Reviewed,
UniProtKB/Swiss-Prot P56559 (ARL4C_HUMAN)
Last modified
November 25, 2008.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: ADP-ribosylation factor-like protein 4C Alternative name(s): ADP-ribosylation factor-like protein 7 ADP-ribosylation factor-like protein LAK | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 192 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Binds and exchanges GTP and GDP. |
| Subcellular location | NucleusBy similarity. |
| Sequence similarities | Belongs to the small GTPase superfamily. Arf family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Nucleus |
| Ligand | GTP-binding Nucleotide-binding |
| PTM | Lipoprotein Myristate |
Gene Ontology (GO) | |
| Biological process | small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro |
| Cellular component | nucleus Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | GTP binding Inferred from electronic annotation. Source: InterPro GTPase activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Potential | ||||||
| Chain | 2 – 192 | 191 | ADP-ribosylation factor-like protein 4C | PRO_0000207462 | |||||
Regions | |||||||||
| Nucleotide binding | 20 – 27 | 8 | GTP By similarity | ||||||
| Nucleotide binding | 68 – 72 | 5 | GTP By similarity | ||||||
| Nucleotide binding | 127 – 130 | 4 | GTP By similarity | ||||||
Amino acid modifications | |||||||||
| Lipidation | 2 | 1 | N-myristoyl glycine Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal." Jacobs S., Schilf C., Fliegert F., Koling S., Weber Y., Schurmann A., Joost H.-G. FEBS Lett. 456:384-388(1999) [PubMed: 10462049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis. |
| [2] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [3] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Ovary. |
| [5] | "ADP-ribosylation factor-like protein LAK." Abe Y., Nezu K., Ueda N. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-192. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Y17804 mRNA. Translation: CAB44355.1. AF493892 mRNA. Translation: AAM12606.1. BT019378 mRNA. Translation: AAV38185.1. BT019379 mRNA. Translation: AAV38186.1. BC001051 mRNA. No translation available. BC089043 mRNA. Translation: AAH89043.1. AB016811 mRNA. Translation: BAA75473.1. Different initiation. | |
| RefSeq | NP_005728.2. |
| UniGene | Hs.699342 Hs.705494 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1RRF based on UniProtKB P32889. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P56559. |
Genome annotation databases | |
| Ensembl | ENSG00000188042. Homo sapiens. [Contig view] |
| GeneID | 10123. |
| KEGG | hsa:10123. |
Organism-specific databases | |
| HGNC | HGNC:698. ARL4C. |
| MIM | 604787. gene. |
| PharmGKB | PA24991. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | P56559. |
Gene expression databases | |
| ArrayExpress | P56559. |
| CleanEx | HS_ARL4C. |
| GermOnline | ENSG00000188042. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006688. ARF. IPR006689. ARF/SAR. IPR001806. Ras_trnsfrmng. IPR005225. Small_GTP_bd. [Graphical view] |
| PANTHER | PTHR11711. ARF/SAR. 1 hit. |
| Pfam | PF00025. Arf. 1 hit. [Graphical view] |
| PRINTS | PR00449. RASTRNSFRMNG. PR00328. SAR1GTPBP. |
| SMART | SM00177. ARF. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00231. small_GTP. 1 hit. |
| PROSITE | PS01019. ARF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 38287. |
| SOURCE | Search... |
Entry information
| Entry name | ARL4C_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P56559 Secondary accession number(s): Q9BVN1, Q9UQ34 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


