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P56656 (CP239_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C39

EC=1.14.14.1
Alternative name(s):
CYPIIC39
Gene names
Name:Cyp2c39
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET).

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Liver.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C39
PRO_0000051722

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict471I → M in AAD13721. Ref.1
Sequence conflict471I → M in AAI39291. Ref.4
Sequence conflict471I → M in AAI39292. Ref.4
Sequence conflict501V → F in AAD13721. Ref.1
Sequence conflict501V → F in AAI39291. Ref.4
Sequence conflict501V → F in AAI39292. Ref.4
Sequence conflict4601S → P in AAD13721. Ref.1
Sequence conflict4601S → P in AAI39291. Ref.4
Sequence conflict4601S → P in AAI39292. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P56656 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: EE583A2B53CFC410

FASTA49055,827
        10         20         30         40         50         60 
MDLVTFLVLT LSSLILLSLW RQSCGRGSLP PGPTPFPIIG NFLQIDIKNV SQSLTNFSKA 

        70         80         90        100        110        120 
YGPVFTLYLG SRPTVVLHGY EAVKEALIDH GEEFSDRGSI PMVEKINNGL GIVFSNGNRW 

       130        140        150        160        170        180 
KEIRRFTLTT LRNLGMGKRN IEDRVQEEAQ CLVEELRKTK GSPCDPTFIL SCAPCNVICS 

       190        200        210        220        230        240 
IIFQDRFDYK DKDFLMLMEK LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNVKYI 

       250        260        270        280        290        300 
RSYLLEKIKE HQESLDVTNP RDFIDYYLIK QKQANHIQQA EFSLENLACT INNLFAAGTE 

       310        320        330        340        350        360 
TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV IGRHRSPCMQ DRNHMPYTDA MIHEVQRFIN 

       370        380        390        400        410        420 
LVPNNIPRAV TCDIKFRNYL IPKGTTVVTS LTSVLHDSKE FPNPELFDPG HFLDANGNFK 

       430        440        450        460        470        480 
KSDHFMPFSA GKRVCAGEGL ARMELFLFLT TILQNFKLKS LVHPKDIDMI PFVNGLIALP 

       490 
PHYQVCIIPR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF047726 mRNA. Translation: AAD13721.1.
AC117790 Genomic DNA. No translation available.
AC139233 Genomic DNA. No translation available.
CH466534 Genomic DNA. Translation: EDL41819.1.
BC139290 mRNA. Translation: AAI39291.1.
BC139291 mRNA. Translation: AAI39292.1.
CCDSCCDS29795.1.
RefSeqNP_034133.2. NM_010003.2.
UniGeneMm.42101.

3D structure databases

ProteinModelPortalP56656.
SMRP56656. Positions 30-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP56656. 2 interactions.
MINTMINT-1865726.

PTM databases

PhosphoSiteP56656.

Proteomic databases

PaxDbP56656.
PRIDEP56656.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025968; ENSMUSP00000025968; ENSMUSG00000025003.
GeneID13098.
KEGGmmu:13098.
UCSCuc008hkb.2. mouse.

Organism-specific databases

CTD13098.
MGIMGI:1306818. Cyp2c39.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00680000099783.
HOVERGENHBG015789.
InParanoidP56656.
KOK07413.
OMANLACTIN.
OrthoDBEOG7RBZ85.
TreeFamTF352043.

Enzyme and pathway databases

SABIO-RKP56656.

Gene expression databases

GenevestigatorP56656.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283086.
PROP56656.
SOURCESearch...

Entry information

Entry nameCP239_MOUSE
AccessionPrimary (citable) accession number: P56656
Secondary accession number(s): B9EIA6, G5E854
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot