P56521 (HDA19_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Probable histone deacetylase 19 EC=3.5.1.98 Alternative name(s): RPD3 homolog
Organism	Zea mays (Maize)
Taxonomic identifier	4577 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone deacetylase family. HD type 1 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: EC histone deacetylase activity (H3-K16 specific) Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	Probable histone deacetylase 19		PRO_0000114722
Regions
	Region	23 – 334	312	Histone deacetylase
Sites
	Active site	154	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56521 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: C45387CF3A38906F	FASTA	513	57,546
	10 20 30 40 50 60 MDPSSAGSGG NSLPSVGPDG QKRRVCYFYD PDVGNYYYGQ GHPMKPHRIR MTHSLLARYG 70 80 90 100 110 120 LLNQMQVYRP NPARERELCR FHAEEYINFL RSVTPETQQD QIRLLKRFNV GEECPVLDGL 130 140 150 160 170 180 YSFCQTYAGA SVGGAVKFNH GHDIAINWSG GLHHAKKCEA SGFCYVNDIV LAILELLKHH 190 200 210 220 230 240 ERVLYVDIDI HHGDGVEEAF YTTDRVMTVS FHKFGDYFPG TGDIRDIGHS KGKYYSLNVP 250 260 270 280 290 300 LDDGIDDESY QSLFKPIMGK VMEVFRPGAV VLQCGADSLS GDRLGCFNLS IKGHAECVRY 310 320 330 340 350 360 MRSFNVPLLL LGGGGYTIRN VARCWCYETG VALGQEPEDK MPVNEYYEYF GPDYTLHVAP 370 380 390 400 410 420 SNMENKNTRQ QLDDIRSKLS KLRHAPSVHF QERVPDTEIP EQDEDQDDPD ERHDPDSDME 430 440 450 460 470 480 VDDHKAVEES SRRSILGIKI KREFGENATR VQDGGRVASE HRGLEPMAED IGSSKQAPQA 490 500 510 DASAMAIDEP SNVKNEPESS TKLQGQAAAY HKP

References

[1]	"Identification and characterisation of an RPD3 homologue from maize (Zea mays L.) that is able to complement an rpd3 null mutant of Saccharomyces cerevisiae." Rossi V., Hartings H., Motto M. Mol. Gen. Genet. 258:288-296(1998) [PubMed: 9645435] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Wisconsin 22.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF035815 mRNA. Translation: AAC50038.1.
PIR	T01413.
UniGene	Zm.2498.
3D structure databases
ProteinModelPortal	P56521.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Gramene	P56521.
MaizeGDB	2665840.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. IPR023801. His_deacetylse_dom. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...

Entry information

Entry name

HDA19_MAIZE

Accession

Primary (citable) accession number: P56521

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	November 16, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program