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P56594

- CP2CL_CANFA

UniProt

P56594 - CP2CL_CANFA

Protein

Cytochrome P450 2C21

Gene

CYP2C21

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Showed testosterone hydrolase activity.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi432 – 4321Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C21 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC21
    Cytochrome P450 DM1-1
    Gene namesi
    Name:CYP2C21
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 487›487Cytochrome P450 2C21PRO_0000051710Add
    BLAST

    Proteomic databases

    PaxDbiP56594.

    Expressioni

    Tissue specificityi

    Liver.

    Structurei

    3D structure databases

    ProteinModelPortaliP56594.
    SMRiP56594. Positions 27-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiP56594.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P56594-1 [UniParc]FASTAAdd to Basket

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    FIVLVICLSC LISFFLWNQN RAKGKLPPGP TPLPIIGNIL QINTKNVSKS    50
    LSKLAENYGP VFTVYFGMKP TVVLYGYEAV KEALIDRSEE FSGRGHFPLL 100
    DWTIQGLGIV FSNGEKWKQT RRFSLTVLRN MGMGKKTVED RIQEEALYLV 150
    EALKKTNASP CDPTFLLGCA PCNVICSIIF QNRFEYDDKD FLTLLEYFHE 200
    NLLISSTSWI QLYNAFPLLI HYLPGSHHVL FKNIANQFKF ISEKIKEHEE 250
    SLNFSNPRDF IDYFLIKIEK EKHNKQSEFT MDNLIITIWD VFSAGTETTS 300
    TTLRYGLLVL LKHPDVTAKV QEEIHRVVGR HRSPCMQDRS CMPYTDAVVH 350
    EIQRYIDLVP NNLPHSVTQD IKFREYLIPK GTTILTSLTS VLHDEKGFPN 400
    PDQFDPGHFL DENGSFKKSD YFMAFSAGKR VCVGEGLARM ELFLLLTNIL 450
    QHFTLKPLVD PKDIDTTPIA NGLGATPPSY KLCFVPV 487
    Length:487
    Mass (Da):55,531
    Last modified:July 15, 1999 - v2
    Checksum:iE1390CACC7DD577D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Sequence conflicti337 – 3426Missing no nucleotide entry (PubMed:2122230)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049909 mRNA. Translation: AAC05209.1.
    UniGeneiCfa.3741.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049909 mRNA. Translation: AAC05209.1 .
    UniGenei Cfa.3741.

    3D structure databases

    ProteinModelPortali P56594.
    SMRi P56594. Positions 27-487.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P56594.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi P56594.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a new canine cytochrome P450 cDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression."
      Blaisdell J., Goldstein J.A., Bai S.A.
      Drug Metab. Dispos. 26:278-283(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
      Tissue: Liver.
    2. "Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs."
      Uchida T., Komori M., Kitada M., Kamataki T.
      Mol. Pharmacol. 38:644-651(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-487.
      Strain: Beagle.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2CL_CANFA
    AccessioniPrimary (citable) accession number: P56594
    Secondary accession number(s): O62734
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3