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P56594

- CP2CL_CANFA

UniProt

P56594 - CP2CL_CANFA

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Protein
Cytochrome P450 2C21
Gene
CYP2C21
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Showed testosterone hydrolase activity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi432 – 4321Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C21 (EC:1.14.14.1)
Alternative name(s):
CYPIIC21
Cytochrome P450 DM1-1
Gene namesi
Name:CYP2C21
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 487›487Cytochrome P450 2C21
PRO_0000051710Add
BLAST

Proteomic databases

PaxDbiP56594.

Expressioni

Tissue specificityi

Liver.

Structurei

3D structure databases

ProteinModelPortaliP56594.
SMRiP56594. Positions 27-487.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP56594.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P56594-1 [UniParc]FASTAAdd to Basket

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FIVLVICLSC LISFFLWNQN RAKGKLPPGP TPLPIIGNIL QINTKNVSKS    50
LSKLAENYGP VFTVYFGMKP TVVLYGYEAV KEALIDRSEE FSGRGHFPLL 100
DWTIQGLGIV FSNGEKWKQT RRFSLTVLRN MGMGKKTVED RIQEEALYLV 150
EALKKTNASP CDPTFLLGCA PCNVICSIIF QNRFEYDDKD FLTLLEYFHE 200
NLLISSTSWI QLYNAFPLLI HYLPGSHHVL FKNIANQFKF ISEKIKEHEE 250
SLNFSNPRDF IDYFLIKIEK EKHNKQSEFT MDNLIITIWD VFSAGTETTS 300
TTLRYGLLVL LKHPDVTAKV QEEIHRVVGR HRSPCMQDRS CMPYTDAVVH 350
EIQRYIDLVP NNLPHSVTQD IKFREYLIPK GTTILTSLTS VLHDEKGFPN 400
PDQFDPGHFL DENGSFKKSD YFMAFSAGKR VCVGEGLARM ELFLLLTNIL 450
QHFTLKPLVD PKDIDTTPIA NGLGATPPSY KLCFVPV 487
Length:487
Mass (Da):55,531
Last modified:July 15, 1999 - v2
Checksum:iE1390CACC7DD577D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti337 – 3426Missing no nucleotide entry 1 Publication

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049909 mRNA. Translation: AAC05209.1.
UniGeneiCfa.3741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049909 mRNA. Translation: AAC05209.1 .
UniGenei Cfa.3741.

3D structure databases

ProteinModelPortali P56594.
SMRi P56594. Positions 27-487.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P56594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P56594.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a new canine cytochrome P450 cDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression."
    Blaisdell J., Goldstein J.A., Bai S.A.
    Drug Metab. Dispos. 26:278-283(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Beagle.
    Tissue: Liver.
  2. "Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs."
    Uchida T., Komori M., Kitada M., Kamataki T.
    Mol. Pharmacol. 38:644-651(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-487.
    Strain: Beagle.
    Tissue: Liver.

Entry informationi

Entry nameiCP2CL_CANFA
AccessioniPrimary (citable) accession number: P56594
Secondary accession number(s): O62734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 15, 1999
Last modified: December 11, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi