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P56654

- CP237_MOUSE

UniProt

P56654 - CP237_MOUSE

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Protein
Cytochrome P450 2C37
Gene
Cyp2c37
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Metabolizes arachidonic acid to produce 12-hydroxyeicosatetraenoic acid (HETE).

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C37 (EC:1.14.14.1)
Alternative name(s):
CYPIIC37
Gene namesi
Name:Cyp2c37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1306806. Cyp2c37.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C37
PRO_0000051720Add
BLAST

Proteomic databases

MaxQBiP56654.
PaxDbiP56654.
PRIDEiP56654.

PTM databases

PhosphoSiteiP56654.

Expressioni

Tissue specificityi

Liver.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiP56654.
GenevestigatoriP56654.

Interactioni

Protein-protein interaction databases

IntActiP56654. 2 interactions.
MINTiMINT-1863877.
STRINGi10090.ENSMUSP00000045362.

Structurei

3D structure databases

ProteinModelPortaliP56654.
SMRiP56654. Positions 30-489.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00680000099783.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP56654.
KOiK07413.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56654-1 [UniParc]FASTAAdd to Basket

« Hide

MDPILVLVLT LSCLFLLSLW RQSSERGKLP PGPTPLPIIG NILQIDVKDI    50
CQSFTNLSKV YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GEEFAGRGRF 100
PVFDKATNGM GLAFSKGNVW KNTRRFSLMT LRNLGMGKRS IEDRVQEEAR 150
CLVEELRKTN GSPCDPTFIL GCAPCNVICS IIFQDRFDYK DRDFLNLMEK 200
LNEITKILSS PWLQICNTYP ALLDYCPGSH KQFFKNYASI KNFLLEKIKE 250
HEESLDVTIP RDFIDYFLIN GGQEDGNQPL QNRLEHLAIT VTDLFSAGTE 300
TTSTTLRYAI LLLLKYPHVT AKVQEEIEHV IGKHRSPCMQ DRSRMPYTDA 350
MIHEVQRFID LIPNSLPHEV TSDIKFRNYF IPKGTTVITS LSSVLHDSTE 400
FPNPEKFDPG HFLDENGKFK KSDYFIPFST GKRICAGEGL ARMELFLFLT 450
SILQNFNLKP LVHPKDIDVT PMLIGLASVP PAFQLCFIPS 490
Length:490
Mass (Da):55,606
Last modified:July 27, 2011 - v2
Checksum:i9623AACA4B5E5DBD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391S → C in AAD13719. 1 Publication
Sequence conflicti239 – 2391S → C in AAH57912. 1 Publication
Sequence conflicti310 – 3101I → L in AAD13719. 1 Publication
Sequence conflicti310 – 3101I → L in AAH57912. 1 Publication
Sequence conflicti325 – 3251E → K in AAD13719. 1 Publication
Sequence conflicti325 – 3251E → K in AAH57912. 1 Publication
Sequence conflicti372 – 3721S → C in AAD13719. 1 Publication
Sequence conflicti372 – 3721S → C in AAH57912. 1 Publication
Sequence conflicti406 – 4061K → V in AAD13719. 1 Publication
Sequence conflicti406 – 4061K → V in AAH57912. 1 Publication
Sequence conflicti415 – 4151E → G in AAD13719. 1 Publication
Sequence conflicti415 – 4151E → G in AAH57912. 1 Publication
Sequence conflicti426 – 4261I → M in AAD13719. 1 Publication
Sequence conflicti426 – 4261I → M in AAH57912. 1 Publication
Sequence conflicti455 – 4551N → S in AAD13719. 1 Publication
Sequence conflicti455 – 4551N → S in AAH57912. 1 Publication
Sequence conflicti477 – 4771A → G in AAD13719. 1 Publication
Sequence conflicti477 – 4771A → G in AAH57912. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047542 mRNA. Translation: AAD13719.1.
AC148014 Genomic DNA. No translation available.
BC057912 mRNA. Translation: AAH57912.1.
CCDSiCCDS29799.1.
RefSeqiNP_034131.2. NM_010001.2.
UniGeneiMm.38963.

Genome annotation databases

EnsembliENSMUST00000049178; ENSMUSP00000045362; ENSMUSG00000042248.
GeneIDi13096.
KEGGimmu:13096.
UCSCiuc008hkf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047542 mRNA. Translation: AAD13719.1 .
AC148014 Genomic DNA. No translation available.
BC057912 mRNA. Translation: AAH57912.1 .
CCDSi CCDS29799.1.
RefSeqi NP_034131.2. NM_010001.2.
UniGenei Mm.38963.

3D structure databases

ProteinModelPortali P56654.
SMRi P56654. Positions 30-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P56654. 2 interactions.
MINTi MINT-1863877.
STRINGi 10090.ENSMUSP00000045362.

PTM databases

PhosphoSitei P56654.

Proteomic databases

MaxQBi P56654.
PaxDbi P56654.
PRIDEi P56654.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049178 ; ENSMUSP00000045362 ; ENSMUSG00000042248 .
GeneIDi 13096.
KEGGi mmu:13096.
UCSCi uc008hkf.2. mouse.

Organism-specific databases

CTDi 13096.
MGIi MGI:1306806. Cyp2c37.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00680000099783.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P56654.
KOi K07413.
OrthoDBi EOG7RBZ85.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Miscellaneous databases

ChiTaRSi Cyp2c37. mouse.
NextBioi 283078.
PROi P56654.
SOURCEi Search...

Gene expression databases

Bgeei P56654.
Genevestigatori P56654.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."
    Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.
    Arch. Biochem. Biophys. 357:45-57(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiCP237_MOUSE
AccessioniPrimary (citable) accession number: P56654
Secondary accession number(s): E9QKN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi