P56611 (SCX1_TITBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Toxin Tb1 Alternative name(s): PT-Mice-beta* NaTx6.2 Tb-gamma
Organism	Tityus bahiensis (Brazilian scorpion)
Taxonomic identifier	50343 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Tityus

Protein attributes

Sequence length	84 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing By similarity. Is lethal to mice (Ref.1).
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ion channel impairing toxin Neurotoxin Sodium channel inhibitor Toxin
PTM	Amidation Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sodium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.1
	Chain	21 – 81	61	Toxin Tb1		PRO_0000035298
Amino acid modifications
	Modified residue	81	1	Cysteine amide Probable
	Disulfide bond	31 ↔ 81		By similarity
	Disulfide bond	35 ↔ 57		By similarity
	Disulfide bond	43 ↔ 62		By similarity
	Disulfide bond	47 ↔ 64		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56611 [UniParc]. Last modified December 15, 1998. Version 1. Checksum: A24A2ACA7F768136	FASTA	84	9,384
	10 20 30 40 50 60 MKGMILFISC LLLIGIVVEC KEGYLMDHEG CKLSCFIRPS GYCGSECKIK KGSSGYCAWP 70 80 ACYCYGLPNW VKVWDRATNK CGKK

References

[1]	"Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus." Becerril B., Corona M., Coronas F.I., Zamudio F.Z., Calderon-Aranda E.S., Fletcher P.L. Jr., Martin B.M., Possani L.D. Biochem. J. 313:753-760(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 21-81, BIOASSAY. Tissue: Venom.
[2]	"Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins." Guerrero-Vargas J.A., Mourao C.B., Quintero-Hernandez V., Possani L.D., Schwartz E.F. PLoS ONE 7:E30478-E30478(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.

Cross-references

Sequence databases
PIR	S62868.
3D structure databases
ProteinModelPortal	P56611.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. IPR018218. Scorpion_toxinL. IPR002061. Scorpion_toxinL/defesin. [Graphical view]
Pfam	PF00537. Toxin_3. 1 hit. [Graphical view]
PRINTS	PR00285. SCORPNTOXIN.
SMART	SM00505. Knot1. 1 hit. [Graphical view]
SUPFAM	SSF57095. SSF57095. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SCX1_TITBA

Accession

Primary (citable) accession number: P56611

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program