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P56592 (CP1A2_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A2

EC=1.14.14.1
Alternative name(s):
CYPIA2
Cytochrome P450-D2
DAH2
Gene names
Name:CYP1A2
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Constitutively expressed in liver.

Induction

By polychlorinated biphenyl (PCB) in liver and kidney.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 512511Cytochrome P450 1A2
PRO_0000051649

Sites

Metal binding4541Iron (heme axial ligand) By similarity
Binding site2221Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P56592 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: E49DF4C54F4B3CFB

FASTA51257,637
        10         20         30         40         50         60 
MALSQMATGL LLASTIFCLI LWVVKAWQPR LPKGLKSPPG PWGWPLLGNV LTLGKSPHLA 

        70         80         90        100        110        120 
LSRLSQRYGD VLQIRIGSTP VLVLSGLDTI RQALVRQGDD FKGRPDLYSL SLITDSQSMS 

       130        140        150        160        170        180 
FSPDSGPVWA AGRRLAQNAL NTFSIASDPA SSCSCYLEEH VSKEAEALLS RLQEQMAEVG 

       190        200        210        220        230        240 
RFDPYNQVLL SVANVIGAMC FGHHFSQRSE EMLPLLMSSS DFVETVSSGN PLDFFPILQY 

       250        260        270        280        290        300 
MPNSALQRFK NFNQTFVQSL QKIVQEHYQD FDERSVQDIT GALLKHNEKS SRASDGHIPQ 

       310        320        330        340        350        360 
EKIVNLINDI FGAGFDTVTT AISWSLMYLV ANPEIQRQIQ KELDTVIGRA RQPRLSDRPQ 

       370        380        390        400        410        420 
LPLMEAFILE IFRHTSFVPF TIPHSTTKDT TLKGFYIPKE CCVFINQWQV NHDQQVWGDP 

       430        440        450        460        470        480 
FAFRPERFLT ADGTTINKTL SEKVMLFGMG KRRCIGEVLA KWEIFLFLAI LLQRLEFSVP 

       490        500        510 
AGVKVDLTPI YGLTMKHTRC EHVQARPRFS IK 

« Hide

References

[1]"A novel form of cytochrome P-450 in beagle dogs. P-450-D3 is a low spin form of cytochrome P-450 but with catalytic and structural properties similar to P-450d."
Ohta K., Motoya M., Komori M., Miura T., Kitada M., Kamataki T.
Biochem. Pharmacol. 38:91-96(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-17.
Strain: Beagle.
Tissue: Liver.
[2]"Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs."
Uchida T., Komori M., Kitada M., Kamataki T.
Mol. Pharmacol. 38:644-651(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-512.
Strain: Beagle.
Tissue: Liver.

Cross-references

Sequence databases

PIRB37222.

3D structure databases

ProteinModelPortalP56592.
SMRP56592. Positions 30-510.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP56592.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG2124.
HOVERGENHBG106944.
InParanoidP56592.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A2_CANFA
AccessionPrimary (citable) accession number: P56592
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: December 11, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families