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P56552

- DEF_PENBA

UniProt

P56552 - DEF_PENBA

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Protein

Defensin-like protein

Gene
N/A
Organism
Pentadiplandra brazzeana
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Taste-modifying protein; sweet-tasting. It is 2000 sweeter than sucrose on a molar basis.1 Publication
Has a pH-specific antimicrobial activity against bacteria (B.subtilis, E.coli and S.aureus) and the fungus C.albicans.1 Publication

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
  2. defense response to fungus Source: UniProtKB-KW
  3. killing of cells of other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Fungicide, Taste-modifying protein

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-like protein
Alternative name(s):
Brazzein
OrganismiPentadiplandra brazzeana
Taxonomic identifieri43545 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesPentadiplandraceaePentadiplandra

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5454Defensin-like proteinPRO_0000221427Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Pyrrolidone carboxylic acid1 Publication
Disulfide bondi4 ↔ 52
Disulfide bondi16 ↔ 37
Disulfide bondi22 ↔ 47
Disulfide bondi26 ↔ 49

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1
54
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74
Helixi13 – 164
Beta strandi17 – 204
Helixi21 – 3010
Beta strandi33 – 397
Beta strandi41 – 433
Beta strandi45 – 528

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BRZNMR-A2-54[»]
2BRZNMR-A2-54[»]
2KGQNMR-A2-54[»]
2KYQNMR-A3-54[»]
2LY5NMR-A2-54[»]
2LY6NMR-A2-54[»]
4HE7X-ray1.80A1-54[»]
DisProtiDP00582.
ProteinModelPortaliP56552.
SMRiP56552. Positions 1-54.

Miscellaneous databases

EvolutionaryTraceiP56552.

Family & Domainsi

Sequence similaritiesi

Belongs to the DEFL family.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.

Sequencei

Sequence statusi: Complete.

P56552-1 [UniParc]FASTAAdd to Basket

« Hide

QDKCKKVYEN YPVSKCQLAN QCNYDCKLDK HARSGECFYD EKRNLQCICD   50
YCEY 54
Length:54
Mass (Da):6,498
Last modified:July 15, 1998 - v1
Checksum:i5BAB4D7215291252
GO

Sequence databases

PIRiS51208.

Cross-referencesi

Sequence databases

PIRi S51208.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BRZ NMR - A 2-54 [» ]
2BRZ NMR - A 2-54 [» ]
2KGQ NMR - A 2-54 [» ]
2KYQ NMR - A 3-54 [» ]
2LY5 NMR - A 2-54 [» ]
2LY6 NMR - A 2-54 [» ]
4HE7 X-ray 1.80 A 1-54 [» ]
DisProti DP00582.
ProteinModelPortali P56552.
SMRi P56552. Positions 1-54.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P56552.

Family and domain databases

Gene3Di 3.30.30.10. 1 hit.
InterProi IPR003614. Scorpion_toxin-like.
[Graphical view ]
SUPFAMi SSF57095. SSF57095. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Brazzein, a new high-potency thermostable sweet protein from Pentadiplandra brazzeana B."
    Ming D., Hellekant G.
    FEBS Lett. 355:106-108(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Fruit.
  2. "Multidimensional signatures in antimicrobial peptides."
    Yount N.Y., Yeaman M.R.
    Proc. Natl. Acad. Sci. U.S.A. 101:7363-7368(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Solution structure of the thermostable sweet-tasting protein brazzein."
    Caldwell J.E., Abildgaard F., Dzakula Z., Ming D., Hellekant G., Markley J.L.
    Nat. Struct. Biol. 5:427-431(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiDEF_PENBA
AccessioniPrimary (citable) accession number: P56552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3