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P56521

- HDA19_MAIZE

UniProt

P56521 - HDA19_MAIZE

Protein

Probable histone deacetylase 19

Gene
N/A
Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei154 – 1541By similarity

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. DNA mediated transformation Source: EnsemblPlants/Gramene
    2. histone acetylation Source: EnsemblPlants/Gramene
    3. jasmonic acid and ethylene-dependent systemic resistance Source: EnsemblPlants/Gramene
    4. negative regulation of transcription, DNA-templated Source: EnsemblPlants/Gramene
    5. pathogenesis Source: EnsemblPlants/Gramene
    6. regulation of multicellular organismal development Source: EnsemblPlants/Gramene
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable histone deacetylase 19 (EC:3.5.1.98)
    Alternative name(s):
    RPD3 homolog
    OrganismiZea mays (Maize)
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiP56521.
    MaizeGDBi2665840.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Probable histone deacetylase 19PRO_0000114722Add
    BLAST

    Proteomic databases

    PRIDEiP56521.

    Structurei

    3D structure databases

    ProteinModelPortaliP56521.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 334312Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    P56521-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPSSAGSGG NSLPSVGPDG QKRRVCYFYD PDVGNYYYGQ GHPMKPHRIR    50
    MTHSLLARYG LLNQMQVYRP NPARERELCR FHAEEYINFL RSVTPETQQD 100
    QIRLLKRFNV GEECPVLDGL YSFCQTYAGA SVGGAVKFNH GHDIAINWSG 150
    GLHHAKKCEA SGFCYVNDIV LAILELLKHH ERVLYVDIDI HHGDGVEEAF 200
    YTTDRVMTVS FHKFGDYFPG TGDIRDIGHS KGKYYSLNVP LDDGIDDESY 250
    QSLFKPIMGK VMEVFRPGAV VLQCGADSLS GDRLGCFNLS IKGHAECVRY 300
    MRSFNVPLLL LGGGGYTIRN VARCWCYETG VALGQEPEDK MPVNEYYEYF 350
    GPDYTLHVAP SNMENKNTRQ QLDDIRSKLS KLRHAPSVHF QERVPDTEIP 400
    EQDEDQDDPD ERHDPDSDME VDDHKAVEES SRRSILGIKI KREFGENATR 450
    VQDGGRVASE HRGLEPMAED IGSSKQAPQA DASAMAIDEP SNVKNEPESS 500
    TKLQGQAAAY HKP 513
    Length:513
    Mass (Da):57,546
    Last modified:July 15, 1998 - v1
    Checksum:iC45387CF3A38906F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035815 mRNA. Translation: AAC50038.1.
    PIRiT01413.
    UniGeneiZm.2498.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035815 mRNA. Translation: AAC50038.1 .
    PIRi T01413.
    UniGenei Zm.2498.

    3D structure databases

    ProteinModelPortali P56521.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P56521.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei P56521.
    MaizeGDBi 2665840.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterisation of an RPD3 homologue from maize (Zea mays L.) that is able to complement an rpd3 null mutant of Saccharomyces cerevisiae."
      Rossi V., Hartings H., Motto M.
      Mol. Gen. Genet. 258:288-296(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Wisconsin 22.

    Entry informationi

    Entry nameiHDA19_MAIZE
    AccessioniPrimary (citable) accession number: P56521
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3