Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein S100-A1

Gene

S100a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably acts as a Ca2+ signal transducer. In response to an increase in intracellular Ca2+ levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity.By similarity

Miscellaneous

Able to bind zinc in vitro; the binding sites are different from the calcium binding sites. The physiological relevance of zinc binding is unclear. Physiological concentrations of potassium antagonize the binding of both divalent cations, especially affecting the high-affinity calcium-binding sites.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A1
Alternative name(s):
S-100 protein alpha chain
S-100 protein subunit alpha
S100 calcium-binding protein A1
Gene namesi
Name:S100a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1338917. S100a1.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • nucleus Source: MGI
  • sarcoplasmic reticulum Source: MGI

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001439622 – 94Protein S100-A1Add BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86S-nitrosocysteineBy similarity1

Keywords - PTMi

S-nitrosylation

Proteomic databases

EPDiP56565.
MaxQBiP56565.
PaxDbiP56565.
PeptideAtlasiP56565.
PRIDEiP56565.
TopDownProteomicsiP56565.

PTM databases

iPTMnetiP56565.
PhosphoSitePlusiP56565.

Expressioni

Gene expression databases

CleanExiMM_S100A1.

Interactioni

Subunit structurei

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER. Interacts with CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
S100a4P070916EBI-1544186,EBI-1544173

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203048. 1 interactor.
IntActiP56565. 1 interactor.
MINTiMINT-239042.
STRINGi10090.ENSMUSP00000058237.

Structurei

3D structure databases

ProteinModelPortaliP56565.
SMRiP56565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXZ2. Eukaryota.
ENOG4111987. LUCA.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP56565.
PhylomeDBiP56565.

Family and domain databases

CDDicd05025. S-100A1. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028486. S100-A1.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PANTHERiPTHR11639:SF86. PTHR11639:SF86. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSELESAME TLINVFHAHS GQEGDKYKLS KKELKDLLQT ELSGFLDVQK
60 70 80 90
DADAVDKVMK ELDENGDGEV DFKEYVVLVA ALTVACNNFF WETS
Length:94
Mass (Da):10,505
Last modified:January 23, 2007 - v2
Checksum:i6060736751C4ED15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22Q → E in AA207749 (Ref. 1) Curated1
Sequence conflicti22Q → H in AA432539 (Ref. 1) Curated1
Sequence conflicti22Q → K in AAC64108 (PubMed:9920416).Curated1
Sequence conflicti22Q → M in AA500563 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA000715 mRNA. No translation available.
AA207749 mRNA. No translation available.
AA500563 mRNA. No translation available.
AA432539 mRNA. No translation available.
AF087687 mRNA. Translation: AAC64108.1.
CCDSiCCDS38503.1.
RefSeqiNP_035439.1. NM_011309.3.
UniGeneiMm.24662.

Genome annotation databases

GeneIDi20193.
KEGGimmu:20193.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiS10A1_MOUSE
AccessioniPrimary (citable) accession number: P56565
Secondary accession number(s): O88949
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families