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P56602

- PPOX_BOVIN

UniProt

P56602 - PPOX_BOVIN

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Protein

Protoporphyrinogen oxidase

Gene

PPOX

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.1 Publication

Catalytic activityi

Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.1 Publication

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421FAD; via amide nitrogenBy similarity
Binding sitei257 – 2571FAD; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei449 – 4491FAD; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146FADBy similarity
Nucleotide bindingi34 – 352FADBy similarity
Nucleotide bindingi57 – 604FADBy similarity
Nucleotide bindingi454 – 4563FADBy similarity

GO - Molecular functioni

  1. oxygen-dependent protoporphyrinogen oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiREACT_212036. Heme biosynthesis.
UniPathwayiUPA00251; UER00324.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoporphyrinogen oxidase (EC:1.3.3.4)
Short name:
PPO
Gene namesi
Name:PPOX
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 3

Subcellular locationi

Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Intermembrane side By similarity. Mitochondrion 1 Publication
Note: Bound to the mitochondrial inner membrane with its active site facing the cytosolic side.By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Protoporphyrinogen oxidasePRO_0000135269Add
BLAST

Expressioni

Tissue specificityi

Detected in liver (at protein level).1 Publication

Interactioni

Subunit structurei

Monomer. Homodimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000053328.

Structurei

3D structure databases

ProteinModelPortaliP56602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protoporphyrinogen oxidase family.Curated

Phylogenomic databases

eggNOGiCOG1232.
GeneTreeiENSGT00390000008744.
KOiK00231.
OMAiWIRSIRG.
OrthoDBiEOG7DJSMB.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.660.20. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR016040. NAD(P)-bd_dom.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

Sequencei

Sequence statusi: Complete.

P56602-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRTVVVLGG GISGLAASYY LSRAPCPPKV VLVEGSERLG GWIRSVRGPD
60 70 80 90 100
GAIFELGPRG IRPAGALGAR TLLLVSELGL DSEVLPVRGD HPAAQNRFLY
110 120 130 140 150
VGGALHALPS GIRGLLRPSP PFSKPLFWAG LRDLTTPRGK DPDETVHSFA
160 170 180 190 200
QRRLGPEVAS LAMDSLCRGV FAGNSRELSI RSCFPSLFQA EQTHRSILLG
210 220 230 240 250
LLLGAGRGPQ LDSALIRQAQ AERWSQWSLR GGLETLPQAL HAHLTSRGVS
260 270 280 290 300
VLQGQPVCGL SLQAEGRWKV SLEDSSLEAD HIISAIPASV LSKLLPAEAT
310 320 330 340 350
PLARALSTIT AVSVAVVNLQ YRGARLPVQG FGHLVPSSED PVILGIVYDS
360 370 380 390 400
VAFPEQDGSL PGLRLTVMLG GSWLQTLEAR GCVLSQELLQ QEAEKAAATQ
410 420 430 440 450
LGLNEPPSHC LVHLHKNSIP QYTLGHWQKL ESAAQFLAAQ KLPLTLAGAS
460 470
YEGVAVNDCI ESGRQAAARV LGTEPNS
Length:477
Mass (Da):50,612
Last modified:February 19, 2014 - v2
Checksum:iE2A4581893001BEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02006959 Genomic DNA. No translation available.
PIRiS65629.
RefSeqiNP_001179355.1. NM_001192426.1.
XP_005203553.1. XM_005203496.1.
XP_005203554.1. XM_005203497.1.
UniGeneiBt.4335.

Genome annotation databases

EnsembliENSBTAT00000061124; ENSBTAP00000053328; ENSBTAG00000021894.
GeneIDi515770.
KEGGibta:515770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02006959 Genomic DNA. No translation available.
PIRi S65629.
RefSeqi NP_001179355.1. NM_001192426.1.
XP_005203553.1. XM_005203496.1.
XP_005203554.1. XM_005203497.1.
UniGenei Bt.4335.

3D structure databases

ProteinModelPortali P56602.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000053328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000061124 ; ENSBTAP00000053328 ; ENSBTAG00000021894 .
GeneIDi 515770.
KEGGi bta:515770.

Organism-specific databases

CTDi 5498.

Phylogenomic databases

eggNOGi COG1232.
GeneTreei ENSGT00390000008744.
KOi K00231.
OMAi WIRSIRG.
OrthoDBi EOG7DJSMB.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00324 .
Reactomei REACT_212036. Heme biosynthesis.

Miscellaneous databases

NextBioi 20871996.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.660.20. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR016040. NAD(P)-bd_dom.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. "Induction of terminal enzymes for heme biosynthesis during differentiation of mouse erythroleukemia cells."
    Taketani S., Yoshinaga T., Furukawa T., Kohno H., Tokunaga R., Nishimura K., Inokuchi H.
    Eur. J. Biochem. 230:760-765(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-14 AND 164-178, FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Liver.

Entry informationi

Entry nameiPPOX_BOVIN
AccessioniPrimary (citable) accession number: P56602
Secondary accession number(s): E1BPX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 19, 2014
Last modified: November 26, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3