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P56518 (HDAC1_STRPU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 1

Short name=HD1
EC=3.5.1.98
Gene names
Name:HDAC1
OrganismStrongylocentrotus purpuratus (Purple sea urchin) [Reference proteome]
Taxonomic identifier7668 [NCBI]
Taxonomic lineageEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Histone deacetylase 1
PRO_0000114690

Regions

Region9 – 320312Histone deacetylase

Sites

Active site1401 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56518 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: B3D11A844A2088E9

FASTA57664,078
        10         20         30         40         50         60 
MASTGTKKRV CYYYDGDVGN YYYGQGHPMK PHRIRMTHNL ILNYGLYRKM EIYRPHKAVM 

        70         80         90        100        110        120 
EEMTKYHSDD YVKFLRTIRP DNMSEYTKQM QRFNVGEDCP VFDGLYEFCQ LSSGGSVAGA 

       130        140        150        160        170        180 
VKLNKQQTDI AINWAGGLHH AKKSEASGFC YVNDIVLAIL ELLKYHQRVL YIDIDIHHGD 

       190        200        210        220        230        240 
GVEEAFYTTD RVMTVSFHKY GEYFPGTGDL RDIGAGKGKY YAVNFPLRDG IDDESYDKIF 

       250        260        270        280        290        300 
KPIMCKVMEM YQPSAICLQC GADSLSGDRL GCFNLTLKGH AKCVEFMKQY NLPLLLMGGG 

       310        320        330        340        350        360 
GYTIRNVARC WTYETSTALG VEIANELPYN DYFEYFGPDF KLHISPSNMT NQNTGEYLDK 

       370        380        390        400        410        420 
IKTRLYENMR MIPHAPGVQM QPIPEDAIPD DSDAEDEAEN PDKRISIMAQ DKRIQRDDEF 

       430        440        450        460        470        480 
SDSEDEGETR LPGEGGRRDH RSHKAKRSKI DDSPGKEADK EAKSSDASKE AKPAAEPQAV 

       490        500        510        520        530        540 
PMDTTPAPPP KKSEDKPEAS KPTEVKAKPA EKEPGEGEAS PADLVVPVPK VSAPSEGATL 

       550        560        570 
PAVTIPPSSG TSQPPADPPV SAPTPTPASA PAEKQD 

« Hide

References

[1]"Histone deacetylase mRNA temporally and spatially regulated in its expression in sea urchin embryos."
Nemer M.
Dev. Growth Differ. 40:583-590(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF032919 mRNA. Translation: AAB87685.1.
RefSeqNP_999711.1. NM_214546.1.
UniGeneSpu.881.

3D structure databases

ProteinModelPortalP56518.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7668.P56518.

Proteomic databases

PRIDEP56518.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaSPU_008768-tr; SPU_008768-tr; SPU_008768.
GeneID373339.
KEGGspu:373339.

Organism-specific databases

CTD3065.

Phylogenomic databases

eggNOGCOG0123.
HOGENOMHOG000225180.
InParanoidP56518.
KOK06067.
OMAAYESIFV.
OrthoDBEOG7DNNTW.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Entry information

Entry nameHDAC1_STRPU
AccessionPrimary (citable) accession number: P56518
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families