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Protein

Cytochrome P450 2C37

Gene

Cyp2c37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metabolizes arachidonic acid to produce 12-hydroxyeicosatetraenoic acid (HETE).

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211981 Xenobiotics
R-MMU-211999 CYP2E1 reactions
R-MMU-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-MMU-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-MMU-9027307 Biosynthesis of maresin-like SPMs

Chemistry databases

SwissLipidsiSLP:000001671

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C37 (EC:1.14.14.1)
Alternative name(s):
CYPIIC37
Gene namesi
Name:Cyp2c37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1306806 Cyp2c37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517201 – 490Cytochrome P450 2C37Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphoserineBy similarity1
Modified residuei249N6-acetyllysineBy similarity1
Modified residuei375N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP56654
PaxDbiP56654
PeptideAtlasiP56654
PRIDEiP56654

PTM databases

iPTMnetiP56654
PhosphoSitePlusiP56654

Expressioni

Tissue specificityi

Liver.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSMUSG00000042248
GenevisibleiP56654 MM

Interactioni

Protein-protein interaction databases

IntActiP56654, 2 interactors
MINTiP56654
STRINGi10090.ENSMUSP00000045362

Structurei

3D structure databases

ProteinModelPortaliP56654
SMRiP56654
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP56654
KOiK07413
OMAiTSNTIEF
OrthoDBiEOG091G0BT8
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P56654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPILVLVLT LSCLFLLSLW RQSSERGKLP PGPTPLPIIG NILQIDVKDI
60 70 80 90 100
CQSFTNLSKV YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GEEFAGRGRF
110 120 130 140 150
PVFDKATNGM GLAFSKGNVW KNTRRFSLMT LRNLGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN GSPCDPTFIL GCAPCNVICS IIFQDRFDYK DRDFLNLMEK
210 220 230 240 250
LNEITKILSS PWLQICNTYP ALLDYCPGSH KQFFKNYASI KNFLLEKIKE
260 270 280 290 300
HEESLDVTIP RDFIDYFLIN GGQEDGNQPL QNRLEHLAIT VTDLFSAGTE
310 320 330 340 350
TTSTTLRYAI LLLLKYPHVT AKVQEEIEHV IGKHRSPCMQ DRSRMPYTDA
360 370 380 390 400
MIHEVQRFID LIPNSLPHEV TSDIKFRNYF IPKGTTVITS LSSVLHDSTE
410 420 430 440 450
FPNPEKFDPG HFLDENGKFK KSDYFIPFST GKRICAGEGL ARMELFLFLT
460 470 480 490
SILQNFNLKP LVHPKDIDVT PMLIGLASVP PAFQLCFIPS
Length:490
Mass (Da):55,606
Last modified:July 27, 2011 - v2
Checksum:i9623AACA4B5E5DBD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239S → C in AAD13719 (PubMed:9721182).Curated1
Sequence conflicti239S → C in AAH57912 (PubMed:15489334).Curated1
Sequence conflicti310I → L in AAD13719 (PubMed:9721182).Curated1
Sequence conflicti310I → L in AAH57912 (PubMed:15489334).Curated1
Sequence conflicti325E → K in AAD13719 (PubMed:9721182).Curated1
Sequence conflicti325E → K in AAH57912 (PubMed:15489334).Curated1
Sequence conflicti372S → C in AAD13719 (PubMed:9721182).Curated1
Sequence conflicti372S → C in AAH57912 (PubMed:15489334).Curated1
Sequence conflicti406K → V in AAD13719 (PubMed:9721182).Curated1
Sequence conflicti406K → V in AAH57912 (PubMed:15489334).Curated1
Sequence conflicti415E → G in AAD13719 (PubMed:9721182).Curated1
Sequence conflicti415E → G in AAH57912 (PubMed:15489334).Curated1
Sequence conflicti426I → M in AAD13719 (PubMed:9721182).Curated1
Sequence conflicti426I → M in AAH57912 (PubMed:15489334).Curated1
Sequence conflicti455N → S in AAD13719 (PubMed:9721182).Curated1
Sequence conflicti455N → S in AAH57912 (PubMed:15489334).Curated1
Sequence conflicti477A → G in AAD13719 (PubMed:9721182).Curated1
Sequence conflicti477A → G in AAH57912 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047542 mRNA Translation: AAD13719.1
AC148014 Genomic DNA No translation available.
BC057912 mRNA Translation: AAH57912.1
CCDSiCCDS29799.1
RefSeqiNP_034131.2, NM_010001.2
UniGeneiMm.38963

Genome annotation databases

EnsembliENSMUST00000049178; ENSMUSP00000045362; ENSMUSG00000042248
GeneIDi13096
KEGGimmu:13096
UCSCiuc008hkf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCP237_MOUSE
AccessioniPrimary (citable) accession number: P56654
Secondary accession number(s): E9QKN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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