Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P56565

- S10A1_MOUSE

UniProt

P56565 - S10A1_MOUSE

Protein

Protein S100-A1

Gene

S100a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi20 – 33141; low affinityPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi63 – 74122; high affinityPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of heart contraction Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A1
    Alternative name(s):
    S-100 protein alpha chain
    S-100 protein subunit alpha
    S100 calcium-binding protein A1
    Gene namesi
    Name:S100a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1338917. S100a1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. sarcoplasmic reticulum Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 9493Protein S100-A1PRO_0000143962Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei86 – 861S-nitrosocysteineBy similarity

    Keywords - PTMi

    S-nitrosylation

    Proteomic databases

    MaxQBiP56565.
    PaxDbiP56565.
    PRIDEiP56565.

    Expressioni

    Gene expression databases

    CleanExiMM_S100A1.
    GenevestigatoriP56565.

    Interactioni

    Subunit structurei

    Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    S100a4P070916EBI-1544186,EBI-1544173

    Protein-protein interaction databases

    BioGridi203048. 1 interaction.
    IntActiP56565. 1 interaction.
    MINTiMINT-239042.

    Structurei

    3D structure databases

    ProteinModelPortaliP56565.
    SMRiP56565. Positions 2-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 4836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG277258.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    PhylomeDBiP56565.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028486. S100-A1.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view]
    PANTHERiPTHR11639:SF66. PTHR11639:SF66. 1 hit.
    PfamiPF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56565-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSELESAME TLINVFHAHS GQEGDKYKLS KKELKDLLQT ELSGFLDVQK   50
    DADAVDKVMK ELDENGDGEV DFKEYVVLVA ALTVACNNFF WETS 94
    Length:94
    Mass (Da):10,505
    Last modified:January 23, 2007 - v2
    Checksum:i6060736751C4ED15
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221Q → E in AA207749. 1 PublicationCurated
    Sequence conflicti22 – 221Q → H in AA432539. 1 PublicationCurated
    Sequence conflicti22 – 221Q → K in AAC64108. (PubMed:9920416)Curated
    Sequence conflicti22 – 221Q → M in AA500563. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AA000715 mRNA. No translation available.
    AA207749 mRNA. No translation available.
    AA500563 mRNA. No translation available.
    AA432539 mRNA. No translation available.
    AF087687 mRNA. Translation: AAC64108.1.
    CCDSiCCDS38503.1.
    RefSeqiNP_035439.1. NM_011309.3.
    UniGeneiMm.24662.

    Genome annotation databases

    GeneIDi20193.
    KEGGimmu:20193.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AA000715 mRNA. No translation available.
    AA207749 mRNA. No translation available.
    AA500563 mRNA. No translation available.
    AA432539 mRNA. No translation available.
    AF087687 mRNA. Translation: AAC64108.1 .
    CCDSi CCDS38503.1.
    RefSeqi NP_035439.1. NM_011309.3.
    UniGenei Mm.24662.

    3D structure databases

    ProteinModelPortali P56565.
    SMRi P56565. Positions 2-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203048. 1 interaction.
    IntActi P56565. 1 interaction.
    MINTi MINT-239042.

    Proteomic databases

    MaxQBi P56565.
    PaxDbi P56565.
    PRIDEi P56565.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 20193.
    KEGGi mmu:20193.

    Organism-specific databases

    CTDi 6271.
    MGIi MGI:1338917. S100a1.

    Phylogenomic databases

    eggNOGi NOG277258.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    PhylomeDBi P56565.

    Miscellaneous databases

    NextBioi 297747.
    PROi P56565.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_S100A1.
    Genevestigatori P56565.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028486. S100-A1.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view ]
    PANTHERi PTHR11639:SF66. PTHR11639:SF66. 1 hit.
    Pfami PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiS10A1_MOUSE
    AccessioniPrimary (citable) accession number: P56565
    Secondary accession number(s): O88949
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3