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P56655

- CP238_MOUSE

UniProt

P56655 - CP238_MOUSE

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Protein

Cytochrome P450 2C38

Gene

Cyp2c38

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Metabolizes arachidonic acid to produce 11,12-epoxyeicosatrienoic acid (EET).

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C38 (EC:1.14.14.1)
Alternative name(s):
CYPIIC38
Gene namesi
Name:Cyp2c38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1306819. Cyp2c38.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C38PRO_0000051721Add
BLAST

Proteomic databases

PaxDbiP56655.
PRIDEiP56655.

Expressioni

Tissue specificityi

Liver, brain, kidney, and intestine, with trace amounts in lung and heart.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

GenevestigatoriP56655.

Interactioni

Protein-protein interaction databases

MINTiMINT-1865676.

Structurei

3D structure databases

ProteinModelPortaliP56655.
SMRiP56655. Positions 28-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP56655.
KOiK07413.
OMAiSHENLAC.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56655-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLVTFLVLT LSSLILLSLW RQRSRRGRLP PGPTPFPIIG NFLQIDVKNF
60 70 80 90 100
NQSLTNFSKT YGPVFTLYLG SRPIVVLHGY EAVKEALIDH GEEFSGRENI
110 120 130 140 150
PMSEKINNGL GITFSNGNSW KETRRFTLMT LRNLGMGKRN IEDRVREEAQ
160 170 180 190 200
CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQDRFDYK DKDFLMLMKK
210 220 230 240 250
LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNFKYI RSYLLEKVKE
260 270 280 290 300
HQESLDVTNP RDFIDYFLIK QKQANHIEQA EYSLENLVCT INNLFAAGTE
310 320 330 340 350
TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV VGRHRSPCMQ DRSRMPYTDA
360 370 380 390 400
MIHEVQRFIN LVPNNLPHAV TCDIKFRNYI IPKGTTVVTS LTSVLHDSKE
410 420 430 440 450
FPNPEMFDPG HFLDANGNFK KSDYFMTFSA GKRVCAGEGL ARMELFLILT
460 470 480 490
TILQNFKLKS LVHPKDIDMI PFVNGLITLP PHYQLCFIPL
Length:490
Mass (Da):56,229
Last modified:October 3, 2012 - v2
Checksum:i876444B4A6C1343A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601T → A in AAD13720. (PubMed:9721182)Curated
Sequence conflicti60 – 601T → A in AAI50722. (PubMed:15489334)Curated
Sequence conflicti98 – 981E → G in AAD13720. (PubMed:9721182)Curated
Sequence conflicti98 – 981E → G in AAI50722. (PubMed:15489334)Curated
Sequence conflicti125 – 1251R → H in AAD13720. (PubMed:9721182)Curated
Sequence conflicti125 – 1251R → H in AAI50722. (PubMed:15489334)Curated
Sequence conflicti188 – 1881D → H in AAD13720. (PubMed:9721182)Curated
Sequence conflicti188 – 1881D → H in AAI50722. (PubMed:15489334)Curated
Sequence conflicti253 – 2531E → A in AAD13720. (PubMed:9721182)Curated
Sequence conflicti253 – 2531E → A in AAI50722. (PubMed:15489334)Curated
Sequence conflicti257 – 2571V → F in AAD13720. (PubMed:9721182)Curated
Sequence conflicti257 – 2571V → F in AAI50722. (PubMed:15489334)Curated
Sequence conflicti344 – 3441R → H in AAD13720. (PubMed:9721182)Curated
Sequence conflicti344 – 3441R → H in AAI50722. (PubMed:15489334)Curated
Sequence conflicti470 – 4701I → M in AAD13720. (PubMed:9721182)Curated
Sequence conflicti470 – 4701I → M in AAI50722. (PubMed:15489334)Curated
Sequence conflicti478 – 4781T → A in AAD13720. (PubMed:9721182)Curated
Sequence conflicti478 – 4781T → A in AAI50722. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047725 mRNA. Translation: AAD13720.1.
AC139233 Genomic DNA. No translation available.
BC150721 mRNA. Translation: AAI50722.1.
CCDSiCCDS29794.1.
RefSeqiNP_034132.2. NM_010002.3.
UniGeneiMm.42100.

Genome annotation databases

EnsembliENSMUST00000035488; ENSMUSP00000044722; ENSMUSG00000032808.
GeneIDi13097.
KEGGimmu:13097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047725 mRNA. Translation: AAD13720.1 .
AC139233 Genomic DNA. No translation available.
BC150721 mRNA. Translation: AAI50722.1 .
CCDSi CCDS29794.1.
RefSeqi NP_034132.2. NM_010002.3.
UniGenei Mm.42100.

3D structure databases

ProteinModelPortali P56655.
SMRi P56655. Positions 28-490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1865676.

Proteomic databases

PaxDbi P56655.
PRIDEi P56655.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035488 ; ENSMUSP00000044722 ; ENSMUSG00000032808 .
GeneIDi 13097.
KEGGi mmu:13097.

Organism-specific databases

CTDi 13097.
MGIi MGI:1306819. Cyp2c38.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P56655.
KOi K07413.
OMAi SHENLAC.
OrthoDBi EOG7RBZ85.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Miscellaneous databases

NextBioi 283082.
PROi P56655.
SOURCEi Search...

Gene expression databases

Genevestigatori P56655.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
    Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
    Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCP238_MOUSE
AccessioniPrimary (citable) accession number: P56655
Secondary accession number(s): B2RWV4, F8VPK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3