Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P56616

- UBE2C_XENLA

UniProt

P56616 - UBE2C_XENLA

Protein

Ubiquitin-conjugating enzyme E2 C

Gene

ube2c

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (15 Dec 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei114 – 1141Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
    2. exit from mitosis Source: UniProtKB
    3. free ubiquitin chain polymerization Source: UniProtKB
    4. protein K11-linked ubiquitination Source: UniProtKB
    5. ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 C (EC:6.3.2.19)
    Alternative name(s):
    UBC-X
    Ubiquitin carrier protein C
    Ubiquitin-protein ligase C
    Gene namesi
    Name:ube2c
    Synonyms:ubch10, ubcx
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Subcellular locationi

    GO - Cellular componenti

    1. anaphase-promoting complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Ubiquitin-conjugating enzyme E2 CPRO_0000082562Add
    BLAST

    Post-translational modificationi

    Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiP56616.

    Interactioni

    Subunit structurei

    Component of the APC/C complex.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP56616.
    SMRiP56616. Positions 31-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG063308.
    KOiK06688.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56616-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASQNVDPAA ASSVASRKGQ ESGTSAARGS VGKRLQQELM TLMMSGDKGI    50
    SAFPESDNLF KWIGTIDGAV GTVYEDLRYK LSLEFPSGYP YNAPTVKFVT 100
    PCFHPNVDSH GNICLDILKD KWSALYDVRT ILLSLQSLLG EPNNESPLNP 150
    YAAELWQNQT AYKKHLHEQY QKQVREKEI 179
    Length:179
    Mass (Da):19,897
    Last modified:December 15, 1998 - v1
    Checksum:i0F7C242CE55996BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC075141 mRNA. Translation: AAH75141.1.
    RefSeqiNP_001086346.1. NM_001092877.1.
    UniGeneiXl.27784.

    Genome annotation databases

    GeneIDi444775.
    KEGGixla:444775.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC075141 mRNA. Translation: AAH75141.1 .
    RefSeqi NP_001086346.1. NM_001092877.1.
    UniGenei Xl.27784.

    3D structure databases

    ProteinModelPortali P56616.
    SMRi P56616. Positions 31-174.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P56616.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 444775.
    KEGGi xla:444775.

    Organism-specific databases

    CTDi 11065.

    Phylogenomic databases

    HOVERGENi HBG063308.
    KOi K06688.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation."
      Yu H., King R.W., Peters J.-M., Kirschner M.W.
      Curr. Biol. 6:455-466(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 63-80 AND 99-108.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiUBE2C_XENLA
    AccessioniPrimary (citable) accession number: P56616
    Secondary accession number(s): Q6DJN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3