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Protein

Eukaryotic translation initiation factor 6

Gene

EIF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.UniRule annotation3 Publications

GO - Molecular functioni

  1. ribosomal large subunit binding Source: UniProtKB-HAMAP
  2. ribosome binding Source: UniProtKB
  3. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. mature ribosome assembly Source: UniProtKB
  2. ribosomal large subunit biogenesis Source: UniProtKB-HAMAP
  3. ribosomal subunit export from nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Alternative name(s):
B(2)GCN homolog
B4 integrin interactor
CAB
p27(BBP)
Gene namesi
Name:EIF6UniRule annotation
Synonyms:EIF3A, ITGB4BPUniRule annotation
ORF Names:OK/SW-cl.27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:6159. EIF6.

Subcellular locationi

Cytoplasm. Nucleusnucleolus
Note: Shuttles between cytoplasm and nucleus/nucleolus.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProtKB
  3. lamin filament Source: Ensembl
  4. nucleolus Source: UniProtKB-SubCell
  5. nucleoplasm Source: HPA
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29958.

Protein family/group databases

Allergomei8361. Hom s eIF6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Eukaryotic translation initiation factor 6PRO_0000153734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131Phosphotyrosine1 Publication
Modified residuei165 – 1651PhosphothreonineUniRule annotation
Modified residuei166 – 1661PhosphoserineUniRule annotation
Modified residuei174 – 1741Phosphoserine; by CK1UniRule annotation2 Publications
Modified residuei175 – 1751Phosphoserine; by CK1UniRule annotation2 Publications
Modified residuei235 – 2351Phosphoserine; by PKCUniRule annotation1 Publication
Modified residuei239 – 2391Phosphoserine2 Publications
Modified residuei243 – 2431Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP56537.
PaxDbiP56537.
PeptideAtlasiP56537.
PRIDEiP56537.

2D gel databases

OGPiP56537.
REPRODUCTION-2DPAGEIPI00010105.
SWISS-2DPAGEP56537.

PTM databases

PhosphoSiteiP56537.

Expressioni

Tissue specificityi

Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).1 Publication

Gene expression databases

BgeeiP56537.
CleanExiHS_EIF3A.
HS_EIF6.
ExpressionAtlasiP56537. baseline and differential.
GenevestigatoriP56537.

Organism-specific databases

HPAiHPA040873.

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit. Interacts with GNB2L1.UniRule annotation1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DHX58Q96C102EBI-372243,EBI-744193
EIF2AK2P195252EBI-372243,EBI-640775
NREPQ166125EBI-372243,EBI-718657
OAS3Q9Y6K52EBI-372243,EBI-6115729
PrkcbP684042EBI-372243,EBI-397048From a different organism.

Protein-protein interaction databases

BioGridi109898. 113 interactions.
IntActiP56537. 15 interactions.
MINTiMINT-2804329.
STRINGi9606.ENSP00000363559.

Structurei

3D structure databases

ProteinModelPortaliP56537.
SMRiP56537. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1976.
GeneTreeiENSGT00390000015972.
HOGENOMiHOG000230605.
HOVERGENiHBG001300.
InParanoidiP56537.
KOiK03264.
OMAiNDWCAFT.
PhylomeDBiP56537.
TreeFamiTF105396.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P56537-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH
60 70 80 90 100
ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD TVQIRRVEER
110 120 130 140 150
LSALGNVTTC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TVADQVLVGS
160 170 180 190 200
YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP LVAGTVNRGS EVIAAGMVVN
210 220 230 240
DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL IDSLT
Length:245
Mass (Da):26,599
Last modified:July 14, 1998 - v1
Checksum:i5BA97CD5DB0C17C3
GO
Isoform 2 (identifier: P56537-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-123: SVFEGELSDT...VALVHPDLDR → RCGGSPGAYG...AAASSGACVW

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:226
Mass (Da):23,735
Checksum:iA14404615A3FE42B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 362Missing in AAK39426 (PubMed:11290417).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei36 – 12388SVFEG…PDLDR → RCGGSPGAYGGGEACAGVKS SGSGRVPAPLPRHHRVHVPT VCSRASSPIPSPWCTRLSPA AASSGACVW in isoform 2. CuratedVSP_046747Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022229 mRNA. Translation: AAB97735.1.
Y11435 mRNA. Translation: CAA72243.1.
AF289541, AF289540 Genomic DNA. Translation: AAK39426.1.
AF047433 mRNA. Translation: AAC39897.1.
AK314969 mRNA. Translation: BAG37470.1.
AB062289 mRNA. Translation: BAB93472.1.
CR456764 mRNA. Translation: CAG33045.1.
AL121753 Genomic DNA. Translation: CAX12724.1.
CH471077 Genomic DNA. Translation: EAW76221.1.
BC001119 mRNA. Translation: AAH01119.1.
BC011845 mRNA. Translation: AAH11845.1.
BC019305 mRNA. Translation: AAH19305.1.
CCDSiCCDS13249.1. [P56537-1]
CCDS13250.1. [P56537-2]
RefSeqiNP_001254739.1. NM_001267810.1. [P56537-1]
NP_002203.1. NM_002212.3. [P56537-1]
NP_852131.1. NM_181466.2. [P56537-2]
NP_852133.1. NM_181468.2. [P56537-1]
UniGeneiHs.743992.

Genome annotation databases

EnsembliENST00000374436; ENSP00000363559; ENSG00000242372. [P56537-1]
ENST00000374443; ENSP00000363566; ENSG00000242372. [P56537-2]
ENST00000374450; ENSP00000363574; ENSG00000242372. [P56537-1]
ENST00000621148; ENSP00000483289; ENSG00000242372. [P56537-1]
GeneIDi3692.
KEGGihsa:3692.
UCSCiuc002xbv.2. human. [P56537-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022229 mRNA. Translation: AAB97735.1.
Y11435 mRNA. Translation: CAA72243.1.
AF289541, AF289540 Genomic DNA. Translation: AAK39426.1.
AF047433 mRNA. Translation: AAC39897.1.
AK314969 mRNA. Translation: BAG37470.1.
AB062289 mRNA. Translation: BAB93472.1.
CR456764 mRNA. Translation: CAG33045.1.
AL121753 Genomic DNA. Translation: CAX12724.1.
CH471077 Genomic DNA. Translation: EAW76221.1.
BC001119 mRNA. Translation: AAH01119.1.
BC011845 mRNA. Translation: AAH11845.1.
BC019305 mRNA. Translation: AAH19305.1.
CCDSiCCDS13249.1. [P56537-1]
CCDS13250.1. [P56537-2]
RefSeqiNP_001254739.1. NM_001267810.1. [P56537-1]
NP_002203.1. NM_002212.3. [P56537-1]
NP_852131.1. NM_181466.2. [P56537-2]
NP_852133.1. NM_181468.2. [P56537-1]
UniGeneiHs.743992.

3D structure databases

ProteinModelPortaliP56537.
SMRiP56537. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109898. 113 interactions.
IntActiP56537. 15 interactions.
MINTiMINT-2804329.
STRINGi9606.ENSP00000363559.

Protein family/group databases

Allergomei8361. Hom s eIF6.

PTM databases

PhosphoSiteiP56537.

2D gel databases

OGPiP56537.
REPRODUCTION-2DPAGEIPI00010105.
SWISS-2DPAGEP56537.

Proteomic databases

MaxQBiP56537.
PaxDbiP56537.
PeptideAtlasiP56537.
PRIDEiP56537.

Protocols and materials databases

DNASUi3692.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374436; ENSP00000363559; ENSG00000242372. [P56537-1]
ENST00000374443; ENSP00000363566; ENSG00000242372. [P56537-2]
ENST00000374450; ENSP00000363574; ENSG00000242372. [P56537-1]
ENST00000621148; ENSP00000483289; ENSG00000242372. [P56537-1]
GeneIDi3692.
KEGGihsa:3692.
UCSCiuc002xbv.2. human. [P56537-1]

Organism-specific databases

CTDi3692.
GeneCardsiGC20M033885.
HGNCiHGNC:6159. EIF6.
HPAiHPA040873.
MIMi602912. gene.
neXtProtiNX_P56537.
PharmGKBiPA29958.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1976.
GeneTreeiENSGT00390000015972.
HOGENOMiHOG000230605.
HOVERGENiHBG001300.
InParanoidiP56537.
KOiK03264.
OMAiNDWCAFT.
PhylomeDBiP56537.
TreeFamiTF105396.

Miscellaneous databases

ChiTaRSiEIF6. human.
GeneWikiiEIF6.
GenomeRNAii3692.
NextBioi14465.
PROiP56537.
SOURCEiSearch...

Gene expression databases

BgeeiP56537.
CleanExiHS_EIF3A.
HS_EIF6.
ExpressionAtlasiP56537. baseline and differential.
GenevestigatoriP56537.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6."
    Si K., Chaudhuri J., Chevesich J., Maitra U.
    Proc. Natl. Acad. Sci. U.S.A. 94:14285-14290(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  2. "Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells."
    Biffo S., Sanvito F., Costa S., Preve L., Pignatelli R., Spinardi L., Marchisio P.C.
    J. Biol. Chem. 272:30314-30321(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "The human ITGB4BP gene is constitutively expressed in vitro, but highly modulated in vivo."
    Donadini A., Giodini A., Sanvito F., Marchisio P.C., Biffo S.
    Gene 266:35-43(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  4. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
    Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
    Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
    Shichijo S., Itoh K.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon adenocarcinoma.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung, Muscle and Ovary.
  11. "The beta4 integrin interactor p27(BBP/eIF6) is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly."
    Sanvito F., Piatti S., Villa A., Bossi M., Lucchini G., Marchisio P.C., Biffo S.
    J. Cell Biol. 144:823-837(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  12. "Phosphorylation of mammalian eukaryotic translation initiation factor 6 and its Saccharomyces cerevisiae homologue Tif6p: evidence that phosphorylation of Tif6p regulates its nucleocytoplasmic distribution and is required for yeast cell growth."
    Basu U., Si K., Deng H., Maitra U.
    Mol. Cell. Biol. 23:6187-6199(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-174 AND SER-175, SUBCELLULAR LOCATION, NUCLEOCYTOPLASMIC SHUTTLING.
  13. "Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly."
    Ceci M., Gaviraghi C., Gorrini C., Sala L.A., Offenhauser N., Marchisio P.C., Biffo S.
    Nature 426:579-584(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, PHOSPHORYLATION AT SER-235, INTERACTION WITH GNB2L1.
  14. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239 AND SER-243, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. Cited for: FUNCTION.
  20. "Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6."
    Biswas A., Mukherjee S., Das S., Shields D., Chow C.W., Maitra U.
    J. Biol. Chem. 286:3129-3138(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-174 AND SER-175 BY CSNK1D/CK1, SUBCELLULAR LOCATION.
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiIF6_HUMAN
AccessioniPrimary (citable) accession number: P56537
Secondary accession number(s): B7ZBG9, Q6IBN8, Q96TD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1998
Last sequence update: July 14, 1998
Last modified: March 3, 2015
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Translation initiation factors
    List of translation initiation factor entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.