P56632 (NU4LM_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-ubiquinone oxidoreductase chain 4L
EC=1.6.5.3

Alternative name(s):
NADH dehydrogenase subunit 4L

Gene names

Name:	MT-ND4L
Synonyms:	MTND4L, NADH4L, ND4L

Encoded on

Mitochondrion

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol.
Subcellular location	Mitochondrion membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 4L family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion
Domain	Transmembrane Transmembrane helix
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 98	98	NADH-ubiquinone oxidoreductase chain 4L		PRO_0000118473
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	61 – 81	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P56632 [UniParc]. Last modified December 15, 1998. Version 1. Checksum: 828C7F511A4E3AFA	FASTA	98	10,824
	10 20 30 40 50 60 MPLVYMNIIM AFAIALAGLL MYRSHLMSSL LCLEGMMLSL FIMSTLIILN THFTLANMMP 70 80 90 IILLVFAACE AALGLSLLVM VSNTYGTDYV QNLNLLQC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete mitochondrial DNA sequence of the pig (Sus scrofa)." Ursing B.M., Arnason U. J. Mol. Evol. 47:302-306(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete nucleotide sequence of pig (Sus scrofa) mitochondrial genome and dating evolutionary divergence within artiodactyla." Lin C.S., Sun Y.L., Liu C.Y., Yang P.C., Chang L.C., Cheng I.C., Mao S.J.T., Huang M.C. Gene 236:107-114(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Landrace.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ002189 Genomic DNA. Translation: CAA05240.1. AF034253 Genomic DNA. Translation: AAD34193.1.
PIR	T10980.
RefSeq	NP_008642.1. NC_000845.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	808509.
KEGG	ssc:808509.
Organism-specific databases
CTD	4539.
Phylogenomic databases
eggNOG	NOG260597.
HOVERGEN	HBG071122.
KO	K03882.
OrthoDB	EOG4DZ1WV.
ProtClustDB	MTH00107.
Family and domain databases
InterPro	IPR001133. NADH_UbQ_OxRdtase_chain4L/K. [Graphical view]
PANTHER	PTHR11434. PTHR11434. 1 hit.
Pfam	PF00420. Oxidored_q2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU4LM_PIG

Accession

Primary (citable) accession number: P56632

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program