UniProtKB - P56545 (CTBP2_HUMAN)
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Protein
C-terminal-binding protein 2
Gene
CTBP2
Organism
Homo sapiens (Human)
Status
Functioni
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).By similarity
Isoform 2 probably acts as a scaffold for specialized synapses.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 106 | NADBy similarity | 1 | |
Binding sitei | 210 | NAD1 Publication | 1 | |
Active sitei | 272 | By similarity | 1 | |
Binding sitei | 296 | NAD1 Publication | 1 | |
Active sitei | 301 | By similarity | 1 | |
Active sitei | 321 | Proton donorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 186 – 191 | NAD1 Publication | 6 | |
Nucleotide bindingi | 243 – 249 | NAD1 Publication | 7 | |
Nucleotide bindingi | 270 – 272 | NAD1 Publication | 3 | |
Nucleotide bindingi | 321 – 324 | NAD1 Publication | 4 |
GO - Molecular functioni
- glyoxylate reductase (NADP) activity Source: GO_Central
- hydroxypyruvate reductase activity Source: GO_Central
- NAD binding Source: InterPro
- protein-containing complex binding Source: CAFA
- protein homodimerization activity Source: GO_Central
- protein kinase binding Source: CAFA
- transcription corepressor activity Source: GO_Central
GO - Biological processi
- negative regulation of cell proliferation Source: ProtInc
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of retinoic acid receptor signaling pathway Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- transcription, DNA-templated Source: UniProtKB-KW
- viral genome replication Source: ProtInc
- white fat cell differentiation Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase, Repressor |
Biological process | Differentiation, Host-virus interaction, Transcription, Transcription regulation |
Ligand | NAD |
Enzyme and pathway databases
Reactomei | R-HSA-4641265 Repression of WNT target genes R-HSA-5339700 TCF7L2 mutants don't bind CTBP |
SignaLinki | P56545 |
SIGNORi | P56545 |
Names & Taxonomyi
Protein namesi | Recommended name: C-terminal-binding protein 2Short name: CtBP2 |
Gene namesi | Name:CTBP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175029.16 |
HGNCi | HGNC:2495 CTBP2 |
MIMi | 602619 gene |
neXtProti | NX_P56545 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1488 |
OpenTargetsi | ENSG00000175029 |
PharmGKBi | PA26996 |
Chemistry databases
ChEMBLi | CHEMBL3797016 |
Polymorphism and mutation databases
BioMutai | CTBP2 |
DMDMi | 3182976 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076044 | 1 – 445 | C-terminal-binding protein 2Add BLAST | 445 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 22 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 428 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | P56545 |
MaxQBi | P56545 |
PaxDbi | P56545 |
PeptideAtlasi | P56545 |
PRIDEi | P56545 |
PTM databases
iPTMneti | P56545 |
PhosphoSitePlusi | P56545 |
Expressioni
Tissue specificityi
Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.
Gene expression databases
Bgeei | ENSG00000175029 |
CleanExi | HS_CTBP2 |
ExpressionAtlasi | P56545 baseline and differential |
Genevisiblei | P56545 HS |
Organism-specific databases
HPAi | CAB031916 HPA023559 HPA023564 HPA044971 |
Interactioni
Subunit structurei
Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity). Interacts with PNN, NRIP1 and WIZ. Interacts with human adenovirus 5 E1A protein; this interaction seems to potentiate viral replication (PubMed:23747199). Interacts with MCRIP1 (PubMed:25728771).By similarity6 Publications
Binary interactionsi
GO - Molecular functioni
- protein homodimerization activity Source: GO_Central
- protein kinase binding Source: CAFA
Protein-protein interaction databases
BioGridi | 107870112 interactors. |
CORUMi | P56545 |
DIPi | DIP-42104N |
IntActi | P56545 107 interactors. |
MINTi | P56545 |
STRINGi | 9606.ENSP00000311825 |
Chemistry databases
BindingDBi | P56545 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 35 – 38 | Combined sources | 4 | |
Helixi | 47 – 51 | Combined sources | 5 | |
Turni | 52 – 54 | Combined sources | 3 | |
Beta strandi | 56 – 59 | Combined sources | 4 | |
Helixi | 65 – 67 | Combined sources | 3 | |
Helixi | 70 – 75 | Combined sources | 6 | |
Beta strandi | 76 – 81 | Combined sources | 6 | |
Beta strandi | 83 – 85 | Combined sources | 3 | |
Helixi | 89 – 93 | Combined sources | 5 | |
Beta strandi | 100 – 106 | Combined sources | 7 | |
Helixi | 113 – 118 | Combined sources | 6 | |
Beta strandi | 122 – 124 | Combined sources | 3 | |
Beta strandi | 128 – 130 | Combined sources | 3 | |
Helixi | 131 – 147 | Combined sources | 17 | |
Helixi | 149 – 157 | Combined sources | 9 | |
Helixi | 165 – 171 | Combined sources | 7 | |
Turni | 172 – 174 | Combined sources | 3 | |
Beta strandi | 182 – 186 | Combined sources | 5 | |
Helixi | 190 – 199 | Combined sources | 10 | |
Helixi | 200 – 202 | Combined sources | 3 | |
Beta strandi | 205 – 209 | Combined sources | 5 | |
Helixi | 217 – 220 | Combined sources | 4 | |
Helixi | 229 – 235 | Combined sources | 7 | |
Beta strandi | 237 – 241 | Combined sources | 5 | |
Helixi | 255 – 258 | Combined sources | 4 | |
Beta strandi | 265 – 269 | Combined sources | 5 | |
Helixi | 273 – 275 | Combined sources | 3 | |
Helixi | 278 – 286 | Combined sources | 9 | |
Beta strandi | 289 – 296 | Combined sources | 8 | |
Beta strandi | 299 – 302 | Combined sources | 4 | |
Turni | 309 – 312 | Combined sources | 4 | |
Beta strandi | 314 – 318 | Combined sources | 5 | |
Helixi | 327 – 346 | Combined sources | 20 | |
Turni | 349 – 352 | Combined sources | 4 | |
Beta strandi | 354 – 356 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2OME | X-ray | 2.80 | A/B/C/D/E/F/G/H | 31-364 | [»] | |
4LCJ | X-ray | 2.86 | A/B/C/D/E/F/G/H | 31-362 | [»] | |
ProteinModelPortali | P56545 | |||||
SMRi | P56545 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P56545 |
Family & Domainsi
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG0067 Eukaryota COG0111 LUCA |
GeneTreei | ENSGT00530000063021 |
HOVERGENi | HBG001898 |
InParanoidi | P56545 |
KOi | K04496 |
OMAi | INGGYYA |
OrthoDBi | EOG091G08GS |
PhylomeDBi | P56545 |
TreeFami | TF313593 |
Family and domain databases
InterProi | View protein in InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P56545-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI
60 70 80 90 100
LKDLATVAFC DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV
110 120 130 140 150
IVRIGSGYDN VDIKAAGELG IAVCNIPSAA VEETADSTIC HILNLYRRNT
160 170 180 190 200
WLYQALREGT RVQSVEQIRE VASGAARIRG ETLGLIGFGR TGQAVAVRAK
210 220 230 240 250
AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS LHCNLNEHNH
260 270 280 290 300
HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES
310 320 330 340 350
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP
360 370 380 390 400
ESLRNCVNKE FFVTSAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP
410 420 430 440
AAMEGIIPGG IPVTHNLPTV AHPSQAPSPN QPTKHGDNRE HPNEQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 87 | L → F in AAG45951 (PubMed:11163272).Curated | 1 | ||
Sequence conflicti | 88 | T → N in AAG45951 (PubMed:11163272).Curated | 1 | ||
Sequence conflicti | 112 | D → N in AAG45951 (PubMed:11163272).Curated | 1 | ||
Sequence conflicti | 292 | G → R in AAH37900 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 411 | I → T in AAH47018 (PubMed:15489334).Curated | 1 | ||
Isoform 2 (identifier: P56545-2) | |||||
Sequence conflicti | 455 | Y → H in AAG45951 (PubMed:11163272).Curated | 1 | ||
Sequence conflicti | 539 | Q → E in AAG45951 (PubMed:11163272).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027615 | 1 – 20 | MALVD…RICEG → MPVPSRHINIGRSQSWDAAG WYEGPWENAESLRPLGRRSS LTYGTAEGTWFEPNHRPQDA ALPVAAEPYLYREAVYNSVA ARKGSTPDFTFYDSRQAVMS GRSPLLPREYYSDPSGAARV PKEPPLYRDPGVSRPVPSYG VLGSRTSWDPMQGRSPALQD AGHLYRDPGGKMIPQGRQTQ SRAASPGRYGREQPDTRYGA EVPAYPLSQVFSDISERPID PAPARQVAPTCLVVDPSSAA APEGSTGVAPGALNRGYGPA RESIPSKMAYETYEADLSTF QGPGGKRTVLPEFLAFLRAE GLAEATLGALLQQGFDSPAV LATLEDADIKSVAPNLGQAR VLSRLANSCRTEMQLRRQDR GGPLPRARSSSFSHRSELLH GDLASLGAAAPLQTASPRAG DPARRPSSAPSQHLLETAAT YSAPGVGTHAPHFPSNSGYS SPTPCALTARLSPTYPLQAG VALTNPGPSNPLHPGPRTAY STAYTVPMELLKRERNVAAS PLPSPHGSPQVLRKPGAPLG PSTLPPASQSLHTPHSPYQK VARRTGAPIIVSTMLAPEPS in isoform 2. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_058946 | 1 – 19 | MALVD…DRICE → MRPGLPGPTGLCAQTSSRGQ KSVLKQKESCGIWQLYHFLS RKQEPRWEPCVSGSSSGDGA VADLADELRGYPALCCTLPV HSYRSWA in isoform 3. Add BLAST | 19 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000309035; ENSP00000311825; ENSG00000175029 [P56545-2] ENST00000334808; ENSP00000357816; ENSG00000175029 [P56545-3] ENST00000337195; ENSP00000338615; ENSG00000175029 [P56545-1] ENST00000411419; ENSP00000410474; ENSG00000175029 [P56545-1] ENST00000494626; ENSP00000436285; ENSG00000175029 [P56545-1] ENST00000531469; ENSP00000434630; ENSG00000175029 [P56545-1] |
GeneIDi | 1488 |
KEGGi | hsa:1488 |
UCSCi | uc001lie.5 human [P56545-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | CTBP2_HUMAN | |
Accessioni | P56545Primary (citable) accession number: P56545 Secondary accession number(s): A8K2X5 Q9H2T8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | April 25, 2018 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |