Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P56556

- NDUA6_HUMAN

UniProt

P56556 - NDUA6_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Gene

NDUFA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  3. respiratory electron transport chain Source: Reactome
  4. response to oxidative stress Source: UniProtKB
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Alternative name(s):
Complex I-B14
Short name:
CI-B14
LYR motif-containing protein 6
NADH-ubiquinone oxidoreductase B14 subunit
Gene namesi
Name:NDUFA6
Synonyms:LYRM6, NADHB14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:7690. NDUFA6.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial membrane Source: UniProtKB
  3. mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6PRO_0000174302Add
BLAST

Proteomic databases

MaxQBiP56556.
PaxDbiP56556.
PRIDEiP56556.

PTM databases

PhosphoSiteiP56556.

Expressioni

Gene expression databases

BgeeiP56556.
CleanExiHS_NDUFA6.
ExpressionAtlasiP56556. baseline and differential.
GenevestigatoriP56556.

Organism-specific databases

HPAiHPA056934.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

BioGridi110780. 5 interactions.
IntActiP56556. 5 interactions.
MINTiMINT-1381261.
STRINGi9606.ENSP00000330937.

Structurei

3D structure databases

ProteinModelPortaliP56556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiNOG283416.
GeneTreeiENSGT00390000018898.
HOGENOMiHOG000200993.
HOVERGENiHBG002032.
InParanoidiP56556.
KOiK03950.
OMAiPIFSRDL.
PhylomeDBiP56556.
TreeFamiTF105625.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR016488. NADH_Ub_cplx-1_asu_su-6.
[Graphical view]
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
PIRSFiPIRSF006643. NDUA6. 1 hit.

Sequencei

Sequence statusi: Complete.

P56556-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKDIRPRSA RAACKGVGLW SGCFGKMAGS GVRQATSTAS TFVKPIFSRD
60 70 80 90 100
MNEAKRRVRE LYRAWYREVP NTVHQFQLDI TVKMGRDKVR EMFMKNAHVT
110 120 130 140 150
DPRVVDLLVI KGKIELEETI KVWKQRTHVM RFFHETEAPR PKDFLSKFYV

GHDP
Length:154
Mass (Da):17,871
Last modified:June 15, 2010 - v3
Checksum:iC3423B7B75A6336A
GO

Sequence cautioni

The sequence AAC04267.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAF84563.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAG38151.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence EAW60489.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321V → F in CAG32995. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351A → V.1 Publication
Corresponds to variant rs1801311 [ dbSNP | Ensembl ].
VAR_014483

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR456529 mRNA. Translation: CAG30415.1.
AL021878 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW60489.1. Different initiation.
AK291874 mRNA. Translation: BAF84563.1. Different initiation.
AK316562 mRNA. Translation: BAG38151.1. Different initiation.
AF047182 mRNA. Translation: AAC04267.1. Different initiation.
CR456714 mRNA. Translation: CAG32995.1.
CR541997 mRNA. Translation: CAG46794.1.
BC002772 mRNA. Translation: AAH02772.1.
CCDSiCCDS33656.1.
PIRiJC5821.
RefSeqiNP_002481.2. NM_002490.3.
UniGeneiHs.274416.

Genome annotation databases

EnsembliENST00000498737; ENSP00000418842; ENSG00000184983.
ENST00000602404; ENSP00000473461; ENSG00000184983.
ENST00000605916; ENSP00000475402; ENSG00000272765.
ENST00000617763; ENSP00000482543; ENSG00000184983.
GeneIDi4700.
KEGGihsa:4700.
UCSCiuc003bcb.3. human.

Polymorphism databases

DMDMi298286909.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR456529 mRNA. Translation: CAG30415.1 .
AL021878 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW60489.1 . Different initiation.
AK291874 mRNA. Translation: BAF84563.1 . Different initiation.
AK316562 mRNA. Translation: BAG38151.1 . Different initiation.
AF047182 mRNA. Translation: AAC04267.1 . Different initiation.
CR456714 mRNA. Translation: CAG32995.1 .
CR541997 mRNA. Translation: CAG46794.1 .
BC002772 mRNA. Translation: AAH02772.1 .
CCDSi CCDS33656.1.
PIRi JC5821.
RefSeqi NP_002481.2. NM_002490.3.
UniGenei Hs.274416.

3D structure databases

ProteinModelPortali P56556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110780. 5 interactions.
IntActi P56556. 5 interactions.
MINTi MINT-1381261.
STRINGi 9606.ENSP00000330937.

Chemistry

BindingDBi P56556.
ChEMBLi CHEMBL2363065.

PTM databases

PhosphoSitei P56556.

Polymorphism databases

DMDMi 298286909.

Proteomic databases

MaxQBi P56556.
PaxDbi P56556.
PRIDEi P56556.

Protocols and materials databases

DNASUi 4700.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000498737 ; ENSP00000418842 ; ENSG00000184983 .
ENST00000602404 ; ENSP00000473461 ; ENSG00000184983 .
ENST00000605916 ; ENSP00000475402 ; ENSG00000272765 .
ENST00000617763 ; ENSP00000482543 ; ENSG00000184983 .
GeneIDi 4700.
KEGGi hsa:4700.
UCSCi uc003bcb.3. human.

Organism-specific databases

CTDi 4700.
GeneCardsi GC22M042481.
HGNCi HGNC:7690. NDUFA6.
HPAi HPA056934.
MIMi 602138. gene.
neXtProti NX_P56556.
PharmGKBi PA31496.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283416.
GeneTreei ENSGT00390000018898.
HOGENOMi HOG000200993.
HOVERGENi HBG002032.
InParanoidi P56556.
KOi K03950.
OMAi PIFSRDL.
PhylomeDBi P56556.
TreeFami TF105625.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSi NDUFA6. human.
GeneWikii NDUFA6.
GenomeRNAii 4700.
NextBioi 18124.
PROi P56556.
SOURCEi Search...

Gene expression databases

Bgeei P56556.
CleanExi HS_NDUFA6.
ExpressionAtlasi P56556. baseline and differential.
Genevestigatori P56556.

Family and domain databases

InterProi IPR008011. Complex1_LYR.
IPR016488. NADH_Ub_cplx-1_asu_su-6.
[Graphical view ]
Pfami PF05347. Complex1_LYR. 1 hit.
[Graphical view ]
PIRSFi PIRSF006643. NDUA6. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-154, VARIANT VAL-35.
    Tissue: Skeletal muscle.
  5. "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits."
    Ton C., Hwang D.M., Dempsey A.A., Liew C.-C.
    Biochem. Biophys. Res. Commun. 241:589-594(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-154.
    Tissue: Heart.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-154.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-154.
    Tissue: Lymph.
  8. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
    Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
    J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNDUA6_HUMAN
AccessioniPrimary (citable) accession number: P56556
Secondary accession number(s): B2RE54
, O43675, Q6FGW0, Q6IBT8, Q6IC39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3