Reviewed,
UniProtKB/Swiss-Prot P56656 (CP239_MOUSE)
Last modified
October 13, 2009.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytochrome P450 2C39 EC=1.14.14.1 Alternative name(s): CYPIIC39 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 490 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET). |
| Catalytic activity | RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. |
| Cofactor | Heme group By similarity. |
| Subcellular location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Tissue specificity | Liver. |
| Induction | P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Microsome |
| Ligand | Heme Iron Metal-binding |
| Molecular function | Monooxygenase Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membraneInferred from electronic annotation. Source: UniProtKB-SubCell microsomeInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | aromatase activity Inferred from electronic annotation. Source: EC electron carrier activityInferred from electronic annotation. Source: InterPro heme bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid." Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A. Arch. Biochem. Biophys. 357:45-57(1998) [PubMed: 9721182] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF047726 mRNA. Translation: AAD13721.1. BC139290 mRNA. Translation: AAI39291.1. BC139291 mRNA. Translation: AAI39292.1. | |
| IPI | IPI00114780. |
| UniGene | Mm.42101 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DT6 based on UniProtKB P00179. |
| SMR | P56656. Positions 44-489. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P56656. |
PTM databases | |
| PhosphoSite | P56656. |
Proteomic databases | |
| PRIDE | P56656. |
Genome annotation databases | |
| Ensembl | ENSMUST00000025968; ENSMUSP00000025968; ENSMUSG00000025003; Mus musculus. [Genome view] |
| UCSC | uc008hkb.1. mouse. |
Organism-specific databases | |
| CTD | 13098. |
| MGI | MGI:1306818. Cyp2c39. |
Phylogenomic databases | |
| HOVERGEN | P56656. |
Enzyme and pathway databases | |
| BRENDA | 1.14.14.1. 244. |
Gene expression databases | |
| ArrayExpress | P56656. |
| Bgee | P56656. |
| Genevestigator | P56656. |
| GermOnline | ENSMUSG00000025003. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view] |
| Gene3D | G3DSA:1.10.630.10. Cyt_P450. 1 hit. |
| PANTHER | PTHR19383. Cyt_P450. 1 hit. |
| Pfam | PF00067. p450. 1 hit. [Graphical view] |
| PRINTS | PR00463. EP450I. PR00385. P450. |
| PROSITE | PS00086. CYTOCHROME_P450. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 283086. |
| SOURCE | Search... |
Entry information
| Entry name | CP239_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P56656 Secondary accession number(s): B9EIA6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


