRRFTLTT LRNLGMGKRN IEDRVQEEAQ 150
CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQDRFDYK DKDFLMLMEK 200
LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNVKYI RSYLLEKIKE 250
HQESLDVTNP RDFIDYYLIK QKQANHIQQA EFSLENLACT INNLFAAGTE 300
TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV IGRHRSPCMQ DRNHMPYTDA 350
MIHEVQRFIN LVPNNIPRAV TCDIKFRNYL IPKGTTVVTS LTSVLHDSKE 400
FPNPELFDPG HFLDANGNFK KSDHFMPFSA GKRVCAGEGL ARMELFLFLT 450
TILQNFKLKS LVHPKDIDMI PFVNGLIALP PHYQVCIIPR 490
Length:490
Mass (Da):55,827
Last modified:October 3, 2012 - v2
Checksum:iEE583A2B53CFC410
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471I → M in AAD13721. 1 Publication
Sequence conflicti47 – 471I → M in AAI39291. 1 Publication
Sequence conflicti47 – 471I → M in AAI39292. 1 Publication
Sequence conflicti50 – 501V → F in AAD13721. 1 Publication
Sequence conflicti50 – 501V → F in AAI39291. 1 Publication
Sequence conflicti50 – 501V → F in AAI39292. 1 Publication
Sequence conflicti460 – 4601S → P in AAD13721. 1 Publication
Sequence conflicti460 – 4601S → P in AAI39291. 1 Publication
Sequence conflicti460 – 4601S → P in AAI39292. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047726 mRNA. Translation: AAD13721.1.
AC117790 Genomic DNA. No translation available.
AC139233 Genomic DNA. No translation available.
CH466534 Genomic DNA. Translation: EDL41819.1.
BC139290 mRNA. Translation: AAI39291.1.
BC139291 mRNA. Translation: AAI39292.1.
CCDSiCCDS29795.1.
RefSeqiNP_034133.2. NM_010003.2.
UniGeneiMm.42101.

Genome annotation databases

EnsembliENSMUST00000025968; ENSMUSP00000025968; ENSMUSG00000025003.
GeneIDi13098.
KEGGimmu:13098.
UCSCiuc008hkb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047726 mRNA. Translation: AAD13721.1 .
AC117790 Genomic DNA. No translation available.
AC139233 Genomic DNA. No translation available.
CH466534 Genomic DNA. Translation: EDL41819.1 .
BC139290 mRNA. Translation: AAI39291.1 .
BC139291 mRNA. Translation: AAI39292.1 .
CCDSi CCDS29795.1.
RefSeqi NP_034133.2. NM_010003.2.
UniGenei Mm.42101.

3D structure databases

ProteinModelPortali P56656.
SMRi P56656. Positions 30-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P56656. 2 interactions.
MINTi MINT-1865726.

PTM databases

PhosphoSitei P56656.

Proteomic databases

PaxDbi P56656.
PRIDEi P56656.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025968 ; ENSMUSP00000025968 ; ENSMUSG00000025003 .
GeneIDi 13098.
KEGGi mmu:13098.
UCSCi uc008hkb.2. mouse.

Organism-specific databases

CTDi 13098.
MGIi MGI:1306818. Cyp2c39.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00680000099783.
HOVERGENi HBG015789.
InParanoidi P56656.
KOi K07413.
OMAi NLACTIN.
OrthoDBi EOG7RBZ85.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RK P56656.

Miscellaneous databases

NextBioi 283086.
PROi P56656.
SOURCEi Search...

Gene expression databases

Genevestigatori P56656.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
    Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
    Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCP239_MOUSE
AccessioniPrimary (citable) accession number: P56656
Secondary accession number(s): B9EIA6, G5E854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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