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Protein

Transmembrane protein 50B

Gene

TMEM50B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi9.B.199.1.2 the 4 tms pf05225 (pf0225) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 50B
Alternative name(s):
HCV p7-trans-regulated protein 3
Gene namesi
Name:TMEM50B
Synonyms:C21orf4
ORF Names:UNQ167/PRO193
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000142188.16
HGNCiHGNC:1280 TMEM50B
MIMi617894 gene
neXtProtiNX_P56557

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142188
PharmGKBiPA25835

Polymorphism and mutation databases

BioMutaiTMEM50B
DMDMi12643476

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001741832 – 158Transmembrane protein 50BAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP56557
PaxDbiP56557
PeptideAtlasiP56557
PRIDEiP56557
ProteomicsDBi56927

PTM databases

iPTMnetiP56557
SwissPalmiP56557

Expressioni

Gene expression databases

BgeeiENSG00000142188
CleanExiHS_TMEM50B
ExpressionAtlasiP56557 baseline and differential
GenevisibleiP56557 HS

Organism-specific databases

HPAiCAB034199
HPA068995

Interactioni

Subunit structurei

May form homotrimers or homodimers.By similarity

Protein-protein interaction databases

BioGridi107212, 1 interactor
IntActiP56557, 2 interactors
STRINGi9606.ENSP00000397773

Structurei

3D structure databases

ProteinModelPortaliP56557
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0220 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3393 Eukaryota
ENOG410YCSG LUCA
GeneTreeiENSGT00390000007434
HOGENOMiHOG000264235
HOVERGENiHBG000997
InParanoidiP56557
OMAiSDGCLGR
OrthoDBiEOG091G0QWW
PhylomeDBiP56557
TreeFamiTF300282

Family and domain databases

InterProiView protein in InterPro
IPR007919 UPF0220
PANTHERiPTHR13180 PTHR13180, 1 hit
PfamiView protein in Pfam
PF05255 UPF0220, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56557-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFLDNFRW PECECIDWSE RRNAVASVVA GILFFTGWWI MIDAAVVYPK
60 70 80 90 100
PEQLNHAFHT CGVFSTLAFF MINAVSNAQV RGDSYESGCL GRTGARVWLF
110 120 130 140 150
IGFMLMFGSL IASMWILFGA YVTQNTDVYP GLAVFFQNAL IFFSTLIYKF

GRTEELWT
Length:158
Mass (Da):17,936
Last modified:December 1, 2000 - v2
Checksum:i515ABB6AAA817DEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045606 mRNA Translation: AAC05974.2
AF039906 Genomic DNA Translation: AAC05090.1
AY820138 mRNA Translation: AAV68502.1
AY358634 mRNA Translation: AAQ88997.1
AK311870 mRNA Translation: BAG34811.1
BX537378 mRNA Translation: CAD97620.1
CH471079 Genomic DNA Translation: EAX09832.1
CH471079 Genomic DNA Translation: EAX09833.1
BC000569 mRNA Translation: AAH00569.1
CCDSiCCDS13625.1
RefSeqiNP_006125.2, NM_006134.6
XP_011528048.1, XM_011529746.1
UniGeneiHs.433668
Hs.655101

Genome annotation databases

EnsembliENST00000420455; ENSP00000397773; ENSG00000142188
ENST00000542230; ENSP00000439768; ENSG00000142188
ENST00000571778; ENSP00000458900; ENSG00000263160
ENST00000573374; ENSP00000460121; ENSG00000263160
GeneIDi757
KEGGihsa:757
UCSCiuc061zqd.1 human

Similar proteinsi

Entry informationi

Entry nameiTM50B_HUMAN
AccessioniPrimary (citable) accession number: P56557
Secondary accession number(s): B2R4L4
, D3DSF1, O60537, Q5PY47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: June 20, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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