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P56538 (IF6_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 6
Short name=eIF-6
Gene names
Name:eIF6
ORF Names:CG17611
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis By similarity.

Subunit structure

Monomer. Associates with the 60S ribosomal subunit By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus › nucleolus By similarity. Note: Shuttles between cytoplasm and nucleus/nucleolus By similarity.

Sequence similarities

Belongs to the eIF-6 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
Ribosome biogenesis
   Cellular componentCytoplasm
Nucleus
   Molecular functionInitiation factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processmature ribosome assembly

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionribosome binding

Inferred from electronic annotation. Source: InterPro

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Eukaryotic translation initiation factor 6
PRO_0000153737

Sequences

Sequence LengthMass (Da)Tools
P56538 [UniParc].

Last modified October 3, 2003. Version 3.
Checksum: 6FAA472072A4156A

FASTA24526,494
        10         20         30         40         50         60 
MALRVQFENN DDIGVFTKLT NTYCLVAIGG SETFYSAFEA ELGDTIPVVH ANVGGCRIIG 

        70         80         90        100        110        120 
RLTVGNRNGL LVPNSTTDEE LQHLRNSLPD AVKIYRVEER LSALGNVIAC NDYVALVHPD 

       130        140        150        160        170        180 
LDKETEEIIA DVLKVEVFRQ TIADNSLVGS YAVLSNQGGM VHPKTSIQDQ DELSSLLQVP 

       190        200        210        220        230        240 
LVAGTVNRGS EVLAAGMVVN DWLSFVGMNT TATEISVIES VFKLNQAQPA TVTTKLRAAL 


IEDMS

« Hide

References

« Hide 'large scale' references
[1]Kaiser S.
Thesis (1996), Johannes-Gutenberg University / Mainz, Germany
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Oregon-R.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X97641 Genomic DNA. No translation available.
AE013599 Genomic DNA. Translation: AAF47074.1.
AY094688 mRNA. Translation: AAM11041.1.
RefSeqNP_659573.1. NM_145105.2.
UniGeneDm.33632.

3D structure databases

ProteinModelPortalP56538.
SMRP56538. Positions 1-224.
ModBaseSearch...

Protein-protein interaction databases

STRINGP56538.

Proteomic databases

PRIDEP56538.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0072235; FBpp0072144; FBgn0034915.
GeneID37776.
KEGGdme:Dmel_CG17611.
NMPDRfig|7227.3.peg.7145.
UCSCCG17611-RA. d. melanogaster.

Organism-specific databases

CTD3692.
FlyBaseFBgn0034915. eIF6.

Phylogenomic databases

eggNOGinNOG05146.
GeneTreeEMGT00050000016227.
InParanoidP56538.
OMAQFENSNE.
OrthoDBEOG46WWRC.
PhylomeDBP56538.

Gene expression databases

ArrayExpressP56538.
BgeeP56538.
GermOnlineCG17611. Drosophila melanogaster.

Family and domain databases

InterProIPR002769. eIF6.
[Graphical view]
KOK03264.
PANTHERPTHR10784. eIF6. 1 hit.
PfamPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFPIRSF006413. IF-6. 1 hit.
SMARTSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsTIGR00323. EIF-6. 1 hit.
ProtoNetSearch...

Other

NextBio805352.

Entry information

Entry nameIF6_DROME
AccessionPrimary (citable) accession number: P56538
Secondary accession number(s): Q8MLQ6, Q9W1I5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2003
Last modified: January 25, 2012
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Translation initiation factors

List of translation initiation factor entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents