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Protein

Cytochrome P450 2C39

Gene

Cyp2c39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET).

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211981 Xenobiotics
R-MMU-211999 CYP2E1 reactions
R-MMU-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-MMU-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-MMU-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKiP56656

Chemistry databases

SwissLipidsiSLP:000001670

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C39 (EC:1.14.14.1)
Alternative name(s):
CYPIIC39
Gene namesi
Name:Cyp2c39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1306818 Cyp2c39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517221 – 490Cytochrome P450 2C39Add BLAST490

Proteomic databases

MaxQBiP56656
PaxDbiP56656
PeptideAtlasiP56656
PRIDEiP56656

PTM databases

iPTMnetiP56656
PhosphoSitePlusiP56656
SwissPalmiP56656

Expressioni

Tissue specificityi

Liver.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSMUSG00000025003
GenevisibleiP56656 MM

Interactioni

Protein-protein interaction databases

IntActiP56656, 2 interactors
MINTiP56656
STRINGi10090.ENSMUSP00000025968

Structurei

3D structure databases

ProteinModelPortaliP56656
SMRiP56656
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOVERGENiHBG015789
InParanoidiP56656
KOiK07413
OMAiQEMMDFI
OrthoDBiEOG091G0BT8
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P56656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVTFLVLT LSSLILLSLW RQSCGRGSLP PGPTPFPIIG NFLQIDIKNV
60 70 80 90 100
SQSLTNFSKA YGPVFTLYLG SRPTVVLHGY EAVKEALIDH GEEFSDRGSI
110 120 130 140 150
PMVEKINNGL GIVFSNGNRW KEIRRFTLTT LRNLGMGKRN IEDRVQEEAQ
160 170 180 190 200
CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQDRFDYK DKDFLMLMEK
210 220 230 240 250
LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNVKYI RSYLLEKIKE
260 270 280 290 300
HQESLDVTNP RDFIDYYLIK QKQANHIQQA EFSLENLACT INNLFAAGTE
310 320 330 340 350
TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV IGRHRSPCMQ DRNHMPYTDA
360 370 380 390 400
MIHEVQRFIN LVPNNIPRAV TCDIKFRNYL IPKGTTVVTS LTSVLHDSKE
410 420 430 440 450
FPNPELFDPG HFLDANGNFK KSDHFMPFSA GKRVCAGEGL ARMELFLFLT
460 470 480 490
TILQNFKLKS LVHPKDIDMI PFVNGLIALP PHYQVCIIPR
Length:490
Mass (Da):55,827
Last modified:October 3, 2012 - v2
Checksum:iEE583A2B53CFC410
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47I → M in AAD13721 (PubMed:9721182).Curated1
Sequence conflicti47I → M in AAI39291 (PubMed:15489334).Curated1
Sequence conflicti47I → M in AAI39292 (PubMed:15489334).Curated1
Sequence conflicti50V → F in AAD13721 (PubMed:9721182).Curated1
Sequence conflicti50V → F in AAI39291 (PubMed:15489334).Curated1
Sequence conflicti50V → F in AAI39292 (PubMed:15489334).Curated1
Sequence conflicti460S → P in AAD13721 (PubMed:9721182).Curated1
Sequence conflicti460S → P in AAI39291 (PubMed:15489334).Curated1
Sequence conflicti460S → P in AAI39292 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047726 mRNA Translation: AAD13721.1
AC117790 Genomic DNA No translation available.
AC139233 Genomic DNA No translation available.
CH466534 Genomic DNA Translation: EDL41819.1
BC139290 mRNA Translation: AAI39291.1
BC139291 mRNA Translation: AAI39292.1
CCDSiCCDS29795.1
RefSeqiNP_034133.2, NM_010003.2
UniGeneiMm.42101

Genome annotation databases

EnsembliENSMUST00000025968; ENSMUSP00000025968; ENSMUSG00000025003
GeneIDi13098
KEGGimmu:13098
UCSCiuc008hkb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCP239_MOUSE
AccessioniPrimary (citable) accession number: P56656
Secondary accession number(s): B9EIA6, G5E854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2012
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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