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Protein

Putative peroxiredoxin

Gene
N/A
Organism
Malassezia furfur (Pityriasis versicolor infection agent) (Pityrosporum furfur)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.By similarity

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys Prx, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.By similarity

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56Cysteine sulfenic acid (-SOH) intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntioxidant, Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peroxiredoxin (EC:1.11.1.15)
Alternative name(s):
MF2
Thioredoxin reductase
Allergen: Mal f 3
OrganismiMalassezia furfur (Pityriasis versicolor infection agent) (Pityrosporum furfur)
Taxonomic identifieri55194 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaMalasseziomycetesMalassezialesMalasseziaceaeMalassezia

Subcellular locationi

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3362. Mala f 3.0101.
469. Mala f 3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000056607‹1 – 166Putative peroxiredoxinAdd BLAST›166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26Interchain (with C-56); in linked formBy similarity
Disulfide bondi56Interchain (with C-26); in linked formBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer; disulfide-linked, upon oxidation.By similarity

Structurei

3D structure databases

ProteinModelPortaliP56578.
SMRiP56578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – 166ThioredoxinPROSITE-ProRule annotationAdd BLAST›166

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi164 – 166Microbody targeting signalBy similarity3

Sequence similaritiesi

Belongs to the peroxiredoxin family. Prx5 subfamily.Curated

Keywords - Domaini

Redox-active center

Family and domain databases

InterProiView protein in InterPro
IPR013740. Redoxin.
IPR036249. Thioredoxin-like_sf.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF08534. Redoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

P56578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EIGSTIPNAT FAYVPYSPEL EDHKVCGMPT SFQSHERWKG KKVVIVAVPG
60 70 80 90 100
AFTPTCTANH VPPYVEKIQE LKSKGVDEVV VISANDPFVL SAWGITEHAK
110 120 130 140 150
DNLTFAQDVN CEFSKHFNAT LDLSSKGMGL RTARYALIAN DLKVEYFGID
160
EGEPKQSSAA TVLSKL
Length:166
Mass (Da):18,146
Last modified:December 15, 1998 - v1
Checksum:i22AF20B892645B97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011805 mRNA. Translation: BAA32436.1.
PIRiJE0227.

Similar proteinsi

Entry informationi

Entry nameiMALF3_MALFU
AccessioniPrimary (citable) accession number: P56578
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: October 25, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families