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Protein

Inter-alpha-trypsin inhibitor heavy chain H3

Gene

ITIH3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H3
Short name:
ITI heavy chain H3
Short name:
ITI-HC3
Short name:
Inter-alpha-inhibitor heavy chain 3
Gene namesi
Name:ITIH3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000031243721 – 34By similarityAdd BLAST14
ChainiPRO_000014090035 – 651Inter-alpha-trypsin inhibitor heavy chain H3Add BLAST617
PropeptideiPRO_0000312438652 – 891By similarityAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei651Aspartate 1-(chondroitin 4-sulfate)-esterBy similarity1

Keywords - PTMi

Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP56652.
PRIDEiP56652.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007846.

Interactioni

Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010322.

Structurei

3D structure databases

ProteinModelPortaliP56652.
SMRiP56652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 158VITPROSITE-ProRule annotationAdd BLAST130
Domaini284 – 467VWFAPROSITE-ProRule annotationAdd BLAST184

Sequence similaritiesi

Belongs to the ITIH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
GeneTreeiENSGT00550000074468.
HOGENOMiHOG000000680.
HOVERGENiHBG057734.
InParanoidiP56652.
OMAiVVDSHRM.
OrthoDBiEOG091G01HF.
TreeFamiTF328982.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
IPR036465. vWFA_dom_sf.
PfamiView protein in Pfam
PF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
SMARTiView protein in SMART
SM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiView protein in PROSITE
PS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAQWPYLI LALLSGLAVS GFPRNPSLLL GKRSLPGRAV DGIEVYSTKV
60 70 80 90 100
NCKVTSRFAH NVVTTRAVNH ANTAKEVSFD VELPKTAFIT NFTLTIDGVT
110 120 130 140 150
YPGKVKEKEV AKKQYEKAVS QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV
160 170 180 190 200
TFELTYEELL KRHKGKYEMY LKVQPKQLVK HFEITVDIFE PQGISTLDAE
210 220 230 240 250
ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT DSLLKGDFII
260 270 280 290 300
TYDVNRESPA NVQIVNGYFV HFFAPQGLPV VPKSVVFVID VSGSMHGRKM
310 320 330 340 350
EQTKDALLKI LEDVKQDDYL NFILFSGDVT TWKDSLVPAT PENIQEASKF
360 370 380 390 400
VMDIQDRGMT NINDALLRGI SMLNKAREEH TVPERSTSII IMLTDGDANV
410 420 430 440 450
GESRPEKIQE NVRNAIGGKF PLYNLGFGNN LNYNFLENMA LENHGLARRI
460 470 480 490 500
YEDSDANLQL QGFYEEVANP LLTGVEVEYP QNAILDLTQN SYQHFYDGSE
510 520 530 540 550
IVVAGRLADE DMNSFKAAVK GHGAINDLTF TEEVDMKEME KALQERDYIF
560 570 580 590 600
GDYIERLWAY LTIEQLLDKR KNAQGEEKEI LTAQALELSL KYHFVTPLTS
610 620 630 640 650
MVVTKPEDNE NQTAIANKPG EGPLDAEEVP SMAYLTSYQA PQTPYYYVDG
660 670 680 690 700
DPHFIIQIPE KDDAICFNID EDPGTVLRLI QDPVTGLTVN GQIIGEKTGR
710 720 730 740 750
SDSQTRRTYF GKLGIASAQM DFRIEVTREN ITLWNGDSLS TFSWLDTVMV
760 770 780 790 800
TQDGLSVMIN RKKNMVVSFG DGVTFVVVLH QVWKKEPAHH DFLGFYVVNS
810 820 830 840 850
RGMSAQTHGL LGQFFHPFDF QVSDVHPGSD PTKPDATMVV KNHQLTVTRG
860 870 880 890
SQKDYRKDIS VGRNVACWFV HNNGQGLIDG IHRDYIVPNL F
Length:891
Mass (Da):99,551
Last modified:November 13, 2007 - v2
Checksum:iBF70AAC245557CE8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38R → G in ABG67028 (PubMed:16305752).Curated1
Sequence conflicti218S → N AA sequence (PubMed:7504674).Curated1
Sequence conflicti225S → F AA sequence (PubMed:7504674).Curated1
Sequence conflicti228 – 229PS → VV AA sequence (PubMed:7504674).Curated2
Sequence conflicti532E → K in ABG67028 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151419 mRNA. Translation: AAI51420.1.
BT026189 mRNA. Translation: ABG67028.1.
RefSeqiNP_001095368.1. NM_001101898.2.
UniGeneiBt.21243.

Genome annotation databases

EnsembliENSBTAT00000010322; ENSBTAP00000010322; ENSBTAG00000007846.
GeneIDi508355.
KEGGibta:508355.

Similar proteinsi

Entry informationi

Entry nameiITIH3_BOVIN
AccessioniPrimary (citable) accession number: P56652
Secondary accession number(s): A7MB92, Q0V8M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 13, 2007
Last modified: October 25, 2017
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families