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P56592

- CP1A2_CANFA

UniProt

P56592 - CP1A2_CANFA

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Protein
Cytochrome P450 1A2
Gene
CYP1A2
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei222 – 2221Substrate By similarity
Metal bindingi454 – 4541Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Cytochrome P450-D2
DAH2
Gene namesi
Name:CYP1A2
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 512511Cytochrome P450 1A2
PRO_0000051649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651O-linked (GlcNAc) By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP56592.

Expressioni

Tissue specificityi

Constitutively expressed in liver.

Inductioni

By polychlorinated biphenyl (PCB) in liver and kidney.

Structurei

3D structure databases

ProteinModelPortaliP56592.
SMRiP56592. Positions 30-510.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOVERGENiHBG106944.
InParanoidiP56592.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56592-1 [UniParc]FASTAAdd to Basket

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MALSQMATGL LLASTIFCLI LWVVKAWQPR LPKGLKSPPG PWGWPLLGNV    50
LTLGKSPHLA LSRLSQRYGD VLQIRIGSTP VLVLSGLDTI RQALVRQGDD 100
FKGRPDLYSL SLITDSQSMS FSPDSGPVWA AGRRLAQNAL NTFSIASDPA 150
SSCSCYLEEH VSKEAEALLS RLQEQMAEVG RFDPYNQVLL SVANVIGAMC 200
FGHHFSQRSE EMLPLLMSSS DFVETVSSGN PLDFFPILQY MPNSALQRFK 250
NFNQTFVQSL QKIVQEHYQD FDERSVQDIT GALLKHNEKS SRASDGHIPQ 300
EKIVNLINDI FGAGFDTVTT AISWSLMYLV ANPEIQRQIQ KELDTVIGRA 350
RQPRLSDRPQ LPLMEAFILE IFRHTSFVPF TIPHSTTKDT TLKGFYIPKE 400
CCVFINQWQV NHDQQVWGDP FAFRPERFLT ADGTTINKTL SEKVMLFGMG 450
KRRCIGEVLA KWEIFLFLAI LLQRLEFSVP AGVKVDLTPI YGLTMKHTRC 500
EHVQARPRFS IK 512
Length:512
Mass (Da):57,637
Last modified:January 23, 2007 - v2
Checksum:iE49DF4C54F4B3CFB
GO

Sequence databases

PIRiB37222.

Cross-referencesi

Sequence databases

PIRi B37222.

3D structure databases

ProteinModelPortali P56592.
SMRi P56592. Positions 30-510.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P56592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG2124.
HOVERGENi HBG106944.
InParanoidi P56592.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel form of cytochrome P-450 in beagle dogs. P-450-D3 is a low spin form of cytochrome P-450 but with catalytic and structural properties similar to P-450d."
    Ohta K., Motoya M., Komori M., Miura T., Kitada M., Kamataki T.
    Biochem. Pharmacol. 38:91-96(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-17.
    Strain: Beagle.
    Tissue: Liver.
  2. "Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs."
    Uchida T., Komori M., Kitada M., Kamataki T.
    Mol. Pharmacol. 38:644-651(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-512.
    Strain: Beagle.
    Tissue: Liver.

Entry informationi

Entry nameiCP1A2_CANFA
AccessioniPrimary (citable) accession number: P56592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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