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Protein

Kinesin heavy chain isoform 5C

Gene

Kif5c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in synaptic transmission (By similarity). Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi86 – 93ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • apolipoprotein receptor binding Source: RGD
  • ATPase activity Source: RGD
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
  • microtubule binding Source: RGD

GO - Biological processi

  • anterograde dendritic transport of messenger ribonucleoprotein complex Source: SynGO
  • ATP metabolic process Source: RGD
  • axon guidance Source: GO_Central
  • dendritic transport of messenger ribonucleoprotein complex Source: RGD
  • motor neuron axon guidance Source: RGD
  • mRNA transport Source: UniProtKB

Keywordsi

Molecular functionMotor protein
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin heavy chain isoform 5C
Alternative name(s):
Kinesin heavy chain neuron-specific 2
Gene namesi
Name:Kif5c
Synonyms:Nkhc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1308539 Kif5c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253571 – ›239Kinesin heavy chain isoform 5CAdd BLAST›239

Proteomic databases

PaxDbiP56536
PeptideAtlasiP56536
PRIDEiP56536

Interactioni

Subunit structurei

Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 Interacts with TRAK1. Interacts with ZFYVE27 (By similarity). Interacts with KLC3 (PubMed:11319135).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RHOT1Q8IXI25EBI-994504,EBI-1396430From Homo sapiens.

GO - Molecular functioni

  • apolipoprotein receptor binding Source: RGD
  • microtubule binding Source: RGD

Protein-protein interaction databases

IntActiP56536, 8 interactors
MINTiP56536
STRINGi10116.ENSRNOP00000006341

Structurei

Secondary structure

1239
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Beta strandi10 – 15Combined sources6
Helixi20 – 24Combined sources5
Beta strandi31 – 34Combined sources4
Turni35 – 37Combined sources3
Beta strandi38 – 41Combined sources4
Beta strandi50 – 53Combined sources4
Helixi59 – 66Combined sources8
Helixi68 – 75Combined sources8
Beta strandi79 – 85Combined sources7
Helixi92 – 96Combined sources5
Turni103 – 105Combined sources3
Helixi108 – 121Combined sources14
Beta strandi127 – 139Combined sources13
Beta strandi142 – 145Combined sources4
Beta strandi156 – 158Combined sources3
Beta strandi164 – 166Combined sources3
Beta strandi172 – 174Combined sources3
Helixi177 – 192Combined sources16
Helixi198 – 204Combined sources7
Beta strandi205 – 217Combined sources13
Turni218 – 220Combined sources3
Beta strandi223 – 232Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KINX-ray2.00A2-239[»]
3KINX-ray3.10A/C2-239[»]
ProteinModelPortaliP56536
SMRiP56536
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56536

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – ›239Kinesin motorPROSITE-ProRule annotationAdd BLAST›232

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni174 – ›239Microtubule-bindingAdd BLAST›66

Domaini

Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000216718
HOVERGENiHBG103852
InParanoidiP56536
PhylomeDBiP56536

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Fragment.

P56536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPAECSIK VMCRFRPLNE AEILRGDKFI PKFKGEETVV IGQGKPYVFD
60 70 80 90 100
RVLPPNTTQE QVYNACAKQI VKDVLEGYNG TIFAYGQTSS GKTHTMEGKL
110 120 130 140 150
HDPQLMGIIP RIAHDIFDHI YSMDENLEFH IKVSYFEIYL DKIRDLLDVS
160 170 180 190 200
KTNLAVHEDK NRVPYVKGCT ERFVSSPEEV MDVIDEGKAN RHVAVTNMNE
210 220 230
HSSRSHSIFL INIKQENVET EKKLSGKLYL VDLAGSEKV
Length:239
Mass (Da):27,165
Last modified:January 23, 2007 - v2
Checksum:iC96C5FFE4F8E1D7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei2391

Sequence databases

UniGeneiRn.50843

Genome annotation databases

UCSCiRGD:1308539 rat

Similar proteinsi

Entry informationi

Entry nameiKIF5C_RAT
AccessioniPrimary (citable) accession number: P56536
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health