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Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228SubstrateBy similarity1
Metal bindingi461Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
DAH1
Gene namesi
Name:CYP1A1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516251 – 524Cytochrome P450 1A1Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71O-linked (GlcNAc)By similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP56590.

Expressioni

Inductioni

By polychlorinated biphenyl (PCB) in liver and kidney.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000026483.

Structurei

3D structure databases

ProteinModelPortaliP56590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP56590.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSMFRLSIP ISASELLLAS TVFCLVLWVV KAWQPRLPKG LKSPPGPWGW
60 70 80 90 100
PVLGNVLTLG KSPHLALSRL SQRYGDVLQI RIGSTPVLVL SGLDTIRQAL
110 120 130 140 150
VRQGDDFKGR PDLYSFSLVT DGQSLTFSPD SGPVWAARRR LAQNALKSFS
160 170 180 190 200
IASDPASSCS CYLEEHVSKE AEVLLSRLQE QMAEVGRFDP YRYIVVSVAN
210 220 230 240 250
VICAMCFSKR YDHDDQELLS LVNLSNEFGE GVASANPLDF FPILRYLPNP
260 270 280 290 300
ALDFFKDLNK RFYSFMQKMV KEHYKTFEKG QIRDVTDSLI EHCQDKRLDE
310 320 330 340 350
NANIQLSDEK IVNVVLDLFG AGFDTVTTAI SWSLLYLVTN PNVQKKIQKE
360 370 380 390 400
LDTVIGRARQ PRLSDRPQLP YMEAFILETF RHASFVPFTI PHSTTRDTSL
410 420 430 440 450
SGFYIPKGRC VFVNQWQINH DQKLWGNPSE FQPERFLTLD GTINKALSEK
460 470 480 490 500
VILFGLGKRK CIGETIARLE VFLFLAILLQ QVEFSVPEGT KVDMTPIYGL
510 520
TMKHARCEHF QVRVRTEGAE SPAA
Length:524
Mass (Da):59,209
Last modified:December 15, 1998 - v1
Checksum:i0BBD2C651C13EB40
GO

Sequence databases

PIRiC37222.

Cross-referencesi

Sequence databases

PIRiC37222.

3D structure databases

ProteinModelPortaliP56590.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000026483.

Proteomic databases

PaxDbiP56590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP56590.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP1A1_CANLF
AccessioniPrimary (citable) accession number: P56590
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: October 5, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-2 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.