Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P56533

- BADH_GADMC

UniProt

P56533 - BADH_GADMC

Protein

Betaine aldehyde dehydrogenase

Gene

aldh9A1

Organism
Gadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.
    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei166 – 1661Transition state stabilizer
    Active sitei263 – 2631Proton acceptor
    Active sitei297 – 2971Nucleophile

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi241 – 2466NADBy similarity

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Betaine aldehyde dehydrogenase (EC:1.2.1.8)
    Short name:
    BADH
    Alternative name(s):
    Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
    Gene namesi
    Name:aldh9A1
    OrganismiGadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
    Taxonomic identifieri8053 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Betaine aldehyde dehydrogenasePRO_0000056532Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.

    Protein-protein interaction databases

    DIPiDIP-2908N.

    Structurei

    Secondary structure

    1
    503
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 54
    Helixi7 – 93
    Turni12 – 143
    Beta strandi22 – 243
    Beta strandi27 – 293
    Beta strandi38 – 414
    Turni43 – 453
    Beta strandi48 – 525
    Helixi57 – 7418
    Helixi79 – 9517
    Helixi97 – 10812
    Helixi112 – 13221
    Helixi133 – 1353
    Beta strandi138 – 1425
    Helixi144 – 1463
    Beta strandi148 – 1558
    Beta strandi157 – 1626
    Beta strandi165 – 1673
    Helixi168 – 18114
    Beta strandi185 – 1895
    Helixi196 – 20712
    Beta strandi214 – 2174
    Helixi222 – 2309
    Beta strandi236 – 2416
    Helixi243 – 25412
    Turni255 – 2573
    Beta strandi259 – 2635
    Beta strandi269 – 2724
    Helixi278 – 28710
    Helixi291 – 2944
    Beta strandi302 – 3065
    Helixi307 – 3093
    Helixi310 – 32213
    Helixi342 – 35817
    Beta strandi361 – 3644
    Helixi374 – 3763
    Beta strandi385 – 3895
    Helixi395 – 3984
    Beta strandi403 – 4119
    Helixi414 – 4229
    Beta strandi428 – 4336
    Helixi437 – 44610
    Beta strandi449 – 4557
    Helixi470 – 4723
    Beta strandi473 – 4753
    Helixi481 – 4855
    Beta strandi486 – 4949

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A4SX-ray2.10A/B/C/D1-503[»]
    1BPWX-ray2.80A/B/C/D1-503[»]
    ProteinModelPortaliP56533.
    SMRiP56533. Positions 1-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP56533.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    HOVERGENiHBG000097.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56533-1 [UniParc]FASTAAdd to Basket

    « Hide

    AQLVDSMPSA STGSVVVTDD LNYWGGRRIK SKDGATTEPV FEPATGRVLC    50
    QMVPCGAEEV DQAVQSAQAA YLKWSKMAGI ERSRVMLEAA RIIRERRDNI 100
    AKLEVINNGK TITEAEYDID AAWQCIEYYA GLAPTLSGQH IQLPGGAFAY 150
    TRREPLGVCA GILAWNYPFM IAAWKCAPAL ACGNAVVFKP SPMTPVTGVI 200
    LAEIFHEAGV PVGLVNVVQG GAETGSLLCH HPNVAKVSFT GSVPTGKKVM 250
    EMSAKTVKHV TLELGGKSPL LIFKDCELEN AVRGALMANF LTQGQVCTNG 300
    TRVFVQREIM PQFLEEVVKR TKAIVVGDPL LTETRMGGLI SKPQLDKVLG 350
    FVAQAKKEGA RVLCGGEPLT PSDPKLKNGY FMSPCVLDNC RDDMTCVKEE 400
    IFGPVMSVLP FDTEEEVLQR ANNTTFGLAS GVFTRDISRA HRVAANLEAG 450
    TCYINTYSIS PVEVPFGGYK MSGFGRENGQ ATVDYYSQLK TVIVEMGDVD 500
    SLF 503
    Length:503
    Mass (Da):54,368
    Last modified:July 15, 1998 - v1
    Checksum:i1CB2FB92FA89E577
    GO

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A4S X-ray 2.10 A/B/C/D 1-503 [» ]
    1BPW X-ray 2.80 A/B/C/D 1-503 [» ]
    ProteinModelPortali P56533.
    SMRi P56533. Positions 1-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-2908N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000097.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .

    Miscellaneous databases

    EvolutionaryTracei P56533.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of betaine aldehyde dehydrogenase at 2.1-A resolution."
      Johansson K., El-Ahmad M., Ramaswamy S., Hjelmqvist L., Joernvall H., Eklund H.
      Protein Sci. 7:2106-2117(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
      Tissue: Liver.

    Entry informationi

    Entry nameiBADH_GADMC
    AccessioniPrimary (citable) accession number: P56533
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3