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P56591

- CP1A1_SHEEP

UniProt

P56591 - CP1A1_SHEEP

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Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311SubstrateBy similarity
Metal bindingi464 – 4641Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Cytochrome P450-C
Cytochrome P4501A1
Gene namesi
Name:CYP1A1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Cytochrome P450 1A1PRO_0000051633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

By oxygen; in lung.

Structurei

3D structure databases

ProteinModelPortaliP56591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.
KOiK07408.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56591-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWIMFSVFGL PIPISATELL LASAVFCLVF WVVRTWRPRV PQGLKSPPEP
60 70 80 90 100
WGWPCLGHVL TLGKNPHVVL SQLSQRYGDV LQIRIGCTPV LVLSGLDTIR
110 120 130 140 150
QALVRQGDDF KGRPDLYSFT LVSDGQSMTF NPDSGPVWAA RRRLAQNALK
160 170 180 190 200
SFSTASDPAS LSSCYLEEHV SKEAEYLLGK FQELMSGPGR FDPYRYVVVS
210 220 230 240 250
VANVICAICF GRRYDHDDQE FLSLINLSNE FGEITASGNP ADFIPVLRYL
260 270 280 290 300
PNTALDLFKD LNRRFYVFVQ KIVKEHYKTF EKGHIRDITD SLIEHCQDKR
310 320 330 340 350
LDENANIQLS DEKIINVVMD LFGAGFDTVT TAISWSLLYL VTSPRVQKKI
360 370 380 390 400
QEELDTVIGR ARWPQLSDRP QLPYLEAFIL ETFRHSSFVP FTIPHSTTRD
410 420 430 440 450
TNLNGFYIPK GXCVFVNQWQ INHDQKLWED PSEFRPERFL TTDGTVNKVL
460 470 480 490 500
SEKVIIFGLG KRQCIGEIIA RLEVFLFLAI LLHQVEFHVT PGVKVDMTPL
510
YGLTMKHARC EHFQVRIRS
Length:519
Mass (Da):59,230
Last modified:December 15, 1998 - v1
Checksum:i95C0582F1F61EC06
GO

Sequence cautioni

The sequence AAD14317.1 differs from that shown. Reason: Frameshift at position 333. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79795 mRNA. Translation: AAD14317.1. Frameshift.
RefSeqiNP_001123377.1. NM_001129905.1.
UniGeneiOar.816.

Genome annotation databases

GeneIDi100170113.
KEGGioas:100170113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79795 mRNA. Translation: AAD14317.1 . Frameshift.
RefSeqi NP_001123377.1. NM_001129905.1.
UniGenei Oar.816.

3D structure databases

ProteinModelPortali P56591.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100170113.
KEGGi oas:100170113.

Organism-specific databases

CTDi 1543.

Phylogenomic databases

HOVERGENi HBG106944.
KOi K07408.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and transcriptional regulation by oxygen tension."
    Hazinski T.A., Noisin E., Hamon I., Dematteo A.
    J. Clin. Invest. 96:2083-2089(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCP1A1_SHEEP
AccessioniPrimary (citable) accession number: P56591
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Increased expression of this enzyme in lung due to oxygen exposure has been related to hyperoxic injury in microvascular endothelium.

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3