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P56602

- PPOX_BOVIN

UniProt

P56602 - PPOX_BOVIN

Protein

Protoporphyrinogen oxidase

Gene

PPOX

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (19 Feb 2014)
      Previous versions | rss
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    Functioni

    Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.1 Publication

    Catalytic activityi

    Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.1 Publication

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421FAD; via amide nitrogenBy similarity
    Binding sitei257 – 2571FAD; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei449 – 4491FAD; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146FADBy similarity
    Nucleotide bindingi34 – 352FADBy similarity
    Nucleotide bindingi57 – 604FADBy similarity
    Nucleotide bindingi454 – 4563FADBy similarity

    GO - Molecular functioni

    1. oxygen-dependent protoporphyrinogen oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    ReactomeiREACT_212036. Heme biosynthesis.
    UniPathwayiUPA00251; UER00324.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protoporphyrinogen oxidase (EC:1.3.3.4)
    Short name:
    PPO
    Gene namesi
    Name:PPOX
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Intermembrane side By similarity. Mitochondrion 1 Publication
    Note: Bound to the mitochondrial inner membrane with its active site facing the cytosolic side.By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477Protoporphyrinogen oxidasePRO_0000135269Add
    BLAST

    Expressioni

    Tissue specificityi

    Detected in liver (at protein level).1 Publication

    Interactioni

    Subunit structurei

    Monomer. Homodimer By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000053328.

    Structurei

    3D structure databases

    ProteinModelPortaliP56602.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protoporphyrinogen oxidase family.Curated

    Phylogenomic databases

    eggNOGiCOG1232.
    GeneTreeiENSGT00390000008744.
    KOiK00231.
    OMAiWIRSIRG.
    OrthoDBiEOG7DJSMB.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.660.20. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR016040. NAD(P)-bd_dom.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P56602-1 [UniParc]FASTAAdd to Basket

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    MGRTVVVLGG GISGLAASYY LSRAPCPPKV VLVEGSERLG GWIRSVRGPD    50
    GAIFELGPRG IRPAGALGAR TLLLVSELGL DSEVLPVRGD HPAAQNRFLY 100
    VGGALHALPS GIRGLLRPSP PFSKPLFWAG LRDLTTPRGK DPDETVHSFA 150
    QRRLGPEVAS LAMDSLCRGV FAGNSRELSI RSCFPSLFQA EQTHRSILLG 200
    LLLGAGRGPQ LDSALIRQAQ AERWSQWSLR GGLETLPQAL HAHLTSRGVS 250
    VLQGQPVCGL SLQAEGRWKV SLEDSSLEAD HIISAIPASV LSKLLPAEAT 300
    PLARALSTIT AVSVAVVNLQ YRGARLPVQG FGHLVPSSED PVILGIVYDS 350
    VAFPEQDGSL PGLRLTVMLG GSWLQTLEAR GCVLSQELLQ QEAEKAAATQ 400
    LGLNEPPSHC LVHLHKNSIP QYTLGHWQKL ESAAQFLAAQ KLPLTLAGAS 450
    YEGVAVNDCI ESGRQAAARV LGTEPNS 477
    Length:477
    Mass (Da):50,612
    Last modified:February 19, 2014 - v2
    Checksum:iE2A4581893001BEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02006959 Genomic DNA. No translation available.
    PIRiS65629.
    RefSeqiNP_001179355.1. NM_001192426.1.
    XP_005203553.1. XM_005203496.1.
    XP_005203554.1. XM_005203497.1.
    UniGeneiBt.4335.

    Genome annotation databases

    EnsembliENSBTAT00000061124; ENSBTAP00000053328; ENSBTAG00000021894.
    GeneIDi515770.
    KEGGibta:515770.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02006959 Genomic DNA. No translation available.
    PIRi S65629.
    RefSeqi NP_001179355.1. NM_001192426.1.
    XP_005203553.1. XM_005203496.1.
    XP_005203554.1. XM_005203497.1.
    UniGenei Bt.4335.

    3D structure databases

    ProteinModelPortali P56602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000053328.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000061124 ; ENSBTAP00000053328 ; ENSBTAG00000021894 .
    GeneIDi 515770.
    KEGGi bta:515770.

    Organism-specific databases

    CTDi 5498.

    Phylogenomic databases

    eggNOGi COG1232.
    GeneTreei ENSGT00390000008744.
    KOi K00231.
    OMAi WIRSIRG.
    OrthoDBi EOG7DJSMB.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00324 .
    Reactomei REACT_212036. Heme biosynthesis.

    Miscellaneous databases

    NextBioi 20871996.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.660.20. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR016040. NAD(P)-bd_dom.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hereford.
    2. "Induction of terminal enzymes for heme biosynthesis during differentiation of mouse erythroleukemia cells."
      Taketani S., Yoshinaga T., Furukawa T., Kohno H., Tokunaga R., Nishimura K., Inokuchi H.
      Eur. J. Biochem. 230:760-765(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-14 AND 164-178, FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Liver.

    Entry informationi

    Entry nameiPPOX_BOVIN
    AccessioniPrimary (citable) accession number: P56602
    Secondary accession number(s): E1BPX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 19, 2014
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3