Reviewed, UniProtKB/Swiss-Prot P56602 (PPOX_BOVIN)

Names and origin

Protein names

Recommended name:
    Protoporphyrinogen oxidase
      Short name=PPO
    EC=1.3.3.4

Gene names

Name:

PPOX

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	28 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
Catalytic activity	Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.
Cofactor	Binds 1 FAD per dimer By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side By similarity. Note: Bound to the mitochondrial inner membrane with its active site facing the cytosolic side By similarity.
Sequence similarities	Belongs to the protoporphyrinogen oxidase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protoporphyrinogen oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›28	›28	Protoporphyrinogen oxidase		PRO_0000135269
Experimental info
	Non-adjacent residues	13 – 14	2
	Non-terminal residue	1	1
	Non-terminal residue	28	1

Sequences

	Sequence		Length	Mass (Da)
	P56602-1 [UniParc]. Last modified December 15, 1998. Version 1. Checksum: FEDFC3F09CB6A345	FASTA	28	2,777
	10 20 GRTVVVLGGG ISGDSLCRGV FAGNSREL

References

[1]

"Induction of terminal enzymes for heme biosynthesis during differentiation of mouse erythroleukemia cells." Taketani S., Yoshinaga T., Furukawa T., Kohno H., Tokunaga R., Nishimura K., Inokuchi H. Eur. J. Biochem. 230:760-765(1995) [PubMed: 7607249] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver.

Cross-references

Sequence databases
IPI	IPI00826039.
PIR	S65629.
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000021894. Bos taurus. [Contig view]
Phylogenomic databases
HOVERGEN	P56602.
Enzyme and pathway databases
BRENDA	1.3.3.4. 251.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PPOX_BOVIN

Accession

Primary (citable) accession number: P56602

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)