P56559 (ARL4C_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 107.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: ADP-ribosylation factor-like protein 4C Alternative name(s): ADP-ribosylation factor-like protein 7 ADP-ribosylation factor-like protein LAK | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 192 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process. Ref.2 Ref.10 Ref.11 |
| Subunit structure | Interacts with CYTH2. Interacts with alpha tubulin; interaction is independent on the ARL4C GTP or GDP binding status. Ref.10 Ref.11 |
| Subcellular location | Cell projection › filopodium. Cell membrane. Cytoplasm Ref.2 Ref.10. |
| Tissue specificity | Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta. Ref.11 |
| Induction | By liver X-receptor/retinoid X receptor agonists or cholesterol loading. Ref.2 |
| Sequence similarities | Belongs to the small GTPase superfamily. Arf family. |
| Sequence caution | The sequence BAA75473.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transport |
| Cellular component | Cell membrane Cell projection Cytoplasm Membrane |
| Ligand | GTP-binding Nucleotide-binding |
| PTM | Lipoprotein Myristate |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | endocytic recycling Inferred from direct assay Ref.11. Source: UniProtKB small GTPase mediated signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from direct assay Ref.11. Source: UniProtKB filopodiumInferred from electronic annotation. Source: UniProtKB-SubCell nucleusTraceable author statement. Source: ProtInc plasma membraneInferred from direct assay Ref.10. Source: UniProtKB |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activityTraceable author statement. Source: ProtInc alpha-tubulin bindingInferred from direct assay Ref.11. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Potential | ||||||
| Chain | 2 – 192 | 191 | ADP-ribosylation factor-like protein 4C | PRO_0000207462 | |||||
Regions | |||||||||
| Nucleotide binding | 20 – 27 | 8 | GTP By similarity | ||||||
| Nucleotide binding | 68 – 72 | 5 | GTP By similarity | ||||||
| Nucleotide binding | 127 – 130 | 4 | GTP By similarity | ||||||
Amino acid modifications | |||||||||
| Lipidation | 2 | 1 | N-myristoyl glycine Potential | ||||||
Experimental info | |||||||||
| Mutagenesis | 2 | 1 | G → A: Cytoplasmic localization. Ref.2 Ref.10 | ||||||
| Mutagenesis | 27 | 1 | T → N: Does not interact with alpha tubulin. Ref.11 | ||||||
| Mutagenesis | 34 | 1 | K → N: Cytoplasmic localization. Increases GDP-form. Ref.10 | ||||||
| Mutagenesis | 72 | 1 | Q → L: Does not interact with alpha tubulin. Activates transferrin transport from early endosome to recycling endosome. Ref.11 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal." Jacobs S., Schilf C., Fliegert F., Koling S., Weber Y., Schurmann A., Joost H.-G. FEBS Lett. 456:384-388(1999) [PubMed: 10462049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis. |
| [2] | "ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export." Engel T., Lueken A., Bode G., Hobohm U., Lorkowski S., Schlueter B., Rust S., Cullen P., Pech M., Assmann G., Seedorf U. FEBS Lett. 566:241-246(2004) [PubMed: 15147902] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, MUTAGENESIS OF GLY-2, SUBCELLULAR LOCATION. |
| [3] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [6] | "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K.Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [8] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Ovary. |
| [9] | "ADP-ribosylation factor-like protein LAK." Abe Y., Nezu K., Ueda N. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-192. |
| [10] | "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane." Hofmann I., Thompson A., Sanderson C.M., Munro S. Curr. Biol. 17:711-716(2007) [PubMed: 17398095] [Abstract] Cited for: FUNCTION, INTERACTION WITH CYTH2, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-2 AND LYS-34. |
| [11] | "ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport." Wei S.M., Xie C.G., Abe Y., Cai J.T. Biochem. Biophys. Res. Commun. 384:352-356(2009) [PubMed: 19409876] [Abstract] Cited for: FUNCTION, INTERACTION WITH ALPHA TUBULIN, MUTAGENESIS OF THR-27 AND GLN-72, TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Y17804 mRNA. Translation: CAB44355.1. AJ579851 mRNA. Translation: CAE30323.1. AF493892 mRNA. Translation: AAM12606.1. BT019378 mRNA. Translation: AAV38185.1. BT019379 mRNA. Translation: AAV38186.1. AK314119 mRNA. Translation: BAG36810.1. AC097713 Genomic DNA. Translation: AAX93114.1. CH471063 Genomic DNA. Translation: EAW71073.1. BC001051 mRNA. No translation available. BC089043 mRNA. Translation: AAH89043.1. AB016811 mRNA. Translation: BAA75473.1. Different initiation. |
| IPI | IPI00936024. |
| RefSeq | NP_005728.2. NM_005737.3. |
| UniGene | Hs.111554. Hs.727031. |
3D structure databases | |
| ProteinModelPortal | P56559. |
| SMR | P56559. Positions 2-179. |
| ModBase | Search... |
Protein-protein interaction databases | |
| MINT | MINT-2867949. |
| STRING | P56559. |
Polymorphism databases | |
| DMDM | 3913085. |
Proteomic databases | |
| PRIDE | P56559. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000339728; ENSP00000339754; ENSG00000188042. ENST00000390645; ENSP00000375057; ENSG00000188042. |
| GeneID | 10123. |
| KEGG | hsa:10123. |
| UCSC | uc002vvn.1. human. |
Organism-specific databases | |
| CTD | 10123. |
| GeneCards | GC02M235401. |
| H-InvDB | HIX0002941. |
| HGNC | HGNC:698. ARL4C. |
| HPA | HPA028927. |
| MIM | 604787. gene. |
| neXtProt | NX_P56559. |
| PharmGKB | PA24991. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG11017. |
| GeneTree | ENSGT00600000084228. |
| HOVERGEN | HBG002073. |
| InParanoid | P56559. |
| OrthoDB | EOG483D5M. |
| PhylomeDB | P56559. |
Gene expression databases | |
| ArrayExpress | P56559. |
| Bgee | P56559. |
| CleanEx | HS_ARL4C. |
| Genevestigator | P56559. |
| GermOnline | ENSG00000188042. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR005225. Small_GTP-bd_dom. IPR024156. Small_GTPase_ARF. IPR006689. Small_GTPase_ARF/SAR. [Graphical view] |
| KO | K07947. |
| PANTHER | PTHR11711. ARF/SAR. 1 hit. |
| Pfam | PF00025. Arf. 1 hit. [Graphical view] |
| PRINTS | PR00328. SAR1GTPBP. |
| SMART | SM00177. ARF. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00231. Small_GTP. 1 hit. |
| PROSITE | PS51417. ARF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 38287. |
| SOURCE | Search... |
Entry information
| Entry name | ARL4C_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P56559 Secondary accession number(s): Q53R10, Q9BVN1, Q9UQ34 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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