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Protein

Nucleoside diphosphate kinase homolog 5

Gene

NME5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei127 – 1271Pros-phosphohistidine intermediateSequence analysis

GO - Molecular functioni

  • nucleoside diphosphate kinase activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase homolog 5
Short name:
NDK-H 5
Short name:
NDP kinase homolog 5
Alternative name(s):
Inhibitor of p53-induced apoptosis-beta
Short name:
IPIA-beta
Testis-specific nm23 homolog
nm23-H5
Gene namesi
Name:NME5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:7853. NME5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31658.

Polymorphism and mutation databases

BioMutaiNME5.
DMDMi3914118.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Nucleoside diphosphate kinase homolog 5PRO_0000137125Add
BLAST

Proteomic databases

PaxDbiP56597.
PRIDEiP56597.

PTM databases

iPTMnetiP56597.
PhosphoSiteiP56597.

Expressioni

Tissue specificityi

Specifically expressed in testis germinal cells.

Gene expression databases

BgeeiP56597.
CleanExiHS_NME5.
GenevisibleiP56597. HS.

Organism-specific databases

HPAiHPA044555.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DYDC1Q8WWB34EBI-740667,EBI-740680

Protein-protein interaction databases

BioGridi113972. 2 interactions.
IntActiP56597. 3 interactions.
MINTiMINT-1483527.
STRINGi9606.ENSP00000265191.

Structurei

3D structure databases

ProteinModelPortaliP56597.
SMRiP56597. Positions 12-143, 156-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224565.
HOVERGENiHBG000198.
InParanoidiP56597.
KOiK00940.
OMAiDFYAEHY.
OrthoDBiEOG7NSB3J.
PhylomeDBiP56597.
TreeFamiTF354225.

Family and domain databases

InterProiIPR007858. Dpy-30_motif.
IPR012410. NDK_H5.
IPR001564. Nucleoside_diP_kinase.
[Graphical view]
PfamiPF05186. Dpy-30. 1 hit.
PF00334. NDK. 1 hit.
[Graphical view]
PIRSFiPIRSF036504. NDK_H5. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEISMPPPQI YVEKTLAIIK PDIVDKEEEI QDIILRSGFT IVQRRKLRLS
60 70 80 90 100
PEQCSNFYVE KYGKMFFPNL TAYMSSGPLV AMILARHKAI SYWLELLGPN
110 120 130 140 150
NSLVAKETHP DSLRAIYGTD DLRNALHGSN DFAAAEREIR FMFPEVIVEP
160 170 180 190 200
IPIGQAAKDY LNLHIMPTLL EGLTELCKQK PADPLIWLAD WLLKNNPNKP
210
KLCHHPIVEE PY
Length:212
Mass (Da):24,236
Last modified:December 15, 1998 - v1
Checksum:i9D37CD80338159A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14992 mRNA. Translation: CAA75226.1.
AF067724 mRNA. Translation: AAC64358.1.
U90450 mRNA. Translation: AAC69440.1.
AK312181 mRNA. Translation: BAG35114.1.
CH471062 Genomic DNA. Translation: EAW62164.1.
BC026182 mRNA. Translation: AAH26182.1.
CCDSiCCDS4197.1.
RefSeqiNP_003542.1. NM_003551.2.
UniGeneiHs.730856.

Genome annotation databases

EnsembliENST00000265191; ENSP00000265191; ENSG00000112981.
GeneIDi8382.
KEGGihsa:8382.
UCSCiuc003lce.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14992 mRNA. Translation: CAA75226.1.
AF067724 mRNA. Translation: AAC64358.1.
U90450 mRNA. Translation: AAC69440.1.
AK312181 mRNA. Translation: BAG35114.1.
CH471062 Genomic DNA. Translation: EAW62164.1.
BC026182 mRNA. Translation: AAH26182.1.
CCDSiCCDS4197.1.
RefSeqiNP_003542.1. NM_003551.2.
UniGeneiHs.730856.

3D structure databases

ProteinModelPortaliP56597.
SMRiP56597. Positions 12-143, 156-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113972. 2 interactions.
IntActiP56597. 3 interactions.
MINTiMINT-1483527.
STRINGi9606.ENSP00000265191.

PTM databases

iPTMnetiP56597.
PhosphoSiteiP56597.

Polymorphism and mutation databases

BioMutaiNME5.
DMDMi3914118.

Proteomic databases

PaxDbiP56597.
PRIDEiP56597.

Protocols and materials databases

DNASUi8382.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265191; ENSP00000265191; ENSG00000112981.
GeneIDi8382.
KEGGihsa:8382.
UCSCiuc003lce.4. human.

Organism-specific databases

CTDi8382.
GeneCardsiNME5.
HGNCiHGNC:7853. NME5.
HPAiHPA044555.
MIMi603575. gene.
neXtProtiNX_P56597.
PharmGKBiPA31658.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224565.
HOVERGENiHBG000198.
InParanoidiP56597.
KOiK00940.
OMAiDFYAEHY.
OrthoDBiEOG7NSB3J.
PhylomeDBiP56597.
TreeFamiTF354225.

Miscellaneous databases

GenomeRNAii8382.
PROiP56597.
SOURCEiSearch...

Gene expression databases

BgeeiP56597.
CleanExiHS_NME5.
GenevisibleiP56597. HS.

Family and domain databases

InterProiIPR007858. Dpy-30_motif.
IPR012410. NDK_H5.
IPR001564. Nucleoside_diP_kinase.
[Graphical view]
PfamiPF05186. Dpy-30. 1 hit.
PF00334. NDK. 1 hit.
[Graphical view]
PIRSFiPIRSF036504. NDK_H5. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells."
    Munier A., Feral C., Milon L., Pinon V.P.-B., Gyapay G., Capeau J., Guellaen G., Lacombe M.-L.
    FEBS Lett. 434:289-294(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Gall bladder.
  2. Mehus J.G., Lambeth D.O.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "Identification of a homolog of IPIA-alpha."
    Nakamura H., Tsuiki H., Sasaki J., Honda Y., Saya H.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiNDK5_HUMAN
AccessioniPrimary (citable) accession number: P56597
Secondary accession number(s): B2R5G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: June 8, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.