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Protein

Nucleoside diphosphate kinase homolog 5

Gene

NME5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127Pros-phosphohistidine intermediateSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase homolog 5
Short name:
NDK-H 5
Short name:
NDP kinase homolog 5
Alternative name(s):
Inhibitor of p53-induced apoptosis-beta
Short name:
IPIA-beta
Testis-specific nm23 homolog
nm23-H5
Gene namesi
Name:NME5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000112981.4
HGNCiHGNC:7853 NME5
MIMi603575 gene
neXtProtiNX_P56597

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi8382
OpenTargetsiENSG00000112981
PharmGKBiPA31658

Polymorphism and mutation databases

BioMutaiNME5
DMDMi3914118

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001371251 – 212Nucleoside diphosphate kinase homolog 5Add BLAST212

Proteomic databases

PaxDbiP56597
PeptideAtlasiP56597
PRIDEiP56597

PTM databases

iPTMnetiP56597
PhosphoSitePlusiP56597

Expressioni

Tissue specificityi

Specifically expressed in testis germinal cells.

Gene expression databases

BgeeiENSG00000112981
CleanExiHS_NME5
ExpressionAtlasiP56597 baseline and differential
GenevisibleiP56597 HS

Organism-specific databases

HPAiHPA035648
HPA044555

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DYDC1Q8WWB36EBI-740667,EBI-740680

Protein-protein interaction databases

BioGridi1139722 interactors.
IntActiP56597 3 interactors.
MINTiP56597
STRINGi9606.ENSP00000265191

Structurei

3D structure databases

ProteinModelPortaliP56597
SMRiP56597
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
GeneTreeiENSGT00760000119146
HOGENOMiHOG000224565
HOVERGENiHBG000198
InParanoidiP56597
KOiK20790
OMAiKLCHHPI
OrthoDBiEOG091G0FHI
PhylomeDBiP56597
TreeFamiTF354225

Family and domain databases

Gene3Di3.30.70.1411 hit
InterProiView protein in InterPro
IPR007858 Dpy-30_motif
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR012410 NDK_H5
IPR001564 Nucleoside_diP_kinase
PfamiView protein in Pfam
PF05186 Dpy-30, 1 hit
PF00334 NDK, 1 hit
PIRSFiPIRSF036504 NDK_H5, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit

Sequencei

Sequence statusi: Complete.

P56597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEISMPPPQI YVEKTLAIIK PDIVDKEEEI QDIILRSGFT IVQRRKLRLS
60 70 80 90 100
PEQCSNFYVE KYGKMFFPNL TAYMSSGPLV AMILARHKAI SYWLELLGPN
110 120 130 140 150
NSLVAKETHP DSLRAIYGTD DLRNALHGSN DFAAAEREIR FMFPEVIVEP
160 170 180 190 200
IPIGQAAKDY LNLHIMPTLL EGLTELCKQK PADPLIWLAD WLLKNNPNKP
210
KLCHHPIVEE PY
Length:212
Mass (Da):24,236
Last modified:December 15, 1998 - v1
Checksum:i9D37CD80338159A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14992 mRNA Translation: CAA75226.1
AF067724 mRNA Translation: AAC64358.1
U90450 mRNA Translation: AAC69440.1
AK312181 mRNA Translation: BAG35114.1
CH471062 Genomic DNA Translation: EAW62164.1
BC026182 mRNA Translation: AAH26182.1
CCDSiCCDS4197.1
RefSeqiNP_003542.1, NM_003551.2
UniGeneiHs.730856

Genome annotation databases

EnsembliENST00000265191; ENSP00000265191; ENSG00000112981
GeneIDi8382
KEGGihsa:8382
UCSCiuc003lce.4 human

Similar proteinsi

Entry informationi

Entry nameiNDK5_HUMAN
AccessioniPrimary (citable) accession number: P56597
Secondary accession number(s): B2R5G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: March 28, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome