Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome P450 2C38

Gene

Cyp2c38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Metabolizes arachidonic acid to produce 11,12-epoxyeicosatrienoic acid (EET).

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. arachidonic acid epoxygenase activity Source: GO_Central
  2. aromatase activity Source: UniProtKB-EC
  3. caffeine oxidase activity Source: MGI
  4. heme binding Source: GO_Central
  5. iron ion binding Source: InterPro
  6. monooxygenase activity Source: MGI
  7. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
  8. oxygen binding Source: GO_Central
  9. steroid hydroxylase activity Source: GO_Central

GO - Biological processi

  1. epoxygenase P450 pathway Source: GO_Central
  2. exogenous drug catabolic process Source: GO_Central
  3. oxidation-reduction process Source: GO_Central
  4. xenobiotic metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_245291. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C38 (EC:1.14.14.1)
Alternative name(s):
CYPIIC38
Gene namesi
Name:Cyp2c38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1306819. Cyp2c38.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. intracellular membrane-bounded organelle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C38PRO_0000051721Add
BLAST

Proteomic databases

PaxDbiP56655.
PRIDEiP56655.

Expressioni

Tissue specificityi

Liver, brain, kidney, and intestine, with trace amounts in lung and heart.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

GenevestigatoriP56655.

Interactioni

Protein-protein interaction databases

MINTiMINT-1865676.

Structurei

3D structure databases

ProteinModelPortaliP56655.
SMRiP56655. Positions 28-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP56655.
KOiK07413.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56655-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLVTFLVLT LSSLILLSLW RQRSRRGRLP PGPTPFPIIG NFLQIDVKNF
60 70 80 90 100
NQSLTNFSKT YGPVFTLYLG SRPIVVLHGY EAVKEALIDH GEEFSGRENI
110 120 130 140 150
PMSEKINNGL GITFSNGNSW KETRRFTLMT LRNLGMGKRN IEDRVREEAQ
160 170 180 190 200
CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQDRFDYK DKDFLMLMKK
210 220 230 240 250
LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNFKYI RSYLLEKVKE
260 270 280 290 300
HQESLDVTNP RDFIDYFLIK QKQANHIEQA EYSLENLVCT INNLFAAGTE
310 320 330 340 350
TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV VGRHRSPCMQ DRSRMPYTDA
360 370 380 390 400
MIHEVQRFIN LVPNNLPHAV TCDIKFRNYI IPKGTTVVTS LTSVLHDSKE
410 420 430 440 450
FPNPEMFDPG HFLDANGNFK KSDYFMTFSA GKRVCAGEGL ARMELFLILT
460 470 480 490
TILQNFKLKS LVHPKDIDMI PFVNGLITLP PHYQLCFIPL
Length:490
Mass (Da):56,229
Last modified:October 3, 2012 - v2
Checksum:i876444B4A6C1343A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601T → A in AAD13720. (PubMed:9721182)Curated
Sequence conflicti60 – 601T → A in AAI50722. (PubMed:15489334)Curated
Sequence conflicti98 – 981E → G in AAD13720. (PubMed:9721182)Curated
Sequence conflicti98 – 981E → G in AAI50722. (PubMed:15489334)Curated
Sequence conflicti125 – 1251R → H in AAD13720. (PubMed:9721182)Curated
Sequence conflicti125 – 1251R → H in AAI50722. (PubMed:15489334)Curated
Sequence conflicti188 – 1881D → H in AAD13720. (PubMed:9721182)Curated
Sequence conflicti188 – 1881D → H in AAI50722. (PubMed:15489334)Curated
Sequence conflicti253 – 2531E → A in AAD13720. (PubMed:9721182)Curated
Sequence conflicti253 – 2531E → A in AAI50722. (PubMed:15489334)Curated
Sequence conflicti257 – 2571V → F in AAD13720. (PubMed:9721182)Curated
Sequence conflicti257 – 2571V → F in AAI50722. (PubMed:15489334)Curated
Sequence conflicti344 – 3441R → H in AAD13720. (PubMed:9721182)Curated
Sequence conflicti344 – 3441R → H in AAI50722. (PubMed:15489334)Curated
Sequence conflicti470 – 4701I → M in AAD13720. (PubMed:9721182)Curated
Sequence conflicti470 – 4701I → M in AAI50722. (PubMed:15489334)Curated
Sequence conflicti478 – 4781T → A in AAD13720. (PubMed:9721182)Curated
Sequence conflicti478 – 4781T → A in AAI50722. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047725 mRNA. Translation: AAD13720.1.
AC139233 Genomic DNA. No translation available.
BC150721 mRNA. Translation: AAI50722.1.
CCDSiCCDS29794.1.
RefSeqiNP_034132.2. NM_010002.3.
UniGeneiMm.42100.

Genome annotation databases

EnsembliENSMUST00000035488; ENSMUSP00000044722; ENSMUSG00000032808.
GeneIDi13097.
KEGGimmu:13097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047725 mRNA. Translation: AAD13720.1.
AC139233 Genomic DNA. No translation available.
BC150721 mRNA. Translation: AAI50722.1.
CCDSiCCDS29794.1.
RefSeqiNP_034132.2. NM_010002.3.
UniGeneiMm.42100.

3D structure databases

ProteinModelPortaliP56655.
SMRiP56655. Positions 28-490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1865676.

Proteomic databases

PaxDbiP56655.
PRIDEiP56655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035488; ENSMUSP00000044722; ENSMUSG00000032808.
GeneIDi13097.
KEGGimmu:13097.

Organism-specific databases

CTDi13097.
MGIiMGI:1306819. Cyp2c38.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP56655.
KOiK07413.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_245291. Xenobiotics.

Miscellaneous databases

NextBioi283082.
PROiP56655.
SOURCEiSearch...

Gene expression databases

GenevestigatoriP56655.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
    Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
    Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCP238_MOUSE
AccessioniPrimary (citable) accession number: P56655
Secondary accession number(s): B2RWV4, F8VPK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2012
Last modified: February 4, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.