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P56594

- CP2CL_CANFA

UniProt

P56594 - CP2CL_CANFA

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Protein

Cytochrome P450 2C21

Gene

CYP2C21

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Showed testosterone hydrolase activity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi432 – 4321Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C21 (EC:1.14.14.1)
Alternative name(s):
CYPIIC21
Cytochrome P450 DM1-1
Gene namesi
Name:CYP2C21
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 487›487Cytochrome P450 2C21PRO_0000051710Add
BLAST

Proteomic databases

PaxDbiP56594.

Expressioni

Tissue specificityi

Liver.

Structurei

3D structure databases

ProteinModelPortaliP56594.
SMRiP56594. Positions 27-487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP56594.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P56594-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
FIVLVICLSC LISFFLWNQN RAKGKLPPGP TPLPIIGNIL QINTKNVSKS
60 70 80 90 100
LSKLAENYGP VFTVYFGMKP TVVLYGYEAV KEALIDRSEE FSGRGHFPLL
110 120 130 140 150
DWTIQGLGIV FSNGEKWKQT RRFSLTVLRN MGMGKKTVED RIQEEALYLV
160 170 180 190 200
EALKKTNASP CDPTFLLGCA PCNVICSIIF QNRFEYDDKD FLTLLEYFHE
210 220 230 240 250
NLLISSTSWI QLYNAFPLLI HYLPGSHHVL FKNIANQFKF ISEKIKEHEE
260 270 280 290 300
SLNFSNPRDF IDYFLIKIEK EKHNKQSEFT MDNLIITIWD VFSAGTETTS
310 320 330 340 350
TTLRYGLLVL LKHPDVTAKV QEEIHRVVGR HRSPCMQDRS CMPYTDAVVH
360 370 380 390 400
EIQRYIDLVP NNLPHSVTQD IKFREYLIPK GTTILTSLTS VLHDEKGFPN
410 420 430 440 450
PDQFDPGHFL DENGSFKKSD YFMAFSAGKR VCVGEGLARM ELFLLLTNIL
460 470 480
QHFTLKPLVD PKDIDTTPIA NGLGATPPSY KLCFVPV
Length:487
Mass (Da):55,531
Last modified:July 15, 1999 - v2
Checksum:iE1390CACC7DD577D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Sequence conflicti337 – 3426Missing no nucleotide entry (PubMed:2122230)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049909 mRNA. Translation: AAC05209.1.
UniGeneiCfa.3741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049909 mRNA. Translation: AAC05209.1 .
UniGenei Cfa.3741.

3D structure databases

ProteinModelPortali P56594.
SMRi P56594. Positions 27-487.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P56594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P56594.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a new canine cytochrome P450 cDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression."
    Blaisdell J., Goldstein J.A., Bai S.A.
    Drug Metab. Dispos. 26:278-283(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Beagle.
    Tissue: Liver.
  2. "Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs."
    Uchida T., Komori M., Kitada M., Kamataki T.
    Mol. Pharmacol. 38:644-651(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-487.
    Strain: Beagle.
    Tissue: Liver.

Entry informationi

Entry nameiCP2CL_CANFA
AccessioniPrimary (citable) accession number: P56594
Secondary accession number(s): O62734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 15, 1999
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3