Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation.By similarity

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei222SubstrateBy similarity1
Metal bindingi454Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processLipid metabolism, Steroid metabolism, Sterol metabolism
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1By similarity)
Alternative name(s):
CYPIA2
Cholesterol 25-hydroxylaseBy similarity
Cytochrome P450-D2
DAH2
Gene namesi
Name:CYP1A2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000516492 – 512Cytochrome P450 1A2Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65O-linked (GlcNAc) serineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP56592

Expressioni

Tissue specificityi

Constitutively expressed in liver.

Inductioni

By polychlorinated biphenyl (PCB) in liver and kidney.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000035314

Structurei

3D structure databases

ProteinModelPortaliP56592
SMRiP56592
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOVERGENiHBG106944
InParanoidiP56592

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008066 Cyt_P450_E_grp-I_CYP1
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01683 EP450ICYP1A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSQMATGL LLASTIFCLI LWVVKAWQPR LPKGLKSPPG PWGWPLLGNV
60 70 80 90 100
LTLGKSPHLA LSRLSQRYGD VLQIRIGSTP VLVLSGLDTI RQALVRQGDD
110 120 130 140 150
FKGRPDLYSL SLITDSQSMS FSPDSGPVWA AGRRLAQNAL NTFSIASDPA
160 170 180 190 200
SSCSCYLEEH VSKEAEALLS RLQEQMAEVG RFDPYNQVLL SVANVIGAMC
210 220 230 240 250
FGHHFSQRSE EMLPLLMSSS DFVETVSSGN PLDFFPILQY MPNSALQRFK
260 270 280 290 300
NFNQTFVQSL QKIVQEHYQD FDERSVQDIT GALLKHNEKS SRASDGHIPQ
310 320 330 340 350
EKIVNLINDI FGAGFDTVTT AISWSLMYLV ANPEIQRQIQ KELDTVIGRA
360 370 380 390 400
RQPRLSDRPQ LPLMEAFILE IFRHTSFVPF TIPHSTTKDT TLKGFYIPKE
410 420 430 440 450
CCVFINQWQV NHDQQVWGDP FAFRPERFLT ADGTTINKTL SEKVMLFGMG
460 470 480 490 500
KRRCIGEVLA KWEIFLFLAI LLQRLEFSVP AGVKVDLTPI YGLTMKHTRC
510
EHVQARPRFS IK
Length:512
Mass (Da):57,637
Last modified:January 23, 2007 - v2
Checksum:iE49DF4C54F4B3CFB
GO

Sequence databases

PIRiB37222
UniGeneiCfa.14521

Similar proteinsi

Entry informationi

Entry nameiCP1A2_CANLF
AccessioniPrimary (citable) accession number: P56592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health