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Protein

Cytochrome P450 2C37

Gene

Cyp2c37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Metabolizes arachidonic acid to produce 12-hydroxyeicosatetraenoic acid (HETE).

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. arachidonic acid epoxygenase activity Source: GO_Central
  2. aromatase activity Source: UniProtKB-EC
  3. heme binding Source: GO_Central
  4. iron ion binding Source: InterPro
  5. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
  6. oxygen binding Source: GO_Central
  7. steroid hydroxylase activity Source: GO_Central

GO - Biological processi

  1. epoxygenase P450 pathway Source: GO_Central
  2. exogenous drug catabolic process Source: GO_Central
  3. oxidation-reduction process Source: GO_Central
  4. xenobiotic metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_245291. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C37 (EC:1.14.14.1)
Alternative name(s):
CYPIIC37
Gene namesi
Name:Cyp2c37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1306806. Cyp2c37.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. intracellular membrane-bounded organelle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C37PRO_0000051720Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-acetyllysineBy similarity
Modified residuei375 – 3751N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP56654.
PaxDbiP56654.
PRIDEiP56654.

PTM databases

PhosphoSiteiP56654.

Expressioni

Tissue specificityi

Liver.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiP56654.
GenevestigatoriP56654.

Interactioni

Protein-protein interaction databases

IntActiP56654. 2 interactions.
MINTiMINT-1863877.
STRINGi10090.ENSMUSP00000045362.

Structurei

3D structure databases

ProteinModelPortaliP56654.
SMRiP56654. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP56654.
KOiK07413.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPILVLVLT LSCLFLLSLW RQSSERGKLP PGPTPLPIIG NILQIDVKDI
60 70 80 90 100
CQSFTNLSKV YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GEEFAGRGRF
110 120 130 140 150
PVFDKATNGM GLAFSKGNVW KNTRRFSLMT LRNLGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN GSPCDPTFIL GCAPCNVICS IIFQDRFDYK DRDFLNLMEK
210 220 230 240 250
LNEITKILSS PWLQICNTYP ALLDYCPGSH KQFFKNYASI KNFLLEKIKE
260 270 280 290 300
HEESLDVTIP RDFIDYFLIN GGQEDGNQPL QNRLEHLAIT VTDLFSAGTE
310 320 330 340 350
TTSTTLRYAI LLLLKYPHVT AKVQEEIEHV IGKHRSPCMQ DRSRMPYTDA
360 370 380 390 400
MIHEVQRFID LIPNSLPHEV TSDIKFRNYF IPKGTTVITS LSSVLHDSTE
410 420 430 440 450
FPNPEKFDPG HFLDENGKFK KSDYFIPFST GKRICAGEGL ARMELFLFLT
460 470 480 490
SILQNFNLKP LVHPKDIDVT PMLIGLASVP PAFQLCFIPS
Length:490
Mass (Da):55,606
Last modified:July 27, 2011 - v2
Checksum:i9623AACA4B5E5DBD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391S → C in AAD13719 (PubMed:9721182).Curated
Sequence conflicti239 – 2391S → C in AAH57912 (PubMed:15489334).Curated
Sequence conflicti310 – 3101I → L in AAD13719 (PubMed:9721182).Curated
Sequence conflicti310 – 3101I → L in AAH57912 (PubMed:15489334).Curated
Sequence conflicti325 – 3251E → K in AAD13719 (PubMed:9721182).Curated
Sequence conflicti325 – 3251E → K in AAH57912 (PubMed:15489334).Curated
Sequence conflicti372 – 3721S → C in AAD13719 (PubMed:9721182).Curated
Sequence conflicti372 – 3721S → C in AAH57912 (PubMed:15489334).Curated
Sequence conflicti406 – 4061K → V in AAD13719 (PubMed:9721182).Curated
Sequence conflicti406 – 4061K → V in AAH57912 (PubMed:15489334).Curated
Sequence conflicti415 – 4151E → G in AAD13719 (PubMed:9721182).Curated
Sequence conflicti415 – 4151E → G in AAH57912 (PubMed:15489334).Curated
Sequence conflicti426 – 4261I → M in AAD13719 (PubMed:9721182).Curated
Sequence conflicti426 – 4261I → M in AAH57912 (PubMed:15489334).Curated
Sequence conflicti455 – 4551N → S in AAD13719 (PubMed:9721182).Curated
Sequence conflicti455 – 4551N → S in AAH57912 (PubMed:15489334).Curated
Sequence conflicti477 – 4771A → G in AAD13719 (PubMed:9721182).Curated
Sequence conflicti477 – 4771A → G in AAH57912 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047542 mRNA. Translation: AAD13719.1.
AC148014 Genomic DNA. No translation available.
BC057912 mRNA. Translation: AAH57912.1.
CCDSiCCDS29799.1.
RefSeqiNP_034131.2. NM_010001.2.
UniGeneiMm.38963.

Genome annotation databases

EnsembliENSMUST00000049178; ENSMUSP00000045362; ENSMUSG00000042248.
GeneIDi13096.
KEGGimmu:13096.
UCSCiuc008hkf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047542 mRNA. Translation: AAD13719.1.
AC148014 Genomic DNA. No translation available.
BC057912 mRNA. Translation: AAH57912.1.
CCDSiCCDS29799.1.
RefSeqiNP_034131.2. NM_010001.2.
UniGeneiMm.38963.

3D structure databases

ProteinModelPortaliP56654.
SMRiP56654. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56654. 2 interactions.
MINTiMINT-1863877.
STRINGi10090.ENSMUSP00000045362.

PTM databases

PhosphoSiteiP56654.

Proteomic databases

MaxQBiP56654.
PaxDbiP56654.
PRIDEiP56654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049178; ENSMUSP00000045362; ENSMUSG00000042248.
GeneIDi13096.
KEGGimmu:13096.
UCSCiuc008hkf.2. mouse.

Organism-specific databases

CTDi13096.
MGIiMGI:1306806. Cyp2c37.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP56654.
KOiK07413.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_245291. Xenobiotics.

Miscellaneous databases

ChiTaRSiCyp2c37. mouse.
NextBioi283078.
PROiP56654.
SOURCEiSearch...

Gene expression databases

BgeeiP56654.
GenevestigatoriP56654.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
    Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
    Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiCP237_MOUSE
AccessioniPrimary (citable) accession number: P56654
Secondary accession number(s): E9QKN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.