Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P56655 (CP238_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C38

EC=1.14.14.1
Alternative name(s):
CYPIIC38
Gene names
Name:Cyp2c38
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Metabolizes arachidonic acid to produce 11,12-epoxyeicosatrienoic acid (EET).

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Liver, brain, kidney, and intestine, with trace amounts in lung and heart.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C38
PRO_0000051721

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict601T → A in AAD13720. Ref.1
Sequence conflict601T → A in AAI50722. Ref.3
Sequence conflict981E → G in AAD13720. Ref.1
Sequence conflict981E → G in AAI50722. Ref.3
Sequence conflict1251R → H in AAD13720. Ref.1
Sequence conflict1251R → H in AAI50722. Ref.3
Sequence conflict1881D → H in AAD13720. Ref.1
Sequence conflict1881D → H in AAI50722. Ref.3
Sequence conflict2531E → A in AAD13720. Ref.1
Sequence conflict2531E → A in AAI50722. Ref.3
Sequence conflict2571V → F in AAD13720. Ref.1
Sequence conflict2571V → F in AAI50722. Ref.3
Sequence conflict3441R → H in AAD13720. Ref.1
Sequence conflict3441R → H in AAI50722. Ref.3
Sequence conflict4701I → M in AAD13720. Ref.1
Sequence conflict4701I → M in AAI50722. Ref.3
Sequence conflict4781T → A in AAD13720. Ref.1
Sequence conflict4781T → A in AAI50722. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P56655 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 876444B4A6C1343A

FASTA49056,229
        10         20         30         40         50         60 
MDLVTFLVLT LSSLILLSLW RQRSRRGRLP PGPTPFPIIG NFLQIDVKNF NQSLTNFSKT 

        70         80         90        100        110        120 
YGPVFTLYLG SRPIVVLHGY EAVKEALIDH GEEFSGRENI PMSEKINNGL GITFSNGNSW 

       130        140        150        160        170        180 
KETRRFTLMT LRNLGMGKRN IEDRVREEAQ CLVEELRKTK GSPCDPTFIL SCAPCNVICS 

       190        200        210        220        230        240 
IIFQDRFDYK DKDFLMLMKK LNENVKILSS PWLQVCNNFP LLIDYCPGSH HKVLKNFKYI 

       250        260        270        280        290        300 
RSYLLEKVKE HQESLDVTNP RDFIDYFLIK QKQANHIEQA EYSLENLVCT INNLFAAGTE 

       310        320        330        340        350        360 
TTSTTLRYAL LLLMKYPDVT AKVQEEIDHV VGRHRSPCMQ DRSRMPYTDA MIHEVQRFIN 

       370        380        390        400        410        420 
LVPNNLPHAV TCDIKFRNYI IPKGTTVVTS LTSVLHDSKE FPNPEMFDPG HFLDANGNFK 

       430        440        450        460        470        480 
KSDYFMTFSA GKRVCAGEGL ARMELFLILT TILQNFKLKS LVHPKDIDMI PFVNGLITLP 

       490 
PHYQLCFIPL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF047725 mRNA. Translation: AAD13720.1.
AC139233 Genomic DNA. No translation available.
BC150721 mRNA. Translation: AAI50722.1.
RefSeqNP_034132.2. NM_010002.3.
UniGeneMm.42100.

3D structure databases

ProteinModelPortalP56655.
SMRP56655. Positions 28-490.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1865676.

Proteomic databases

PaxDbP56655.
PRIDEP56655.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035488; ENSMUSP00000044722; ENSMUSG00000032808.
GeneID13097.
KEGGmmu:13097.

Organism-specific databases

CTD13097.
MGIMGI:1306819. Cyp2c38.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00680000099783.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidB2RWV4.
KOK07413.
OrthoDBEOG7RBZ85.
TreeFamTF352043.

Gene expression databases

GenevestigatorP56655.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283082.
PROP56655.
SOURCESearch...

Entry information

Entry nameCP238_MOUSE
AccessionPrimary (citable) accession number: P56655
Secondary accession number(s): B2RWV4, F8VPK7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 3, 2012
Last modified: March 19, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot