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P56517

- HDAC1_CHICK

UniProt

P56517 - HDAC1_CHICK

Protein

Histone deacetylase 1

Gene

HDAC1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei141 – 1411By similarity

    GO - Molecular functioni

    1. core promoter binding Source: Ensembl
    2. histone deacetylase activity Source: UniProtKB
    3. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    6. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    7. RNA polymerase II transcription corepressor activity Source: Ensembl
    8. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. chromatin modification Source: UniProtKB
    2. negative regulation by host of viral transcription Source: Ensembl
    3. negative regulation of androgen receptor signaling pathway Source: Ensembl
    4. positive regulation of cell proliferation Source: Ensembl
    5. positive regulation of receptor biosynthetic process Source: Ensembl
    6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BRENDAi3.5.1.98. 1306.
    ReactomeiREACT_197098. G0 and Early G1.
    REACT_197541. Factors involved in megakaryocyte development and platelet production.
    REACT_198075. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_198082. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_198137. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_203085. formation of the beta-catenin:TCF transactivating complex.
    REACT_203522. deactivation of the beta-catenin transactivating complex.
    REACT_209209. p75NTR negatively regulates cell cycle via SC1.
    REACT_223355. NoRC negatively regulates rRNA expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 1 (EC:3.5.1.98)
    Short name:
    HD1
    Gene namesi
    Name:HDAC1
    Synonyms:HDAC1A
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 23

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Ensembl
    3. histone deacetylase complex Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. NuRD complex Source: Ensembl
    6. Sin3 complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Histone deacetylase 1PRO_0000114689Add
    BLAST

    Proteomic databases

    PaxDbiP56517.
    PRIDEiP56517.

    Interactioni

    Subunit structurei

    Forms a complex with RBAP48.By similarity

    Protein-protein interaction databases

    BioGridi675010. 2 interactions.
    STRINGi9031.ENSGALP00000005212.

    Structurei

    3D structure databases

    ProteinModelPortaliP56517.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni9 – 321313Histone deacetylaseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi299 – 3024Poly-Gly
    Compositional biasi396 – 3994Poly-Glu
    Compositional biasi446 – 4538Poly-Glu

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    GeneTreeiENSGT00530000062889.
    HOGENOMiHOG000225180.
    HOVERGENiHBG057112.
    InParanoidiP56517.
    KOiK06067.
    OMAiLTQGTKR.
    OrthoDBiEOG7DNNTW.
    PhylomeDBiP56517.
    TreeFamiTF106171.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    P56517-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK    50
    MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC 100
    PVFDGLFEFC QLSAGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF 150
    CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK 200
    YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVISKVME 250
    TFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG 300
    GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM 350
    TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQPIPEDAVQ EDSGDEEEED 400
    PEKRISIRNS DKRISCDEEF SDSEDEGEGG RKNVANFKKA KRVKTEEEKE 450
    EEEKKDEKEE EKAKEEKAEP KGVKEETKST 480
    Length:480
    Mass (Da):54,939
    Last modified:July 15, 1998 - v1
    Checksum:i82C78CE285C779D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 42LT → VM in AAB99850. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039751 mRNA. Translation: AAB96923.1.
    AF043328 mRNA. Translation: AAB99850.1.
    AF044169 mRNA. Translation: AAC00504.1.
    RefSeqiNP_989487.1. NM_204156.1.
    UniGeneiGga.10603.

    Genome annotation databases

    EnsembliENSGALT00000005221; ENSGALP00000005212; ENSGALG00000003297.
    GeneIDi373961.
    KEGGigga:373961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039751 mRNA. Translation: AAB96923.1 .
    AF043328 mRNA. Translation: AAB99850.1 .
    AF044169 mRNA. Translation: AAC00504.1 .
    RefSeqi NP_989487.1. NM_204156.1.
    UniGenei Gga.10603.

    3D structure databases

    ProteinModelPortali P56517.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 675010. 2 interactions.
    STRINGi 9031.ENSGALP00000005212.

    Chemistry

    BindingDBi P56517.

    Proteomic databases

    PaxDbi P56517.
    PRIDEi P56517.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000005221 ; ENSGALP00000005212 ; ENSGALG00000003297 .
    GeneIDi 373961.
    KEGGi gga:373961.

    Organism-specific databases

    CTDi 3065.

    Phylogenomic databases

    eggNOGi COG0123.
    GeneTreei ENSGT00530000062889.
    HOGENOMi HOG000225180.
    HOVERGENi HBG057112.
    InParanoidi P56517.
    KOi K06067.
    OMAi LTQGTKR.
    OrthoDBi EOG7DNNTW.
    PhylomeDBi P56517.
    TreeFami TF106171.

    Enzyme and pathway databases

    BRENDAi 3.5.1.98. 1306.
    Reactomei REACT_197098. G0 and Early G1.
    REACT_197541. Factors involved in megakaryocyte development and platelet production.
    REACT_198075. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_198082. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_198137. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_203085. formation of the beta-catenin:TCF transactivating complex.
    REACT_203522. deactivation of the beta-catenin transactivating complex.
    REACT_209209. p75NTR negatively regulates cell cycle via SC1.
    REACT_223355. NoRC negatively regulates rRNA expression.

    Miscellaneous databases

    NextBioi 20813492.
    PROi P56517.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. Takami Y.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Sun J.M., Chen H.Y., Davie J.R.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHDAC1_CHICK
    AccessioniPrimary (citable) accession number: P56517
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3