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Protein

Putative peroxiredoxin

Gene
N/A
Organism
Malassezia furfur (Pityriasis versicolor infection agent) (Pityrosporum furfur)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.By similarity

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys Prx, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.By similarity

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Cysteine sulfenic acid (-SOH) intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntioxidant, Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peroxiredoxin (EC:1.11.1.15)
Alternative name(s):
MF1
Thioredoxin reductase
Allergen: Mal f 2
OrganismiMalassezia furfur (Pityriasis versicolor infection agent) (Pityrosporum furfur)
Taxonomic identifieri55194 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaMalasseziomycetesMalassezialesMalasseziaceaeMalassezia

Subcellular locationi

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3361. Mala f 2.0101.
468. Mala f 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566061 – 177Putative peroxiredoxinAdd BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34Interchain (with C-64); in linked formBy similarity
Disulfide bondi64Interchain (with C-34); in linked formBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer; disulfide-linked, upon oxidation.By similarity

Structurei

3D structure databases

ProteinModelPortaliP56577.
SMRiP56577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 177ThioredoxinPROSITE-ProRule annotationAdd BLAST170

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi175 – 177Microbody targeting signalBy similarity3

Sequence similaritiesi

Belongs to the peroxiredoxin family. Prx5 subfamily.Curated

Keywords - Domaini

Redox-active center

Family and domain databases

InterProiView protein in InterPro
IPR013740. Redoxin.
IPR036249. Thioredoxin-like_sf.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF08534. Redoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P56577-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGDPTATAK GNEIPDTLMG YIPWTPELDS GEVCGIPTTF KTRDEWKGKK
60 70 80 90 100
VVIVSIPGAY TPICHQQHIP PLVKRVDELK AKGVDAVYVI ASNDPFVMAA
110 120 130 140 150
WGNFNNAKDK VVFATDIDLA FSKALGATID LSAKHFGERT ARYALIIDDN
160 170
KIVDFASDEG DTGKLQNASI DTILTKV
Length:177
Mass (Da):19,193
Last modified:December 15, 1998 - v1
Checksum:i1E1F907C68E51031
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011804 Genomic DNA. Translation: BAA32435.1.
PIRiJE0226.

Similar proteinsi

Entry informationi

Entry nameiMALF2_MALFU
AccessioniPrimary (citable) accession number: P56577
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: October 25, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families