Reviewed, UniProtKB/Swiss-Prot P56559 (ARL4C_HUMAN)

Names and origin

Protein names

Recommended name:
    ADP-ribosylation factor-like protein 4C
Alternative name(s):
    ADP-ribosylation factor-like protein 7
    ADP-ribosylation factor-like protein LAK

Gene names

Name:	ARL4C
Synonyms:	ARL7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Binds and exchanges GTP and GDP.
Subcellular location	NucleusBy similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Myristate
Gene Ontology (GO)
Biological process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Ref.1 Traceable author statement. Source: ProtInc
Molecular function	GTP binding Inferred from electronic annotation. Source: InterPro GTPase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Potential
	Chain	2 – 192	191	ADP-ribosylation factor-like protein 4C		PRO_0000207462
Regions
	Nucleotide binding	20 – 27	8	GTP By similarity
	Nucleotide binding	68 – 72	5	GTP By similarity
	Nucleotide binding	127 – 130	4	GTP By similarity
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine Potential

Sequences

	Sequence		Length	Mass (Da)
	P56559-1 [UniParc]. Last modified December 15, 1998. Version 1. Checksum: 389BD49CF9E6D10D	FASTA	192	21,487
	10 20 30 40 50 60 MGNISSNISA FQSLHIVMLG LDSAGKTTVL YRLKFNEFVN TVPTIGFNTE KIKLSNGTAK 70 80 90 100 110 120 GISCHFWDVG GQEKLRPLWK SYSRCTDGII YVVDSVDVDR LEEAKTELHK VTKFAENQGT 130 140 150 160 170 180 PLLVIANKQD LPKSLPVAEI EKQLALHELI PATTYHVQPA CAIIGEGLTE GMDKLYEMIL 190 KRRKSLKQKK KR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal." Jacobs S., Schilf C., Fliegert F., Koling S., Weber Y., Schurmann A., Joost H.-G. FEBS Lett. 456:384-388(1999) [PubMed: 10462049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Ovary.
[5]	"ADP-ribosylation factor-like protein LAK." Abe Y., Nezu K., Ueda N. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-192.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y17804 mRNA. Translation: CAB44355.1. AF493892 mRNA. Translation: AAM12606.1. BT019378 mRNA. Translation: AAV38185.1. BT019379 mRNA. Translation: AAV38186.1. BC001051 mRNA. No translation available. BC089043 mRNA. Translation: AAH89043.1. AB016811 mRNA. Translation: BAA75473.1. Different initiation.
RefSeq	NP_005728.2.
UniGene	Hs.699342 Hs.705494
3D structure databases
HSSP	HSSP built from PDB template 1RRF based on UniProtKB P32889.
ModBase	Search...
PTM databases
PhosphoSite	P56559.
Genome annotation databases
Ensembl	ENSG00000188042. Homo sapiens. [Contig view]
GeneID	10123.
KEGG	hsa:10123.
Organism-specific databases
HGNC	HGNC:698. ARL4C.
MIM	604787. gene.
PharmGKB	PA24991.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	P56559.
Gene expression databases
ArrayExpress	P56559.
CleanEx	HS_ARL4C.
GermOnline	ENSG00000188042. Homo sapiens.
Family and domain databases
InterPro	IPR006688. ARF. IPR006689. ARF/SAR. IPR001806. Ras_trnsfrmng. IPR005225. Small_GTP_bd. [Graphical view]
PANTHER	PTHR11711. ARF/SAR. 1 hit.
Pfam	PF00025. Arf. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG. PR00328. SAR1GTPBP.
SMART	SM00177. ARF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS01019. ARF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	38287.
SOURCE	Search...

Entry information

Entry name

ARL4C_HUMAN

Accession

Primary (citable) accession number: P56559
Secondary accession number(s): Q9BVN1, Q9UQ34

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	November 25, 2008
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)