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Reviewed, UniProtKB/Swiss-Prot P56519 (HDAC2_CHICK)

Last modified September 22, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Histone deacetylase 2
      Short name=HD2
    EC=3.5.1.98
Gene names
Name: HDAC2
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the histone deacetylase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionChromatin regulator
Hydrolase
Repressor
Gene Ontology (GO)
   Biological processregulation of transcription

Inferred from electronic annotation. Source: UniProtKB-KW

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Traceable author statement. Source: UniProtKB

histone deacetylase complex

Traceable author statement. Source: UniProtKB

   Molecular functionhistone deacetylase activity

Traceable author statement. Source: UniProtKB

transcription factor binding

Traceable author statement. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Histone deacetylase 2
PRO_0000114695

Regions

Region9 – 322314Histone deacetylase
Compositional bias300 – 3034Poly-Gly

Sites

Active site1421 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56519-1 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 4F79B9C0D4A2D065

FASTA48855,153
        10         20         30         40         50         60 
MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 

        70         80         90        100        110        120 
TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA 

       130        140        150        160        170        180 
GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH 

       190        200        210        220        230        240 
GDGVEEAFYT TDRVMTVSEV SMVNNFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ 

       250        260        270        280        290        300 
IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG 

       310        320        330        340        350        360 
GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM 

       370        380        390        400        410        420 
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE 

       430        440        450        460        470        480 
FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKAD VKEEDKSKDN SGEKTDTKGA 


KSEQLSNP 

« Hide

References

[1]Takami Y.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

AF039752 mRNA. Translation: AAB96924.1.
IPIIPI00596260.
RefSeqNP_990162.1.
UniGeneGga.2951

3D structure databases

HSSPHSSP built from PDB template 1C3P based on UniProtKB O67135.
ModBaseSearch...

Protein-protein interaction databases

STRINGP56519.

Genome annotation databases

EnsemblENSGALT00000024179; ENSGALP00000024133; ENSGALG00000014991; Gallus gallus. [Genome view]
GeneID395635.
KEGGgga:395635.

Organism-specific databases

CTD395635.

Phylogenomic databases

HOGENOMP56519.
HOVERGENP56519.

Family and domain databases

InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
[Graphical view]
Gene3DG3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHERPTHR10625. His_deacetylse. 1 hit.
PTHR10625:SF28. His_deacetylse_1. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Entry information

Entry nameHDAC2_CHICK
AccessionPrimary (citable) accession number: P56519
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 22, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents