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Protein

Mitochondrial uncoupling protein 3

Gene

Ucp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity).By similarity

GO - Molecular functioni

  • oxidative phosphorylation uncoupler activity Source: MGI

GO - Biological processi

  • aging Source: Ensembl
  • cellular response to hormone stimulus Source: Ensembl
  • fatty acid metabolic process Source: MGI
  • mitochondrial transport Source: InterPro
  • proton transport Source: GOC
  • response to activity Source: Ensembl
  • response to cold Source: Ensembl
  • response to glucocorticoid Source: Ensembl
  • response to hypoxia Source: Ensembl
  • response to insulin Source: Ensembl
  • response to nutrient Source: Ensembl
  • response to superoxide Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-167826. The fatty acid cycling model.
R-MMU-167827. The proton buffering model.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 3
Short name:
UCP 3
Alternative name(s):
Solute carrier family 25 member 9
Gene namesi
Name:Ucp3
Synonyms:Slc25a9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1099787. Ucp3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3222Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei74 – 9623Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei117 – 13317Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei180 – 19617Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei214 – 23320Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei268 – 29023Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Mitochondrial uncoupling protein 3PRO_0000090673Add
BLAST

Proteomic databases

MaxQBiP56501.
PaxDbiP56501.
PRIDEiP56501.

Expressioni

Gene expression databases

BgeeiP56501.
ExpressionAtlasiP56501. baseline and differential.
GenevisibleiP56501. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032958.

Structurei

3D structure databases

ProteinModelPortaliP56501.
SMRiP56501. Positions 15-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10292Solcar 1Add
BLAST
Repeati111 – 20292Solcar 2Add
BLAST
Repeati211 – 29686Solcar 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni275 – 29723Purine nucleotide bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP56501.
KOiK15103.
OMAiKGTWPNI.
OrthoDBiEOG793B7Z.
PhylomeDBiP56501.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGLQPSEVP PTTVVKFLGA GTAACFADLL TFPLDTAKVR LQIQGENPGA
60 70 80 90 100
QSVQYRGVLG TILTMVRTEG PRSPYSGLVA GLHRQMSFAS IRIGLYDSVK
110 120 130 140 150
QFYTPKGADH SSVAIRILAG CTTGAMAVTC AQPTDVVKVR FQAMIRLGTG
160 170 180 190 200
GERKYRGTMD AYRTIAREEG VRGLWKGTWP NITRNAIVNC AEMVTYDIIK
210 220 230 240 250
EKLLESHLFT DNFPCHFVSA FGAGFCATVV ASPVDVVKTR YMNAPLGRYR
260 270 280 290 300
SPLHCMLKMV AQEGPTAFYK GFVPSFLRLG AWNVMMFVTY EQLKRALMKV

QVLRESPF
Length:308
Mass (Da):33,911
Last modified:July 15, 1998 - v1
Checksum:i12CAD7674DF7D0C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791W → L in BAA31989 (PubMed:9600108).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032902 mRNA. Translation: AAB87084.1.
AB010742 mRNA. Translation: BAA25697.1.
AF030164 mRNA. Translation: AAD01892.1.
AB008216 mRNA. Translation: BAA33502.1.
AF053352 mRNA. Translation: AAC28328.1.
AB013132 mRNA. Translation: BAA31989.1.
AF019883 mRNA. Translation: AAB71543.1.
CCDSiCCDS21497.1.
RefSeqiNP_033490.1. NM_009464.3.
UniGeneiMm.6254.

Genome annotation databases

EnsembliENSMUST00000032958; ENSMUSP00000032958; ENSMUSG00000032942.
ENSMUST00000107059; ENSMUSP00000102674; ENSMUSG00000032942.
GeneIDi22229.
KEGGimmu:22229.
UCSCiuc009ina.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032902 mRNA. Translation: AAB87084.1.
AB010742 mRNA. Translation: BAA25697.1.
AF030164 mRNA. Translation: AAD01892.1.
AB008216 mRNA. Translation: BAA33502.1.
AF053352 mRNA. Translation: AAC28328.1.
AB013132 mRNA. Translation: BAA31989.1.
AF019883 mRNA. Translation: AAB71543.1.
CCDSiCCDS21497.1.
RefSeqiNP_033490.1. NM_009464.3.
UniGeneiMm.6254.

3D structure databases

ProteinModelPortaliP56501.
SMRiP56501. Positions 15-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032958.

Proteomic databases

MaxQBiP56501.
PaxDbiP56501.
PRIDEiP56501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032958; ENSMUSP00000032958; ENSMUSG00000032942.
ENSMUST00000107059; ENSMUSP00000102674; ENSMUSG00000032942.
GeneIDi22229.
KEGGimmu:22229.
UCSCiuc009ina.1. mouse.

Organism-specific databases

CTDi7352.
MGIiMGI:1099787. Ucp3.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP56501.
KOiK15103.
OMAiKGTWPNI.
OrthoDBiEOG793B7Z.
PhylomeDBiP56501.
TreeFamiTF323211.

Enzyme and pathway databases

ReactomeiR-MMU-167826. The fatty acid cycling model.
R-MMU-167827. The proton buffering model.

Miscellaneous databases

PROiP56501.
SOURCEiSearch...

Gene expression databases

BgeeiP56501.
ExpressionAtlasiP56501. baseline and differential.
GenevisibleiP56501. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Sanchis D., Fleury C., Bouillaud F., Ricquier D.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. "Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map."
    Yoshitomi H., Yamazaki K., Tanaka I.
    Gene 215:77-84(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Embryo.
  3. Grujic D., Zhan C.-Y., Sleiker L.J., Lowell B.B.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Skeletal muscle.
  4. "Cloning of mouse UCP3 cDNA."
    Son C., Hosoda K., Matsuda J., Nakao K.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Skeletal muscle.
  5. "Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes."
    Gong D.W., He Y., Reitman M.L.
    Biochem. Biophys. Res. Commun. 256:27-32(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "Transcriptional regulation of muscle-specific genes during myoblast differentiation."
    Shimokawa T., Kato M., Ezaki O., Hashimoto S.
    Biochem. Biophys. Res. Commun. 246:287-292(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-180.
    Strain: C57BL/6J.
    Tissue: Skeletal muscle.
  7. Yan X., Ramsay T.G.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 162-252.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue and Heart.

Entry informationi

Entry nameiUCP3_MOUSE
AccessioniPrimary (citable) accession number: P56501
Secondary accession number(s): O88293
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.