Reviewed, UniProtKB/Swiss-Prot P56656 (CP239_MOUSE)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 2C39
    EC=1.14.14.1
Alternative name(s):
    CYPIIC39

Gene names

Name:

Cyp2c39

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET).
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue specificity	Liver.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Cytochrome P450 2C39		PRO_0000051722
Sites
	Metal binding	435	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56656-1 [UniParc]. Last modified July 15, 1999. Version 1. Checksum: 97EF56D0A4B728C3	FASTA	490	55,903
	10 20 30 40 50 60 MDLVTFLVLT LSSLILLSLW RQSCGRGSLP PGPTPFPIIG NFLQIDMKNF SQSLTNFSKA 70 80 90 100 110 120 YGPVFTLYLG SRPTVVLHGY EAVKEALIDH GEEFSDRGSI PMVEKINNGL GIVFSNGNRW 130 140 150 160 170 180 KEIRRFTLTT LRNLGMGKRN IEDRVQEEAQ CLVEELRKTK GSPCDPTFIL SCAPCNVICS 190 200 210 220 230 240 IIFQDRFDYK DKDFLMLMEK LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNVKYI 250 260 270 280 290 300 RSYLLEKIKE HQESLDVTNP RDFIDYYLIK QKQANHIQQA EFSLENLACT INNLFAAGTE 310 320 330 340 350 360 TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV IGRHRSPCMQ DRNHMPYTDA MIHEVQRFIN 370 380 390 400 410 420 LVPNNIPRAV TCDIKFRNYL IPKGTTVVTS LTSVLHDSKE FPNPELFDPG HFLDANGNFK 430 440 450 460 470 480 KSDHFMPFSA GKRVCAGEGL ARMELFLFLT TILQNFKLKP LVHPKDIDMI PFVNGLIALP 490 PHYQVCIIPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid." Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A. Arch. Biochem. Biophys. 357:45-57(1998) [PubMed: 9721182] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF047726 mRNA. Translation: AAD13721.1. BC139290 mRNA. Translation: AAI39291.1. BC139291 mRNA. Translation: AAI39292.1.
IPI	IPI00114780.
UniGene	Mm.42101
3D structure databases
HSSP	HSSP built from PDB template 1DT6 based on UniProtKB P00179.
SMR	P56656. Positions 44-489.
ModBase	Search...
Protein-protein interaction databases
STRING	P56656.
PTM databases
PhosphoSite	P56656.
Proteomic databases
PRIDE	P56656.
Genome annotation databases
Ensembl	ENSMUST00000025968; ENSMUSP00000025968; ENSMUSG00000025003; Mus musculus. [Genome view]
UCSC	uc008hkb.1. mouse.
Organism-specific databases
CTD	13098.
MGI	MGI:1306818. Cyp2c39.
Phylogenomic databases
HOVERGEN	P56656.
Enzyme and pathway databases
BRENDA	1.14.14.1. 244.
Gene expression databases
ArrayExpress	P56656.
Bgee	P56656.
Genevestigator	P56656.
GermOnline	ENSMUSG00000025003. Mus musculus.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	283086.
SOURCE	Search...

Entry information

Entry name

CP239_MOUSE

Accession

Primary (citable) accession number: P56656
Secondary accession number(s): B9EIA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	October 13, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)