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Protein

Mitochondrial uncoupling protein 2

Gene

Ucp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).By similarity

GO - Biological processi

  • aging Source: RGD
  • cellular response to amino acid starvation Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to hormone stimulus Source: RGD
  • cellular response to insulin stimulus Source: RGD
  • female pregnancy Source: RGD
  • liver regeneration Source: RGD
  • mitochondrial transport Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
  • positive regulation of cell death Source: RGD
  • regulation of mitochondrial membrane potential Source: Ensembl
  • response to fatty acid Source: RGD
  • response to glucose Source: RGD
  • response to hypoxia Source: RGD
  • response to superoxide Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-167826. The fatty acid cycling model.
R-RNO-167827. The proton buffering model.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 2
Short name:
UCP 2
Alternative name(s):
Solute carrier family 25 member 8
Gene namesi
Name:Ucp2
Synonyms:Slc25a8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3932. Ucp2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial matrixSequence analysis10
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini33 – 77Mitochondrial intermembraneSequence analysisAdd BLAST45
Transmembranei78 – 100Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini101 – 119Mitochondrial matrixSequence analysisAdd BLAST19
Transmembranei120 – 136Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini137 – 180Mitochondrial intermembraneSequence analysisAdd BLAST44
Transmembranei181 – 197Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini198 – 214Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei215 – 234Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini235 – 268Mitochondrial intermembraneSequence analysisAdd BLAST34
Transmembranei269 – 291Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini292 – 309Mitochondrial matrixSequence analysisAdd BLAST18

GO - Cellular componenti

  • cytoplasm Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906671 – 309Mitochondrial uncoupling protein 2Add BLAST309

Proteomic databases

PaxDbiP56500.
PRIDEiP56500.

PTM databases

PhosphoSitePlusiP56500.

Expressioni

Tissue specificityi

Expressed in a variety of organs, with predominant expression in the heart, lung and spleen.

Gene expression databases

BgeeiENSRNOG00000017854.
GenevisibleiP56500. RN.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024156.

Structurei

3D structure databases

ProteinModelPortaliP56500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 106Solcar 1Add BLAST96
Repeati114 – 203Solcar 2Add BLAST90
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni276 – 298Purine nucleotide bindingBy similarityAdd BLAST23

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP56500.
KOiK15103.
OMAiLLKAHLM.
OrthoDBiEOG091G0BQ7.
PhylomeDBiP56500.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGL
60 70 80 90 100
ARTAASAQYR GVLGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY
110 120 130 140 150
DSVKQFYTKG SEHAGIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA
160 170 180 190 200
GGGRRYQSTV EAYKTIAREE GIRGLWKGTS PNVARNAIVN CTELVTYDLI
210 220 230 240 250
KDTLLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY
260 270 280 290 300
HSAGHCALTM LRKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA

AYESREAPF
Length:309
Mass (Da):33,377
Last modified:July 15, 1998 - v1
Checksum:i3297935CF997AA0E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → L in BAA28832 (PubMed:9512646).Curated1
Sequence conflicti268A → T in BAA25698 (Ref. 3) Curated1
Sequence conflicti268A → T in AAH62230 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039033 mRNA. Translation: AAC98733.1.
AB006613 mRNA. Translation: BAA23383.1.
AB010743 mRNA. Translation: BAA25698.1.
AB005143 mRNA. Translation: BAA28832.1.
BC062230 mRNA. Translation: AAH62230.1.
RefSeqiNP_062227.2. NM_019354.3.
UniGeneiRn.13333.

Genome annotation databases

EnsembliENSRNOT00000024156; ENSRNOP00000024156; ENSRNOG00000017854.
GeneIDi54315.
KEGGirno:54315.
UCSCiRGD:3932. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039033 mRNA. Translation: AAC98733.1.
AB006613 mRNA. Translation: BAA23383.1.
AB010743 mRNA. Translation: BAA25698.1.
AB005143 mRNA. Translation: BAA28832.1.
BC062230 mRNA. Translation: AAH62230.1.
RefSeqiNP_062227.2. NM_019354.3.
UniGeneiRn.13333.

3D structure databases

ProteinModelPortaliP56500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024156.

PTM databases

PhosphoSitePlusiP56500.

Proteomic databases

PaxDbiP56500.
PRIDEiP56500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024156; ENSRNOP00000024156; ENSRNOG00000017854.
GeneIDi54315.
KEGGirno:54315.
UCSCiRGD:3932. rat.

Organism-specific databases

CTDi7351.
RGDi3932. Ucp2.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP56500.
KOiK15103.
OMAiLLKAHLM.
OrthoDBiEOG091G0BQ7.
PhylomeDBiP56500.
TreeFamiTF323211.

Enzyme and pathway databases

ReactomeiR-RNO-167826. The fatty acid cycling model.
R-RNO-167827. The proton buffering model.

Miscellaneous databases

PROiP56500.

Gene expression databases

BgeeiENSRNOG00000017854.
GenevisibleiP56500. RN.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUCP2_RAT
AccessioniPrimary (citable) accession number: P56500
Secondary accession number(s): O70178, O88183, Q6GST1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.