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P56656

- CP239_MOUSE

UniProt

P56656 - CP239_MOUSE

Protein

Cytochrome P450 2C39

Gene

Cyp2c39

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET).

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    SABIO-RKP56656.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C39 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC39
    Gene namesi
    Name:Cyp2c39
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1306818. Cyp2c39.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C39PRO_0000051722Add
    BLAST

    Proteomic databases

    PaxDbiP56656.
    PRIDEiP56656.

    PTM databases

    PhosphoSiteiP56656.

    Expressioni

    Tissue specificityi

    Liver.

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    GenevestigatoriP56656.

    Interactioni

    Protein-protein interaction databases

    IntActiP56656. 2 interactions.
    MINTiMINT-1865726.

    Structurei

    3D structure databases

    ProteinModelPortaliP56656.
    SMRiP56656. Positions 30-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00680000099783.
    HOVERGENiHBG015789.
    InParanoidiP56656.
    KOiK07413.
    OMAiNLACTIN.
    OrthoDBiEOG7RBZ85.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56656-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLVTFLVLT LSSLILLSLW RQSCGRGSLP PGPTPFPIIG NFLQIDIKNV    50
    SQSLTNFSKA YGPVFTLYLG SRPTVVLHGY EAVKEALIDH GEEFSDRGSI 100
    PMVEKINNGL GIVFSNGNRW KEIRRFTLTT LRNLGMGKRN IEDRVQEEAQ 150
    CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQDRFDYK DKDFLMLMEK 200
    LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNVKYI RSYLLEKIKE 250
    HQESLDVTNP RDFIDYYLIK QKQANHIQQA EFSLENLACT INNLFAAGTE 300
    TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV IGRHRSPCMQ DRNHMPYTDA 350
    MIHEVQRFIN LVPNNIPRAV TCDIKFRNYL IPKGTTVVTS LTSVLHDSKE 400
    FPNPELFDPG HFLDANGNFK KSDHFMPFSA GKRVCAGEGL ARMELFLFLT 450
    TILQNFKLKS LVHPKDIDMI PFVNGLIALP PHYQVCIIPR 490
    Length:490
    Mass (Da):55,827
    Last modified:October 3, 2012 - v2
    Checksum:iEE583A2B53CFC410
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471I → M in AAD13721. (PubMed:9721182)Curated
    Sequence conflicti47 – 471I → M in AAI39291. (PubMed:15489334)Curated
    Sequence conflicti47 – 471I → M in AAI39292. (PubMed:15489334)Curated
    Sequence conflicti50 – 501V → F in AAD13721. (PubMed:9721182)Curated
    Sequence conflicti50 – 501V → F in AAI39291. (PubMed:15489334)Curated
    Sequence conflicti50 – 501V → F in AAI39292. (PubMed:15489334)Curated
    Sequence conflicti460 – 4601S → P in AAD13721. (PubMed:9721182)Curated
    Sequence conflicti460 – 4601S → P in AAI39291. (PubMed:15489334)Curated
    Sequence conflicti460 – 4601S → P in AAI39292. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047726 mRNA. Translation: AAD13721.1.
    AC117790 Genomic DNA. No translation available.
    AC139233 Genomic DNA. No translation available.
    CH466534 Genomic DNA. Translation: EDL41819.1.
    BC139290 mRNA. Translation: AAI39291.1.
    BC139291 mRNA. Translation: AAI39292.1.
    CCDSiCCDS29795.1.
    RefSeqiNP_034133.2. NM_010003.2.
    UniGeneiMm.42101.

    Genome annotation databases

    EnsembliENSMUST00000025968; ENSMUSP00000025968; ENSMUSG00000025003.
    GeneIDi13098.
    KEGGimmu:13098.
    UCSCiuc008hkb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047726 mRNA. Translation: AAD13721.1 .
    AC117790 Genomic DNA. No translation available.
    AC139233 Genomic DNA. No translation available.
    CH466534 Genomic DNA. Translation: EDL41819.1 .
    BC139290 mRNA. Translation: AAI39291.1 .
    BC139291 mRNA. Translation: AAI39292.1 .
    CCDSi CCDS29795.1.
    RefSeqi NP_034133.2. NM_010003.2.
    UniGenei Mm.42101.

    3D structure databases

    ProteinModelPortali P56656.
    SMRi P56656. Positions 30-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P56656. 2 interactions.
    MINTi MINT-1865726.

    PTM databases

    PhosphoSitei P56656.

    Proteomic databases

    PaxDbi P56656.
    PRIDEi P56656.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025968 ; ENSMUSP00000025968 ; ENSMUSG00000025003 .
    GeneIDi 13098.
    KEGGi mmu:13098.
    UCSCi uc008hkb.2. mouse.

    Organism-specific databases

    CTDi 13098.
    MGIi MGI:1306818. Cyp2c39.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00680000099783.
    HOVERGENi HBG015789.
    InParanoidi P56656.
    KOi K07413.
    OMAi NLACTIN.
    OrthoDBi EOG7RBZ85.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    SABIO-RK P56656.

    Miscellaneous databases

    NextBioi 283086.
    PROi P56656.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P56656.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
      Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
      Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCP239_MOUSE
    AccessioniPrimary (citable) accession number: P56656
    Secondary accession number(s): B9EIA6, G5E854
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3