P56602 (PPOX_BOVIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 59.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protoporphyrinogen oxidase Short name=PPO EC=1.3.3.4 | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) [Reference proteome] | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 28 AA. |
| Sequence status | Fragments. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. |
| Catalytic activity | Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2. |
| Cofactor | Binds 1 FAD per dimer By similarity. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side By similarity. Note: Bound to the mitochondrial inner membrane with its active site facing the cytosolic side By similarity. |
| Sequence similarities | Belongs to the protoporphyrinogen oxidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Heme biosynthesis Porphyrin biosynthesis |
| Cellular component | Membrane Mitochondrion Mitochondrion inner membrane |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway |
| Cellular_component | mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | oxygen-dependent protoporphyrinogen oxidase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "Induction of terminal enzymes for heme biosynthesis during differentiation of mouse erythroleukemia cells." Taketani S., Yoshinaga T., Furukawa T., Kohno H., Tokunaga R., Nishimura K., Inokuchi H. Eur. J. Biochem. 230:760-765(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| IPI | IPI00826039. |
| PIR | S65629. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9913.ENSBTAP00000053328. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| eggNOG | COG1232. |
Enzyme and pathway databases | |
| BioCyc | CATTLE:515770-MONOMER. |
| UniPathway | UPA00251; UER00324. |
Family and domain databases | |
| ProtoNet | Search... |
Entry information
| Entry name | PPOX_BOVIN | ||||||||
| Accession | Primary (citable) accession number: P56602 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |