Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eukaryotic translation initiation factor 6

Gene

eIF6

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

  • ribosomal large subunit binding Source: GO_Central
  • ribosome binding Source: InterPro
  • translation initiation factor activity Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:eIF6UniRule annotation
ORF Names:CG17611
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034915 eIF6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537371 – 245Eukaryotic translation initiation factor 6Add BLAST245

Proteomic databases

PaxDbiP56538
PRIDEiP56538

Expressioni

Gene expression databases

BgeeiFBgn0034915
GenevisibleiP56538 DM

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

BioGridi633713 interactors.
STRINGi7227.FBpp0072144

Structurei

3D structure databases

ProteinModelPortaliP56538
SMRiP56538
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185 Eukaryota
COG1976 LUCA
GeneTreeiENSGT00390000015972
InParanoidiP56538
KOiK03264
OMAiNDWCAFT
OrthoDBiEOG091G0HYF
PhylomeDBiP56538

Family and domain databases

CDDicd00527 IF6, 1 hit
HAMAPiMF_00032 eIF_6, 1 hit
InterProiView protein in InterPro
IPR002769 eIF6
PANTHERiPTHR10784 PTHR10784, 1 hit
PfamiView protein in Pfam
PF01912 eIF-6, 1 hit
PIRSFiPIRSF006413 IF-6, 1 hit
SMARTiView protein in SMART
SM00654 eIF6, 1 hit
TIGRFAMsiTIGR00323 eIF-6, 1 hit

Sequencei

Sequence statusi: Complete.

P56538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRVQFENN DDIGVFTKLT NTYCLVAIGG SETFYSAFEA ELGDTIPVVH
60 70 80 90 100
ANVGGCRIIG RLTVGNRNGL LVPNSTTDEE LQHLRNSLPD AVKIYRVEER
110 120 130 140 150
LSALGNVIAC NDYVALVHPD LDKETEEIIA DVLKVEVFRQ TIADNSLVGS
160 170 180 190 200
YAVLSNQGGM VHPKTSIQDQ DELSSLLQVP LVAGTVNRGS EVLAAGMVVN
210 220 230 240
DWLSFVGMNT TATEISVIES VFKLNQAQPA TVTTKLRAAL IEDMS
Length:245
Mass (Da):26,494
Last modified:October 3, 2003 - v3
Checksum:i6FAA472072A4156A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97641 Genomic DNA No translation available.
AE013599 Genomic DNA Translation: AAF47074.1
AY094688 mRNA Translation: AAM11041.1
RefSeqiNP_659573.1, NM_145105.3
UniGeneiDm.33632

Genome annotation databases

EnsemblMetazoaiFBtr0072235; FBpp0072144; FBgn0034915
GeneIDi37776
KEGGidme:Dmel_CG17611
UCSCiCG17611-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiIF6_DROME
AccessioniPrimary (citable) accession number: P56538
Secondary accession number(s): Q8MLQ6, Q9W1I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2003
Last modified: March 28, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome