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Protein

Cytochrome P450 2C38

Gene

Cyp2c38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metabolizes arachidonic acid to produce 11,12-epoxyeicosatrienoic acid (EET).

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211981 Xenobiotics
R-MMU-211999 CYP2E1 reactions
R-MMU-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-MMU-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-MMU-9027307 Biosynthesis of maresin-like SPMs

Chemistry databases

SwissLipidsiSLP:000001669

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C38 (EC:1.14.14.1)
Alternative name(s):
CYPIIC38
Gene namesi
Name:Cyp2c38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1306819 Cyp2c38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517211 – 490Cytochrome P450 2C38Add BLAST490

Proteomic databases

MaxQBiP56655
PaxDbiP56655
PeptideAtlasiP56655
PRIDEiP56655

PTM databases

iPTMnetiP56655
PhosphoSitePlusiP56655

Expressioni

Tissue specificityi

Liver, brain, kidney, and intestine, with trace amounts in lung and heart.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSMUSG00000032808
GenevisibleiP56655 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044722

Structurei

3D structure databases

ProteinModelPortaliP56655
SMRiP56655
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP56655
KOiK07413
OMAiMIAGAFE
OrthoDBiEOG091G0BT8
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P56655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVTFLVLT LSSLILLSLW RQRSRRGRLP PGPTPFPIIG NFLQIDVKNF
60 70 80 90 100
NQSLTNFSKT YGPVFTLYLG SRPIVVLHGY EAVKEALIDH GEEFSGRENI
110 120 130 140 150
PMSEKINNGL GITFSNGNSW KETRRFTLMT LRNLGMGKRN IEDRVREEAQ
160 170 180 190 200
CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQDRFDYK DKDFLMLMKK
210 220 230 240 250
LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNFKYI RSYLLEKVKE
260 270 280 290 300
HQESLDVTNP RDFIDYFLIK QKQANHIEQA EYSLENLVCT INNLFAAGTE
310 320 330 340 350
TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV VGRHRSPCMQ DRSRMPYTDA
360 370 380 390 400
MIHEVQRFIN LVPNNLPHAV TCDIKFRNYI IPKGTTVVTS LTSVLHDSKE
410 420 430 440 450
FPNPEMFDPG HFLDANGNFK KSDYFMTFSA GKRVCAGEGL ARMELFLILT
460 470 480 490
TILQNFKLKS LVHPKDIDMI PFVNGLITLP PHYQLCFIPL
Length:490
Mass (Da):56,229
Last modified:October 3, 2012 - v2
Checksum:i876444B4A6C1343A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60T → A in AAD13720 (PubMed:9721182).Curated1
Sequence conflicti60T → A in AAI50722 (PubMed:15489334).Curated1
Sequence conflicti98E → G in AAD13720 (PubMed:9721182).Curated1
Sequence conflicti98E → G in AAI50722 (PubMed:15489334).Curated1
Sequence conflicti125R → H in AAD13720 (PubMed:9721182).Curated1
Sequence conflicti125R → H in AAI50722 (PubMed:15489334).Curated1
Sequence conflicti188D → H in AAD13720 (PubMed:9721182).Curated1
Sequence conflicti188D → H in AAI50722 (PubMed:15489334).Curated1
Sequence conflicti253E → A in AAD13720 (PubMed:9721182).Curated1
Sequence conflicti253E → A in AAI50722 (PubMed:15489334).Curated1
Sequence conflicti257V → F in AAD13720 (PubMed:9721182).Curated1
Sequence conflicti257V → F in AAI50722 (PubMed:15489334).Curated1
Sequence conflicti344R → H in AAD13720 (PubMed:9721182).Curated1
Sequence conflicti344R → H in AAI50722 (PubMed:15489334).Curated1
Sequence conflicti470I → M in AAD13720 (PubMed:9721182).Curated1
Sequence conflicti470I → M in AAI50722 (PubMed:15489334).Curated1
Sequence conflicti478T → A in AAD13720 (PubMed:9721182).Curated1
Sequence conflicti478T → A in AAI50722 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047725 mRNA Translation: AAD13720.1
AC139233 Genomic DNA No translation available.
BC150721 mRNA Translation: AAI50722.1
CCDSiCCDS29794.1
RefSeqiNP_034132.2, NM_010002.3
UniGeneiMm.42100

Genome annotation databases

EnsembliENSMUST00000035488; ENSMUSP00000044722; ENSMUSG00000032808
GeneIDi13097
KEGGimmu:13097
UCSCiuc008hka.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCP238_MOUSE
AccessioniPrimary (citable) accession number: P56655
Secondary accession number(s): B2RWV4, F8VPK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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