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Protein

Betaine aldehyde dehydrogenase

Gene

aldh9A1

Organism
Gadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.
Proteins known to be involved in this subpathway in this organism are:
  1. Betaine aldehyde dehydrogenase (aldh9A1)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei166Transition state stabilizer1
Active sitei263Proton acceptor1
Active sitei297Nucleophile1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi241 – 246NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Alternative name(s):
Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
Gene namesi
Name:aldh9A1
OrganismiGadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
Taxonomic identifieri8053 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000565321 – 503Betaine aldehyde dehydrogenaseAdd BLAST503

Proteomic databases

PRIDEiP56533.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

DIPiDIP-2908N.

Structurei

Secondary structure

1503
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 5Combined sources4
Helixi7 – 9Combined sources3
Turni12 – 14Combined sources3
Beta strandi22 – 24Combined sources3
Beta strandi27 – 29Combined sources3
Beta strandi38 – 41Combined sources4
Turni43 – 45Combined sources3
Beta strandi48 – 52Combined sources5
Helixi57 – 74Combined sources18
Helixi79 – 95Combined sources17
Helixi97 – 108Combined sources12
Helixi112 – 132Combined sources21
Helixi133 – 135Combined sources3
Beta strandi138 – 142Combined sources5
Helixi144 – 146Combined sources3
Beta strandi148 – 155Combined sources8
Beta strandi157 – 162Combined sources6
Beta strandi165 – 167Combined sources3
Helixi168 – 181Combined sources14
Beta strandi185 – 189Combined sources5
Helixi196 – 207Combined sources12
Beta strandi214 – 217Combined sources4
Helixi222 – 230Combined sources9
Beta strandi236 – 241Combined sources6
Helixi243 – 254Combined sources12
Turni255 – 257Combined sources3
Beta strandi259 – 263Combined sources5
Beta strandi269 – 272Combined sources4
Helixi278 – 287Combined sources10
Helixi291 – 294Combined sources4
Beta strandi302 – 306Combined sources5
Helixi307 – 309Combined sources3
Helixi310 – 322Combined sources13
Helixi342 – 358Combined sources17
Beta strandi361 – 364Combined sources4
Helixi374 – 376Combined sources3
Beta strandi385 – 389Combined sources5
Helixi395 – 398Combined sources4
Beta strandi403 – 411Combined sources9
Helixi414 – 422Combined sources9
Beta strandi428 – 433Combined sources6
Helixi437 – 446Combined sources10
Beta strandi449 – 455Combined sources7
Helixi470 – 472Combined sources3
Beta strandi473 – 475Combined sources3
Helixi481 – 485Combined sources5
Beta strandi486 – 494Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4SX-ray2.10A/B/C/D1-503[»]
1BPWX-ray2.80A/B/C/D1-503[»]
ProteinModelPortaliP56533.
SMRiP56533.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56533.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOVERGENiHBG000097.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AQLVDSMPSA STGSVVVTDD LNYWGGRRIK SKDGATTEPV FEPATGRVLC
60 70 80 90 100
QMVPCGAEEV DQAVQSAQAA YLKWSKMAGI ERSRVMLEAA RIIRERRDNI
110 120 130 140 150
AKLEVINNGK TITEAEYDID AAWQCIEYYA GLAPTLSGQH IQLPGGAFAY
160 170 180 190 200
TRREPLGVCA GILAWNYPFM IAAWKCAPAL ACGNAVVFKP SPMTPVTGVI
210 220 230 240 250
LAEIFHEAGV PVGLVNVVQG GAETGSLLCH HPNVAKVSFT GSVPTGKKVM
260 270 280 290 300
EMSAKTVKHV TLELGGKSPL LIFKDCELEN AVRGALMANF LTQGQVCTNG
310 320 330 340 350
TRVFVQREIM PQFLEEVVKR TKAIVVGDPL LTETRMGGLI SKPQLDKVLG
360 370 380 390 400
FVAQAKKEGA RVLCGGEPLT PSDPKLKNGY FMSPCVLDNC RDDMTCVKEE
410 420 430 440 450
IFGPVMSVLP FDTEEEVLQR ANNTTFGLAS GVFTRDISRA HRVAANLEAG
460 470 480 490 500
TCYINTYSIS PVEVPFGGYK MSGFGRENGQ ATVDYYSQLK TVIVEMGDVD

SLF
Length:503
Mass (Da):54,368
Last modified:July 15, 1998 - v1
Checksum:i1CB2FB92FA89E577
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4SX-ray2.10A/B/C/D1-503[»]
1BPWX-ray2.80A/B/C/D1-503[»]
ProteinModelPortaliP56533.
SMRiP56533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-2908N.

Proteomic databases

PRIDEiP56533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000097.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Miscellaneous databases

EvolutionaryTraceiP56533.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBADH_GADMC
AccessioniPrimary (citable) accession number: P56533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.