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P56654

- CP237_MOUSE

UniProt

P56654 - CP237_MOUSE

Protein

Cytochrome P450 2C37

Gene

Cyp2c37

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Metabolizes arachidonic acid to produce 12-hydroxyeicosatetraenoic acid (HETE).

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C37 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC37
    Gene namesi
    Name:Cyp2c37
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1306806. Cyp2c37.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C37PRO_0000051720Add
    BLAST

    Proteomic databases

    MaxQBiP56654.
    PaxDbiP56654.
    PRIDEiP56654.

    PTM databases

    PhosphoSiteiP56654.

    Expressioni

    Tissue specificityi

    Liver.

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    BgeeiP56654.
    GenevestigatoriP56654.

    Interactioni

    Protein-protein interaction databases

    IntActiP56654. 2 interactions.
    MINTiMINT-1863877.
    STRINGi10090.ENSMUSP00000045362.

    Structurei

    3D structure databases

    ProteinModelPortaliP56654.
    SMRiP56654. Positions 30-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00680000099783.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiP56654.
    KOiK07413.
    OrthoDBiEOG7RBZ85.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56654-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPILVLVLT LSCLFLLSLW RQSSERGKLP PGPTPLPIIG NILQIDVKDI    50
    CQSFTNLSKV YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GEEFAGRGRF 100
    PVFDKATNGM GLAFSKGNVW KNTRRFSLMT LRNLGMGKRS IEDRVQEEAR 150
    CLVEELRKTN GSPCDPTFIL GCAPCNVICS IIFQDRFDYK DRDFLNLMEK 200
    LNEITKILSS PWLQICNTYP ALLDYCPGSH KQFFKNYASI KNFLLEKIKE 250
    HEESLDVTIP RDFIDYFLIN GGQEDGNQPL QNRLEHLAIT VTDLFSAGTE 300
    TTSTTLRYAI LLLLKYPHVT AKVQEEIEHV IGKHRSPCMQ DRSRMPYTDA 350
    MIHEVQRFID LIPNSLPHEV TSDIKFRNYF IPKGTTVITS LSSVLHDSTE 400
    FPNPEKFDPG HFLDENGKFK KSDYFIPFST GKRICAGEGL ARMELFLFLT 450
    SILQNFNLKP LVHPKDIDVT PMLIGLASVP PAFQLCFIPS 490
    Length:490
    Mass (Da):55,606
    Last modified:July 27, 2011 - v2
    Checksum:i9623AACA4B5E5DBD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti239 – 2391S → C in AAD13719. (PubMed:9721182)Curated
    Sequence conflicti239 – 2391S → C in AAH57912. (PubMed:15489334)Curated
    Sequence conflicti310 – 3101I → L in AAD13719. (PubMed:9721182)Curated
    Sequence conflicti310 – 3101I → L in AAH57912. (PubMed:15489334)Curated
    Sequence conflicti325 – 3251E → K in AAD13719. (PubMed:9721182)Curated
    Sequence conflicti325 – 3251E → K in AAH57912. (PubMed:15489334)Curated
    Sequence conflicti372 – 3721S → C in AAD13719. (PubMed:9721182)Curated
    Sequence conflicti372 – 3721S → C in AAH57912. (PubMed:15489334)Curated
    Sequence conflicti406 – 4061K → V in AAD13719. (PubMed:9721182)Curated
    Sequence conflicti406 – 4061K → V in AAH57912. (PubMed:15489334)Curated
    Sequence conflicti415 – 4151E → G in AAD13719. (PubMed:9721182)Curated
    Sequence conflicti415 – 4151E → G in AAH57912. (PubMed:15489334)Curated
    Sequence conflicti426 – 4261I → M in AAD13719. (PubMed:9721182)Curated
    Sequence conflicti426 – 4261I → M in AAH57912. (PubMed:15489334)Curated
    Sequence conflicti455 – 4551N → S in AAD13719. (PubMed:9721182)Curated
    Sequence conflicti455 – 4551N → S in AAH57912. (PubMed:15489334)Curated
    Sequence conflicti477 – 4771A → G in AAD13719. (PubMed:9721182)Curated
    Sequence conflicti477 – 4771A → G in AAH57912. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047542 mRNA. Translation: AAD13719.1.
    AC148014 Genomic DNA. No translation available.
    BC057912 mRNA. Translation: AAH57912.1.
    CCDSiCCDS29799.1.
    RefSeqiNP_034131.2. NM_010001.2.
    UniGeneiMm.38963.

    Genome annotation databases

    EnsembliENSMUST00000049178; ENSMUSP00000045362; ENSMUSG00000042248.
    GeneIDi13096.
    KEGGimmu:13096.
    UCSCiuc008hkf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047542 mRNA. Translation: AAD13719.1 .
    AC148014 Genomic DNA. No translation available.
    BC057912 mRNA. Translation: AAH57912.1 .
    CCDSi CCDS29799.1.
    RefSeqi NP_034131.2. NM_010001.2.
    UniGenei Mm.38963.

    3D structure databases

    ProteinModelPortali P56654.
    SMRi P56654. Positions 30-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P56654. 2 interactions.
    MINTi MINT-1863877.
    STRINGi 10090.ENSMUSP00000045362.

    PTM databases

    PhosphoSitei P56654.

    Proteomic databases

    MaxQBi P56654.
    PaxDbi P56654.
    PRIDEi P56654.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049178 ; ENSMUSP00000045362 ; ENSMUSG00000042248 .
    GeneIDi 13096.
    KEGGi mmu:13096.
    UCSCi uc008hkf.2. mouse.

    Organism-specific databases

    CTDi 13096.
    MGIi MGI:1306806. Cyp2c37.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00680000099783.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi P56654.
    KOi K07413.
    OrthoDBi EOG7RBZ85.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Miscellaneous databases

    ChiTaRSi Cyp2c37. mouse.
    NextBioi 283078.
    PROi P56654.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56654.
    Genevestigatori P56654.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
      Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
      Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP237_MOUSE
    AccessioniPrimary (citable) accession number: P56654
    Secondary accession number(s): E9QKN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3