Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Caveolin-3

Gene

CAV3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.

GO - Molecular functioni

  • calcium channel regulator activity Source: BHF-UCL
  • connexin binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • potassium channel inhibitor activity Source: BHF-UCL
  • protein complex binding Source: UniProtKB
  • protein complex scaffold Source: BHF-UCL
  • protein C-terminus binding Source: UniProtKB
  • sodium channel regulator activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33399-MONOMER.
ReactomeiR-HSA-445355. Smooth Muscle Contraction.
SignaLinkiP56539.

Protein family/group databases

TCDBi1.F.1.2.1. the synaptosomal vesicle fusion pore (svf-pore) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-3
Alternative name(s):
M-caveolin
Gene namesi
Name:CAV3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1529. CAV3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 83CytoplasmicSequence analysisAdd BLAST83
Intramembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 151CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

  • caveola Source: UniProtKB
  • cell surface Source: Ensembl
  • dystrophin-associated glycoprotein complex Source: UniProtKB
  • endoplasmic reticulum Source: MGI
  • Golgi membrane Source: UniProtKB-SubCell
  • intercalated disc Source: Ensembl
  • intracellular membrane-bounded organelle Source: HPA
  • membrane raft Source: BHF-UCL
  • neuromuscular junction Source: BHF-UCL
  • plasma membrane Source: BHF-UCL
  • sarcolemma Source: BHF-UCL
  • T-tubule Source: BHF-UCL
  • vesicle Source: Ensembl
  • Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Limb-girdle muscular dystrophy 1C (LGMD1C)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA degenerative myopathy characterized by calf hypertrophy and mild to moderate proximal muscle weakness. Inheritance can be autosomal dominant or recessive.
See also OMIM:607801
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01151227R → Q in HYPCK, RMD, LGMD1C and MPDT. 6 PublicationsCorresponds to variant rs116840778dbSNPEnsembl.1
Natural variantiVAR_01537428D → E in RMD and LGMD1C. 1 PublicationCorresponds to variant rs116840782dbSNPEnsembl.1
Natural variantiVAR_02101633N → K in LGMD1C and MPDT. 2 PublicationsCorresponds to variant rs1008642dbSNPEnsembl.1
Natural variantiVAR_02101744V → E in LGMD1C. 1 PublicationCorresponds to variant rs116840788dbSNPEnsembl.1
Natural variantiVAR_01151346A → T in LGMD1C and RMD; decreased surface expression of the CAV3 protein. 3 PublicationsCorresponds to variant rs116840789dbSNPEnsembl.1
Natural variantiVAR_00140264 – 66Missing in LGMD1C. 1 Publication3
Natural variantiVAR_02101864T → P in LGMD1C. 1 PublicationCorresponds to variant rs199476332dbSNPEnsembl.1
Natural variantiVAR_001403105P → L in LGMD1C and RMD. 2 PublicationsCorresponds to variant rs116840805dbSNPEnsembl.1
HyperCKmia (HYPCK)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by persistent elevated levels of serum creatine kinase without muscle weakness.
See also OMIM:123320
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01151227R → Q in HYPCK, RMD, LGMD1C and MPDT. 6 PublicationsCorresponds to variant rs116840778dbSNPEnsembl.1
Natural variantiVAR_02954029P → L in HYPCK. 1 PublicationCorresponds to variant rs116840786dbSNPEnsembl.1
Natural variantiVAR_01074257V → M in HYPCK. 1 PublicationCorresponds to variant rs116840795dbSNPEnsembl.1
Natural variantiVAR_02954497Missing in HYPCK. 1 Publication1
Rippling muscle disease (RMD)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare disorder characterized by mechanically triggered contractions of skeletal muscle. In RMD, mechanical stimulation leads to electrically silent muscle contractions that spread to neighboring fibers that cause visible ripples to move over the muscle.
See also OMIM:606072
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01151227R → Q in HYPCK, RMD, LGMD1C and MPDT. 6 PublicationsCorresponds to variant rs116840778dbSNPEnsembl.1
Natural variantiVAR_01537428D → E in RMD and LGMD1C. 1 PublicationCorresponds to variant rs116840782dbSNPEnsembl.1
Natural variantiVAR_01151346A → T in LGMD1C and RMD; decreased surface expression of the CAV3 protein. 3 PublicationsCorresponds to variant rs116840789dbSNPEnsembl.1
Natural variantiVAR_01151446A → V in RMD. 1 PublicationCorresponds to variant rs116840773dbSNPEnsembl.1
Natural variantiVAR_02954153S → G in RMD. 1 PublicationCorresponds to variant rs116840794dbSNPEnsembl.1
Natural variantiVAR_01620787L → P in RMD. 1 PublicationCorresponds to variant rs28936685dbSNPEnsembl.1
Natural variantiVAR_01620893A → T in RMD. 2 PublicationsCorresponds to variant rs28936686dbSNPEnsembl.1
Natural variantiVAR_001403105P → L in LGMD1C and RMD. 2 PublicationsCorresponds to variant rs116840805dbSNPEnsembl.1
Cardiomyopathy, familial hypertrophic (CMH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:192600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02954364T → S in CMH. 1 PublicationCorresponds to variant rs121909280dbSNPEnsembl.1
Long QT syndrome 9 (LQT9)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
See also OMIM:611818
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04369578T → M in LQT9 and SIDS. 2 PublicationsCorresponds to variant rs72546668dbSNPEnsembl.1
Natural variantiVAR_04369679L → R in LQT9 and SIDS. 1 PublicationCorresponds to variant rs121909282dbSNPEnsembl.1
Natural variantiVAR_04369785A → T in LQT9. 1 PublicationCorresponds to variant rs104893715dbSNPEnsembl.1
Natural variantiVAR_04369897F → C in LQT9; increase in late sodium current. 1 PublicationCorresponds to variant rs104893714dbSNPEnsembl.1
Natural variantiVAR_043699141S → R in LQT9; increase in late sodium current. 1 PublicationCorresponds to variant rs104893713dbSNPEnsembl.1
Sudden infant death syndrome (SIDS)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionSIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.
See also OMIM:272120
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04369414V → L in SIDS. 1 PublicationCorresponds to variant rs121909281dbSNPEnsembl.1
Natural variantiVAR_04369578T → M in LQT9 and SIDS. 2 PublicationsCorresponds to variant rs72546668dbSNPEnsembl.1
Natural variantiVAR_04369679L → R in LQT9 and SIDS. 1 PublicationCorresponds to variant rs121909282dbSNPEnsembl.1
Myopathy, distal, Tateyama type (MPDT)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by progressive muscular atrophy and muscle weakness beginning in the hands, the legs, or the feet. Muscle atrophy may be restricted to the small muscles of the hands and feet.
See also OMIM:614321
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01151227R → Q in HYPCK, RMD, LGMD1C and MPDT. 6 PublicationsCorresponds to variant rs116840778dbSNPEnsembl.1
Natural variantiVAR_02101633N → K in LGMD1C and MPDT. 2 PublicationsCorresponds to variant rs1008642dbSNPEnsembl.1

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Limb-girdle muscular dystrophy, Long QT syndrome

Organism-specific databases

DisGeNETi859.
MalaCardsiCAV3.
MIMi123320. phenotype.
192600. phenotype.
272120. phenotype.
606072. phenotype.
607801. phenotype.
611818. phenotype.
614321. phenotype.
OpenTargetsiENSG00000182533.
Orphaneti265. Autosomal dominant limb-girdle muscular dystrophy type 1C.
155. Familial isolated hypertrophic cardiomyopathy.
97238. Rippling muscle disease.
101016. Romano-Ward syndrome.
PharmGKBiPA26109.

Polymorphism and mutation databases

BioMutaiCAV3.
DMDMi3182930.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441401 – 151Caveolin-3Add BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)1 Publication

Post-translational modificationi

Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP56539.
MaxQBiP56539.
PaxDbiP56539.
PeptideAtlasiP56539.
PRIDEiP56539.

PTM databases

PhosphoSitePlusiP56539.
SwissPalmiP56539.

Expressioni

Tissue specificityi

Expressed predominantly in muscle.1 Publication

Gene expression databases

BgeeiENSG00000182533.
CleanExiHS_CAV3.
ExpressionAtlasiP56539. baseline and differential.
GenevisibleiP56539. HS.

Organism-specific databases

HPAiCAB017518.
CAB018557.
HPA054488.

Interactioni

Subunit structurei

Homooligomer. Interacts with DLG1 and KCNA5; forms a ternary complex (By similarity). Interacts with TRIM72 (By similarity). Interacts with MUSK; may regulate MUSK signaling (By similarity). Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD. Interacts with DYSF. Interacts with BVES (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MP034192EBI-3905936,EBI-10042882From a different organism.

GO - Molecular functioni

  • connexin binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • protein complex binding Source: UniProtKB
  • protein complex scaffold Source: BHF-UCL
  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107307. 48 interactors.
IntActiP56539. 4 interactors.
MINTiMINT-3021471.
STRINGi9606.ENSP00000341940.

Structurei

3D structure databases

ProteinModelPortaliP56539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 114Required for interaction with DAG11 PublicationAdd BLAST51

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiENOG410IXSQ. Eukaryota.
ENOG41121CB. LUCA.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP56539.
KOiK12959.
OMAiVKDIHFK.
OrthoDBiEOG091G0M1R.
PhylomeDBiP56539.
TreeFamiTF315736.

Family and domain databases

InterProiIPR031091. CAV-3.
IPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF16. PTHR10844:SF16. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAEEHTDLE AQIVKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPVG
60 70 80 90 100
TYSFDGVWKV SYTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI
110 120 130 140 150
WAVVPCIKSY LIEIQCISHI YSLCIRTFCN PLFAALGQVC SSIKVVLRKE

V
Length:151
Mass (Da):17,259
Last modified:July 15, 1998 - v1
Checksum:iC695E14F5B8F4753
GO

Sequence cautioni

The sequence AAC14931 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAF84581 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04369414V → L in SIDS. 1 PublicationCorresponds to variant rs121909281dbSNPEnsembl.1
Natural variantiVAR_01151227R → Q in HYPCK, RMD, LGMD1C and MPDT. 6 PublicationsCorresponds to variant rs116840778dbSNPEnsembl.1
Natural variantiVAR_01537428D → E in RMD and LGMD1C. 1 PublicationCorresponds to variant rs116840782dbSNPEnsembl.1
Natural variantiVAR_02954029P → L in HYPCK. 1 PublicationCorresponds to variant rs116840786dbSNPEnsembl.1
Natural variantiVAR_02101633N → K in LGMD1C and MPDT. 2 PublicationsCorresponds to variant rs1008642dbSNPEnsembl.1
Natural variantiVAR_02101744V → E in LGMD1C. 1 PublicationCorresponds to variant rs116840788dbSNPEnsembl.1
Natural variantiVAR_01151346A → T in LGMD1C and RMD; decreased surface expression of the CAV3 protein. 3 PublicationsCorresponds to variant rs116840789dbSNPEnsembl.1
Natural variantiVAR_01151446A → V in RMD. 1 PublicationCorresponds to variant rs116840773dbSNPEnsembl.1
Natural variantiVAR_02954153S → G in RMD. 1 PublicationCorresponds to variant rs116840794dbSNPEnsembl.1
Natural variantiVAR_02954256G → S.3 PublicationsCorresponds to variant rs72546667dbSNPEnsembl.1
Natural variantiVAR_01074257V → M in HYPCK. 1 PublicationCorresponds to variant rs116840795dbSNPEnsembl.1
Natural variantiVAR_02669661S → R in a patient with mild proximal myopathy. 1 PublicationCorresponds to variant rs116840796dbSNPEnsembl.1
Natural variantiVAR_00140264 – 66Missing in LGMD1C. 1 Publication3
Natural variantiVAR_02101864T → P in LGMD1C. 1 PublicationCorresponds to variant rs199476332dbSNPEnsembl.1
Natural variantiVAR_02954364T → S in CMH. 1 PublicationCorresponds to variant rs121909280dbSNPEnsembl.1
Natural variantiVAR_01074372C → W.3 PublicationsCorresponds to variant rs116840776dbSNPEnsembl.1
Natural variantiVAR_04369578T → M in LQT9 and SIDS. 2 PublicationsCorresponds to variant rs72546668dbSNPEnsembl.1
Natural variantiVAR_04369679L → R in LQT9 and SIDS. 1 PublicationCorresponds to variant rs121909282dbSNPEnsembl.1
Natural variantiVAR_04369785A → T in LQT9. 1 PublicationCorresponds to variant rs104893715dbSNPEnsembl.1
Natural variantiVAR_01620787L → P in RMD. 1 PublicationCorresponds to variant rs28936685dbSNPEnsembl.1
Natural variantiVAR_01620893A → T in RMD. 2 PublicationsCorresponds to variant rs28936686dbSNPEnsembl.1
Natural variantiVAR_04369897F → C in LQT9; increase in late sodium current. 1 PublicationCorresponds to variant rs104893714dbSNPEnsembl.1
Natural variantiVAR_02954497Missing in HYPCK. 1 Publication1
Natural variantiVAR_001403105P → L in LGMD1C and RMD. 2 PublicationsCorresponds to variant rs116840805dbSNPEnsembl.1
Natural variantiVAR_029545126R → H.1 PublicationCorresponds to variant rs116840777dbSNPEnsembl.1
Natural variantiVAR_043699141S → R in LQT9; increase in late sodium current. 1 PublicationCorresponds to variant rs104893713dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043101 mRNA. Translation: AAC14931.1. Different initiation.
Y14747 mRNA. Translation: CAA75042.1.
AF036367, AF036366 Genomic DNA. Translation: AAC39758.1.
AF036365 mRNA. Translation: AAC39756.1.
AK291892 mRNA. Translation: BAF84581.1. Different initiation.
AC068312 Genomic DNA. No translation available.
BC069368 mRNA. Translation: AAH69368.1.
BC102033 mRNA. Translation: AAI02034.1.
BC102036 mRNA. Translation: AAI02037.1.
BC102037 mRNA. Translation: AAI02038.1.
CCDSiCCDS2569.1.
RefSeqiNP_001225.1. NM_001234.4.
NP_203123.1. NM_033337.2.
UniGeneiHs.98303.

Genome annotation databases

EnsembliENST00000343849; ENSP00000341940; ENSG00000182533.
ENST00000397368; ENSP00000380525; ENSG00000182533.
GeneIDi859.
KEGGihsa:859.
UCSCiuc003bra.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

CAV3/LGMD1C

Caveolin-3/LGMD-1C page

Wikipedia

Caveolin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043101 mRNA. Translation: AAC14931.1. Different initiation.
Y14747 mRNA. Translation: CAA75042.1.
AF036367, AF036366 Genomic DNA. Translation: AAC39758.1.
AF036365 mRNA. Translation: AAC39756.1.
AK291892 mRNA. Translation: BAF84581.1. Different initiation.
AC068312 Genomic DNA. No translation available.
BC069368 mRNA. Translation: AAH69368.1.
BC102033 mRNA. Translation: AAI02034.1.
BC102036 mRNA. Translation: AAI02037.1.
BC102037 mRNA. Translation: AAI02038.1.
CCDSiCCDS2569.1.
RefSeqiNP_001225.1. NM_001234.4.
NP_203123.1. NM_033337.2.
UniGeneiHs.98303.

3D structure databases

ProteinModelPortaliP56539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107307. 48 interactors.
IntActiP56539. 4 interactors.
MINTiMINT-3021471.
STRINGi9606.ENSP00000341940.

Protein family/group databases

TCDBi1.F.1.2.1. the synaptosomal vesicle fusion pore (svf-pore) family.

PTM databases

PhosphoSitePlusiP56539.
SwissPalmiP56539.

Polymorphism and mutation databases

BioMutaiCAV3.
DMDMi3182930.

Proteomic databases

EPDiP56539.
MaxQBiP56539.
PaxDbiP56539.
PeptideAtlasiP56539.
PRIDEiP56539.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343849; ENSP00000341940; ENSG00000182533.
ENST00000397368; ENSP00000380525; ENSG00000182533.
GeneIDi859.
KEGGihsa:859.
UCSCiuc003bra.4. human.

Organism-specific databases

CTDi859.
DisGeNETi859.
GeneCardsiCAV3.
GeneReviewsiCAV3.
HGNCiHGNC:1529. CAV3.
HPAiCAB017518.
CAB018557.
HPA054488.
MalaCardsiCAV3.
MIMi123320. phenotype.
192600. phenotype.
272120. phenotype.
601253. gene.
606072. phenotype.
607801. phenotype.
611818. phenotype.
614321. phenotype.
neXtProtiNX_P56539.
OpenTargetsiENSG00000182533.
Orphaneti265. Autosomal dominant limb-girdle muscular dystrophy type 1C.
155. Familial isolated hypertrophic cardiomyopathy.
97238. Rippling muscle disease.
101016. Romano-Ward syndrome.
PharmGKBiPA26109.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXSQ. Eukaryota.
ENOG41121CB. LUCA.
GeneTreeiENSGT00390000014924.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiP56539.
KOiK12959.
OMAiVKDIHFK.
OrthoDBiEOG091G0M1R.
PhylomeDBiP56539.
TreeFamiTF315736.

Enzyme and pathway databases

BioCyciZFISH:G66-33399-MONOMER.
ReactomeiR-HSA-445355. Smooth Muscle Contraction.
SignaLinkiP56539.

Miscellaneous databases

GeneWikiiCaveolin_3.
GenomeRNAii859.
PROiP56539.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182533.
CleanExiHS_CAV3.
ExpressionAtlasiP56539. baseline and differential.
GenevisibleiP56539. HS.

Family and domain databases

InterProiIPR031091. CAV-3.
IPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view]
PANTHERiPTHR10844. PTHR10844. 1 hit.
PTHR10844:SF16. PTHR10844:SF16. 1 hit.
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAV3_HUMAN
AccessioniPrimary (citable) accession number: P56539
Secondary accession number(s): A8K777, Q3T1A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.