Reviewed, UniProtKB/Swiss-Prot P56654 (CP237_MOUSE)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 2C37
    EC=1.14.14.1
Alternative name(s):
    CYPIIC37

Gene names

Name:

Cyp2c37

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Metabolizes arachidonic acid to produce 12-hydroxyeicosatetraenoic acid (HETE).
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue specificity	Liver.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Cytochrome P450 2C37		PRO_0000051720
Sites
	Metal binding	435	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56654-1 [UniParc]. Last modified July 15, 1999. Version 1. Checksum: 287A71D2D0BC7B5B	FASTA	490	55,513
	10 20 30 40 50 60 MDPILVLVLT LSCLFLLSLW RQSSERGKLP PGPTPLPIIG NILQIDVKDI CQSFTNLSKV 70 80 90 100 110 120 YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GEEFAGRGRF PVFDKATNGM GLAFSKGNVW 130 140 150 160 170 180 KNTRRFSLMT LRNLGMGKRS IEDRVQEEAR CLVEELRKTN GSPCDPTFIL GCAPCNVICS 190 200 210 220 230 240 IIFQDRFDYK DRDFLNLMEK LNEITKILSS PWLQICNTYP ALLDYCPGSH KQFFKNYACI 250 260 270 280 290 300 KNFLLEKIKE HEESLDVTIP RDFIDYFLIN GGQEDGNQPL QNRLEHLAIT VTDLFSAGTE 310 320 330 340 350 360 TTSTTLRYAL LLLLKYPHVT AKVQKEIEHV IGKHRSPCMQ DRSRMPYTDA MIHEVQRFID 370 380 390 400 410 420 LIPNSLPHEV TCDIKFRNYF IPKGTTVITS LSSVLHDSTE FPNPEVFDPG HFLDGNGKFK 430 440 450 460 470 480 KSDYFMPFST GKRICAGEGL ARMELFLFLT SILQSFNLKP LVHPKDIDVT PMLIGLGSVP 490 PAFQLCFIPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid." Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A. Arch. Biochem. Biophys. 357:45-57(1998) [PubMed: 9721182] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF047542 mRNA. Translation: AAD13719.1. BC057912 mRNA. Translation: AAH57912.1.
IPI	IPI00114778.
UniGene	Mm.38963
3D structure databases
HSSP	HSSP built from PDB template 1DT6 based on UniProtKB P00179.
SMR	P56654. Positions 44-489.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000042248. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:1306806. Cyp2c37.
Phylogenomic databases
HOGENOM	P56654.
HOVERGEN	P56654.
Enzyme and pathway databases
BRENDA	1.14.14.1. 244.
Gene expression databases
ArrayExpress	P56654.
Bgee	P56654.
GermOnline	ENSMUSG00000042248. Mus musculus.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

CP237_MOUSE

Accession

Primary (citable) accession number: P56654

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)