Cytochrome P450 2C39 - Mus musculus (Mouse)

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P56656 (CP239_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 88. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome P450 2C39
EC=1.14.14.1

Alternative name(s):
CYPIIC39

Gene names

Name:

Cyp2c39

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET).
Catalytic activity	RH + reduced flavoprotein + O₂ = ROH + oxidized flavoprotein + H₂O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue specificity	Liver.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 490

490

Cytochrome P450 2C39

PRO_0000051722

Sites

Metal binding

435

Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict

I → M in AAD13721. Ref.1

Sequence conflict

I → M in AAI39291. Ref.4

Sequence conflict

I → M in AAI39292. Ref.4

Sequence conflict

V → F in AAD13721. Ref.1

Sequence conflict

V → F in AAI39291. Ref.4

Sequence conflict

V → F in AAI39292. Ref.4

Sequence conflict

460

S → P in AAD13721. Ref.1

Sequence conflict

460

S → P in AAI39291. Ref.4

Sequence conflict

460

S → P in AAI39292. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

P56656 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: EE583A2B53CFC410
Show »

FASTA

490

55,827

        10         20         30         40         50         60 
MDLVTFLVLT LSSLILLSLW RQSCGRGSLP PGPTPFPIIG NFLQIDIKNV SQSLTNFSKA 

        70         80         90        100        110        120 
YGPVFTLYLG SRPTVVLHGY EAVKEALIDH GEEFSDRGSI PMVEKINNGL GIVFSNGNRW 

       130        140        150        160        170        180 
KEIRRFTLTT LRNLGMGKRN IEDRVQEEAQ CLVEELRKTK GSPCDPTFIL SCAPCNVICS 

       190        200        210        220        230        240 
IIFQDRFDYK DKDFLMLMEK LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNVKYI 

       250        260        270        280        290        300 
RSYLLEKIKE HQESLDVTNP RDFIDYYLIK QKQANHIQQA EFSLENLACT INNLFAAGTE 

       310        320        330        340        350        360 
TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV IGRHRSPCMQ DRNHMPYTDA MIHEVQRFIN 

       370        380        390        400        410        420 
LVPNNIPRAV TCDIKFRNYL IPKGTTVVTS LTSVLHDSKE FPNPELFDPG HFLDANGNFK 

       430        440        450        460        470        480 
KSDHFMPFSA GKRVCAGEGL ARMELFLFLT TILQNFKLKS LVHPKDIDMI PFVNGLIALP 

       490 
PHYQVCIIPR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid." Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A. Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF047726 mRNA. Translation: AAD13721.1. AC117790 Genomic DNA. No translation available. AC139233 Genomic DNA. No translation available. CH466534 Genomic DNA. Translation: EDL41819.1. BC139290 mRNA. Translation: AAI39291.1. BC139291 mRNA. Translation: AAI39292.1.
IPI	IPI00114780.
RefSeq	NP_034133.2. NM_010003.2.
UniGene	Mm.42101.
3D structure databases
ProteinModelPortal	P56656.
SMR	P56656. Positions 30-489.
ModBase	Search...
PTM databases
PhosphoSite	P56656.
Proteomic databases
PaxDb	P56656.
PRIDE	P56656.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025968; ENSMUSP00000025968; ENSMUSG00000025003.
GeneID	13098.
KEGG	mmu:13098.
Organism-specific databases
CTD	13098.
MGI	MGI:1306818. Cyp2c39.
Phylogenomic databases
eggNOG	COG2124.
GeneTree	ENSGT00680000099783.
HOVERGEN	HBG015789.
InParanoid	P56656.
KO	K07413.
OMA	SEYSHEN.
OrthoDB	EOG48WC22.
Enzyme and pathway databases
SABIO-RK	P56656.
Gene expression databases
Genevestigator	P56656.
GermOnline	ENSMUSG00000025003. Mus musculus.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	283086.
SOURCE	Search...

Entry information

Entry name

CP239_MOUSE

Accession

Primary (citable) accession number: P56656
Secondary accession number(s): B9EIA6, G5E854

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	October 3, 2012
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents