P56602 (PPOX_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protoporphyrinogen oxidase
Short name=PPO
EC=1.3.3.4

Gene names

Name:

PPOX

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	28 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Catalytic activity	Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.
Cofactor	Binds 1 FAD per dimer By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side By similarity. Note: Bound to the mitochondrial inner membrane with its active site facing the cytosolic side By similarity.
Sequence similarities	Belongs to the protoporphyrinogen oxidase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxygen-dependent protoporphyrinogen oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›28	›28	Protoporphyrinogen oxidase		PRO_0000135269
Experimental info
	Non-adjacent residues	13 – 14	2
	Non-terminal residue	1	1
	Non-terminal residue	28	1

Sequences

	Sequence		Length	Mass (Da)
	P56602 [UniParc]. Last modified December 15, 1998. Version 1. Checksum: FEDFC3F09CB6A345	FASTA	28	2,777
	10 20 GRTVVVLGGG ISGDSLCRGV FAGNSREL

References

[1]

"Induction of terminal enzymes for heme biosynthesis during differentiation of mouse erythroleukemia cells." Taketani S., Yoshinaga T., Furukawa T., Kohno H., Tokunaga R., Nishimura K., Inokuchi H. Eur. J. Biochem. 230:760-765(1995) [PubMed: 7607249] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver.

Cross-references

Sequence databases
IPI	IPI00826039.
PIR	S65629.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P56602.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	maNOG14590.
GeneTree	ENSGT00390000008744.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PPOX_BOVIN

Accession

Primary (citable) accession number: P56602

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	September 21, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program