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Protein

Eukaryotic translation initiation factor 6

Gene

eIF6

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

  • ribosomal large subunit binding Source: GO_Central
  • ribosome binding Source: InterPro
  • translation initiation factor activity Source: FlyBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:eIF6UniRule annotation
ORF Names:CG17611
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034915. eIF6.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleusnucleolus UniRule annotation

  • Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Eukaryotic translation initiation factor 6PRO_0000153737Add
BLAST

Proteomic databases

PaxDbiP56538.
PRIDEiP56538.

Expressioni

Gene expression databases

BgeeiP56538.
GenevisibleiP56538. DM.

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

BioGridi63371. 3 interactions.
STRINGi7227.FBpp0072144.

Structurei

3D structure databases

ProteinModelPortaliP56538.
SMRiP56538. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
GeneTreeiENSGT00390000015972.
InParanoidiP56538.
KOiK03264.
OMAiNDWCAFT.
OrthoDBiEOG7V4B05.
PhylomeDBiP56538.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

P56538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRVQFENN DDIGVFTKLT NTYCLVAIGG SETFYSAFEA ELGDTIPVVH
60 70 80 90 100
ANVGGCRIIG RLTVGNRNGL LVPNSTTDEE LQHLRNSLPD AVKIYRVEER
110 120 130 140 150
LSALGNVIAC NDYVALVHPD LDKETEEIIA DVLKVEVFRQ TIADNSLVGS
160 170 180 190 200
YAVLSNQGGM VHPKTSIQDQ DELSSLLQVP LVAGTVNRGS EVLAAGMVVN
210 220 230 240
DWLSFVGMNT TATEISVIES VFKLNQAQPA TVTTKLRAAL IEDMS
Length:245
Mass (Da):26,494
Last modified:October 3, 2003 - v3
Checksum:i6FAA472072A4156A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97641 Genomic DNA. No translation available.
AE013599 Genomic DNA. Translation: AAF47074.1.
AY094688 mRNA. Translation: AAM11041.1.
RefSeqiNP_659573.1. NM_145105.3.
UniGeneiDm.33632.

Genome annotation databases

EnsemblMetazoaiFBtr0072235; FBpp0072144; FBgn0034915.
GeneIDi37776.
KEGGidme:Dmel_CG17611.
UCSCiCG17611-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97641 Genomic DNA. No translation available.
AE013599 Genomic DNA. Translation: AAF47074.1.
AY094688 mRNA. Translation: AAM11041.1.
RefSeqiNP_659573.1. NM_145105.3.
UniGeneiDm.33632.

3D structure databases

ProteinModelPortaliP56538.
SMRiP56538. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63371. 3 interactions.
STRINGi7227.FBpp0072144.

Proteomic databases

PaxDbiP56538.
PRIDEiP56538.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072235; FBpp0072144; FBgn0034915.
GeneIDi37776.
KEGGidme:Dmel_CG17611.
UCSCiCG17611-RA. d. melanogaster.

Organism-specific databases

CTDi3692.
FlyBaseiFBgn0034915. eIF6.

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
GeneTreeiENSGT00390000015972.
InParanoidiP56538.
KOiK03264.
OMAiNDWCAFT.
OrthoDBiEOG7V4B05.
PhylomeDBiP56538.

Miscellaneous databases

GenomeRNAii37776.
PROiP56538.

Gene expression databases

BgeeiP56538.
GenevisibleiP56538. DM.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Kaiser S.
    Thesis (1996), Johannes-Gutenberg University / Mainz, Germany
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-R.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiIF6_DROME
AccessioniPrimary (citable) accession number: P56538
Secondary accession number(s): Q8MLQ6, Q9W1I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2003
Last modified: July 6, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.