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P56537

- IF6_HUMAN

UniProt

P56537 - IF6_HUMAN

Protein

Eukaryotic translation initiation factor 6

Gene

EIF6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.3 PublicationsUniRule annotation

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. ribosomal large subunit binding Source: UniProtKB-HAMAP
    3. ribosome binding Source: UniProtKB
    4. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mature ribosome assembly Source: UniProtKB
    2. ribosomal large subunit biogenesis Source: UniProtKB-HAMAP
    3. ribosomal subunit export from nucleus Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis, Ribosome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 6UniRule annotation
    Short name:
    eIF-6UniRule annotation
    Alternative name(s):
    B(2)GCN homolog
    B4 integrin interactor
    CAB
    p27(BBP)
    Gene namesi
    Name:EIF6UniRule annotation
    Synonyms:EIF3A, ITGB4BPUniRule annotation
    ORF Names:OK/SW-cl.27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:6159. EIF6.

    Subcellular locationi

    Cytoplasm. Nucleusnucleolus
    Note: Shuttles between cytoplasm and nucleus/nucleolus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt
    3. lamin filament Source: Ensembl
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29958.

    Protein family/group databases

    Allergomei8361. Hom s eIF6.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Eukaryotic translation initiation factor 6PRO_0000153734Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei113 – 1131Phosphotyrosine1 Publication
    Modified residuei165 – 1651PhosphothreonineUniRule annotation
    Modified residuei166 – 1661PhosphoserineUniRule annotation
    Modified residuei174 – 1741Phosphoserine; by CK12 PublicationsUniRule annotation
    Modified residuei175 – 1751Phosphoserine; by CK12 PublicationsUniRule annotation
    Modified residuei235 – 2351Phosphoserine; by PKC1 PublicationUniRule annotation
    Modified residuei239 – 2391Phosphoserine2 PublicationsUniRule annotation
    Modified residuei243 – 2431Phosphoserine1 PublicationUniRule annotation

    Post-translational modificationi

    Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.6 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP56537.
    PaxDbiP56537.
    PeptideAtlasiP56537.
    PRIDEiP56537.

    2D gel databases

    OGPiP56537.
    REPRODUCTION-2DPAGEIPI00010105.
    SWISS-2DPAGEP56537.

    PTM databases

    PhosphoSiteiP56537.

    Expressioni

    Tissue specificityi

    Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).1 Publication

    Gene expression databases

    BgeeiP56537.
    CleanExiHS_EIF3A.
    HS_EIF6.
    GenevestigatoriP56537.

    Organism-specific databases

    HPAiHPA040873.

    Interactioni

    Subunit structurei

    Monomer. Associates with the 60S ribosomal subunit. Interacts with GNB2L1.1 PublicationUniRule annotation

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DHX58Q96C102EBI-372243,EBI-744193
    EIF2AK2P195252EBI-372243,EBI-640775
    NREPQ166125EBI-372243,EBI-718657
    OAS3Q9Y6K52EBI-372243,EBI-6115729
    PrkcbP684042EBI-372243,EBI-397048From a different organism.

    Protein-protein interaction databases

    BioGridi109898. 111 interactions.
    IntActiP56537. 15 interactions.
    MINTiMINT-2804329.
    STRINGi9606.ENSP00000363559.

    Structurei

    3D structure databases

    ProteinModelPortaliP56537.
    SMRiP56537. Positions 1-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eIF-6 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1976.
    HOGENOMiHOG000230605.
    HOVERGENiHBG001300.
    InParanoidiP56537.
    KOiK03264.
    OMAiNDWCAFT.
    PhylomeDBiP56537.
    TreeFamiTF105396.

    Family and domain databases

    HAMAPiMF_00032. eIF_6.
    InterProiIPR002769. eIF6.
    [Graphical view]
    PANTHERiPTHR10784. PTHR10784. 1 hit.
    PfamiPF01912. eIF-6. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006413. IF-6. 1 hit.
    SMARTiSM00654. eIF6. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00323. eIF-6. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P56537-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH    50
    ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD TVQIRRVEER 100
    LSALGNVTTC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TVADQVLVGS 150
    YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP LVAGTVNRGS EVIAAGMVVN 200
    DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL IDSLT 245
    Length:245
    Mass (Da):26,599
    Last modified:July 15, 1998 - v1
    Checksum:i5BA97CD5DB0C17C3
    GO
    Isoform 2 (identifier: P56537-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-123: SVFEGELSDT...VALVHPDLDR → RCGGSPGAYG...AAASSGACVW

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:226
    Mass (Da):23,735
    Checksum:iA14404615A3FE42B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 362Missing in AAK39426. (PubMed:11290417)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei36 – 12388SVFEG…PDLDR → RCGGSPGAYGGGEACAGVKS SGSGRVPAPLPRHHRVHVPT VCSRASSPIPSPWCTRLSPA AASSGACVW in isoform 2. CuratedVSP_046747Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022229 mRNA. Translation: AAB97735.1.
    Y11435 mRNA. Translation: CAA72243.1.
    AF289541, AF289540 Genomic DNA. Translation: AAK39426.1.
    AF047433 mRNA. Translation: AAC39897.1.
    AK314969 mRNA. Translation: BAG37470.1.
    AB062289 mRNA. Translation: BAB93472.1.
    CR456764 mRNA. Translation: CAG33045.1.
    AL121753 Genomic DNA. Translation: CAX12724.1.
    CH471077 Genomic DNA. Translation: EAW76221.1.
    BC001119 mRNA. Translation: AAH01119.1.
    BC011845 mRNA. Translation: AAH11845.1.
    BC019305 mRNA. Translation: AAH19305.1.
    CCDSiCCDS13249.1. [P56537-1]
    CCDS13250.1. [P56537-2]
    RefSeqiNP_001254739.1. NM_001267810.1. [P56537-1]
    NP_002203.1. NM_002212.3. [P56537-1]
    NP_852131.1. NM_181466.2. [P56537-2]
    NP_852133.1. NM_181468.2. [P56537-1]
    UniGeneiHs.743992.

    Genome annotation databases

    EnsembliENST00000374436; ENSP00000363559; ENSG00000242372. [P56537-1]
    ENST00000374443; ENSP00000363566; ENSG00000242372. [P56537-2]
    ENST00000374450; ENSP00000363574; ENSG00000242372. [P56537-1]
    GeneIDi3692.
    KEGGihsa:3692.
    UCSCiuc002xbv.2. human. [P56537-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022229 mRNA. Translation: AAB97735.1 .
    Y11435 mRNA. Translation: CAA72243.1 .
    AF289541 , AF289540 Genomic DNA. Translation: AAK39426.1 .
    AF047433 mRNA. Translation: AAC39897.1 .
    AK314969 mRNA. Translation: BAG37470.1 .
    AB062289 mRNA. Translation: BAB93472.1 .
    CR456764 mRNA. Translation: CAG33045.1 .
    AL121753 Genomic DNA. Translation: CAX12724.1 .
    CH471077 Genomic DNA. Translation: EAW76221.1 .
    BC001119 mRNA. Translation: AAH01119.1 .
    BC011845 mRNA. Translation: AAH11845.1 .
    BC019305 mRNA. Translation: AAH19305.1 .
    CCDSi CCDS13249.1. [P56537-1 ]
    CCDS13250.1. [P56537-2 ]
    RefSeqi NP_001254739.1. NM_001267810.1. [P56537-1 ]
    NP_002203.1. NM_002212.3. [P56537-1 ]
    NP_852131.1. NM_181466.2. [P56537-2 ]
    NP_852133.1. NM_181468.2. [P56537-1 ]
    UniGenei Hs.743992.

    3D structure databases

    ProteinModelPortali P56537.
    SMRi P56537. Positions 1-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109898. 111 interactions.
    IntActi P56537. 15 interactions.
    MINTi MINT-2804329.
    STRINGi 9606.ENSP00000363559.

    Protein family/group databases

    Allergomei 8361. Hom s eIF6.

    PTM databases

    PhosphoSitei P56537.

    2D gel databases

    OGPi P56537.
    REPRODUCTION-2DPAGE IPI00010105.
    SWISS-2DPAGE P56537.

    Proteomic databases

    MaxQBi P56537.
    PaxDbi P56537.
    PeptideAtlasi P56537.
    PRIDEi P56537.

    Protocols and materials databases

    DNASUi 3692.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374436 ; ENSP00000363559 ; ENSG00000242372 . [P56537-1 ]
    ENST00000374443 ; ENSP00000363566 ; ENSG00000242372 . [P56537-2 ]
    ENST00000374450 ; ENSP00000363574 ; ENSG00000242372 . [P56537-1 ]
    GeneIDi 3692.
    KEGGi hsa:3692.
    UCSCi uc002xbv.2. human. [P56537-1 ]

    Organism-specific databases

    CTDi 3692.
    GeneCardsi GC20M033881.
    HGNCi HGNC:6159. EIF6.
    HPAi HPA040873.
    MIMi 602912. gene.
    neXtProti NX_P56537.
    PharmGKBi PA29958.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1976.
    HOGENOMi HOG000230605.
    HOVERGENi HBG001300.
    InParanoidi P56537.
    KOi K03264.
    OMAi NDWCAFT.
    PhylomeDBi P56537.
    TreeFami TF105396.

    Miscellaneous databases

    ChiTaRSi EIF6. human.
    GeneWikii EIF6.
    GenomeRNAii 3692.
    NextBioi 14465.
    PROi P56537.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56537.
    CleanExi HS_EIF3A.
    HS_EIF6.
    Genevestigatori P56537.

    Family and domain databases

    HAMAPi MF_00032. eIF_6.
    InterProi IPR002769. eIF6.
    [Graphical view ]
    PANTHERi PTHR10784. PTHR10784. 1 hit.
    Pfami PF01912. eIF-6. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006413. IF-6. 1 hit.
    SMARTi SM00654. eIF6. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00323. eIF-6. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6."
      Si K., Chaudhuri J., Chevesich J., Maitra U.
      Proc. Natl. Acad. Sci. U.S.A. 94:14285-14290(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    2. "Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells."
      Biffo S., Sanvito F., Costa S., Preve L., Pignatelli R., Spinardi L., Marchisio P.C.
      J. Biol. Chem. 272:30314-30321(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "The human ITGB4BP gene is constitutively expressed in vitro, but highly modulated in vivo."
      Donadini A., Giodini A., Sanvito F., Marchisio P.C., Biffo S.
      Gene 266:35-43(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    4. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
      Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
      Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    6. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S., Itoh K.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon adenocarcinoma.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung, Muscle and Ovary.
    11. "The beta4 integrin interactor p27(BBP/eIF6) is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly."
      Sanvito F., Piatti S., Villa A., Bossi M., Lucchini G., Marchisio P.C., Biffo S.
      J. Cell Biol. 144:823-837(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    12. "Phosphorylation of mammalian eukaryotic translation initiation factor 6 and its Saccharomyces cerevisiae homologue Tif6p: evidence that phosphorylation of Tif6p regulates its nucleocytoplasmic distribution and is required for yeast cell growth."
      Basu U., Si K., Deng H., Maitra U.
      Mol. Cell. Biol. 23:6187-6199(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-174 AND SER-175, SUBCELLULAR LOCATION, NUCLEOCYTOPLASMIC SHUTTLING.
    13. "Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly."
      Ceci M., Gaviraghi C., Gorrini C., Sala L.A., Offenhauser N., Marchisio P.C., Biffo S.
      Nature 426:579-584(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, PHOSPHORYLATION AT SER-235, INTERACTION WITH GNB2L1.
    14. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239 AND SER-243, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: FUNCTION.
    20. "Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6."
      Biswas A., Mukherjee S., Das S., Shields D., Chow C.W., Maitra U.
      J. Biol. Chem. 286:3129-3138(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-174 AND SER-175 BY CSNK1D/CK1, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiIF6_HUMAN
    AccessioniPrimary (citable) accession number: P56537
    Secondary accession number(s): B7ZBG9, Q6IBN8, Q96TD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Translation initiation factors
      List of translation initiation factor entries
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3