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P56645

- PER3_HUMAN

UniProt

P56645 - PER3_HUMAN

Protein

Period circadian protein homolog 3

Gene

PER3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 4 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme.4 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. signal transducer activity Source: InterPro

    GO - Biological processi

    1. circadian regulation of gene expression Source: InterPro
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. regulation of circadian sleep/wake cycle, sleep Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Period circadian protein homolog 3
    Short name:
    hPER3
    Alternative name(s):
    Cell growth-inhibiting gene 13 protein
    Circadian clock protein PERIOD 3
    Gene namesi
    Name:PER3
    ORF Names:GIG13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8847. PER3.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33186.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12011201Period circadian protein homolog 3PRO_0000162633Add
    BLAST

    Post-translational modificationi

    Phosphorylation by CSNK1E is weak and appears to require association with PER1 and translocation to the nucleus.By similarity
    Ubiquitinated.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP56645.
    PaxDbiP56645.
    PRIDEiP56645.

    PTM databases

    PhosphoSiteiP56645.

    Expressioni

    Gene expression databases

    ArrayExpressiP56645.
    BgeeiP56645.
    CleanExiHS_PER3.
    GenevestigatoriP56645.

    Organism-specific databases

    HPAiHPA019530.

    Interactioni

    Subunit structurei

    Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1, PER2, CRY1, CRY2, and TIMELESS; interaction with CRY1 and CRY2 is weak and not rhythmic. Interacts with FBXW11 and BTRC.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CHEK2O960172EBI-2827813,EBI-1180783

    Protein-protein interaction databases

    BioGridi114386. 7 interactions.
    IntActiP56645. 4 interactions.
    MINTiMINT-8052823.
    STRINGi9606.ENSP00000355031.

    Structurei

    3D structure databases

    ProteinModelPortaliP56645.
    SMRiP56645. Positions 36-415.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini121 – 18868PAS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini262 – 32867PAS 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini337 – 38044PACAdd
    BLAST
    Repeati965 – 982181Add
    BLAST
    Repeati983 – 1000182Add
    BLAST
    Repeati1001 – 1018183Add
    BLAST
    Repeati1019 – 1036184Add
    BLAST
    Repeati1037 – 1054185Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni555 – 760206CSNK1E binding domainBy similarityAdd
    BLAST
    Regioni965 – 1054905 X 18 AA tandem repeats of S-[HP]-[AP]-T-[AT]-[GST]-[ATV]-L-S-[MT]-G-[LS]-P-P-[MRS]-[EKR]-[NST]-PAdd
    BLAST
    Regioni1123 – 120179CRY binding domainBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi55 – 6410Nuclear export signal 1By similarity
    Motifi403 – 41210Nuclear export signal 3By similarity
    Motifi729 – 74517Nuclear localization signalBy similarityAdd
    BLAST
    Motifi925 – 9328Nuclear export signal 2By similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi567 – 5704Poly-Ser
    Compositional biasi750 – 7534Poly-Ser
    Compositional biasi769 – 895127Pro-richAdd
    BLAST
    Compositional biasi962 – 1081120Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG269786.
    HOVERGENiHBG008167.
    KOiK02633.
    OMAiFKHVGLT.
    OrthoDBiEOG7S7SD0.
    PhylomeDBiP56645.
    TreeFamiTF318445.

    Family and domain databases

    InterProiIPR001610. PAC.
    IPR000014. PAS.
    IPR015524. Per_circ_prot_3.
    IPR022728. Period_circadian-like_C.
    [Graphical view]
    PANTHERiPTHR11269:SF13. PTHR11269:SF13. 1 hit.
    PfamiPF12114. Period_C. 1 hit.
    [Graphical view]
    SMARTiSM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF55785. SSF55785. 1 hit.
    PROSITEiPS50112. PAS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P56645-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPRGEAPGPG RRGAKDEALG EESGERWSPE FHLQRKLADS SHSEQQDRNR     50
    VSEELIMVVQ EMKKYFPSER RNKPSTLDAL NYALRCVHSV QANSEFFQIL 100
    SQNGAPQADV SMYSLEELAT IASEHTSKNT DTFVAVFSFL SGRLVHISEQ 150
    AALILNRKKD VLASSHFVDL LAPQDMRVFY AHTARAQLPF WNNWTQRAAR 200
    YECAPVKPFF CRIRGGEDRK QEKCHSPFRI IPYLIHVHHP AQPELESEPC 250
    CLTVVEKIHS GYEAPRIPVN KRIFTTTHTP GCVFLEVDEK AVPLLGYLPQ 300
    DLIGTSILSY LHPEDRSLMV AIHQKVLKYA GHPPFEHSPI RFCTQNGDYI 350
    ILDSSWSSFV NPWSRKISFI IGRHKVRTSP LNEDVFATKI KKMNDNDKDI 400
    TELQEQIYKL LLQPVHVSVS SGYGSLGSSG SQEQLVSIAS SSEASGHRVE 450
    ETKAEQMTLQ QVYASVNKIK NLGQQLYIES MTKSSFKPVT GTRTEPNGGG 500
    ECKTFTSFHQ TLKNNSVYTE PCEDLRNDEH SPSYQQINCI DSVIRYLKSY 550
    NIPALKRKCI SCTNTTSSSS EEDKQNHKAD DVQALQAGLQ IPAIPKSEMP 600
    TNGRSIDTGG GAPQILSTAM LSLGSGISQC GYSSTIVHVP PPETARDATL 650
    FCEPWTLNMQ PAPLTSEEFK HVGLTAAVLS AHTQKEEQNY VDKFREKILS 700
    SPYSSYLQQE SRSKAKYSYF QGDSTSKQTR SAGCRKGKHK RKKLPEPPDS 750
    SSSNTGSGPR RGAHQNAQPC CPSAASSPHT SSPTFPPAAM VPSQAPYLVP 800
    AFPLPAATSP GREYAAPGTA PEGLHGLPLS EGLQPYPAFP FPYLDTFMTV 850
    FLPDPPVCPL LSPSFLPCPF LGATASSAIS PSMSSAMSPT LDPPPSVTSQ 900
    RREEEKWEAQ SEGHPFITSR SSSPLQLNLL QEEMPRPSES PDQMRRNTCP 950
    QTEYCVTGNN GSESSPATTG ALSTGSPPRE NPSHPTASAL STGSPPMKNP 1000
    SHPTASALST GSPPMKNPSH PTASTLSMGL PPSRTPSHPT ATVLSTGSPP 1050
    SESPSRTGSA ASGSSDSSIY LTSSVYSSKI SQNGQQSQDV QKKETFPNVA 1100
    EEPIWRMIRQ TPERILMTYQ VPERVKEVVL KEDLEKLESM RQQQPQFSHG 1150
    QKEELAKVYN WIQSQTVTQE IDIQACVTCE NEDSADGAAT SCGQVLVEDS 1200
    C 1201
    Length:1,201
    Mass (Da):131,888
    Last modified:January 11, 2011 - v4
    Checksum:i8129C4246EDD1816
    GO
    Isoform 2 (identifier: P56645-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         197-197: R → RA
         499-499: G → GGESANGG
         954-954: Y → YQ

    Show »
    Length:1,210
    Mass (Da):132,660
    Checksum:iD63BD326292813F6
    GO

    Sequence cautioni

    The sequence BAB32925.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti943 – 9431Q → R in BAB32925. (PubMed:11306557)Curated

    Polymorphismi

    The number of repeats of 18 amino acids in positions 966 to 1055 is polymorphic and varies among at least 2 different alleles. Alleles corresponding in size to a 4 (PER3.4) and 5 (PER3.5) repeats have been described. The sequence shown is that of allele PER3.5. In most populations around 10% of individuals are homozygous for the 5-repeat (PER3.5), whereas approximately 50% are homozygous for the 4-repeat (PER3.4). In some populations in Papua New Guinea the prevalence of the various genotypes appears to be reversed. These repeats and polymorphism are not present in non-primate mammals. Homozygosity for PER3.5 is more likely to show morning preference, whereas homozygosity for the PER3.4 associates with evening preferences. PER3.5 homozygous show vulnerability to sleep loss with a greater cognitive decline in response to total sleep deprivation (PubMed:11306557, PubMed:17346965, PubMed:19716732, PubMed:24439663, PubMed:24577121).5 Publications

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti639 – 6391V → G Associated with delayed sleep phase syndrome (DSPS). 2 Publications
    Corresponds to variant rs10462020 [ dbSNP | Ensembl ].
    VAR_025532
    Natural varianti827 – 8271L → P.1 Publication
    Corresponds to variant rs228696 [ dbSNP | Ensembl ].
    VAR_022428
    Natural varianti856 – 8561P → A.1 Publication
    Corresponds to variant rs228697 [ dbSNP | Ensembl ].
    VAR_015514
    Natural varianti1001 – 101818Missing Associated with eveningness and better cognitive performance during sleep deprivation exepriments.
    Corresponds to variant rs57875989 [ dbSNP | Ensembl ].
    VAR_071049Add
    BLAST
    Natural varianti1007 – 10071A → T.
    Corresponds to variant rs1776342 [ dbSNP | Ensembl ].
    VAR_028728
    Natural varianti1010 – 10101T → I.
    Corresponds to variant rs12033719 [ dbSNP | Ensembl ].
    VAR_028729
    Natural varianti1028 – 10281M → T Only found in PER3.4 allele. 1 Publication
    Corresponds to variant rs2640909 [ dbSNP | Ensembl ].
    VAR_025533
    Natural varianti1081 – 10811S → C.
    Corresponds to variant rs2640905 [ dbSNP | Ensembl ].
    VAR_028730
    Natural varianti1149 – 11491H → R.1 Publication
    Corresponds to variant rs10462021 [ dbSNP | Ensembl ].
    VAR_025534

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei197 – 1971R → RA in isoform 2. 1 PublicationVSP_040326
    Alternative sequencei499 – 4991G → GGESANGG in isoform 2. 1 PublicationVSP_040327
    Alternative sequencei954 – 9541Y → YQ in isoform 2. 1 PublicationVSP_040328

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047521 Genomic DNA. Translation: BAB63250.1.
    AB047530 Genomic DNA. Translation: BAB63251.1.
    AB047531 Genomic DNA. Translation: BAB63252.1.
    AB047532 Genomic DNA. Translation: BAB63253.1.
    AB047533 Genomic DNA. Translation: BAB63254.1.
    AB047534 Genomic DNA. Translation: BAB63255.1.
    AB047686 mRNA. Translation: BAB32925.2. Different initiation.
    AL157954 mRNA. Translation: CAB76084.1.
    AY493418 mRNA. Translation: AAS72879.1.
    Z98884 Genomic DNA. Translation: CAI21435.1.
    Z98884 Genomic DNA. Translation: CAI21436.1.
    CCDSiCCDS89.1. [P56645-1]
    RefSeqiNP_001276790.1. NM_001289861.1.
    NP_001276791.1. NM_001289862.1. [P56645-2]
    NP_001276792.1. NM_001289863.1.
    NP_001276793.1. NM_001289864.1.
    NP_058515.1. NM_016831.2. [P56645-1]
    UniGeneiHs.162200.

    Genome annotation databases

    EnsembliENST00000361923; ENSP00000355031; ENSG00000049246. [P56645-1]
    ENST00000377532; ENSP00000366755; ENSG00000049246. [P56645-2]
    GeneIDi8863.
    KEGGihsa:8863.
    UCSCiuc001aoo.3. human. [P56645-1]
    uc001aop.3. human. [P56645-2]

    Polymorphism databases

    DMDMi317373535.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047521 Genomic DNA. Translation: BAB63250.1 .
    AB047530 Genomic DNA. Translation: BAB63251.1 .
    AB047531 Genomic DNA. Translation: BAB63252.1 .
    AB047532 Genomic DNA. Translation: BAB63253.1 .
    AB047533 Genomic DNA. Translation: BAB63254.1 .
    AB047534 Genomic DNA. Translation: BAB63255.1 .
    AB047686 mRNA. Translation: BAB32925.2 . Different initiation.
    AL157954 mRNA. Translation: CAB76084.1 .
    AY493418 mRNA. Translation: AAS72879.1 .
    Z98884 Genomic DNA. Translation: CAI21435.1 .
    Z98884 Genomic DNA. Translation: CAI21436.1 .
    CCDSi CCDS89.1. [P56645-1 ]
    RefSeqi NP_001276790.1. NM_001289861.1.
    NP_001276791.1. NM_001289862.1. [P56645-2 ]
    NP_001276792.1. NM_001289863.1.
    NP_001276793.1. NM_001289864.1.
    NP_058515.1. NM_016831.2. [P56645-1 ]
    UniGenei Hs.162200.

    3D structure databases

    ProteinModelPortali P56645.
    SMRi P56645. Positions 36-415.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114386. 7 interactions.
    IntActi P56645. 4 interactions.
    MINTi MINT-8052823.
    STRINGi 9606.ENSP00000355031.

    PTM databases

    PhosphoSitei P56645.

    Polymorphism databases

    DMDMi 317373535.

    Proteomic databases

    MaxQBi P56645.
    PaxDbi P56645.
    PRIDEi P56645.

    Protocols and materials databases

    DNASUi 8863.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361923 ; ENSP00000355031 ; ENSG00000049246 . [P56645-1 ]
    ENST00000377532 ; ENSP00000366755 ; ENSG00000049246 . [P56645-2 ]
    GeneIDi 8863.
    KEGGi hsa:8863.
    UCSCi uc001aoo.3. human. [P56645-1 ]
    uc001aop.3. human. [P56645-2 ]

    Organism-specific databases

    CTDi 8863.
    GeneCardsi GC01P007844.
    HGNCi HGNC:8847. PER3.
    HPAi HPA019530.
    MIMi 603427. gene.
    neXtProti NX_P56645.
    PharmGKBi PA33186.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG269786.
    HOVERGENi HBG008167.
    KOi K02633.
    OMAi FKHVGLT.
    OrthoDBi EOG7S7SD0.
    PhylomeDBi P56645.
    TreeFami TF318445.

    Miscellaneous databases

    ChiTaRSi PER3. human.
    GeneWikii PER3.
    GenomeRNAii 8863.
    NextBioi 33281.
    PROi P56645.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56645.
    Bgeei P56645.
    CleanExi HS_PER3.
    Genevestigatori P56645.

    Family and domain databases

    InterProi IPR001610. PAC.
    IPR000014. PAS.
    IPR015524. Per_circ_prot_3.
    IPR022728. Period_circadian-like_C.
    [Graphical view ]
    PANTHERi PTHR11269:SF13. PTHR11269:SF13. 1 hit.
    Pfami PF12114. Period_C. 1 hit.
    [Graphical view ]
    SMARTi SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55785. SSF55785. 1 hit.
    PROSITEi PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-91 AND 724-882 (ISOFORMS 1/2), VARIANTS GLY-639; PRO-827; ALA-856; 1001-SER--PRO-1018; THR-1028 AND ARG-1149.
    2. Rhodes S., Huckle E.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Identification of a growth inhibition gene."
      Kim J.W.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference."
      Archer S.N., Robilliard D.L., Skene D.J., Smits M., Williams A., Arendt J., von Schantz M.
      Sleep 26:413-415(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF VARIANT 1001-SER--PRO-1018 DEL ASSOCIATED WITH DIURNAL PREFERENCE.
    6. "SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein."
      Shirogane T., Jin J., Ang X.L., Harper J.W.
      J. Biol. Chem. 280:26863-26872(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FBXW11 AND BTRC.
    7. "PER3 polymorphism predicts sleep structure and waking performance."
      Viola A.U., Archer S.N., James L.M., Groeger J.A., Lo J.C., Skene D.J., von Schantz M., Dijk D.J.
      Curr. Biol. 17:613-618(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SLEEP HOMEOSTASIS, CHARACTERIZATION OF VARIANT 1001-SER--PRO-1018 DEL.
    8. "PERIOD3, circadian phenotypes, and sleep homeostasis."
      Dijk D.J., Archer S.N.
      Sleep Med. Rev. 14:151-160(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SLEEP HOMEOSTASIS, CHARACTERIZATION OF VARIANT 1001-SER--PRO-1018 DEL, REVIEW.
    9. "Metabolism and the circadian clock converge."
      Eckel-Mahan K., Sassone-Corsi P.
      Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    10. "Sleep ability mediates individual differences in the vulnerability to sleep loss: evidence from a PER3 polymorphism."
      Maire M., Reichert C.F., Gabel V., Viola A.U., Strobel W., Krebs J., Landolt H.P., Bachmann V., Cajochen C., Schmidt C.
      Cortex 52:47-59(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SLEEP HOMEOSTASIS, CHARACTERIZATION OF VARIANT 1001-SER--PRO-1018 DEL.
    11. "A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism."
      Hasan S., van der Veen D.R., Winsky-Sommerer R., Hogben A., Laing E.E., Koentgen F., Dijk D.J., Archer S.N.
      FASEB J. 28:1-14(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SLEEP HOMEOSTASIS, CHARACTERIZATION OF VARIANT 1001-SER--PRO-1018 DEL.
    12. "Molecular architecture of the mammalian circadian clock."
      Partch C.L., Green C.B., Takahashi J.S.
      Trends Cell Biol. 24:90-99(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    13. Cited for: VARIANT GLY-639.

    Entry informationi

    Entry nameiPER3_HUMAN
    AccessioniPrimary (citable) accession number: P56645
    Secondary accession number(s): Q5H8X4
    , Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 132 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3