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P56565

- S10A1_MOUSE

UniProt

P56565 - S10A1_MOUSE

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Protein

Protein S100-A1

Gene
S100a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinity By similarityAdd
BLAST
Calcium bindingi63 – 74122; high affinity By similarityAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: IntAct

GO - Biological processi

  1. regulation of heart contraction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A1
Alternative name(s):
S-100 protein alpha chain
S-100 protein subunit alpha
S100 calcium-binding protein A1
Gene namesi
Name:S100a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1338917. S100a1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. sarcoplasmic reticulum Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 9493Protein S100-A1PRO_0000143962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861S-nitrosocysteine By similarity

Keywords - PTMi

S-nitrosylation

Proteomic databases

MaxQBiP56565.
PaxDbiP56565.
PRIDEiP56565.

Expressioni

Gene expression databases

CleanExiMM_S100A1.
GenevestigatoriP56565.

Interactioni

Subunit structurei

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
S100a4P070916EBI-1544186,EBI-1544173

Protein-protein interaction databases

BioGridi203048. 1 interaction.
IntActiP56565. 1 interaction.
MINTiMINT-239042.

Structurei

3D structure databases

ProteinModelPortaliP56565.
SMRiP56565. Positions 2-94.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 4836EF-hand 1Add
BLAST
Domaini50 – 8536EF-hand 2Add
BLAST

Sequence similaritiesi

Belongs to the S-100 family.
Contains 2 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG277258.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
PhylomeDBiP56565.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028486. S100-A1.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF66. PTHR11639:SF66. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56565-1 [UniParc]FASTAAdd to Basket

« Hide

MGSELESAME TLINVFHAHS GQEGDKYKLS KKELKDLLQT ELSGFLDVQK   50
DADAVDKVMK ELDENGDGEV DFKEYVVLVA ALTVACNNFF WETS 94
Length:94
Mass (Da):10,505
Last modified:January 23, 2007 - v2
Checksum:i6060736751C4ED15
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221Q → E in AA207749. 1 Publication
Sequence conflicti22 – 221Q → H in AA432539. 1 Publication
Sequence conflicti22 – 221Q → K in AAC64108. 1 Publication
Sequence conflicti22 – 221Q → M in AA500563. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AA000715 mRNA. No translation available.
AA207749 mRNA. No translation available.
AA500563 mRNA. No translation available.
AA432539 mRNA. No translation available.
AF087687 mRNA. Translation: AAC64108.1.
CCDSiCCDS38503.1.
RefSeqiNP_035439.1. NM_011309.3.
UniGeneiMm.24662.

Genome annotation databases

GeneIDi20193.
KEGGimmu:20193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AA000715 mRNA. No translation available.
AA207749 mRNA. No translation available.
AA500563 mRNA. No translation available.
AA432539 mRNA. No translation available.
AF087687 mRNA. Translation: AAC64108.1 .
CCDSi CCDS38503.1.
RefSeqi NP_035439.1. NM_011309.3.
UniGenei Mm.24662.

3D structure databases

ProteinModelPortali P56565.
SMRi P56565. Positions 2-94.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203048. 1 interaction.
IntActi P56565. 1 interaction.
MINTi MINT-239042.

Proteomic databases

MaxQBi P56565.
PaxDbi P56565.
PRIDEi P56565.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 20193.
KEGGi mmu:20193.

Organism-specific databases

CTDi 6271.
MGIi MGI:1338917. S100a1.

Phylogenomic databases

eggNOGi NOG277258.
HOGENOMi HOG000246968.
HOVERGENi HBG001479.
PhylomeDBi P56565.

Miscellaneous databases

NextBioi 297747.
PROi P56565.
SOURCEi Search...

Gene expression databases

CleanExi MM_S100A1.
Genevestigatori P56565.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028486. S100-A1.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view ]
PANTHERi PTHR11639:SF66. PTHR11639:SF66. 1 hit.
Pfami PF01023. S_100. 1 hit.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiS10A1_MOUSE
AccessioniPrimary (citable) accession number: P56565
Secondary accession number(s): O88949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi