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P56533

- BADH_GADMC

UniProt

P56533 - BADH_GADMC

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Protein
Betaine aldehyde dehydrogenase
Gene
aldh9A1
Organism
Gadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.
An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei166 – 1661Transition state stabilizer
Active sitei263 – 2631Proton acceptor
Active sitei297 – 2971Nucleophile

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi241 – 2466NAD By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Alternative name(s):
Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
Gene namesi
Name:aldh9A1
OrganismiGadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
Taxonomic identifieri8053 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Betaine aldehyde dehydrogenase
PRO_0000056532Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

DIPiDIP-2908N.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 54
Helixi7 – 93
Turni12 – 143
Beta strandi22 – 243
Beta strandi27 – 293
Beta strandi38 – 414
Turni43 – 453
Beta strandi48 – 525
Helixi57 – 7418
Helixi79 – 9517
Helixi97 – 10812
Helixi112 – 13221
Helixi133 – 1353
Beta strandi138 – 1425
Helixi144 – 1463
Beta strandi148 – 1558
Beta strandi157 – 1626
Beta strandi165 – 1673
Helixi168 – 18114
Beta strandi185 – 1895
Helixi196 – 20712
Beta strandi214 – 2174
Helixi222 – 2309
Beta strandi236 – 2416
Helixi243 – 25412
Turni255 – 2573
Beta strandi259 – 2635
Beta strandi269 – 2724
Helixi278 – 28710
Helixi291 – 2944
Beta strandi302 – 3065
Helixi307 – 3093
Helixi310 – 32213
Helixi342 – 35817
Beta strandi361 – 3644
Helixi374 – 3763
Beta strandi385 – 3895
Helixi395 – 3984
Beta strandi403 – 4119
Helixi414 – 4229
Beta strandi428 – 4336
Helixi437 – 44610
Beta strandi449 – 4557
Helixi470 – 4723
Beta strandi473 – 4753
Helixi481 – 4855
Beta strandi486 – 4949

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A4SX-ray2.10A/B/C/D1-503[»]
1BPWX-ray2.80A/B/C/D1-503[»]
ProteinModelPortaliP56533.
SMRiP56533. Positions 1-503.

Miscellaneous databases

EvolutionaryTraceiP56533.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000097.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56533-1 [UniParc]FASTAAdd to Basket

« Hide

AQLVDSMPSA STGSVVVTDD LNYWGGRRIK SKDGATTEPV FEPATGRVLC    50
QMVPCGAEEV DQAVQSAQAA YLKWSKMAGI ERSRVMLEAA RIIRERRDNI 100
AKLEVINNGK TITEAEYDID AAWQCIEYYA GLAPTLSGQH IQLPGGAFAY 150
TRREPLGVCA GILAWNYPFM IAAWKCAPAL ACGNAVVFKP SPMTPVTGVI 200
LAEIFHEAGV PVGLVNVVQG GAETGSLLCH HPNVAKVSFT GSVPTGKKVM 250
EMSAKTVKHV TLELGGKSPL LIFKDCELEN AVRGALMANF LTQGQVCTNG 300
TRVFVQREIM PQFLEEVVKR TKAIVVGDPL LTETRMGGLI SKPQLDKVLG 350
FVAQAKKEGA RVLCGGEPLT PSDPKLKNGY FMSPCVLDNC RDDMTCVKEE 400
IFGPVMSVLP FDTEEEVLQR ANNTTFGLAS GVFTRDISRA HRVAANLEAG 450
TCYINTYSIS PVEVPFGGYK MSGFGRENGQ ATVDYYSQLK TVIVEMGDVD 500
SLF 503
Length:503
Mass (Da):54,368
Last modified:July 15, 1998 - v1
Checksum:i1CB2FB92FA89E577
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A4S X-ray 2.10 A/B/C/D 1-503 [» ]
1BPW X-ray 2.80 A/B/C/D 1-503 [» ]
ProteinModelPortali P56533.
SMRi P56533. Positions 1-503.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-2908N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000097.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .

Miscellaneous databases

EvolutionaryTracei P56533.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of betaine aldehyde dehydrogenase at 2.1-A resolution."
    Johansson K., El-Ahmad M., Ramaswamy S., Hjelmqvist L., Joernvall H., Eklund H.
    Protein Sci. 7:2106-2117(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
    Tissue: Liver.

Entry informationi

Entry nameiBADH_GADMC
AccessioniPrimary (citable) accession number: P56533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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