Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein S100-A1

Gene

S100a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as a Ca2+ signal transducer. In response to an increase in intracellular Ca2+ levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity.By similarity

Miscellaneous

Able to bind zinc in vitro; the binding sites are different from the calcium binding sites. The physiological relevance of zinc binding is unclear. Physiological concentrations of potassium antagonize the binding of both divalent cations, especially affecting the high-affinity calcium-binding sites.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A1
Alternative name(s):
S-100 protein alpha chain
S-100 protein subunit alpha
S100 calcium-binding protein A1
Gene namesi
Name:S100a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1338917 S100a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439621 – 94Protein S100-A1Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86S-nitrosocysteineBy similarity1

Keywords - PTMi

S-nitrosylation

Proteomic databases

EPDiP56565
MaxQBiP56565
PaxDbiP56565
PeptideAtlasiP56565
PRIDEiP56565
TopDownProteomicsiP56565

PTM databases

iPTMnetiP56565
PhosphoSitePlusiP56565

Expressioni

Gene expression databases

CleanExiMM_S100A1

Interactioni

Subunit structurei

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER. Interacts with CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
S100a4P070916EBI-1544186,EBI-1544173

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203048, 1 interactor
IntActiP56565, 1 interactor
STRINGi10090.ENSMUSP00000058237

Structurei

3D structure databases

ProteinModelPortaliP56565
SMRiP56565
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXZ2 Eukaryota
ENOG4111987 LUCA
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP56565
PhylomeDBiP56565

Family and domain databases

CDDicd05025 S-100A1, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR028486 S100-A1
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF66 PTHR11639:SF66, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

P56565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSELESAME TLINVFHAHS GQEGDKYKLS KKELKDLLQT ELSGFLDVQK
60 70 80 90
DADAVDKVMK ELDENGDGEV DFKEYVVLVA ALTVACNNFF WETS
Length:94
Mass (Da):10,505
Last modified:January 23, 2007 - v2
Checksum:i6060736751C4ED15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22Q → E in AA207749 (Ref. 1) Curated1
Sequence conflicti22Q → H in AA432539 (Ref. 1) Curated1
Sequence conflicti22Q → K in AAC64108 (PubMed:9920416).Curated1
Sequence conflicti22Q → M in AA500563 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA000715 mRNA No translation available.
AA207749 mRNA No translation available.
AA500563 mRNA No translation available.
AA432539 mRNA No translation available.
AF087687 mRNA Translation: AAC64108.1
CCDSiCCDS38503.1
RefSeqiNP_035439.1, NM_011309.3
UniGeneiMm.24662

Genome annotation databases

GeneIDi20193
KEGGimmu:20193

Similar proteinsi

Entry informationi

Entry nameiS10A1_MOUSE
AccessioniPrimary (citable) accession number: P56565
Secondary accession number(s): O88949
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health