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Protein

Histone deacetylase 1

Gene

HDAC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei141 – 1411By similarity

GO - Molecular functioni

  1. core promoter binding Source: Ensembl
  2. histone deacetylase activity Source: UniProtKB
  3. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  6. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  7. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  8. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  9. RNA polymerase II transcription corepressor activity Source: Ensembl
  10. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. ATP-dependent chromatin remodeling Source: Ensembl
  2. chromatin modification Source: UniProtKB
  3. negative regulation by host of viral transcription Source: Ensembl
  4. negative regulation of androgen receptor signaling pathway Source: Ensembl
  5. positive regulation of cell proliferation Source: Ensembl
  6. positive regulation of receptor biosynthetic process Source: Ensembl
  7. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BRENDAi3.5.1.98. 1306.
ReactomeiREACT_271785. G0 and Early G1.
REACT_282783. repression of WNT target genes.
REACT_284637. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_286472. Factors involved in megakaryocyte development and platelet production.
REACT_311887. formation of the beta-catenin:TCF transactivating complex.
REACT_320040. deactivation of the beta-catenin transactivating complex.
REACT_320439. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_320742. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_326801. p75NTR negatively regulates cell cycle via SC1.
REACT_340836. NoRC negatively regulates rRNA expression.
REACT_344213. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 1 (EC:3.5.1.98)
Short name:
HD1
Gene namesi
Name:HDAC1
Synonyms:HDAC1A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 23

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Ensembl
  3. histone deacetylase complex Source: UniProtKB
  4. nucleus Source: UniProtKB
  5. NuRD complex Source: Ensembl
  6. Sin3 complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Histone deacetylase 1PRO_0000114689Add
BLAST

Proteomic databases

PaxDbiP56517.
PRIDEiP56517.

Interactioni

Subunit structurei

Forms a complex with RBAP48.By similarity

Protein-protein interaction databases

BioGridi675010. 2 interactions.
STRINGi9031.ENSGALP00000005212.

Structurei

3D structure databases

ProteinModelPortaliP56517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 321313Histone deacetylaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi299 – 3024Poly-Gly
Compositional biasi396 – 3994Poly-Glu
Compositional biasi446 – 4538Poly-Glu

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062889.
HOGENOMiHOG000225180.
HOVERGENiHBG057112.
InParanoidiP56517.
KOiK06067.
OMAiLTQGTKR.
OrthoDBiEOG7DNNTW.
PhylomeDBiP56517.
TreeFamiTF106171.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

P56517-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK
60 70 80 90 100
MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC
110 120 130 140 150
PVFDGLFEFC QLSAGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF
160 170 180 190 200
CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK
210 220 230 240 250
YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVISKVME
260 270 280 290 300
TFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG
310 320 330 340 350
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM
360 370 380 390 400
TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQPIPEDAVQ EDSGDEEEED
410 420 430 440 450
PEKRISIRNS DKRISCDEEF SDSEDEGEGG RKNVANFKKA KRVKTEEEKE
460 470 480
EEEKKDEKEE EKAKEEKAEP KGVKEETKST
Length:480
Mass (Da):54,939
Last modified:July 14, 1998 - v1
Checksum:i82C78CE285C779D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 42LT → VM in AAB99850 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039751 mRNA. Translation: AAB96923.1.
AF043328 mRNA. Translation: AAB99850.1.
AF044169 mRNA. Translation: AAC00504.1.
RefSeqiNP_989487.1. NM_204156.1.
UniGeneiGga.10603.

Genome annotation databases

EnsembliENSGALT00000005221; ENSGALP00000005212; ENSGALG00000003297.
GeneIDi373961.
KEGGigga:373961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039751 mRNA. Translation: AAB96923.1.
AF043328 mRNA. Translation: AAB99850.1.
AF044169 mRNA. Translation: AAC00504.1.
RefSeqiNP_989487.1. NM_204156.1.
UniGeneiGga.10603.

3D structure databases

ProteinModelPortaliP56517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi675010. 2 interactions.
STRINGi9031.ENSGALP00000005212.

Proteomic databases

PaxDbiP56517.
PRIDEiP56517.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000005221; ENSGALP00000005212; ENSGALG00000003297.
GeneIDi373961.
KEGGigga:373961.

Organism-specific databases

CTDi3065.

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062889.
HOGENOMiHOG000225180.
HOVERGENiHBG057112.
InParanoidiP56517.
KOiK06067.
OMAiLTQGTKR.
OrthoDBiEOG7DNNTW.
PhylomeDBiP56517.
TreeFamiTF106171.

Enzyme and pathway databases

BRENDAi3.5.1.98. 1306.
ReactomeiREACT_271785. G0 and Early G1.
REACT_282783. repression of WNT target genes.
REACT_284637. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_286472. Factors involved in megakaryocyte development and platelet production.
REACT_311887. formation of the beta-catenin:TCF transactivating complex.
REACT_320040. deactivation of the beta-catenin transactivating complex.
REACT_320439. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_320742. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_326801. p75NTR negatively regulates cell cycle via SC1.
REACT_340836. NoRC negatively regulates rRNA expression.
REACT_344213. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

NextBioi20813492.
PROiP56517.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

  1. Takami Y.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Sun J.M., Chen H.Y., Davie J.R.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHDAC1_CHICK
AccessioniPrimary (citable) accession number: P56517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1998
Last sequence update: July 14, 1998
Last modified: March 31, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.