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Protein

Secretory carrier-associated membrane protein 1

Gene

Scamp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: RGD

GO - Biological processi

  • endocytosis Source: RGD
  • protein transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 1
Short name:
Secretory carrier membrane protein 1
Alternative name(s):
SCAMP 37
Gene namesi
Name:Scamp1
Synonyms:Scamp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3625. Scamp1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 155CytoplasmicSequence analysisAdd BLAST154
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 181LumenalSequence analysis5
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 217CytoplasmicSequence analysisAdd BLAST15
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 261LumenalSequence analysisAdd BLAST23
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 338CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

  • clathrin-coated vesicle Source: ParkinsonsUK-UCL
  • integral component of membrane Source: UniProtKB
  • recycling endosome membrane Source: UniProtKB
  • terminal bouton Source: ParkinsonsUK-UCL
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001912532 – 338Secretory carrier-associated membrane protein 1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei45PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP56603.
PRIDEiP56603.

PTM databases

iPTMnetiP56603.
PhosphoSitePlusiP56603.
SwissPalmiP56603.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010774.

Interactioni

Subunit structurei

Interacts with SLC9A7 (By similarity). Interacts with SYNRG and ITSN1.By similarity1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

BioGridi248159. 1 interactor.
MINTiMINT-130188.
STRINGi10116.ENSRNOP00000014602.

Family & Domainsi

Sequence similaritiesi

Belongs to the SCAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3088. Eukaryota.
ENOG410XSJN. LUCA.
HOGENOMiHOG000294221.
HOVERGENiHBG071938.
InParanoidiP56603.
KOiK19995.
PhylomeDBiP56603.
TreeFamiTF313797.

Family and domain databases

InterProiIPR007273. SCAMP.
[Graphical view]
PANTHERiPTHR10687. PTHR10687. 1 hit.
PfamiPF04144. SCAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFDSNPFA DPDLNNPFKD PSVTQVTRNV PPGLDEYNPF SDSRTPPPGG
60 70 80 90 100
VKMPNVPNTQ PAIMKPTEEH PAYTQITKEH ALAQAELLKR QEELERKAAE
110 120 130 140 150
LDRREREMQN LSQHGRKNNW PPLPSNFPVG PCFYQDFSVD IPVEFQKTVK
160 170 180 190 200
LMYYLWMFHA VTLFLNIFGC LAWFCVDSSR AVDFGLSILW FLLFTPCSFV
210 220 230 240 250
CWYRPLYGAF RSDSSFRFFV FFFVYICQFA VHVLQAAGFH NWGNCGWISS
260 270 280 290 300
LTGLNKNIPV GIMMIIIAAL FTASAVISLV MFKKVHGLYR TTGASFEKAQ
310 320 330
QEFATGVMSN KTVQTAAANA ASTAATSAAQ NAFKGNQM
Length:338
Mass (Da):37,999
Last modified:December 15, 1998 - v1
Checksum:i72E3BAD6A8FEBF59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22079 mRNA. No translation available.
PIRiS37395.
RefSeqiNP_001094106.1. NM_001100636.1.
UniGeneiRn.20374.

Genome annotation databases

GeneIDi29521.
KEGGirno:29521.
UCSCiRGD:3625. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22079 mRNA. No translation available.
PIRiS37395.
RefSeqiNP_001094106.1. NM_001100636.1.
UniGeneiRn.20374.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248159. 1 interactor.
MINTiMINT-130188.
STRINGi10116.ENSRNOP00000014602.

PTM databases

iPTMnetiP56603.
PhosphoSitePlusiP56603.
SwissPalmiP56603.

Proteomic databases

PaxDbiP56603.
PRIDEiP56603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29521.
KEGGirno:29521.
UCSCiRGD:3625. rat.

Organism-specific databases

CTDi9522.
RGDi3625. Scamp1.

Phylogenomic databases

eggNOGiKOG3088. Eukaryota.
ENOG410XSJN. LUCA.
HOGENOMiHOG000294221.
HOVERGENiHBG071938.
InParanoidiP56603.
KOiK19995.
PhylomeDBiP56603.
TreeFamiTF313797.

Miscellaneous databases

PROiP56603.

Gene expression databases

BgeeiENSRNOG00000010774.

Family and domain databases

InterProiIPR007273. SCAMP.
[Graphical view]
PANTHERiPTHR10687. PTHR10687. 1 hit.
PfamiPF04144. SCAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCAM1_RAT
AccessioniPrimary (citable) accession number: P56603
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.