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Protein

Transmembrane protein 50B

Gene

TMEM50B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 50B
Alternative name(s):
HCV p7-trans-regulated protein 3
Gene namesi
Name:TMEM50B
Synonyms:C21orf4
ORF Names:UNQ167/PRO193
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:1280. TMEM50B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821HelicalSequence analysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: LIFEdb
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25835.

Polymorphism and mutation databases

BioMutaiTMEM50B.
DMDMi12643476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 158157Transmembrane protein 50BPRO_0000174183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP56557.
PaxDbiP56557.
PRIDEiP56557.

PTM databases

SwissPalmiP56557.

Expressioni

Gene expression databases

BgeeiP56557.
CleanExiHS_TMEM50B.
ExpressionAtlasiP56557. baseline and differential.
GenevisibleiP56557. HS.

Organism-specific databases

HPAiCAB034199.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000397773.

Structurei

3D structure databases

ProteinModelPortaliP56557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0220 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3393. Eukaryota.
ENOG410YCSG. LUCA.
GeneTreeiENSGT00390000007434.
HOGENOMiHOG000264235.
HOVERGENiHBG000997.
InParanoidiP56557.
OMAiYSDGCLG.
PhylomeDBiP56557.
TreeFamiTF300282.

Family and domain databases

InterProiIPR007919. UPF0220.
[Graphical view]
PANTHERiPTHR13180. PTHR13180. 1 hit.
PfamiPF05255. UPF0220. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56557-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFLDNFRW PECECIDWSE RRNAVASVVA GILFFTGWWI MIDAAVVYPK
60 70 80 90 100
PEQLNHAFHT CGVFSTLAFF MINAVSNAQV RGDSYESGCL GRTGARVWLF
110 120 130 140 150
IGFMLMFGSL IASMWILFGA YVTQNTDVYP GLAVFFQNAL IFFSTLIYKF

GRTEELWT
Length:158
Mass (Da):17,936
Last modified:December 1, 2000 - v2
Checksum:i515ABB6AAA817DEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045606 mRNA. Translation: AAC05974.2.
AF039906 Genomic DNA. Translation: AAC05090.1.
AY820138 mRNA. Translation: AAV68502.1.
AY358634 mRNA. Translation: AAQ88997.1.
AK311870 mRNA. Translation: BAG34811.1.
BX537378 mRNA. Translation: CAD97620.1.
CH471079 Genomic DNA. Translation: EAX09832.1.
CH471079 Genomic DNA. Translation: EAX09833.1.
BC000569 mRNA. Translation: AAH00569.1.
CCDSiCCDS13625.1.
RefSeqiNP_006125.2. NM_006134.6.
XP_011528048.1. XM_011529746.1.
XP_011545336.1. XM_011547034.1.
UniGeneiHs.433668.
Hs.655101.

Genome annotation databases

EnsembliENST00000420455; ENSP00000397773; ENSG00000142188.
ENST00000542230; ENSP00000439768; ENSG00000142188.
ENST00000571778; ENSP00000458900; ENSG00000263160.
ENST00000573374; ENSP00000460121; ENSG00000263160.
GeneIDi757.
KEGGihsa:757.
UCSCiuc061zqd.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045606 mRNA. Translation: AAC05974.2.
AF039906 Genomic DNA. Translation: AAC05090.1.
AY820138 mRNA. Translation: AAV68502.1.
AY358634 mRNA. Translation: AAQ88997.1.
AK311870 mRNA. Translation: BAG34811.1.
BX537378 mRNA. Translation: CAD97620.1.
CH471079 Genomic DNA. Translation: EAX09832.1.
CH471079 Genomic DNA. Translation: EAX09833.1.
BC000569 mRNA. Translation: AAH00569.1.
CCDSiCCDS13625.1.
RefSeqiNP_006125.2. NM_006134.6.
XP_011528048.1. XM_011529746.1.
XP_011545336.1. XM_011547034.1.
UniGeneiHs.433668.
Hs.655101.

3D structure databases

ProteinModelPortaliP56557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000397773.

PTM databases

SwissPalmiP56557.

Polymorphism and mutation databases

BioMutaiTMEM50B.
DMDMi12643476.

Proteomic databases

MaxQBiP56557.
PaxDbiP56557.
PRIDEiP56557.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420455; ENSP00000397773; ENSG00000142188.
ENST00000542230; ENSP00000439768; ENSG00000142188.
ENST00000571778; ENSP00000458900; ENSG00000263160.
ENST00000573374; ENSP00000460121; ENSG00000263160.
GeneIDi757.
KEGGihsa:757.
UCSCiuc061zqd.1. human.

Organism-specific databases

CTDi757.
GeneCardsiTMEM50B.
H-InvDBHIX0175060.
HGNCiHGNC:1280. TMEM50B.
HPAiCAB034199.
neXtProtiNX_P56557.
PharmGKBiPA25835.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3393. Eukaryota.
ENOG410YCSG. LUCA.
GeneTreeiENSGT00390000007434.
HOGENOMiHOG000264235.
HOVERGENiHBG000997.
InParanoidiP56557.
OMAiYSDGCLG.
PhylomeDBiP56557.
TreeFamiTF300282.

Miscellaneous databases

ChiTaRSiTMEM50B. human.
GenomeRNAii757.
PROiP56557.

Gene expression databases

BgeeiP56557.
CleanExiHS_TMEM50B.
ExpressionAtlasiP56557. baseline and differential.
GenevisibleiP56557. HS.

Family and domain databases

InterProiIPR007919. UPF0220.
[Graphical view]
PANTHERiPTHR13180. PTHR13180. 1 hit.
PfamiPF05255. UPF0220. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster."
    Reboul J., Gardiner K., Monneron D., Uze G., Lutfalla G.
    Genome Res. 9:242-250(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Screening and identification of genes trans-regulated by HCV p7 protein with microarray assay."
    Guo J., Cheng J., Ji D., Zhao L.-F., Zhang L.-Y.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM50B_HUMAN
AccessioniPrimary (citable) accession number: P56557
Secondary accession number(s): B2R4L4
, D3DSF1, O60537, Q5PY47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: June 8, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.