Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P56654 (CP237_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C37

EC=1.14.14.1
Alternative name(s):
CYPIIC37
Gene names
Name:Cyp2c37
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Metabolizes arachidonic acid to produce 12-hydroxyeicosatetraenoic acid (HETE).

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Liver.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C37
PRO_0000051720

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict2391S → C in AAD13719. Ref.1
Sequence conflict2391S → C in AAH57912. Ref.3
Sequence conflict3101I → L in AAD13719. Ref.1
Sequence conflict3101I → L in AAH57912. Ref.3
Sequence conflict3251E → K in AAD13719. Ref.1
Sequence conflict3251E → K in AAH57912. Ref.3
Sequence conflict3721S → C in AAD13719. Ref.1
Sequence conflict3721S → C in AAH57912. Ref.3
Sequence conflict4061K → V in AAD13719. Ref.1
Sequence conflict4061K → V in AAH57912. Ref.3
Sequence conflict4151E → G in AAD13719. Ref.1
Sequence conflict4151E → G in AAH57912. Ref.3
Sequence conflict4261I → M in AAD13719. Ref.1
Sequence conflict4261I → M in AAH57912. Ref.3
Sequence conflict4551N → S in AAD13719. Ref.1
Sequence conflict4551N → S in AAH57912. Ref.3
Sequence conflict4771A → G in AAD13719. Ref.1
Sequence conflict4771A → G in AAH57912. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P56654 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 9623AACA4B5E5DBD

FASTA49055,606
        10         20         30         40         50         60 
MDPILVLVLT LSCLFLLSLW RQSSERGKLP PGPTPLPIIG NILQIDVKDI CQSFTNLSKV 

        70         80         90        100        110        120 
YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GEEFAGRGRF PVFDKATNGM GLAFSKGNVW 

       130        140        150        160        170        180 
KNTRRFSLMT LRNLGMGKRS IEDRVQEEAR CLVEELRKTN GSPCDPTFIL GCAPCNVICS 

       190        200        210        220        230        240 
IIFQDRFDYK DRDFLNLMEK LNEITKILSS PWLQICNTYP ALLDYCPGSH KQFFKNYASI 

       250        260        270        280        290        300 
KNFLLEKIKE HEESLDVTIP RDFIDYFLIN GGQEDGNQPL QNRLEHLAIT VTDLFSAGTE 

       310        320        330        340        350        360 
TTSTTLRYAI LLLLKYPHVT AKVQEEIEHV IGKHRSPCMQ DRSRMPYTDA MIHEVQRFID 

       370        380        390        400        410        420 
LIPNSLPHEV TSDIKFRNYF IPKGTTVITS LSSVLHDSTE FPNPEKFDPG HFLDENGKFK 

       430        440        450        460        470        480 
KSDYFIPFST GKRICAGEGL ARMELFLFLT SILQNFNLKP LVHPKDIDVT PMLIGLASVP 

       490 
PAFQLCFIPS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF047542 mRNA. Translation: AAD13719.1.
AC148014 Genomic DNA. No translation available.
BC057912 mRNA. Translation: AAH57912.1.
CCDSCCDS29799.1.
RefSeqNP_034131.2. NM_010001.2.
UniGeneMm.38963.

3D structure databases

ProteinModelPortalP56654.
SMRP56654. Positions 30-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP56654. 2 interactions.
MINTMINT-1863877.
STRING10090.ENSMUSP00000045362.

PTM databases

PhosphoSiteP56654.

Proteomic databases

MaxQBP56654.
PaxDbP56654.
PRIDEP56654.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049178; ENSMUSP00000045362; ENSMUSG00000042248.
GeneID13096.
KEGGmmu:13096.
UCSCuc008hkf.2. mouse.

Organism-specific databases

CTD13096.
MGIMGI:1306806. Cyp2c37.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00680000099783.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidP56654.
KOK07413.
OrthoDBEOG7RBZ85.
TreeFamTF352043.

Gene expression databases

BgeeP56654.
GenevestigatorP56654.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCyp2c37. mouse.
NextBio283078.
PROP56654.
SOURCESearch...

Entry information

Entry nameCP237_MOUSE
AccessionPrimary (citable) accession number: P56654
Secondary accession number(s): E9QKN4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot