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Protein

Histone deacetylase 1

Gene

HDAC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei141By similarity1

GO - Molecular functioni

  • histone deacetylase activity Source: UniProtKB
  • NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • chromatin organization Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BRENDAi3.5.1.98 1306
ReactomeiR-GGA-1538133 G0 and Early G1
R-GGA-201722 Formation of the beta-catenin:TCF transactivating complex
R-GGA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-GGA-3769402 Deactivation of the beta-catenin transactivating complex
R-GGA-4551638 SUMOylation of chromatin organization proteins
R-GGA-6804758 Regulation of TP53 Activity through Acetylation
R-GGA-73762 RNA Polymerase I Transcription Initiation
R-GGA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-GGA-8943724 Regulation of PTEN gene transcription
R-GGA-9018519 Estrogen-dependent gene expression
R-GGA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 1 (EC:3.5.1.98)
Short name:
HD1
Gene namesi
Name:HDAC1
Synonyms:HDAC1A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001146891 – 480Histone deacetylase 1Add BLAST480

Proteomic databases

PaxDbiP56517
PRIDEiP56517

Expressioni

Gene expression databases

BgeeiENSGALG00000003297

Interactioni

Subunit structurei

Forms a complex with RBAP48.By similarity

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi675010, 2 interactors
STRINGi9031.ENSGALP00000005212

Structurei

3D structure databases

ProteinModelPortaliP56517
SMRiP56517
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 321Histone deacetylaseAdd BLAST313

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi299 – 302Poly-Gly4
Compositional biasi396 – 399Poly-Glu4
Compositional biasi446 – 453Poly-Glu8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1342 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00910000144047
HOGENOMiHOG000225180
HOVERGENiHBG057112
InParanoidiP56517
KOiK06067
OMAiLWAYETS
OrthoDBiEOG091G067J
PhylomeDBiP56517
TreeFamiTF106171

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

P56517-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK
60 70 80 90 100
MEIYRPHKAN AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC
110 120 130 140 150
PVFDGLFEFC QLSAGGSVAS AVKLNKQQTD IAVNWAGGLH HAKKSEASGF
160 170 180 190 200
CYVNDIVLAI LELLKYHQRV LYIDIDIHHG DGVEEAFYTT DRVMTVSFHK
210 220 230 240 250
YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI FKPVISKVME
260 270 280 290 300
TFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG
310 320 330 340 350
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM
360 370 380 390 400
TNQNTNEYLE KIKQRLFENL RMLPHAPGVQ MQPIPEDAVQ EDSGDEEEED
410 420 430 440 450
PEKRISIRNS DKRISCDEEF SDSEDEGEGG RKNVANFKKA KRVKTEEEKE
460 470 480
EEEKKDEKEE EKAKEEKAEP KGVKEETKST
Length:480
Mass (Da):54,939
Last modified:July 15, 1998 - v1
Checksum:i82C78CE285C779D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 4LT → VM in AAB99850 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039751 mRNA Translation: AAB96923.1
AF043328 mRNA Translation: AAB99850.1
AF044169 mRNA Translation: AAC00504.1
RefSeqiNP_989487.1, NM_204156.1
UniGeneiGga.10603

Genome annotation databases

EnsembliENSGALT00000084635; ENSGALP00000059784; ENSGALG00000003297
GeneIDi373961
KEGGigga:373961

Similar proteinsi

Entry informationi

Entry nameiHDAC1_CHICK
AccessioniPrimary (citable) accession number: P56517
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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