Reviewed, UniProtKB/Swiss-Prot P56578 (MALF3_MALFU)

Names and origin

Protein names	Recommended name:     Putative peroxiredoxin     EC=1.11.1.15 Alternative name(s):     Thioredoxin reductase     MF2     Allergen=Mal f 3
Organism	Malassezia furfur (Pityriasis versicolor infection agent) (Pityrosporum orbiculare)
Taxonomic identifier	55194 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Basidiomycota › Ustilaginomycotina › Ustilaginomycotina incertae sedis › Malasseziales › Malassezia

Protein attributes

Sequence length	166 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
Subcellular location	PeroxisomePotential.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the peroxiredoxin 2 family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Peroxisome
Disease	Allergen
Domain	Redox-active center
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 166	›166	Putative peroxiredoxin		PRO_0000056607
Regions
	Domain	‹1 – 166	›166	Thioredoxin
	Motif	164 – 166	3	Microbody targeting signal By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P56578-1 [UniParc]. Last modified December 15, 1998. Version 1. Checksum: 22AF20B892645B97	FASTA	166	18,146
	10 20 30 40 50 60 EIGSTIPNAT FAYVPYSPEL EDHKVCGMPT SFQSHERWKG KKVVIVAVPG AFTPTCTANH 70 80 90 100 110 120 VPPYVEKIQE LKSKGVDEVV VISANDPFVL SAWGITEHAK DNLTFAQDVN CEFSKHFNAT 130 140 150 160 LDLSSKGMGL RTARYALIAN DLKVEYFGID EGEPKQSSAA TVLSKL

References

[1]

"Identification and cloning of two novel allergens from the lipophilic yeast, Malassezia furfur." Yasueda H., Hashida-Okado T., Saito A., Uchida K., Kuroda M., Onishi Y., Takahashi K., Yamaguchi H., Takesako K., Akiyama K. Biochem. Biophys. Res. Commun. 248:240-244(1998) [PubMed: 9675120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: TIMM 2782.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB011805 mRNA. Translation: BAA32436.1.
PIR	JE0227.
3D structure databases
HSSP	HSSP built from PDB template 1HD2 based on UniProtKB P30044.
ModBase	Search...
Family and domain databases
InterPro	IPR013740. Redoxin. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF08534. Redoxin. 1 hit. [Graphical view]
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MALF3_MALFU

Accession

Primary (citable) accession number: P56578

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	November 25, 2008
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)