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P56521 (HDA19_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable histone deacetylase 19

EC=3.5.1.98
Alternative name(s):
RPD3 homolog
OrganismZea mays (Maize)
Taxonomic identifier4577 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionChromatin regulator
Hydrolase
Repressor
Gene Ontology (GO)
   Biological_processDNA mediated transformation

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

histone acetylation

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

jasmonic acid and ethylene-dependent systemic resistance

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

pathogenesis

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

regulation of multicellular organismal development

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNAD-dependent histone deacetylase activity (H3-K14 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K18 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K9 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H4-K16 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Probable histone deacetylase 19
PRO_0000114722

Regions

Region23 – 334312Histone deacetylase

Sites

Active site1541 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56521 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: C45387CF3A38906F

FASTA51357,546
        10         20         30         40         50         60 
MDPSSAGSGG NSLPSVGPDG QKRRVCYFYD PDVGNYYYGQ GHPMKPHRIR MTHSLLARYG 

        70         80         90        100        110        120 
LLNQMQVYRP NPARERELCR FHAEEYINFL RSVTPETQQD QIRLLKRFNV GEECPVLDGL 

       130        140        150        160        170        180 
YSFCQTYAGA SVGGAVKFNH GHDIAINWSG GLHHAKKCEA SGFCYVNDIV LAILELLKHH 

       190        200        210        220        230        240 
ERVLYVDIDI HHGDGVEEAF YTTDRVMTVS FHKFGDYFPG TGDIRDIGHS KGKYYSLNVP 

       250        260        270        280        290        300 
LDDGIDDESY QSLFKPIMGK VMEVFRPGAV VLQCGADSLS GDRLGCFNLS IKGHAECVRY 

       310        320        330        340        350        360 
MRSFNVPLLL LGGGGYTIRN VARCWCYETG VALGQEPEDK MPVNEYYEYF GPDYTLHVAP 

       370        380        390        400        410        420 
SNMENKNTRQ QLDDIRSKLS KLRHAPSVHF QERVPDTEIP EQDEDQDDPD ERHDPDSDME 

       430        440        450        460        470        480 
VDDHKAVEES SRRSILGIKI KREFGENATR VQDGGRVASE HRGLEPMAED IGSSKQAPQA 

       490        500        510 
DASAMAIDEP SNVKNEPESS TKLQGQAAAY HKP 

« Hide

References

[1]"Identification and characterisation of an RPD3 homologue from maize (Zea mays L.) that is able to complement an rpd3 null mutant of Saccharomyces cerevisiae."
Rossi V., Hartings H., Motto M.
Mol. Gen. Genet. 258:288-296(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Wisconsin 22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF035815 mRNA. Translation: AAC50038.1.
PIRT01413.
UniGeneZm.2498.

3D structure databases

ProteinModelPortalP56521.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP56521.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP56521.
MaizeGDB2665840.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Entry information

Entry nameHDA19_MAIZE
AccessionPrimary (citable) accession number: P56521
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families