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P56545

- CTBP2_HUMAN

UniProt

P56545 - CTBP2_HUMAN

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Protein
C-terminal-binding protein 2
Gene
CTBP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation By similarity.
Isoform 2 probably acts as a scaffold for specialized synapses.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061NAD By similarity
Binding sitei210 – 2101NAD
Active sitei272 – 2721 By similarity
Binding sitei296 – 2961NAD
Active sitei301 – 3011 By similarity
Active sitei321 – 3211Proton donor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi186 – 1916NAD
Nucleotide bindingi243 – 2497NAD
Nucleotide bindingi270 – 2723NAD
Nucleotide bindingi321 – 3244NAD

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
  3. protein binding Source: IntAct
  4. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. negative regulation of cell proliferation Source: ProtInc
  2. negative regulation of transcription, DNA-templated Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
  4. viral genome replication Source: ProtInc
  5. white fat cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

NAD

Enzyme and pathway databases

SignaLinkiP56545.

Names & Taxonomyi

Protein namesi
Recommended name:
C-terminal-binding protein 2
Short name:
CtBP2
Gene namesi
Name:CTBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:2495. CTBP2.

Subcellular locationi

Nucleus Reviewed prediction. Cell junctionsynapse By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. nucleus Source: UniProtKB
  3. synapse Source: UniProtKB-SubCell
  4. transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445C-terminal-binding protein 2
PRO_0000076044Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP56545.
PaxDbiP56545.
PRIDEiP56545.

Expressioni

Tissue specificityi

Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.

Gene expression databases

ArrayExpressiP56545.
BgeeiP56545.
CleanExiHS_CTBP2.
GenevestigatoriP56545.

Organism-specific databases

HPAiCAB031916.
HPA023559.
HPA023564.
HPA044971.

Interactioni

Subunit structurei

Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression By similarity. Interacts with PNN, NRIP1 and WIZ.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL3P207492EBI-741533,EBI-958997
CCNHP519465EBI-741533,EBI-741406
HIC1Q145262EBI-741533,EBI-2507362
PPP1R15AO758072EBI-741533,EBI-714746
PROX1Q927862EBI-741533,EBI-3912635
SOX13Q9UN792EBI-741533,EBI-3928516
Zbp1A2APF72EBI-741533,EBI-6115394From a different organism.

Protein-protein interaction databases

BioGridi107870. 71 interactions.
IntActiP56545. 37 interactions.
MINTiMINT-1188878.
STRINGi9606.ENSP00000311825.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 384
Helixi47 – 515
Turni52 – 543
Beta strandi56 – 594
Helixi65 – 673
Helixi70 – 756
Beta strandi76 – 816
Beta strandi83 – 853
Helixi89 – 935
Beta strandi100 – 1067
Helixi113 – 1186
Beta strandi122 – 1243
Beta strandi128 – 1303
Helixi131 – 14717
Helixi149 – 1579
Helixi165 – 1717
Turni172 – 1743
Beta strandi182 – 1865
Helixi190 – 19910
Helixi200 – 2023
Beta strandi205 – 2095
Helixi217 – 2204
Helixi229 – 2357
Beta strandi237 – 2415
Helixi255 – 2584
Beta strandi265 – 2695
Helixi273 – 2753
Helixi278 – 2869
Beta strandi289 – 2968
Beta strandi299 – 3024
Turni309 – 3124
Beta strandi314 – 3185
Helixi327 – 34620
Turni349 – 3524
Beta strandi354 – 3563

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OMEX-ray2.80A/B/C/D/E/F/G/H31-364[»]
4LCJX-ray2.86A/B/C/D/E/F/G/H31-362[»]
ProteinModelPortaliP56545.
SMRiP56545. Positions 33-362.

Miscellaneous databases

EvolutionaryTraceiP56545.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0111.
HOVERGENiHBG001898.
KOiK04496.
OrthoDBiEOG761BT9.
PhylomeDBiP56545.
TreeFamiTF313593.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P56545-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI    50
LKDLATVAFC DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV 100
IVRIGSGYDN VDIKAAGELG IAVCNIPSAA VEETADSTIC HILNLYRRNT 150
WLYQALREGT RVQSVEQIRE VASGAARIRG ETLGLIGFGR TGQAVAVRAK 200
AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS LHCNLNEHNH 250
HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES 300
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP 350
ESLRNCVNKE FFVTSAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP 400
AAMEGIIPGG IPVTHNLPTV AHPSQAPSPN QPTKHGDNRE HPNEQ 445
Length:445
Mass (Da):48,945
Last modified:July 15, 1998 - v1
Checksum:i0A8C21CEB36807FA
GO
Isoform 2 (identifier: P56545-2) [UniParc]FASTAAdd to Basket

Also known as: Ribeye

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MALVDKHKVKRQRLDRICEG → MPVPSRHINI...VSTMLAPEPS

Show »
Length:985
Mass (Da):106,187
Checksum:i90EC841907295622
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471E → D.
Corresponds to variant rs3198926 [ dbSNP | Ensembl ].
VAR_033844

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020MALVD…RICEG → MPVPSRHINIGRSQSWDAAG WYEGPWENAESLRPLGRRSS LTYGTAEGTWFEPNHRPQDA ALPVAAEPYLYREAVYNSVA ARKGSTPDFTFYDSRQAVMS GRSPLLPREYYSDPSGAARV PKEPPLYRDPGVSRPVPSYG VLGSRTSWDPMQGRSPALQD AGHLYRDPGGKMIPQGRQTQ SRAASPGRYGREQPDTRYGA EVPAYPLSQVFSDISERPID PAPARQVAPTCLVVDPSSAA APEGSTGVAPGALNRGYGPA RESIPSKMAYETYEADLSTF QGPGGKRTVLPEFLAFLRAE GLAEATLGALLQQGFDSPAV LATLEDADIKSVAPNLGQAR VLSRLANSCRTEMQLRRQDR GGPLPRARSSSFSHRSELLH GDLASLGAAAPLQTASPRAG DPARRPSSAPSQHLLETAAT YSAPGVGTHAPHFPSNSGYS SPTPCALTARLSPTYPLQAG VALTNPGPSNPLHPGPRTAY STAYTVPMELLKRERNVAAS PLPSPHGSPQVLRKPGAPLG PSTLPPASQSLHTPHSPYQK VARRTGAPIIVSTMLAPEPS in isoform 2.
VSP_027615Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871L → F in AAG45951. 1 Publication
Sequence conflicti88 – 881T → N in AAG45951. 1 Publication
Sequence conflicti112 – 1121D → N in AAG45951. 1 Publication
Sequence conflicti411 – 4111I → T in AAH47018. 1 Publication
Isoform 2 (identifier: P56545-2)
Sequence conflicti455 – 4551Y → H in AAG45951. 1 Publication
Sequence conflicti539 – 5391Q → E in AAG45951. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016507 mRNA. Translation: AAC39603.1.
AF222711 mRNA. Translation: AAG45951.1.
BT007012 mRNA. Translation: AAP35658.1.
AK290390 mRNA. Translation: BAF83079.1.
AL833398 mRNA. Translation: CAH10590.1.
AL596261, AL731571 Genomic DNA. Translation: CAH72472.1.
AL731571, AL596261 Genomic DNA. Translation: CAI16100.1.
AL731571 Genomic DNA. Translation: CAI16102.1.
CH471066 Genomic DNA. Translation: EAW49247.1.
CH471066 Genomic DNA. Translation: EAW49250.1.
CH471066 Genomic DNA. Translation: EAW49249.1.
BC002486 mRNA. Translation: AAH02486.1.
BC047018 mRNA. Translation: AAH47018.1.
BC052276 mRNA. Translation: AAH52276.1.
BC072020 mRNA. Translation: AAH72020.1.
CCDSiCCDS7643.1. [P56545-1]
CCDS7644.1. [P56545-2]
RefSeqiNP_001077383.1. NM_001083914.1. [P56545-1]
NP_001277143.1. NM_001290214.1. [P56545-1]
NP_001277144.1. NM_001290215.1. [P56545-1]
NP_001320.1. NM_001329.2. [P56545-1]
NP_073713.2. NM_022802.2. [P56545-2]
XP_005269618.1. XM_005269561.1. [P56545-1]
XP_005269619.1. XM_005269562.2. [P56545-1]
XP_005269621.1. XM_005269564.1. [P56545-1]
XP_005269622.1. XM_005269565.1. [P56545-1]
XP_005269624.1. XM_005269567.1. [P56545-1]
XP_005269625.1. XM_005269568.2. [P56545-1]
XP_005269626.1. XM_005269569.1. [P56545-1]
XP_005269627.1. XM_005269570.1. [P56545-1]
XP_005269628.1. XM_005269571.1. [P56545-1]
XP_005269629.1. XM_005269572.2. [P56545-1]
XP_006717704.1. XM_006717641.1. [P56545-1]
XP_006717705.1. XM_006717642.1. [P56545-1]
XP_006717706.1. XM_006717643.1. [P56545-1]
UniGeneiHs.501345.

Genome annotation databases

EnsembliENST00000309035; ENSP00000311825; ENSG00000175029. [P56545-2]
ENST00000337195; ENSP00000338615; ENSG00000175029. [P56545-1]
ENST00000411419; ENSP00000410474; ENSG00000175029. [P56545-1]
ENST00000494626; ENSP00000436285; ENSG00000175029. [P56545-1]
ENST00000531469; ENSP00000434630; ENSG00000175029. [P56545-1]
GeneIDi1488.
KEGGihsa:1488.
UCSCiuc001lie.4. human. [P56545-2]
uc001lif.4. human. [P56545-1]

Polymorphism databases

DMDMi3182976.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016507 mRNA. Translation: AAC39603.1 .
AF222711 mRNA. Translation: AAG45951.1 .
BT007012 mRNA. Translation: AAP35658.1 .
AK290390 mRNA. Translation: BAF83079.1 .
AL833398 mRNA. Translation: CAH10590.1 .
AL596261 , AL731571 Genomic DNA. Translation: CAH72472.1 .
AL731571 , AL596261 Genomic DNA. Translation: CAI16100.1 .
AL731571 Genomic DNA. Translation: CAI16102.1 .
CH471066 Genomic DNA. Translation: EAW49247.1 .
CH471066 Genomic DNA. Translation: EAW49250.1 .
CH471066 Genomic DNA. Translation: EAW49249.1 .
BC002486 mRNA. Translation: AAH02486.1 .
BC047018 mRNA. Translation: AAH47018.1 .
BC052276 mRNA. Translation: AAH52276.1 .
BC072020 mRNA. Translation: AAH72020.1 .
CCDSi CCDS7643.1. [P56545-1 ]
CCDS7644.1. [P56545-2 ]
RefSeqi NP_001077383.1. NM_001083914.1. [P56545-1 ]
NP_001277143.1. NM_001290214.1. [P56545-1 ]
NP_001277144.1. NM_001290215.1. [P56545-1 ]
NP_001320.1. NM_001329.2. [P56545-1 ]
NP_073713.2. NM_022802.2. [P56545-2 ]
XP_005269618.1. XM_005269561.1. [P56545-1 ]
XP_005269619.1. XM_005269562.2. [P56545-1 ]
XP_005269621.1. XM_005269564.1. [P56545-1 ]
XP_005269622.1. XM_005269565.1. [P56545-1 ]
XP_005269624.1. XM_005269567.1. [P56545-1 ]
XP_005269625.1. XM_005269568.2. [P56545-1 ]
XP_005269626.1. XM_005269569.1. [P56545-1 ]
XP_005269627.1. XM_005269570.1. [P56545-1 ]
XP_005269628.1. XM_005269571.1. [P56545-1 ]
XP_005269629.1. XM_005269572.2. [P56545-1 ]
XP_006717704.1. XM_006717641.1. [P56545-1 ]
XP_006717705.1. XM_006717642.1. [P56545-1 ]
XP_006717706.1. XM_006717643.1. [P56545-1 ]
UniGenei Hs.501345.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2OME X-ray 2.80 A/B/C/D/E/F/G/H 31-364 [» ]
4LCJ X-ray 2.86 A/B/C/D/E/F/G/H 31-362 [» ]
ProteinModelPortali P56545.
SMRi P56545. Positions 33-362.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107870. 71 interactions.
IntActi P56545. 37 interactions.
MINTi MINT-1188878.
STRINGi 9606.ENSP00000311825.

Polymorphism databases

DMDMi 3182976.

Proteomic databases

MaxQBi P56545.
PaxDbi P56545.
PRIDEi P56545.

Protocols and materials databases

DNASUi 1488.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309035 ; ENSP00000311825 ; ENSG00000175029 . [P56545-2 ]
ENST00000337195 ; ENSP00000338615 ; ENSG00000175029 . [P56545-1 ]
ENST00000411419 ; ENSP00000410474 ; ENSG00000175029 . [P56545-1 ]
ENST00000494626 ; ENSP00000436285 ; ENSG00000175029 . [P56545-1 ]
ENST00000531469 ; ENSP00000434630 ; ENSG00000175029 . [P56545-1 ]
GeneIDi 1488.
KEGGi hsa:1488.
UCSCi uc001lie.4. human. [P56545-2 ]
uc001lif.4. human. [P56545-1 ]

Organism-specific databases

CTDi 1488.
GeneCardsi GC10M126666.
HGNCi HGNC:2495. CTBP2.
HPAi CAB031916.
HPA023559.
HPA023564.
HPA044971.
MIMi 602619. gene.
neXtProti NX_P56545.
PharmGKBi PA26996.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0111.
HOVERGENi HBG001898.
KOi K04496.
OrthoDBi EOG761BT9.
PhylomeDBi P56545.
TreeFami TF313593.

Enzyme and pathway databases

SignaLinki P56545.

Miscellaneous databases

ChiTaRSi CTBP2. human.
EvolutionaryTracei P56545.
GeneWikii CTBP2.
GenomeRNAii 1488.
NextBioi 6111.
PROi P56545.
SOURCEi Search...

Gene expression databases

ArrayExpressi P56545.
Bgeei P56545.
CleanExi HS_CTBP2.
Genevestigatori P56545.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view ]
PROSITEi PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3."
    Katsanis N., Fisher E.M.C.
    Genomics 47:294-299(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function."
    Schmitz F., Koenigstorfer A., Suedhof T.C.
    Neuron 28:857-872(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Melanoma.
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon, Kidney, Pancreas and Placenta.
  10. "Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation."
    Schaeper U., Boyd J.M., Verma S., Uhlmann E., Subramanian T., Chinnadurai G.
    Proc. Natl. Acad. Sci. U.S.A. 92:10467-10471(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 263-272, PHOSPHORYLATION.
    Tissue: B-cell and Cervix carcinoma.
  11. "Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene."
    Alpatov R., Munguba G.C., Caton P., Joo J.H., Shi Y., Shi Y., Hunt M.E., Sugrue S.P.
    Mol. Cell. Biol. 24:10223-10235(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PNN.
  12. "Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition."
    Castet A., Boulahtouf A., Versini G., Bonnet S., Augereau P., Vignon F., Khochbin S., Jalaguier S., Cavailles V.
    Nucleic Acids Res. 32:1957-1966(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NRIP1.
  13. "Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP."
    Ueda J., Tachibana M., Ikura T., Shinkai Y.
    J. Biol. Chem. 281:20120-20128(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WIZ.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 31-364 IN COMPLEX WITH NAD.

Entry informationi

Entry nameiCTBP2_HUMAN
AccessioniPrimary (citable) accession number: P56545
Secondary accession number(s): A8K2X5
, D3DRF5, O43449, Q5SQP7, Q69YI3, Q86SV0, Q9H2T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 3, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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