P56513 (PLM_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholemman

Alternative name(s):
FXYD domain-containing ion transport regulator 1

Gene names

Name:	FXYD1
Synonyms:	PLM

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	92 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Present in heart, esophagus, stomach, aorta, skeletal muscle, smooth muscle, and liver but absent from brain and kidney.
Post-translational modification	Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK By similarity.
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ionic channel
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chloride channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.1
	Chain	21 – 92	72	Phospholemman		PRO_0000010358
Regions
	Topological domain	21 – 35	15	Extracellular Potential
	Transmembrane	36 – 56	21	Helical; Potential
	Topological domain	57 – 92	36	Cytoplasmic Potential
Amino acid modifications
	Modified residue	79	1	Phosphothreonine By similarity
	Modified residue	83	1	Phosphoserine; by PKA and PKC By similarity
	Modified residue	88	1	Phosphoserine; by PKA By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56513 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 890DE301BF8E740A	FASTA	92	10,500
	10 20 30 40 50 60 MAPLHHILVL CVGFLTTATA EAPQEHDPFT YDYQSLRIGG LIIAGILFIL GILIVLSRRC 70 80 90 RCKFNQQQRT GEPDEEEGTF RSSIRRLSTR RR

References

[1]

"Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardium." Palmer C.J., Scott B.T., Jones L.R. J. Biol. Chem. 266:11126-11130(1991) [PubMed: 1710217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-92. Tissue: Heart ventricle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M63934 mRNA. No translation available.
PIR	A40533.
3D structure databases
ProteinModelPortal	P56513.
SMR	P56513. Positions 21-92.
ModBase	Search...
Protein-protein interaction databases
STRING	P56513.
Protein family/group databases
TCDB	1.A.27.1.1. phospholemman (PLM) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	maNOG21518.
GeneTree	ENSGT00530000063932.
HOVERGEN	HBG008212.
InParanoid	P56513.
OrthoDB	EOG4PG62F.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLM_CANFA

Accession

Primary (citable) accession number: P56513

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	December 14, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program