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Protein

Histone deacetylase 1

Gene

HDAC1

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401By similarity

GO - Molecular functioni

GO - Biological processi

  • chromatin modification Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 1 (EC:3.5.1.98)
Short name:
HD1
Gene namesi
Name:HDAC1
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
ProteomesiUP000007110 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • histone deacetylase complex Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Histone deacetylase 1PRO_0000114690Add
BLAST

Proteomic databases

PRIDEiP56518.

Interactioni

Protein-protein interaction databases

STRINGi7668.SPU_008768tr.

Structurei

3D structure databases

ProteinModelPortaliP56518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 320312Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000225180.
InParanoidiP56518.
KOiK06067.
OMAiACPSPRD.
OrthoDBiEOG7DNNTW.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

P56518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTGTKKRV CYYYDGDVGN YYYGQGHPMK PHRIRMTHNL ILNYGLYRKM
60 70 80 90 100
EIYRPHKAVM EEMTKYHSDD YVKFLRTIRP DNMSEYTKQM QRFNVGEDCP
110 120 130 140 150
VFDGLYEFCQ LSSGGSVAGA VKLNKQQTDI AINWAGGLHH AKKSEASGFC
160 170 180 190 200
YVNDIVLAIL ELLKYHQRVL YIDIDIHHGD GVEEAFYTTD RVMTVSFHKY
210 220 230 240 250
GEYFPGTGDL RDIGAGKGKY YAVNFPLRDG IDDESYDKIF KPIMCKVMEM
260 270 280 290 300
YQPSAICLQC GADSLSGDRL GCFNLTLKGH AKCVEFMKQY NLPLLLMGGG
310 320 330 340 350
GYTIRNVARC WTYETSTALG VEIANELPYN DYFEYFGPDF KLHISPSNMT
360 370 380 390 400
NQNTGEYLDK IKTRLYENMR MIPHAPGVQM QPIPEDAIPD DSDAEDEAEN
410 420 430 440 450
PDKRISIMAQ DKRIQRDDEF SDSEDEGETR LPGEGGRRDH RSHKAKRSKI
460 470 480 490 500
DDSPGKEADK EAKSSDASKE AKPAAEPQAV PMDTTPAPPP KKSEDKPEAS
510 520 530 540 550
KPTEVKAKPA EKEPGEGEAS PADLVVPVPK VSAPSEGATL PAVTIPPSSG
560 570
TSQPPADPPV SAPTPTPASA PAEKQD
Length:576
Mass (Da):64,078
Last modified:July 15, 1998 - v1
Checksum:iB3D11A844A2088E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032919 mRNA. Translation: AAB87685.1.
RefSeqiNP_999711.1. NM_214546.1.
UniGeneiSpu.881.

Genome annotation databases

EnsemblMetazoaiSPU_008768-tr; SPU_008768-tr; SPU_008768.
GeneIDi373339.
KEGGispu:373339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032919 mRNA. Translation: AAB87685.1.
RefSeqiNP_999711.1. NM_214546.1.
UniGeneiSpu.881.

3D structure databases

ProteinModelPortaliP56518.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7668.SPU_008768tr.

Proteomic databases

PRIDEiP56518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSPU_008768-tr; SPU_008768-tr; SPU_008768.
GeneIDi373339.
KEGGispu:373339.

Organism-specific databases

CTDi3065.

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000225180.
InParanoidiP56518.
KOiK06067.
OMAiACPSPRD.
OrthoDBiEOG7DNNTW.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

  1. "Histone deacetylase mRNA temporally and spatially regulated in its expression in sea urchin embryos."
    Nemer M.
    Dev. Growth Differ. 40:583-590(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHDAC1_STRPU
AccessioniPrimary (citable) accession number: P56518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: June 24, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.