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P56533

- BADH_GADMC

UniProt

P56533 - BADH_GADMC

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Protein

Betaine aldehyde dehydrogenase

Gene

aldh9A1

Organism
Gadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei166 – 1661Transition state stabilizer
Active sitei263 – 2631Proton acceptor
Active sitei297 – 2971Nucleophile

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi241 – 2466NADBy similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Alternative name(s):
Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
Gene namesi
Name:aldh9A1
OrganismiGadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
Taxonomic identifieri8053 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Betaine aldehyde dehydrogenasePRO_0000056532Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

DIPiDIP-2908N.

Structurei

Secondary structure

1
503
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 54Combined sources
Helixi7 – 93Combined sources
Turni12 – 143Combined sources
Beta strandi22 – 243Combined sources
Beta strandi27 – 293Combined sources
Beta strandi38 – 414Combined sources
Turni43 – 453Combined sources
Beta strandi48 – 525Combined sources
Helixi57 – 7418Combined sources
Helixi79 – 9517Combined sources
Helixi97 – 10812Combined sources
Helixi112 – 13221Combined sources
Helixi133 – 1353Combined sources
Beta strandi138 – 1425Combined sources
Helixi144 – 1463Combined sources
Beta strandi148 – 1558Combined sources
Beta strandi157 – 1626Combined sources
Beta strandi165 – 1673Combined sources
Helixi168 – 18114Combined sources
Beta strandi185 – 1895Combined sources
Helixi196 – 20712Combined sources
Beta strandi214 – 2174Combined sources
Helixi222 – 2309Combined sources
Beta strandi236 – 2416Combined sources
Helixi243 – 25412Combined sources
Turni255 – 2573Combined sources
Beta strandi259 – 2635Combined sources
Beta strandi269 – 2724Combined sources
Helixi278 – 28710Combined sources
Helixi291 – 2944Combined sources
Beta strandi302 – 3065Combined sources
Helixi307 – 3093Combined sources
Helixi310 – 32213Combined sources
Helixi342 – 35817Combined sources
Beta strandi361 – 3644Combined sources
Helixi374 – 3763Combined sources
Beta strandi385 – 3895Combined sources
Helixi395 – 3984Combined sources
Beta strandi403 – 4119Combined sources
Helixi414 – 4229Combined sources
Beta strandi428 – 4336Combined sources
Helixi437 – 44610Combined sources
Beta strandi449 – 4557Combined sources
Helixi470 – 4723Combined sources
Beta strandi473 – 4753Combined sources
Helixi481 – 4855Combined sources
Beta strandi486 – 4949Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A4SX-ray2.10A/B/C/D1-503[»]
1BPWX-ray2.80A/B/C/D1-503[»]
ProteinModelPortaliP56533.
SMRiP56533. Positions 1-503.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56533.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOVERGENiHBG000097.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56533-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AQLVDSMPSA STGSVVVTDD LNYWGGRRIK SKDGATTEPV FEPATGRVLC
60 70 80 90 100
QMVPCGAEEV DQAVQSAQAA YLKWSKMAGI ERSRVMLEAA RIIRERRDNI
110 120 130 140 150
AKLEVINNGK TITEAEYDID AAWQCIEYYA GLAPTLSGQH IQLPGGAFAY
160 170 180 190 200
TRREPLGVCA GILAWNYPFM IAAWKCAPAL ACGNAVVFKP SPMTPVTGVI
210 220 230 240 250
LAEIFHEAGV PVGLVNVVQG GAETGSLLCH HPNVAKVSFT GSVPTGKKVM
260 270 280 290 300
EMSAKTVKHV TLELGGKSPL LIFKDCELEN AVRGALMANF LTQGQVCTNG
310 320 330 340 350
TRVFVQREIM PQFLEEVVKR TKAIVVGDPL LTETRMGGLI SKPQLDKVLG
360 370 380 390 400
FVAQAKKEGA RVLCGGEPLT PSDPKLKNGY FMSPCVLDNC RDDMTCVKEE
410 420 430 440 450
IFGPVMSVLP FDTEEEVLQR ANNTTFGLAS GVFTRDISRA HRVAANLEAG
460 470 480 490 500
TCYINTYSIS PVEVPFGGYK MSGFGRENGQ ATVDYYSQLK TVIVEMGDVD

SLF
Length:503
Mass (Da):54,368
Last modified:July 15, 1998 - v1
Checksum:i1CB2FB92FA89E577
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A4S X-ray 2.10 A/B/C/D 1-503 [» ]
1BPW X-ray 2.80 A/B/C/D 1-503 [» ]
ProteinModelPortali P56533.
SMRi P56533. Positions 1-503.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-2908N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000097.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .

Miscellaneous databases

EvolutionaryTracei P56533.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of betaine aldehyde dehydrogenase at 2.1-A resolution."
    Johansson K., El-Ahmad M., Ramaswamy S., Hjelmqvist L., Joernvall H., Eklund H.
    Protein Sci. 7:2106-2117(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
    Tissue: Liver.

Entry informationi

Entry nameiBADH_GADMC
AccessioniPrimary (citable) accession number: P56533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3