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P56521

- HDA19_MAIZE

UniProt

P56521 - HDA19_MAIZE

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Protein

Probable histone deacetylase 19

Gene
N/A
Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone deacetylase 19 (EC:3.5.1.98)
Alternative name(s):
RPD3 homolog
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Organism-specific databases

GrameneiP56521.
MaizeGDBi2665840.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Probable histone deacetylase 19PRO_0000114722Add
BLAST

Proteomic databases

PRIDEiP56521.

Structurei

3D structure databases

ProteinModelPortaliP56521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 334312Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

P56521-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPSSAGSGG NSLPSVGPDG QKRRVCYFYD PDVGNYYYGQ GHPMKPHRIR
60 70 80 90 100
MTHSLLARYG LLNQMQVYRP NPARERELCR FHAEEYINFL RSVTPETQQD
110 120 130 140 150
QIRLLKRFNV GEECPVLDGL YSFCQTYAGA SVGGAVKFNH GHDIAINWSG
160 170 180 190 200
GLHHAKKCEA SGFCYVNDIV LAILELLKHH ERVLYVDIDI HHGDGVEEAF
210 220 230 240 250
YTTDRVMTVS FHKFGDYFPG TGDIRDIGHS KGKYYSLNVP LDDGIDDESY
260 270 280 290 300
QSLFKPIMGK VMEVFRPGAV VLQCGADSLS GDRLGCFNLS IKGHAECVRY
310 320 330 340 350
MRSFNVPLLL LGGGGYTIRN VARCWCYETG VALGQEPEDK MPVNEYYEYF
360 370 380 390 400
GPDYTLHVAP SNMENKNTRQ QLDDIRSKLS KLRHAPSVHF QERVPDTEIP
410 420 430 440 450
EQDEDQDDPD ERHDPDSDME VDDHKAVEES SRRSILGIKI KREFGENATR
460 470 480 490 500
VQDGGRVASE HRGLEPMAED IGSSKQAPQA DASAMAIDEP SNVKNEPESS
510
TKLQGQAAAY HKP
Length:513
Mass (Da):57,546
Last modified:July 15, 1998 - v1
Checksum:iC45387CF3A38906F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035815 mRNA. Translation: AAC50038.1.
PIRiT01413.
UniGeneiZm.2498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035815 mRNA. Translation: AAC50038.1 .
PIRi T01413.
UniGenei Zm.2498.

3D structure databases

ProteinModelPortali P56521.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P56521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei P56521.
MaizeGDBi 2665840.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. "Identification and characterisation of an RPD3 homologue from maize (Zea mays L.) that is able to complement an rpd3 null mutant of Saccharomyces cerevisiae."
    Rossi V., Hartings H., Motto M.
    Mol. Gen. Genet. 258:288-296(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Wisconsin 22.

Entry informationi

Entry nameiHDA19_MAIZE
AccessioniPrimary (citable) accession number: P56521
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3