Reviewed, UniProtKB/Swiss-Prot P56577 (MALF2_MALFU)

Names and origin

Protein names	Recommended name:     Putative peroxiredoxin     EC=1.11.1.15 Alternative name(s):     Thioredoxin reductase     MF1     Allergen=Mal f 2
Organism	Malassezia furfur (Pityriasis versicolor infection agent) (Pityrosporum orbiculare)
Taxonomic identifier	55194 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Basidiomycota › Ustilaginomycotina › Ustilaginomycotina incertae sedis › Malasseziales › Malassezia

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
Subcellular location	PeroxisomePotential.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the peroxiredoxin 2 family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Peroxisome
Disease	Allergen
Domain	Redox-active center
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Putative peroxiredoxin		PRO_0000056606
Regions
	Domain	8 – 177	170	Thioredoxin
	Motif	175 – 177	3	Microbody targeting signal By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56577-1 [UniParc]. Last modified December 15, 1998. Version 1. Checksum: 1E1F907C68E51031	FASTA	177	19,193
	10 20 30 40 50 60 MPGDPTATAK GNEIPDTLMG YIPWTPELDS GEVCGIPTTF KTRDEWKGKK VVIVSIPGAY 70 80 90 100 110 120 TPICHQQHIP PLVKRVDELK AKGVDAVYVI ASNDPFVMAA WGNFNNAKDK VVFATDIDLA 130 140 150 160 170 FSKALGATID LSAKHFGERT ARYALIIDDN KIVDFASDEG DTGKLQNASI DTILTKV

References

[1]

"Identification and cloning of two novel allergens from the lipophilic yeast, Malassezia furfur." Yasueda H., Hashida-Okado T., Saito A., Uchida K., Kuroda M., Onishi Y., Takahashi K., Yamaguchi H., Takesako K., Akiyama K. Biochem. Biophys. Res. Commun. 248:240-244(1998) [PubMed: 9675120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: TIMM 2782.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB011804 Genomic DNA. Translation: BAA32435.1.
PIR	JE0226.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR013740. Redoxin. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF08534. Redoxin. 1 hit. [Graphical view]
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MALF2_MALFU

Accession

Primary (citable) accession number: P56577

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	November 25, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)