Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P56590 (CP1A1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A1

EC=1.14.14.1
Alternative name(s):
CYPIA1
DAH1
Gene names
Name:CYP1A1
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By polychlorinated biphenyl (PCB) in liver and kidney.

Sequence similarities

Belongs to the cytochrome P450 family.

Caution

It is uncertain whether Met-1, Met-2 or Met-4 is the initiator.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Cytochrome P450 1A1
PRO_0000051625

Sites

Metal binding4611Iron (heme axial ligand) By similarity
Binding site2281Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P56590 [UniParc].

Last modified December 15, 1998. Version 1.
Checksum: 0BBD2C651C13EB40

FASTA52459,209
        10         20         30         40         50         60 
MMSMFRLSIP ISASELLLAS TVFCLVLWVV KAWQPRLPKG LKSPPGPWGW PVLGNVLTLG 

        70         80         90        100        110        120 
KSPHLALSRL SQRYGDVLQI RIGSTPVLVL SGLDTIRQAL VRQGDDFKGR PDLYSFSLVT 

       130        140        150        160        170        180 
DGQSLTFSPD SGPVWAARRR LAQNALKSFS IASDPASSCS CYLEEHVSKE AEVLLSRLQE 

       190        200        210        220        230        240 
QMAEVGRFDP YRYIVVSVAN VICAMCFSKR YDHDDQELLS LVNLSNEFGE GVASANPLDF 

       250        260        270        280        290        300 
FPILRYLPNP ALDFFKDLNK RFYSFMQKMV KEHYKTFEKG QIRDVTDSLI EHCQDKRLDE 

       310        320        330        340        350        360 
NANIQLSDEK IVNVVLDLFG AGFDTVTTAI SWSLLYLVTN PNVQKKIQKE LDTVIGRARQ 

       370        380        390        400        410        420 
PRLSDRPQLP YMEAFILETF RHASFVPFTI PHSTTRDTSL SGFYIPKGRC VFVNQWQINH 

       430        440        450        460        470        480 
DQKLWGNPSE FQPERFLTLD GTINKALSEK VILFGLGKRK CIGETIARLE VFLFLAILLQ 

       490        500        510        520 
QVEFSVPEGT KVDMTPIYGL TMKHARCEHF QVRVRTEGAE SPAA 

« Hide

References

[1]"Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs."
Uchida T., Komori M., Kitada M., Kamataki T.
Mol. Pharmacol. 38:644-651(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Beagle.
Tissue: Liver.

Cross-references

Sequence databases

PIRC37222.

3D structure databases

ProteinModelPortalP56590.
SMRP56590. Positions 36-513.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036991.
HOVERGENHBG106944.
InParanoidP56590.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A1_CANFA
AccessionPrimary (citable) accession number: P56590
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: December 11, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families