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P56590

- CP1A1_CANFA

UniProt

P56590 - CP1A1_CANFA

Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei228 – 2281SubstrateBy similarity
    Metal bindingi461 – 4611Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    DAH1
    Gene namesi
    Name:CYP1A1
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Cytochrome P450 1A1PRO_0000051625Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Inductioni

    By polychlorinated biphenyl (PCB) in liver and kidney.

    Structurei

    3D structure databases

    ProteinModelPortaliP56590.
    SMRiP56590. Positions 36-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    InParanoidiP56590.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56590-1 [UniParc]FASTAAdd to Basket

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    MMSMFRLSIP ISASELLLAS TVFCLVLWVV KAWQPRLPKG LKSPPGPWGW    50
    PVLGNVLTLG KSPHLALSRL SQRYGDVLQI RIGSTPVLVL SGLDTIRQAL 100
    VRQGDDFKGR PDLYSFSLVT DGQSLTFSPD SGPVWAARRR LAQNALKSFS 150
    IASDPASSCS CYLEEHVSKE AEVLLSRLQE QMAEVGRFDP YRYIVVSVAN 200
    VICAMCFSKR YDHDDQELLS LVNLSNEFGE GVASANPLDF FPILRYLPNP 250
    ALDFFKDLNK RFYSFMQKMV KEHYKTFEKG QIRDVTDSLI EHCQDKRLDE 300
    NANIQLSDEK IVNVVLDLFG AGFDTVTTAI SWSLLYLVTN PNVQKKIQKE 350
    LDTVIGRARQ PRLSDRPQLP YMEAFILETF RHASFVPFTI PHSTTRDTSL 400
    SGFYIPKGRC VFVNQWQINH DQKLWGNPSE FQPERFLTLD GTINKALSEK 450
    VILFGLGKRK CIGETIARLE VFLFLAILLQ QVEFSVPEGT KVDMTPIYGL 500
    TMKHARCEHF QVRVRTEGAE SPAA 524
    Length:524
    Mass (Da):59,209
    Last modified:December 15, 1998 - v1
    Checksum:i0BBD2C651C13EB40
    GO

    Sequence databases

    PIRiC37222.

    Cross-referencesi

    Sequence databases

    PIRi C37222.

    3D structure databases

    ProteinModelPortali P56590.
    SMRi P56590. Positions 36-513.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    InParanoidi P56590.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs."
      Uchida T., Komori M., Kitada M., Kamataki T.
      Mol. Pharmacol. 38:644-651(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_CANFA
    AccessioniPrimary (citable) accession number: P56590
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1, Met-2 or Met-4 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3