Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P56645 (PER3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Period circadian protein homolog 3

Short name=hPER3
Alternative name(s):
Cell growth-inhibiting gene 13 protein
Circadian clock protein PERIOD 3
Gene names
Name:PER3
ORF Names:GIG13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1201 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the circadian clock mechanism which is essential for generating circadian rhythms. Can bind heme.

Subunit structure

Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1, PER2, CRY1, CRY2, and TIMELESS. Interaction with CSNK1D or CSKN1E promotes nuclear location of PER proteins By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS By similarity.

Post-translational modification

Phosphorylation appears to require association with PER1 and translocation to the nucleus By similarity.

Ubiquitinated By similarity.

Sequence similarities

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 2 PAS (PER-ARNT-SIM) domains.

Sequence caution

The sequence BAB32925.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CHEK2O960172EBI-2827813,EBI-1180783

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P56645-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P56645-2)

The sequence of this isoform differs from the canonical sequence as follows:
     197-197: R → RA
     499-499: G → GGESANGG
     954-954: Y → YQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12011201Period circadian protein homolog 3
PRO_0000162633

Regions

Domain121 – 18868PAS 1
Domain262 – 32867PAS 2
Domain337 – 38044PAC
Region502 – 731230CSNK1E binding domain By similarity
Region1123 – 120179CRY binding domain By similarity
Motif400 – 41213Nuclear export signal By similarity
Motif729 – 74517Nuclear localization signal By similarity
Compositional bias567 – 5704Poly-Ser
Compositional bias750 – 7534Poly-Ser
Compositional bias769 – 895127Pro-rich
Compositional bias962 – 1081120Ser-rich

Natural variations

Alternative sequence1971R → RA in isoform 2.
VSP_040326
Alternative sequence4991G → GGESANGG in isoform 2.
VSP_040327
Alternative sequence9541Y → YQ in isoform 2.
VSP_040328
Natural variant6391V → G Associated with delayed sleep phase syndrome (DSPS). Ref.1 Ref.5
Corresponds to variant rs10462020 [ dbSNP | Ensembl ].
VAR_025532
Natural variant8271L → P. Ref.1
Corresponds to variant rs228696 [ dbSNP | Ensembl ].
VAR_022428
Natural variant8561P → A. Ref.1
Corresponds to variant rs228697 [ dbSNP | Ensembl ].
VAR_015514
Natural variant10071A → T.
Corresponds to variant rs1776342 [ dbSNP | Ensembl ].
VAR_028728
Natural variant10101T → I.
Corresponds to variant rs12033719 [ dbSNP | Ensembl ].
VAR_028729
Natural variant10281M → T. Ref.1
Corresponds to variant rs2640909 [ dbSNP | Ensembl ].
VAR_025533
Natural variant10811S → C.
Corresponds to variant rs2640905 [ dbSNP | Ensembl ].
VAR_028730
Natural variant11491H → R. Ref.1
Corresponds to variant rs10462021 [ dbSNP | Ensembl ].
VAR_025534

Experimental info

Sequence conflict9431Q → R in BAB32925. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2011. Version 4.
Checksum: 8129C4246EDD1816

FASTA1,201131,888
        10         20         30         40         50         60 
MPRGEAPGPG RRGAKDEALG EESGERWSPE FHLQRKLADS SHSEQQDRNR VSEELIMVVQ 

        70         80         90        100        110        120 
EMKKYFPSER RNKPSTLDAL NYALRCVHSV QANSEFFQIL SQNGAPQADV SMYSLEELAT 

       130        140        150        160        170        180 
IASEHTSKNT DTFVAVFSFL SGRLVHISEQ AALILNRKKD VLASSHFVDL LAPQDMRVFY 

       190        200        210        220        230        240 
AHTARAQLPF WNNWTQRAAR YECAPVKPFF CRIRGGEDRK QEKCHSPFRI IPYLIHVHHP 

       250        260        270        280        290        300 
AQPELESEPC CLTVVEKIHS GYEAPRIPVN KRIFTTTHTP GCVFLEVDEK AVPLLGYLPQ 

       310        320        330        340        350        360 
DLIGTSILSY LHPEDRSLMV AIHQKVLKYA GHPPFEHSPI RFCTQNGDYI ILDSSWSSFV 

       370        380        390        400        410        420 
NPWSRKISFI IGRHKVRTSP LNEDVFATKI KKMNDNDKDI TELQEQIYKL LLQPVHVSVS 

       430        440        450        460        470        480 
SGYGSLGSSG SQEQLVSIAS SSEASGHRVE ETKAEQMTLQ QVYASVNKIK NLGQQLYIES 

       490        500        510        520        530        540 
MTKSSFKPVT GTRTEPNGGG ECKTFTSFHQ TLKNNSVYTE PCEDLRNDEH SPSYQQINCI 

       550        560        570        580        590        600 
DSVIRYLKSY NIPALKRKCI SCTNTTSSSS EEDKQNHKAD DVQALQAGLQ IPAIPKSEMP 

       610        620        630        640        650        660 
TNGRSIDTGG GAPQILSTAM LSLGSGISQC GYSSTIVHVP PPETARDATL FCEPWTLNMQ 

       670        680        690        700        710        720 
PAPLTSEEFK HVGLTAAVLS AHTQKEEQNY VDKFREKILS SPYSSYLQQE SRSKAKYSYF 

       730        740        750        760        770        780 
QGDSTSKQTR SAGCRKGKHK RKKLPEPPDS SSSNTGSGPR RGAHQNAQPC CPSAASSPHT 

       790        800        810        820        830        840 
SSPTFPPAAM VPSQAPYLVP AFPLPAATSP GREYAAPGTA PEGLHGLPLS EGLQPYPAFP 

       850        860        870        880        890        900 
FPYLDTFMTV FLPDPPVCPL LSPSFLPCPF LGATASSAIS PSMSSAMSPT LDPPPSVTSQ 

       910        920        930        940        950        960 
RREEEKWEAQ SEGHPFITSR SSSPLQLNLL QEEMPRPSES PDQMRRNTCP QTEYCVTGNN 

       970        980        990       1000       1010       1020 
GSESSPATTG ALSTGSPPRE NPSHPTASAL STGSPPMKNP SHPTASALST GSPPMKNPSH 

      1030       1040       1050       1060       1070       1080 
PTASTLSMGL PPSRTPSHPT ATVLSTGSPP SESPSRTGSA ASGSSDSSIY LTSSVYSSKI 

      1090       1100       1110       1120       1130       1140 
SQNGQQSQDV QKKETFPNVA EEPIWRMIRQ TPERILMTYQ VPERVKEVVL KEDLEKLESM 

      1150       1160       1170       1180       1190       1200 
RQQQPQFSHG QKEELAKVYN WIQSQTVTQE IDIQACVTCE NEDSADGAAT SCGQVLVEDS 


C 

« Hide

Isoform 2 [UniParc].

Checksum: D63BD326292813F6
Show »

FASTA1,210132,660

References

« Hide 'large scale' references
[1]"Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome."
Ebisawa T., Uchiyama M., Kajimura N., Mishima K., Kamei Y., Katoh M., Watanabe T., Sekimoto M., Shibui K., Kim K., Kudo Y., Ozeki Y., Sugishita M., Toyoshima R., Inoue Y., Yamada N., Nagase T., Ozaki N. expand/collapse author list , Ohara O., Ishida N., Okawa M., Takahashi K., Yamauchi T.
EMBO Rep. 2:342-346(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-91 AND 724-882 (ISOFORMS 1/2), VARIANTS GLY-639; PRO-827; ALA-856; THR-1028 AND ARG-1149.
[2]Rhodes S., Huckle E.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Identification of a growth inhibition gene."
Kim J.W.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference."
Johansson C., Willeit M., Smedh C., Ekholm J., Paunio T., Kieseppa T., Lichtermann D., Praschak-Rieder N., Neumeister A., Nilsson L.G., Kasper S., Peltonen L., Adolfsson R., Schalling M., Partonen T.
Neuropsychopharmacology 28:734-739(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLY-639.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB047521 Genomic DNA. Translation: BAB63250.1.
AB047530 Genomic DNA. Translation: BAB63251.1.
AB047531 Genomic DNA. Translation: BAB63252.1.
AB047532 Genomic DNA. Translation: BAB63253.1.
AB047533 Genomic DNA. Translation: BAB63254.1.
AB047534 Genomic DNA. Translation: BAB63255.1.
AB047686 mRNA. Translation: BAB32925.2. Different initiation.
AL157954 mRNA. Translation: CAB76084.1.
AY493418 mRNA. Translation: AAS72879.1.
Z98884 Genomic DNA. Translation: CAI21435.1.
Z98884 Genomic DNA. Translation: CAI21436.1.
RefSeqNP_058515.1. NM_016831.2.
UniGeneHs.162200.

3D structure databases

ProteinModelPortalP56645.
SMRP56645. Positions 36-488.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114386. 7 interactions.
IntActP56645. 4 interactions.
MINTMINT-8052823.
STRING9606.ENSP00000355031.

PTM databases

PhosphoSiteP56645.

Polymorphism databases

DMDM317373535.

Proteomic databases

PaxDbP56645.
PRIDEP56645.

Protocols and materials databases

DNASU8863.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361923; ENSP00000355031; ENSG00000049246. [P56645-1]
ENST00000377532; ENSP00000366755; ENSG00000049246. [P56645-2]
GeneID8863.
KEGGhsa:8863.
UCSCuc001aoo.3. human. [P56645-1]
uc001aop.3. human. [P56645-2]

Organism-specific databases

CTD8863.
GeneCardsGC01P007844.
HGNCHGNC:8847. PER3.
HPAHPA019530.
MIM603427. gene.
neXtProtNX_P56645.
PharmGKBPA33186.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG269786.
HOVERGENHBG008167.
KOK02633.
OMAFKHVGLT.
OrthoDBEOG7S7SD0.
PhylomeDBP56645.
TreeFamTF318445.

Gene expression databases

ArrayExpressP56645.
BgeeP56645.
CleanExHS_PER3.
GenevestigatorP56645.

Family and domain databases

InterProIPR001610. PAC.
IPR000014. PAS.
IPR022728. Period_circadian-like_C.
[Graphical view]
PfamPF12114. Period_C. 1 hit.
[Graphical view]
SMARTSM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMSSF55785. SSF55785. 1 hit.
PROSITEPS50112. PAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPER3. human.
GeneWikiPER3.
GenomeRNAi8863.
NextBio33281.
PROP56645.
SOURCESearch...

Entry information

Entry namePER3_HUMAN
AccessionPrimary (citable) accession number: P56645
Secondary accession number(s): Q5H8X4 expand/collapse secondary AC list , Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 127 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM