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P56645

- PER3_HUMAN

UniProt

P56645 - PER3_HUMAN

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Protein

Period circadian protein homolog 3

Gene

PER3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme.4 Publications

GO - Molecular functioni

  1. signal transducer activity Source: InterPro

GO - Biological processi

  1. circadian regulation of gene expression Source: InterPro
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. regulation of circadian sleep/wake cycle, sleep Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Period circadian protein homolog 3
Short name:
hPER3
Alternative name(s):
Cell growth-inhibiting gene 13 protein
Circadian clock protein PERIOD 3
Gene namesi
Name:PER3
ORF Names:GIG13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8847. PER3.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12011201Period circadian protein homolog 3PRO_0000162633Add
BLAST

Post-translational modificationi

Phosphorylation by CSNK1E is weak and appears to require association with PER1 and translocation to the nucleus.By similarity
Ubiquitinated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP56645.
PaxDbiP56645.
PRIDEiP56645.

PTM databases

PhosphoSiteiP56645.

Expressioni

Gene expression databases

BgeeiP56645.
CleanExiHS_PER3.
ExpressionAtlasiP56645. baseline and differential.
GenevestigatoriP56645.

Organism-specific databases

HPAiHPA019530.

Interactioni

Subunit structurei

Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1, PER2, CRY1, CRY2, and TIMELESS; interaction with CRY1 and CRY2 is weak and not rhythmic. Interacts with FBXW11 and BTRC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CHEK2O960172EBI-2827813,EBI-1180783

Protein-protein interaction databases

BioGridi114386. 7 interactions.
IntActiP56645. 4 interactions.
MINTiMINT-8052823.
STRINGi9606.ENSP00000355031.

Structurei

3D structure databases

ProteinModelPortaliP56645.
SMRiP56645. Positions 36-415, 1099-1180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 18868PAS 1PROSITE-ProRule annotationAdd
BLAST
Domaini262 – 32867PAS 2PROSITE-ProRule annotationAdd
BLAST
Domaini337 – 38044PACAdd
BLAST
Repeati965 – 982181Add
BLAST
Repeati983 – 1000182Add
BLAST
Repeati1001 – 1018183Add
BLAST
Repeati1019 – 1036184Add
BLAST
Repeati1037 – 1054185Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni555 – 760206CSNK1E binding domainBy similarityAdd
BLAST
Regioni965 – 1054905 X 18 AA tandem repeats of S-[HP]-[AP]-T-[AT]-[GST]-[ATV]-L-S-[MT]-G-[LS]-P-P-[MRS]-[EKR]-[NST]-PAdd
BLAST
Regioni1123 – 120179CRY binding domainBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi55 – 6410Nuclear export signal 1By similarity
Motifi403 – 41210Nuclear export signal 3By similarity
Motifi729 – 74517Nuclear localization signalBy similarityAdd
BLAST
Motifi925 – 9328Nuclear export signal 2By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi567 – 5704Poly-Ser
Compositional biasi750 – 7534Poly-Ser
Compositional biasi769 – 895127Pro-richAdd
BLAST
Compositional biasi962 – 1081120Ser-richAdd
BLAST

Sequence similaritiesi

Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG269786.
GeneTreeiENSGT00510000046467.
HOVERGENiHBG008167.
InParanoidiP56645.
KOiK02633.
OMAiFKHVGLT.
OrthoDBiEOG7S7SD0.
PhylomeDBiP56645.
TreeFamiTF318445.

Family and domain databases

InterProiIPR001610. PAC.
IPR000014. PAS.
IPR015524. Per_circ_prot_3.
IPR022728. Period_circadian-like_C.
[Graphical view]
PANTHERiPTHR11269:SF13. PTHR11269:SF13. 1 hit.
PfamiPF12114. Period_C. 1 hit.
[Graphical view]
SMARTiSM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS50112. PAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P56645-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRGEAPGPG RRGAKDEALG EESGERWSPE FHLQRKLADS SHSEQQDRNR
60 70 80 90 100
VSEELIMVVQ EMKKYFPSER RNKPSTLDAL NYALRCVHSV QANSEFFQIL
110 120 130 140 150
SQNGAPQADV SMYSLEELAT IASEHTSKNT DTFVAVFSFL SGRLVHISEQ
160 170 180 190 200
AALILNRKKD VLASSHFVDL LAPQDMRVFY AHTARAQLPF WNNWTQRAAR
210 220 230 240 250
YECAPVKPFF CRIRGGEDRK QEKCHSPFRI IPYLIHVHHP AQPELESEPC
260 270 280 290 300
CLTVVEKIHS GYEAPRIPVN KRIFTTTHTP GCVFLEVDEK AVPLLGYLPQ
310 320 330 340 350
DLIGTSILSY LHPEDRSLMV AIHQKVLKYA GHPPFEHSPI RFCTQNGDYI
360 370 380 390 400
ILDSSWSSFV NPWSRKISFI IGRHKVRTSP LNEDVFATKI KKMNDNDKDI
410 420 430 440 450
TELQEQIYKL LLQPVHVSVS SGYGSLGSSG SQEQLVSIAS SSEASGHRVE
460 470 480 490 500
ETKAEQMTLQ QVYASVNKIK NLGQQLYIES MTKSSFKPVT GTRTEPNGGG
510 520 530 540 550
ECKTFTSFHQ TLKNNSVYTE PCEDLRNDEH SPSYQQINCI DSVIRYLKSY
560 570 580 590 600
NIPALKRKCI SCTNTTSSSS EEDKQNHKAD DVQALQAGLQ IPAIPKSEMP
610 620 630 640 650
TNGRSIDTGG GAPQILSTAM LSLGSGISQC GYSSTIVHVP PPETARDATL
660 670 680 690 700
FCEPWTLNMQ PAPLTSEEFK HVGLTAAVLS AHTQKEEQNY VDKFREKILS
710 720 730 740 750
SPYSSYLQQE SRSKAKYSYF QGDSTSKQTR SAGCRKGKHK RKKLPEPPDS
760 770 780 790 800
SSSNTGSGPR RGAHQNAQPC CPSAASSPHT SSPTFPPAAM VPSQAPYLVP
810 820 830 840 850
AFPLPAATSP GREYAAPGTA PEGLHGLPLS EGLQPYPAFP FPYLDTFMTV
860 870 880 890 900
FLPDPPVCPL LSPSFLPCPF LGATASSAIS PSMSSAMSPT LDPPPSVTSQ
910 920 930 940 950
RREEEKWEAQ SEGHPFITSR SSSPLQLNLL QEEMPRPSES PDQMRRNTCP
960 970 980 990 1000
QTEYCVTGNN GSESSPATTG ALSTGSPPRE NPSHPTASAL STGSPPMKNP
1010 1020 1030 1040 1050
SHPTASALST GSPPMKNPSH PTASTLSMGL PPSRTPSHPT ATVLSTGSPP
1060 1070 1080 1090 1100
SESPSRTGSA ASGSSDSSIY LTSSVYSSKI SQNGQQSQDV QKKETFPNVA
1110 1120 1130 1140 1150
EEPIWRMIRQ TPERILMTYQ VPERVKEVVL KEDLEKLESM RQQQPQFSHG
1160 1170 1180 1190 1200
QKEELAKVYN WIQSQTVTQE IDIQACVTCE NEDSADGAAT SCGQVLVEDS

C
Length:1,201
Mass (Da):131,888
Last modified:January 11, 2011 - v4
Checksum:i8129C4246EDD1816
GO
Isoform 2 (identifier: P56645-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-197: R → RA
     499-499: G → GGESANGG
     954-954: Y → YQ

Show »
Length:1,210
Mass (Da):132,660
Checksum:iD63BD326292813F6
GO

Sequence cautioni

The sequence BAB32925.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti943 – 9431Q → R in BAB32925. (PubMed:11306557)Curated

Polymorphismi

The number of repeats of 18 amino acids in positions 966 to 1055 is polymorphic and varies among at least 2 different alleles. Alleles corresponding in size to a 4 (PER3.4) and 5 (PER3.5) repeats have been described. The sequence shown is that of allele PER3.5. In most populations around 10% of individuals are homozygous for the 5-repeat (PER3.5), whereas approximately 50% are homozygous for the 4-repeat (PER3.4). In some populations in Papua New Guinea the prevalence of the various genotypes appears to be reversed. These repeats and polymorphism are not present in non-primate mammals. Homozygosity for PER3.5 is more likely to show morning preference, whereas homozygosity for the PER3.4 associates with evening preferences. PER3.5 homozygous show vulnerability to sleep loss with a greater cognitive decline in response to total sleep deprivation (PubMed:11306557, PubMed:17346965, PubMed:19716732, PubMed:24439663, PubMed:24577121).5 Publications

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti639 – 6391V → G Associated with delayed sleep phase syndrome (DSPS). 2 Publications
Corresponds to variant rs10462020 [ dbSNP | Ensembl ].
VAR_025532
Natural varianti827 – 8271L → P.1 Publication
Corresponds to variant rs228696 [ dbSNP | Ensembl ].
VAR_022428
Natural varianti856 – 8561P → A.1 Publication
Corresponds to variant rs228697 [ dbSNP | Ensembl ].
VAR_015514
Natural varianti1001 – 101818Missing Associated with eveningness and better cognitive performance during sleep deprivation exepriments.
Corresponds to variant rs57875989 [ dbSNP | Ensembl ].
VAR_071049Add
BLAST
Natural varianti1007 – 10071A → T.
Corresponds to variant rs1776342 [ dbSNP | Ensembl ].
VAR_028728
Natural varianti1010 – 10101T → I.
Corresponds to variant rs12033719 [ dbSNP | Ensembl ].
VAR_028729
Natural varianti1028 – 10281M → T Only found in PER3.4 allele. 1 Publication
Corresponds to variant rs2640909 [ dbSNP | Ensembl ].
VAR_025533
Natural varianti1081 – 10811S → C.
Corresponds to variant rs2640905 [ dbSNP | Ensembl ].
VAR_028730
Natural varianti1149 – 11491H → R.1 Publication
Corresponds to variant rs10462021 [ dbSNP | Ensembl ].
VAR_025534

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei197 – 1971R → RA in isoform 2. 1 PublicationVSP_040326
Alternative sequencei499 – 4991G → GGESANGG in isoform 2. 1 PublicationVSP_040327
Alternative sequencei954 – 9541Y → YQ in isoform 2. 1 PublicationVSP_040328

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047521 Genomic DNA. Translation: BAB63250.1.
AB047530 Genomic DNA. Translation: BAB63251.1.
AB047531 Genomic DNA. Translation: BAB63252.1.
AB047532 Genomic DNA. Translation: BAB63253.1.
AB047533 Genomic DNA. Translation: BAB63254.1.
AB047534 Genomic DNA. Translation: BAB63255.1.
AB047686 mRNA. Translation: BAB32925.2. Different initiation.
AL157954 mRNA. Translation: CAB76084.1.
AY493418 mRNA. Translation: AAS72879.1.
Z98884 Genomic DNA. Translation: CAI21435.1.
Z98884 Genomic DNA. Translation: CAI21436.1.
CCDSiCCDS72695.1. [P56645-2]
CCDS89.1. [P56645-1]
RefSeqiNP_001276790.1. NM_001289861.1.
NP_001276791.1. NM_001289862.1. [P56645-2]
NP_001276792.1. NM_001289863.1.
NP_001276793.1. NM_001289864.1.
NP_058515.1. NM_016831.2. [P56645-1]
UniGeneiHs.162200.

Genome annotation databases

EnsembliENST00000361923; ENSP00000355031; ENSG00000049246. [P56645-1]
ENST00000377532; ENSP00000366755; ENSG00000049246. [P56645-2]
ENST00000613533; ENSP00000482093; ENSG00000049246. [P56645-2]
GeneIDi8863.
KEGGihsa:8863.
UCSCiuc001aoo.3. human. [P56645-1]
uc001aop.3. human. [P56645-2]

Polymorphism databases

DMDMi317373535.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047521 Genomic DNA. Translation: BAB63250.1 .
AB047530 Genomic DNA. Translation: BAB63251.1 .
AB047531 Genomic DNA. Translation: BAB63252.1 .
AB047532 Genomic DNA. Translation: BAB63253.1 .
AB047533 Genomic DNA. Translation: BAB63254.1 .
AB047534 Genomic DNA. Translation: BAB63255.1 .
AB047686 mRNA. Translation: BAB32925.2 . Different initiation.
AL157954 mRNA. Translation: CAB76084.1 .
AY493418 mRNA. Translation: AAS72879.1 .
Z98884 Genomic DNA. Translation: CAI21435.1 .
Z98884 Genomic DNA. Translation: CAI21436.1 .
CCDSi CCDS72695.1. [P56645-2 ]
CCDS89.1. [P56645-1 ]
RefSeqi NP_001276790.1. NM_001289861.1.
NP_001276791.1. NM_001289862.1. [P56645-2 ]
NP_001276792.1. NM_001289863.1.
NP_001276793.1. NM_001289864.1.
NP_058515.1. NM_016831.2. [P56645-1 ]
UniGenei Hs.162200.

3D structure databases

ProteinModelPortali P56645.
SMRi P56645. Positions 36-415, 1099-1180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114386. 7 interactions.
IntActi P56645. 4 interactions.
MINTi MINT-8052823.
STRINGi 9606.ENSP00000355031.

PTM databases

PhosphoSitei P56645.

Polymorphism databases

DMDMi 317373535.

Proteomic databases

MaxQBi P56645.
PaxDbi P56645.
PRIDEi P56645.

Protocols and materials databases

DNASUi 8863.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361923 ; ENSP00000355031 ; ENSG00000049246 . [P56645-1 ]
ENST00000377532 ; ENSP00000366755 ; ENSG00000049246 . [P56645-2 ]
ENST00000613533 ; ENSP00000482093 ; ENSG00000049246 . [P56645-2 ]
GeneIDi 8863.
KEGGi hsa:8863.
UCSCi uc001aoo.3. human. [P56645-1 ]
uc001aop.3. human. [P56645-2 ]

Organism-specific databases

CTDi 8863.
GeneCardsi GC01P007844.
HGNCi HGNC:8847. PER3.
HPAi HPA019530.
MIMi 603427. gene.
neXtProti NX_P56645.
PharmGKBi PA33186.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG269786.
GeneTreei ENSGT00510000046467.
HOVERGENi HBG008167.
InParanoidi P56645.
KOi K02633.
OMAi FKHVGLT.
OrthoDBi EOG7S7SD0.
PhylomeDBi P56645.
TreeFami TF318445.

Miscellaneous databases

ChiTaRSi PER3. human.
GeneWikii PER3.
GenomeRNAii 8863.
NextBioi 33281.
PROi P56645.
SOURCEi Search...

Gene expression databases

Bgeei P56645.
CleanExi HS_PER3.
ExpressionAtlasi P56645. baseline and differential.
Genevestigatori P56645.

Family and domain databases

InterProi IPR001610. PAC.
IPR000014. PAS.
IPR015524. Per_circ_prot_3.
IPR022728. Period_circadian-like_C.
[Graphical view ]
PANTHERi PTHR11269:SF13. PTHR11269:SF13. 1 hit.
Pfami PF12114. Period_C. 1 hit.
[Graphical view ]
SMARTi SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view ]
SUPFAMi SSF55785. SSF55785. 1 hit.
PROSITEi PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-91 AND 724-882 (ISOFORMS 1/2), VARIANTS GLY-639; PRO-827; ALA-856; 1001-SER--PRO-1018; THR-1028 AND ARG-1149.
  2. Rhodes S., Huckle E.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Identification of a growth inhibition gene."
    Kim J.W.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference."
    Archer S.N., Robilliard D.L., Skene D.J., Smits M., Williams A., Arendt J., von Schantz M.
    Sleep 26:413-415(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF VARIANT 1001-SER--PRO-1018 DEL ASSOCIATED WITH DIURNAL PREFERENCE.
  6. "SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein."
    Shirogane T., Jin J., Ang X.L., Harper J.W.
    J. Biol. Chem. 280:26863-26872(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FBXW11 AND BTRC.
  7. "PER3 polymorphism predicts sleep structure and waking performance."
    Viola A.U., Archer S.N., James L.M., Groeger J.A., Lo J.C., Skene D.J., von Schantz M., Dijk D.J.
    Curr. Biol. 17:613-618(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SLEEP HOMEOSTASIS, CHARACTERIZATION OF VARIANT 1001-SER--PRO-1018 DEL.
  8. "PERIOD3, circadian phenotypes, and sleep homeostasis."
    Dijk D.J., Archer S.N.
    Sleep Med. Rev. 14:151-160(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SLEEP HOMEOSTASIS, CHARACTERIZATION OF VARIANT 1001-SER--PRO-1018 DEL, REVIEW.
  9. "Metabolism and the circadian clock converge."
    Eckel-Mahan K., Sassone-Corsi P.
    Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "Sleep ability mediates individual differences in the vulnerability to sleep loss: evidence from a PER3 polymorphism."
    Maire M., Reichert C.F., Gabel V., Viola A.U., Strobel W., Krebs J., Landolt H.P., Bachmann V., Cajochen C., Schmidt C.
    Cortex 52:47-59(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SLEEP HOMEOSTASIS, CHARACTERIZATION OF VARIANT 1001-SER--PRO-1018 DEL.
  11. "A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism."
    Hasan S., van der Veen D.R., Winsky-Sommerer R., Hogben A., Laing E.E., Koentgen F., Dijk D.J., Archer S.N.
    FASEB J. 28:1-14(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SLEEP HOMEOSTASIS, CHARACTERIZATION OF VARIANT 1001-SER--PRO-1018 DEL.
  12. "Molecular architecture of the mammalian circadian clock."
    Partch C.L., Green C.B., Takahashi J.S.
    Trends Cell Biol. 24:90-99(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  13. Cited for: VARIANT GLY-639.

Entry informationi

Entry nameiPER3_HUMAN
AccessioniPrimary (citable) accession number: P56645
Secondary accession number(s): Q5H8X4
, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3