Reviewed,
UniProtKB/Swiss-Prot P56517 (HDAC1_CHICK)
Last modified
January 19, 2010.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone deacetylase 1 Short name=HD1 EC=3.5.1.98 | ||||
| Gene names |
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| Organism | Gallus gallus (Chicken) | ||||
| Taxonomic identifier | 9031 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 480 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. |
| Catalytic activity | Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. |
| Subunit structure | Forms a complex with RBAP48 By similarity. |
| Subcellular location | Nucleus Potential. |
| Sequence similarities | Belongs to the histone deacetylase family. Type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Molecular function | Chromatin regulator Hydrolase Repressor |
| Gene Ontology (GO) | |
| Biological process | histone deacetylation Inferred from electronic annotation. Source: InterPro transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Traceable author statement. Source: UniProtKB |
| Molecular function | histone deacetylase activity Traceable author statement. Source: UniProtKB transcription factor bindingTraceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 480 | 480 | Histone deacetylase 1 | PRO_0000114689 | |||||
Regions | |||||||||
| Region | 9 – 321 | 313 | Histone deacetylase | ||||||
| Compositional bias | 299 – 302 | 4 | Poly-Gly | ||||||
| Compositional bias | 396 – 399 | 4 | Poly-Glu | ||||||
| Compositional bias | 446 – 453 | 8 | Poly-Glu | ||||||
Sites | |||||||||
| Active site | 141 | 1 | By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 3 – 4 | 2 | LT → VM in AAB99850. Ref.2 | ||||||
Sequences
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References
| [1] | Takami Y. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | Sun J.M., Chen H.Y., Davie J.R. Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF039751 mRNA. Translation: AAB96923.1. AF043328 mRNA. Translation: AAB99850.1. AF044169 mRNA. Translation: AAC00504.1. |
| IPI | IPI00581674. |
| RefSeq | NP_989487.1. |
| UniGene | Gga.14557 |
3D structure databases | |
| SMR | P56517. Positions 12-373. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P56517. |
Proteomic databases | |
| PRIDE | P56517. |
Genome annotation databases | |
| Ensembl | ENSGALT00000005221; ENSGALP00000005212; ENSGALG00000003297; Gallus gallus. [Genome view] |
| GeneID | 373961. |
| KEGG | gga:373961. |
Organism-specific databases | |
| CTD | 373961. |
Phylogenomic databases | |
| eggNOG | veNOG07374. |
| HOGENOM | HBG396919. |
| HOVERGEN | P56517. |
| InParanoid | P56517. |
| OMA | IFKPVIS. |
| OrthoDB | EOG94XN2W. |
| PhylomeDB | P56517. |
Family and domain databases | |
| InterPro | IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. [Graphical view] |
| Gene3D | G3DSA:3.40.800.20. His_deacetylse. 1 hit. |
| PANTHER | PTHR10625. His_deacetylse. 1 hit. PTHR10625:SF28. His_deacetylse_1. 1 hit. |
| Pfam | PF00850. Hist_deacetyl. 1 hit. [Graphical view] |
| PIRSF | PIRSF037913. His_deacetylse_1. 1 hit. |
| PRINTS | PR01270. HDASUPER. PR01271. HISDACETLASE. |
| ProtoNet | Search... |
Entry information
| Entry name | HDAC1_CHICK | ||||||||
| Accession | Primary (citable) accession number: P56517 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

Clusters with


