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P56565 (S10A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A1
Alternative name(s):
S-100 protein alpha chain
S-100 protein subunit alpha
S100 calcium-binding protein A1
Gene names
Name:S100a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length94 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity By similarity.

Subunit structure

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
   LigandCalcium
Metal-binding
Zinc
   PTMS-nitrosylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentsarcoplasmic reticulum

Inferred from direct assay PubMed 12804600. Source: MGI

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 10869553. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

S100a4P070916EBI-1544186,EBI-1544173

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 9493Protein S100-A1
PRO_0000143962

Regions

Domain13 – 4836EF-hand 1
Domain50 – 8536EF-hand 2
Calcium binding20 – 33141; low affinity By similarity
Calcium binding63 – 74122; high affinity By similarity

Amino acid modifications

Modified residue861S-nitrosocysteine By similarity

Experimental info

Sequence conflict221Q → E in AA207749. Ref.1
Sequence conflict221Q → H in AA432539. Ref.1
Sequence conflict221Q → K in AAC64108. Ref.2
Sequence conflict221Q → M in AA500563. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P56565 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 6060736751C4ED15

FASTA9410,505
        10         20         30         40         50         60 
MGSELESAME TLINVFHAHS GQEGDKYKLS KKELKDLLQT ELSGFLDVQK DADAVDKVMK 

        70         80         90 
ELDENGDGEV DFKEYVVLVA ALTVACNNFF WETS 

« Hide

References

[1]Marra M., Hillier L., Allen M., Bowles M., Dietrich N., Dubuque T., Geisel S., Kucaba T., Lacy M., Le M., Martin J., Morris M., Schellenberg K., Steptoe M., Tan F., Underwood K., Moore B., Theising B. expand/collapse author list , Wylie T., Lennon G., Soares B., Wilson R., Waterston R.
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Clustered organization of S100 genes in human and mouse."
Ridinger K., Ilg E.C., Niggli F.K., Heizmann C.W., Schaefer B.W.
Biochim. Biophys. Acta 1448:254-263(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AA000715 mRNA. No translation available.
AA207749 mRNA. No translation available.
AA500563 mRNA. No translation available.
AA432539 mRNA. No translation available.
AF087687 mRNA. Translation: AAC64108.1.
CCDSCCDS38503.1.
RefSeqNP_035439.1. NM_011309.3.
UniGeneMm.24662.

3D structure databases

ProteinModelPortalP56565.
SMRP56565. Positions 2-94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203048. 1 interaction.
IntActP56565. 1 interaction.
MINTMINT-239042.

Proteomic databases

MaxQBP56565.
PaxDbP56565.
PRIDEP56565.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID20193.
KEGGmmu:20193.

Organism-specific databases

CTD6271.
MGIMGI:1338917. S100a1.

Phylogenomic databases

eggNOGNOG277258.
HOGENOMHOG000246968.
HOVERGENHBG001479.
PhylomeDBP56565.

Gene expression databases

CleanExMM_S100A1.
GenevestigatorP56565.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028486. S100-A1.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERPTHR11639:SF66. PTHR11639:SF66. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297747.
PROP56565.
SOURCESearch...

Entry information

Entry nameS10A1_MOUSE
AccessionPrimary (citable) accession number: P56565
Secondary accession number(s): O88949
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot