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P56616 (UBE2C_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 C

EC=6.3.2.19
Alternative name(s):
UBC-X
Ubiquitin carrier protein C
Ubiquitin-protein ligase C
Gene names
Name:ube2c
Synonyms:ubch10, ubcx
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Component of the APC/C complex By similarity.

Post-translational modification

Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome By similarity.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 179179Ubiquitin-conjugating enzyme E2 C
PRO_0000082562

Sites

Active site1141Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P56616 [UniParc].

Last modified December 15, 1998. Version 1.
Checksum: 0F7C242CE55996BA

FASTA17919,897
        10         20         30         40         50         60 
MASQNVDPAA ASSVASRKGQ ESGTSAARGS VGKRLQQELM TLMMSGDKGI SAFPESDNLF 

        70         80         90        100        110        120 
KWIGTIDGAV GTVYEDLRYK LSLEFPSGYP YNAPTVKFVT PCFHPNVDSH GNICLDILKD 

       130        140        150        160        170 
KWSALYDVRT ILLSLQSLLG EPNNESPLNP YAAELWQNQT AYKKHLHEQY QKQVREKEI 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation."
Yu H., King R.W., Peters J.-M., Kirschner M.W.
Curr. Biol. 6:455-466(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 63-80 AND 99-108.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC075141 mRNA. Translation: AAH75141.1.
RefSeqNP_001086346.1. NM_001092877.1.
UniGeneXl.27784.

3D structure databases

ProteinModelPortalP56616.
SMRP56616. Positions 31-174.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP56616.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID444775.
KEGGxla:444775.

Organism-specific databases

CTD11065.

Phylogenomic databases

HOVERGENHBG063308.
KOK06688.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBE2C_XENLA
AccessionPrimary (citable) accession number: P56616
Secondary accession number(s): Q6DJN4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways