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P56517

- HDAC1_CHICK

UniProt

P56517 - HDAC1_CHICK

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Protein

Histone deacetylase 1

Gene
HDAC1, HDAC1A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei141 – 1411 By similarity

GO - Molecular functioni

  1. core promoter binding Source: Ensembl
  2. histone deacetylase activity Source: UniProtKB
  3. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  6. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  7. RNA polymerase II transcription corepressor activity Source: Ensembl
  8. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. chromatin modification Source: UniProtKB
  2. negative regulation by host of viral transcription Source: Ensembl
  3. negative regulation of androgen receptor signaling pathway Source: Ensembl
  4. positive regulation of cell proliferation Source: Ensembl
  5. positive regulation of receptor biosynthetic process Source: Ensembl
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BRENDAi3.5.1.98. 1306.
ReactomeiREACT_197098. G0 and Early G1.
REACT_197541. Factors involved in megakaryocyte development and platelet production.
REACT_198075. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_198082. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_198137. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_203085. formation of the beta-catenin:TCF transactivating complex.
REACT_203522. deactivation of the beta-catenin transactivating complex.
REACT_209209. p75NTR negatively regulates cell cycle via SC1.
REACT_223355. NoRC negatively regulates rRNA expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 1 (EC:3.5.1.98)
Short name:
HD1
Gene namesi
Name:HDAC1
Synonyms:HDAC1A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 23

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Ensembl
  3. histone deacetylase complex Source: UniProtKB
  4. nucleus Source: UniProtKB
  5. NuRD complex Source: Ensembl
  6. Sin3 complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Histone deacetylase 1PRO_0000114689Add
BLAST

Proteomic databases

PaxDbiP56517.
PRIDEiP56517.

Interactioni

Subunit structurei

Forms a complex with RBAP48 By similarity.

Protein-protein interaction databases

BioGridi675010. 2 interactions.
STRINGi9031.ENSGALP00000005212.

Structurei

3D structure databases

ProteinModelPortaliP56517.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 321313Histone deacetylaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi299 – 3024Poly-Gly
Compositional biasi396 – 3994Poly-Glu
Compositional biasi446 – 4538Poly-Glu

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062889.
HOGENOMiHOG000225180.
HOVERGENiHBG057112.
InParanoidiP56517.
KOiK06067.
OMAiLTQGTKR.
OrthoDBiEOG7DNNTW.
PhylomeDBiP56517.
TreeFamiTF106171.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

P56517-1 [UniParc]FASTAAdd to Basket

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MALTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK    50
MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC 100
PVFDGLFEFC QLSAGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF 150
CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK 200
YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVISKVME 250
TFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG 300
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM 350
TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQPIPEDAVQ EDSGDEEEED 400
PEKRISIRNS DKRISCDEEF SDSEDEGEGG RKNVANFKKA KRVKTEEEKE 450
EEEKKDEKEE EKAKEEKAEP KGVKEETKST 480
Length:480
Mass (Da):54,939
Last modified:July 15, 1998 - v1
Checksum:i82C78CE285C779D9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 42LT → VM in AAB99850. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039751 mRNA. Translation: AAB96923.1.
AF043328 mRNA. Translation: AAB99850.1.
AF044169 mRNA. Translation: AAC00504.1.
RefSeqiNP_989487.1. NM_204156.1.
UniGeneiGga.10603.

Genome annotation databases

EnsembliENSGALT00000005221; ENSGALP00000005212; ENSGALG00000003297.
GeneIDi373961.
KEGGigga:373961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039751 mRNA. Translation: AAB96923.1 .
AF043328 mRNA. Translation: AAB99850.1 .
AF044169 mRNA. Translation: AAC00504.1 .
RefSeqi NP_989487.1. NM_204156.1.
UniGenei Gga.10603.

3D structure databases

ProteinModelPortali P56517.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 675010. 2 interactions.
STRINGi 9031.ENSGALP00000005212.

Chemistry

BindingDBi P56517.

Proteomic databases

PaxDbi P56517.
PRIDEi P56517.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000005221 ; ENSGALP00000005212 ; ENSGALG00000003297 .
GeneIDi 373961.
KEGGi gga:373961.

Organism-specific databases

CTDi 3065.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00530000062889.
HOGENOMi HOG000225180.
HOVERGENi HBG057112.
InParanoidi P56517.
KOi K06067.
OMAi LTQGTKR.
OrthoDBi EOG7DNNTW.
PhylomeDBi P56517.
TreeFami TF106171.

Enzyme and pathway databases

BRENDAi 3.5.1.98. 1306.
Reactomei REACT_197098. G0 and Early G1.
REACT_197541. Factors involved in megakaryocyte development and platelet production.
REACT_198075. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_198082. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_198137. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_203085. formation of the beta-catenin:TCF transactivating complex.
REACT_203522. deactivation of the beta-catenin transactivating complex.
REACT_209209. p75NTR negatively regulates cell cycle via SC1.
REACT_223355. NoRC negatively regulates rRNA expression.

Miscellaneous databases

NextBioi 20813492.
PROi P56517.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. Takami Y.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Sun J.M., Chen H.Y., Davie J.R.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHDAC1_CHICK
AccessioniPrimary (citable) accession number: P56517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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