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Protein

Transmembrane protein 50B

Gene

TMEM50B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi9.B.199.1.2. the 4 tms pf05225 (pf0225) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 50B
Alternative name(s):
HCV p7-trans-regulated protein 3
Gene namesi
Name:TMEM50B
Synonyms:C21orf4
ORF Names:UNQ167/PRO193
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000142188.16.
HGNCiHGNC:1280. TMEM50B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142188.
PharmGKBiPA25835.

Polymorphism and mutation databases

BioMutaiTMEM50B.
DMDMi12643476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001741832 – 158Transmembrane protein 50BAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP56557.
MaxQBiP56557.
PaxDbiP56557.
PeptideAtlasiP56557.
PRIDEiP56557.

PTM databases

SwissPalmiP56557.

Expressioni

Gene expression databases

BgeeiENSG00000142188.
CleanExiHS_TMEM50B.
ExpressionAtlasiP56557. baseline and differential.
GenevisibleiP56557. HS.

Organism-specific databases

HPAiCAB034199.
HPA068995.

Interactioni

Protein-protein interaction databases

IntActiP56557. 2 interactors.
STRINGi9606.ENSP00000397773.

Structurei

3D structure databases

ProteinModelPortaliP56557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0220 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3393. Eukaryota.
ENOG410YCSG. LUCA.
GeneTreeiENSGT00390000007434.
HOGENOMiHOG000264235.
HOVERGENiHBG000997.
InParanoidiP56557.
OMAiSDGCLGR.
OrthoDBiEOG091G0QWW.
PhylomeDBiP56557.
TreeFamiTF300282.

Family and domain databases

InterProiView protein in InterPro
IPR007919. UPF0220.
PANTHERiPTHR13180. PTHR13180. 1 hit.
PfamiView protein in Pfam
PF05255. UPF0220. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56557-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFLDNFRW PECECIDWSE RRNAVASVVA GILFFTGWWI MIDAAVVYPK
60 70 80 90 100
PEQLNHAFHT CGVFSTLAFF MINAVSNAQV RGDSYESGCL GRTGARVWLF
110 120 130 140 150
IGFMLMFGSL IASMWILFGA YVTQNTDVYP GLAVFFQNAL IFFSTLIYKF

GRTEELWT
Length:158
Mass (Da):17,936
Last modified:December 1, 2000 - v2
Checksum:i515ABB6AAA817DEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045606 mRNA. Translation: AAC05974.2.
AF039906 Genomic DNA. Translation: AAC05090.1.
AY820138 mRNA. Translation: AAV68502.1.
AY358634 mRNA. Translation: AAQ88997.1.
AK311870 mRNA. Translation: BAG34811.1.
BX537378 mRNA. Translation: CAD97620.1.
CH471079 Genomic DNA. Translation: EAX09832.1.
CH471079 Genomic DNA. Translation: EAX09833.1.
BC000569 mRNA. Translation: AAH00569.1.
CCDSiCCDS13625.1.
RefSeqiNP_006125.2. NM_006134.6.
XP_011528048.1. XM_011529746.1.
UniGeneiHs.433668.
Hs.655101.

Genome annotation databases

EnsembliENST00000420455; ENSP00000397773; ENSG00000142188.
ENST00000542230; ENSP00000439768; ENSG00000142188.
ENST00000571778; ENSP00000458900; ENSG00000263160.
ENST00000573374; ENSP00000460121; ENSG00000263160.
GeneIDi757.
KEGGihsa:757.
UCSCiuc061zqd.1. human.

Similar proteinsi

Entry informationi

Entry nameiTM50B_HUMAN
AccessioniPrimary (citable) accession number: P56557
Secondary accession number(s): B2R4L4
, D3DSF1, O60537, Q5PY47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: September 27, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries