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P56592

- CP1A2_CANFA

UniProt

P56592 - CP1A2_CANFA

Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei222 – 2221SubstrateBy similarity
    Metal bindingi454 – 4541Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A2 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA2
    Cytochrome P450-D2
    DAH2
    Gene namesi
    Name:CYP1A2
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 512511Cytochrome P450 1A2PRO_0000051649Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP56592.

    Expressioni

    Tissue specificityi

    Constitutively expressed in liver.

    Inductioni

    By polychlorinated biphenyl (PCB) in liver and kidney.

    Structurei

    3D structure databases

    ProteinModelPortaliP56592.
    SMRiP56592. Positions 30-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOVERGENiHBG106944.
    InParanoidiP56592.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56592-1 [UniParc]FASTAAdd to Basket

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    MALSQMATGL LLASTIFCLI LWVVKAWQPR LPKGLKSPPG PWGWPLLGNV    50
    LTLGKSPHLA LSRLSQRYGD VLQIRIGSTP VLVLSGLDTI RQALVRQGDD 100
    FKGRPDLYSL SLITDSQSMS FSPDSGPVWA AGRRLAQNAL NTFSIASDPA 150
    SSCSCYLEEH VSKEAEALLS RLQEQMAEVG RFDPYNQVLL SVANVIGAMC 200
    FGHHFSQRSE EMLPLLMSSS DFVETVSSGN PLDFFPILQY MPNSALQRFK 250
    NFNQTFVQSL QKIVQEHYQD FDERSVQDIT GALLKHNEKS SRASDGHIPQ 300
    EKIVNLINDI FGAGFDTVTT AISWSLMYLV ANPEIQRQIQ KELDTVIGRA 350
    RQPRLSDRPQ LPLMEAFILE IFRHTSFVPF TIPHSTTKDT TLKGFYIPKE 400
    CCVFINQWQV NHDQQVWGDP FAFRPERFLT ADGTTINKTL SEKVMLFGMG 450
    KRRCIGEVLA KWEIFLFLAI LLQRLEFSVP AGVKVDLTPI YGLTMKHTRC 500
    EHVQARPRFS IK 512
    Length:512
    Mass (Da):57,637
    Last modified:January 23, 2007 - v2
    Checksum:iE49DF4C54F4B3CFB
    GO

    Sequence databases

    PIRiB37222.

    Cross-referencesi

    Sequence databases

    PIRi B37222.

    3D structure databases

    ProteinModelPortali P56592.
    SMRi P56592. Positions 30-510.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P56592.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOVERGENi HBG106944.
    InParanoidi P56592.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel form of cytochrome P-450 in beagle dogs. P-450-D3 is a low spin form of cytochrome P-450 but with catalytic and structural properties similar to P-450d."
      Ohta K., Motoya M., Komori M., Miura T., Kitada M., Kamataki T.
      Biochem. Pharmacol. 38:91-96(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-17.
      Strain: Beagle.
      Tissue: Liver.
    2. "Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs."
      Uchida T., Komori M., Kitada M., Kamataki T.
      Mol. Pharmacol. 38:644-651(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-512.
      Strain: Beagle.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A2_CANFA
    AccessioniPrimary (citable) accession number: P56592
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3