Reviewed, UniProtKB/Swiss-Prot P56538 (IF6_DROME)

Names and origin

Protein names

Recommended name:
    Probable eukaryotic translation initiation factor 6
      Short name=eIF-6

Gene names

Name:	eIF6
ORF Names:	CG17611

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex By similarity.
Sequence similarities	Belongs to the eIF-6 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mature ribosome assembly Inferred from electronic annotation. Source: InterPro translation Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ribosome binding Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Probable eukaryotic translation initiation factor 6		PRO_0000153737

Sequences

	Sequence		Length	Mass (Da)
	P56538-1 [UniParc]. Last modified October 3, 2003. Version 3. Checksum: 6FAA472072A4156A	FASTA	245	26,494
	10 20 30 40 50 60 MALRVQFENN DDIGVFTKLT NTYCLVAIGG SETFYSAFEA ELGDTIPVVH ANVGGCRIIG 70 80 90 100 110 120 RLTVGNRNGL LVPNSTTDEE LQHLRNSLPD AVKIYRVEER LSALGNVIAC NDYVALVHPD 130 140 150 160 170 180 LDKETEEIIA DVLKVEVFRQ TIADNSLVGS YAVLSNQGGM VHPKTSIQDQ DELSSLLQVP 190 200 210 220 230 240 LVAGTVNRGS EVLAAGMVVN DWLSFVGMNT TATEISVIES VFKLNQAQPA TVTTKLRAAL IEDMS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Kaiser S. Thesis (1996), Johannes-Gutenberg University / Mainz, Germany Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Oregon-R.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X97641 Genomic DNA. No translation available. AE013599 Genomic DNA. Translation: AAF47074.1. AY094688 mRNA. Translation: AAM11041.1.
RefSeq	NP_659573.1.
UniGene	Dm.33632
3D structure databases
HSSP	HSSP built from PDB template 1G62 based on UniProtKB Q12522.
SMR	P56538. Positions 1-224.
ModBase	Search...
Proteomic databases
PRIDE	P56538.
Genome annotation databases
Ensembl	FBgn0034915. Drosophila melanogaster. [Contig view]
GeneID	37776.
KEGG	dme:Dmel_CG17611.
NMPDR	fig|7227.3.peg.7145.
Organism-specific databases
FlyBase	FBgn0034915. eIF6.
Phylogenomic databases
HOGENOM	P56538.
OMA	P56538. QFENSNE.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-006307-MON.
Gene expression databases
ArrayExpress	P56538.
GermOnline	CG17611. Drosophila melanogaster.
Family and domain databases
InterPro	IPR002769. eIF6. [Graphical view]
PANTHER	PTHR10784. eIF6. 1 hit.
Pfam	PF01912. eIF-6. 1 hit. [Graphical view]
PIRSF	PIRSF006413. IF-6. 1 hit.
ProDom	PD006880. eIF6. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00654. eIF6. 1 hit. [Graphical view]
TIGRFAMs	TIGR00323. eIF-6. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	805352.

Entry information

Entry name

IF6_DROME

Accession

Primary (citable) accession number: P56538
Secondary accession number(s): Q8MLQ6, Q9W1I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	October 3, 2003
Last modified:	June 16, 2009
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project