SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P56591

- CP1A1_SHEEP

UniProt

P56591 - CP1A1_SHEEP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome P450 1A1
Gene
CYP1A1
Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311Substrate By similarity
Metal bindingi464 – 4641Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Cytochrome P450-C
    Cytochrome P4501A1
    Gene namesi
    Name:CYP1A1
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Cytochrome P450 1A1
    PRO_0000051633Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741O-linked (GlcNAc) By similarity

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Inductioni

    By oxygen; in lung.

    Structurei

    3D structure databases

    ProteinModelPortaliP56591.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56591-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWIMFSVFGL PIPISATELL LASAVFCLVF WVVRTWRPRV PQGLKSPPEP    50
    WGWPCLGHVL TLGKNPHVVL SQLSQRYGDV LQIRIGCTPV LVLSGLDTIR 100
    QALVRQGDDF KGRPDLYSFT LVSDGQSMTF NPDSGPVWAA RRRLAQNALK 150
    SFSTASDPAS LSSCYLEEHV SKEAEYLLGK FQELMSGPGR FDPYRYVVVS 200
    VANVICAICF GRRYDHDDQE FLSLINLSNE FGEITASGNP ADFIPVLRYL 250
    PNTALDLFKD LNRRFYVFVQ KIVKEHYKTF EKGHIRDITD SLIEHCQDKR 300
    LDENANIQLS DEKIINVVMD LFGAGFDTVT TAISWSLLYL VTSPRVQKKI 350
    QEELDTVIGR ARWPQLSDRP QLPYLEAFIL ETFRHSSFVP FTIPHSTTRD 400
    TNLNGFYIPK GXCVFVNQWQ INHDQKLWED PSEFRPERFL TTDGTVNKVL 450
    SEKVIIFGLG KRQCIGEIIA RLEVFLFLAI LLHQVEFHVT PGVKVDMTPL 500
    YGLTMKHARC EHFQVRIRS 519
    Length:519
    Mass (Da):59,230
    Last modified:December 15, 1998 - v1
    Checksum:i95C0582F1F61EC06
    GO

    Sequence cautioni

    The sequence AAD14317.1 differs from that shown. Reason: Frameshift at position 333.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S79795 mRNA. Translation: AAD14317.1. Frameshift.
    RefSeqiNP_001123377.1. NM_001129905.1.
    UniGeneiOar.816.

    Genome annotation databases

    GeneIDi100170113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S79795 mRNA. Translation: AAD14317.1 . Frameshift.
    RefSeqi NP_001123377.1. NM_001129905.1.
    UniGenei Oar.816.

    3D structure databases

    ProteinModelPortali P56591.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100170113.

    Organism-specific databases

    CTDi 1543.

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and transcriptional regulation by oxygen tension."
      Hazinski T.A., Noisin E., Hamon I., Dematteo A.
      J. Clin. Invest. 96:2083-2089(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiCP1A1_SHEEP
    AccessioniPrimary (citable) accession number: P56591
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: December 15, 1998
    Last modified: September 3, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Increased expression of this enzyme in lung due to oxygen exposure has been related to hyperoxic injury in microvascular endothelium.

    Caution

    It is uncertain whether Met-1 or Met-4 is the initiator.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi