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Protein

Aquaporin-9

Gene

Aqp9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na+, K+, Cl-, and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-RNO-432047. Passive transport by Aquaporins.

Protein family/group databases

TCDBi1.A.8.9.2. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-9
Short name:
AQP-9
Alternative name(s):
Aquaglyceroporin-9
Gene namesi
Name:Aqp9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi68433. Aqp9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 54ExtracellularSequence analysis4
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 110CytoplasmicSequence analysisAdd BLAST35
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 158ExtracellularSequence analysisAdd BLAST27
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 189CytoplasmicSequence analysis10
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 245ExtracellularSequence analysisAdd BLAST35
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 295CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

  • basolateral plasma membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • intracellular membrane-bounded organelle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639661 – 295Aquaporin-9Add BLAST295

Proteomic databases

PaxDbiP56627.
PRIDEiP56627.

PTM databases

iPTMnetiP56627.
PhosphoSitePlusiP56627.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015949.
GenevisibleiP56627. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021442.

Structurei

3D structure databases

ProteinModelPortaliP56627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi84 – 86NPA 13
Motifi216 – 218NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiP56627.
KOiK09877.
OMAiNKGDANW.
OrthoDBiEOG091G0FMS.
PhylomeDBiP56627.
TreeFamiTF313173.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR015685. Aquaporin_9.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02021. AQUAPORIN9.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSEKDGAKK SLMQRLALKS RIAKETLSEF LGTFIMIVLG CSSIAQAVLS
60 70 80 90 100
RERFGGIITI NIGFASAVVM ALYVTFGISG GHINPAVSFA MCAFGRMEWF
110 120 130 140 150
KFPFYVGAQF LGAFVGAATV FGIYYDGLMA FAGGKLLVVG ENATAFIFAT
160 170 180 190 200
YPAPFISTPG AFVDQVVSTM FLLLIVFAMF DSRNLGVPRG LEPVVIGLLI
210 220 230 240 250
IVLSCSLGLN SGCAMNPARD LSPRLFTALA GWGFEVFTVG NNFWWIPVVG
260 270 280 290
PMIGAFLGGL IYILFIQMHH SKLDPDMKAE PSENNLEKHE LSVIM
Length:295
Mass (Da):31,871
Last modified:December 15, 1998 - v1
Checksum:i09FD8B1DE936E61F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93A → V in BAA33680 (PubMed:10205677).Curated1
Sequence conflicti197G → S in BAA33680 (PubMed:10205677).Curated1
Sequence conflicti207L → P in BAA33680 (PubMed:10205677).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016406 mRNA. Translation: AAC36020.1.
AB013112 mRNA. Translation: BAA33680.1.
BC085731 mRNA. Translation: AAH85731.1.
RefSeqiNP_075249.1. NM_022960.2.
XP_006243424.1. XM_006243362.1.
XP_008764558.1. XM_008766336.2.
UniGeneiRn.30018.

Genome annotation databases

EnsembliENSRNOT00000087980; ENSRNOP00000069377; ENSRNOG00000061883.
GeneIDi65054.
KEGGirno:65054.
UCSCiRGD:68433. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016406 mRNA. Translation: AAC36020.1.
AB013112 mRNA. Translation: BAA33680.1.
BC085731 mRNA. Translation: AAH85731.1.
RefSeqiNP_075249.1. NM_022960.2.
XP_006243424.1. XM_006243362.1.
XP_008764558.1. XM_008766336.2.
UniGeneiRn.30018.

3D structure databases

ProteinModelPortaliP56627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021442.

Protein family/group databases

TCDBi1.A.8.9.2. the major intrinsic protein (mip) family.

PTM databases

iPTMnetiP56627.
PhosphoSitePlusiP56627.

Proteomic databases

PaxDbiP56627.
PRIDEiP56627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000087980; ENSRNOP00000069377; ENSRNOG00000061883.
GeneIDi65054.
KEGGirno:65054.
UCSCiRGD:68433. rat.

Organism-specific databases

CTDi366.
RGDi68433. Aqp9.

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiP56627.
KOiK09877.
OMAiNKGDANW.
OrthoDBiEOG091G0FMS.
PhylomeDBiP56627.
TreeFamiTF313173.

Enzyme and pathway databases

ReactomeiR-RNO-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-RNO-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiP56627.

Gene expression databases

BgeeiENSRNOG00000015949.
GenevisibleiP56627. RN.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR015685. Aquaporin_9.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02021. AQUAPORIN9.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQP9_RAT
AccessioniPrimary (citable) accession number: P56627
Secondary accession number(s): O88815
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.