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P56655

- CP238_MOUSE

UniProt

P56655 - CP238_MOUSE

Protein

Cytochrome P450 2C38

Gene

Cyp2c38

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Metabolizes arachidonic acid to produce 11,12-epoxyeicosatrienoic acid (EET).

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C38 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC38
    Gene namesi
    Name:Cyp2c38
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1306819. Cyp2c38.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C38PRO_0000051721Add
    BLAST

    Proteomic databases

    PaxDbiP56655.
    PRIDEiP56655.

    Expressioni

    Tissue specificityi

    Liver, brain, kidney, and intestine, with trace amounts in lung and heart.

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    GenevestigatoriP56655.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1865676.

    Structurei

    3D structure databases

    ProteinModelPortaliP56655.
    SMRiP56655. Positions 28-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00680000099783.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiB2RWV4.
    KOiK07413.
    OMAiSHENLAC.
    OrthoDBiEOG7RBZ85.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56655-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLVTFLVLT LSSLILLSLW RQRSRRGRLP PGPTPFPIIG NFLQIDVKNF    50
    NQSLTNFSKT YGPVFTLYLG SRPIVVLHGY EAVKEALIDH GEEFSGRENI 100
    PMSEKINNGL GITFSNGNSW KETRRFTLMT LRNLGMGKRN IEDRVREEAQ 150
    CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQDRFDYK DKDFLMLMKK 200
    LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNFKYI RSYLLEKVKE 250
    HQESLDVTNP RDFIDYFLIK QKQANHIEQA EYSLENLVCT INNLFAAGTE 300
    TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV VGRHRSPCMQ DRSRMPYTDA 350
    MIHEVQRFIN LVPNNLPHAV TCDIKFRNYI IPKGTTVVTS LTSVLHDSKE 400
    FPNPEMFDPG HFLDANGNFK KSDYFMTFSA GKRVCAGEGL ARMELFLILT 450
    TILQNFKLKS LVHPKDIDMI PFVNGLITLP PHYQLCFIPL 490
    Length:490
    Mass (Da):56,229
    Last modified:October 3, 2012 - v2
    Checksum:i876444B4A6C1343A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601T → A in AAD13720. (PubMed:9721182)Curated
    Sequence conflicti60 – 601T → A in AAI50722. (PubMed:15489334)Curated
    Sequence conflicti98 – 981E → G in AAD13720. (PubMed:9721182)Curated
    Sequence conflicti98 – 981E → G in AAI50722. (PubMed:15489334)Curated
    Sequence conflicti125 – 1251R → H in AAD13720. (PubMed:9721182)Curated
    Sequence conflicti125 – 1251R → H in AAI50722. (PubMed:15489334)Curated
    Sequence conflicti188 – 1881D → H in AAD13720. (PubMed:9721182)Curated
    Sequence conflicti188 – 1881D → H in AAI50722. (PubMed:15489334)Curated
    Sequence conflicti253 – 2531E → A in AAD13720. (PubMed:9721182)Curated
    Sequence conflicti253 – 2531E → A in AAI50722. (PubMed:15489334)Curated
    Sequence conflicti257 – 2571V → F in AAD13720. (PubMed:9721182)Curated
    Sequence conflicti257 – 2571V → F in AAI50722. (PubMed:15489334)Curated
    Sequence conflicti344 – 3441R → H in AAD13720. (PubMed:9721182)Curated
    Sequence conflicti344 – 3441R → H in AAI50722. (PubMed:15489334)Curated
    Sequence conflicti470 – 4701I → M in AAD13720. (PubMed:9721182)Curated
    Sequence conflicti470 – 4701I → M in AAI50722. (PubMed:15489334)Curated
    Sequence conflicti478 – 4781T → A in AAD13720. (PubMed:9721182)Curated
    Sequence conflicti478 – 4781T → A in AAI50722. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047725 mRNA. Translation: AAD13720.1.
    AC139233 Genomic DNA. No translation available.
    BC150721 mRNA. Translation: AAI50722.1.
    CCDSiCCDS29794.1.
    RefSeqiNP_034132.2. NM_010002.3.
    UniGeneiMm.42100.

    Genome annotation databases

    EnsembliENSMUST00000035488; ENSMUSP00000044722; ENSMUSG00000032808.
    GeneIDi13097.
    KEGGimmu:13097.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047725 mRNA. Translation: AAD13720.1 .
    AC139233 Genomic DNA. No translation available.
    BC150721 mRNA. Translation: AAI50722.1 .
    CCDSi CCDS29794.1.
    RefSeqi NP_034132.2. NM_010002.3.
    UniGenei Mm.42100.

    3D structure databases

    ProteinModelPortali P56655.
    SMRi P56655. Positions 28-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1865676.

    Proteomic databases

    PaxDbi P56655.
    PRIDEi P56655.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035488 ; ENSMUSP00000044722 ; ENSMUSG00000032808 .
    GeneIDi 13097.
    KEGGi mmu:13097.

    Organism-specific databases

    CTDi 13097.
    MGIi MGI:1306819. Cyp2c38.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00680000099783.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi B2RWV4.
    KOi K07413.
    OMAi SHENLAC.
    OrthoDBi EOG7RBZ85.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Miscellaneous databases

    NextBioi 283082.
    PROi P56655.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P56655.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
      Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
      Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCP238_MOUSE
    AccessioniPrimary (citable) accession number: P56655
    Secondary accession number(s): B2RWV4, F8VPK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3