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Protein

Cystatin-A

Gene

Csta

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This is an intracellular thiol proteinase inhibitor.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei4Reactive siteBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-6809371. Formation of the cornified envelope.

Protein family/group databases

MEROPSiI25.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-A
Alternative name(s):
Cystatin-A1
Stefin-A
Cleaved into the following chain:
Gene namesi
Name:Csta
Synonyms:Csta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:3524930. Csta1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002071491 – 97Cystatin-AAdd BLAST97
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004217782 – 97Cystatin-A, N-terminally processedAdd BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP56567.
PaxDbiP56567.
PRIDEiP56567.

PTM databases

PhosphoSitePlusiP56567.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034362.
CleanExiMM_CSTA.
ExpressionAtlasiP56567. baseline and differential.
GenevisibleiP56567. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093795.

Structurei

3D structure databases

ProteinModelPortaliP56567.
SMRiP56567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 50Secondary area of contactBy similarity5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Phylogenomic databases

eggNOGiENOG410J1PC. Eukaryota.
ENOG41121QW. LUCA.
GeneTreeiENSGT00390000015607.
HOGENOMiHOG000294175.
HOVERGENiHBG002292.
InParanoidiP56567.
KOiK13907.
OMAiTGYQTDK.
OrthoDBiEOG091G12NK.
PhylomeDBiP56567.
TreeFamiTF333174.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSiPR00295. STEFINA.
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPGGLTEAR PATAEVQEIA DRVKAQLEEE TNEKYEIFKA VEYKTQVVAG
60 70 80 90
VNYFIKMDVG GGCFTHIKVF KDLSGKNNLE LTGYQTNKTE DDELTYF
Length:97
Mass (Da):10,929
Last modified:December 15, 1998 - v1
Checksum:i5EDBAA66E81F76EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137702 mRNA. Translation: BAE23468.1.
CCDSiCCDS37327.1.
RefSeqiNP_001028411.1. NM_001033239.3.
UniGeneiMm.300592.

Genome annotation databases

EnsembliENSMUST00000096090; ENSMUSP00000093795; ENSMUSG00000034362.
GeneIDi209294.
KEGGimmu:209294.
UCSCiuc007zcf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137702 mRNA. Translation: BAE23468.1.
CCDSiCCDS37327.1.
RefSeqiNP_001028411.1. NM_001033239.3.
UniGeneiMm.300592.

3D structure databases

ProteinModelPortaliP56567.
SMRiP56567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093795.

Protein family/group databases

MEROPSiI25.001.

PTM databases

PhosphoSitePlusiP56567.

Proteomic databases

MaxQBiP56567.
PaxDbiP56567.
PRIDEiP56567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096090; ENSMUSP00000093795; ENSMUSG00000034362.
GeneIDi209294.
KEGGimmu:209294.
UCSCiuc007zcf.1. mouse.

Organism-specific databases

CTDi209294.
MGIiMGI:3524930. Csta1.

Phylogenomic databases

eggNOGiENOG410J1PC. Eukaryota.
ENOG41121QW. LUCA.
GeneTreeiENSGT00390000015607.
HOGENOMiHOG000294175.
HOVERGENiHBG002292.
InParanoidiP56567.
KOiK13907.
OMAiTGYQTDK.
OrthoDBiEOG091G12NK.
PhylomeDBiP56567.
TreeFamiTF333174.

Enzyme and pathway databases

ReactomeiR-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiP56567.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034362.
CleanExiMM_CSTA.
ExpressionAtlasiP56567. baseline and differential.
GenevisibleiP56567. MM.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSiPR00295. STEFINA.
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYTA_MOUSE
AccessioniPrimary (citable) accession number: P56567
Secondary accession number(s): Q3UV05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.