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P56500

- UCP2_RAT

UniProt

P56500 - UCP2_RAT

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Protein
Mitochondrial uncoupling protein 2
Gene
Ucp2, Slc25a8
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat By similarity.

GO - Biological processi

  1. aging Source: RGD
  2. cellular response to amino acid starvation Source: RGD
  3. cellular response to glucose stimulus Source: RGD
  4. cellular response to hormone stimulus Source: RGD
  5. cellular response to insulin stimulus Source: RGD
  6. female pregnancy Source: RGD
  7. liver regeneration Source: RGD
  8. mitochondrial transport Source: RGD
  9. negative regulation of apoptotic process Source: RGD
  10. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
  11. positive regulation of cell death Source: RGD
  12. response to fatty acid Source: RGD
  13. response to glucose Source: RGD
  14. response to hypoxia Source: RGD
  15. response to superoxide Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 2
Short name:
UCP 2
Alternative name(s):
Solute carrier family 25 member 8
Gene namesi
Name:Ucp2
Synonyms:Slc25a8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi3932. Ucp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Mitochondrial matrix Reviewed prediction
Transmembranei11 – 3222Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini33 – 7745Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei78 – 10023Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini101 – 11919Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei120 – 13617Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini137 – 18044Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei181 – 19717Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini198 – 21417Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei215 – 23420Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini235 – 26834Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei269 – 29123Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini292 – 30918Mitochondrial matrix Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Mitochondrial uncoupling protein 2
PRO_0000090667Add
BLAST

Proteomic databases

PaxDbiP56500.
PRIDEiP56500.

Expressioni

Tissue specificityi

Expressed in a variety of organs, with predominant expression in the heart, lung and spleen.

Gene expression databases

GenevestigatoriP56500.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024156.

Structurei

3D structure databases

ProteinModelPortaliP56500.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10696Solcar 1
Add
BLAST
Repeati114 – 20390Solcar 2
Add
BLAST
Repeati212 – 29786Solcar 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni276 – 29823Purine nucleotide binding By similarity
Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300436.
GeneTreeiENSGT00750000117384.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP56500.
KOiK15103.
OMAiSPNIARN.
OrthoDBiEOG793B7Z.
PhylomeDBiP56500.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56500-1 [UniParc]FASTAAdd to Basket

« Hide

MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGL    50
ARTAASAQYR GVLGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY 100
DSVKQFYTKG SEHAGIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA 150
GGGRRYQSTV EAYKTIAREE GIRGLWKGTS PNVARNAIVN CTELVTYDLI 200
KDTLLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY 250
HSAGHCALTM LRKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA 300
AYESREAPF 309
Length:309
Mass (Da):33,377
Last modified:July 15, 1998 - v1
Checksum:i3297935CF997AA0E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → L in BAA28832. 1 Publication
Sequence conflicti268 – 2681A → T in BAA25698. 1 Publication
Sequence conflicti268 – 2681A → T in AAH62230. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039033 mRNA. Translation: AAC98733.1.
AB006613 mRNA. Translation: BAA23383.1.
AB010743 mRNA. Translation: BAA25698.1.
AB005143 mRNA. Translation: BAA28832.1.
BC062230 mRNA. Translation: AAH62230.1.
RefSeqiNP_062227.2. NM_019354.2.
XP_006229846.1. XM_006229784.1.
UniGeneiRn.13333.

Genome annotation databases

EnsembliENSRNOT00000024156; ENSRNOP00000024156; ENSRNOG00000017854.
GeneIDi54315.
KEGGirno:54315.
UCSCiRGD:3932. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039033 mRNA. Translation: AAC98733.1 .
AB006613 mRNA. Translation: BAA23383.1 .
AB010743 mRNA. Translation: BAA25698.1 .
AB005143 mRNA. Translation: BAA28832.1 .
BC062230 mRNA. Translation: AAH62230.1 .
RefSeqi NP_062227.2. NM_019354.2.
XP_006229846.1. XM_006229784.1.
UniGenei Rn.13333.

3D structure databases

ProteinModelPortali P56500.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000024156.

Proteomic databases

PaxDbi P56500.
PRIDEi P56500.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024156 ; ENSRNOP00000024156 ; ENSRNOG00000017854 .
GeneIDi 54315.
KEGGi rno:54315.
UCSCi RGD:3932. rat.

Organism-specific databases

CTDi 7351.
RGDi 3932. Ucp2.

Phylogenomic databases

eggNOGi NOG300436.
GeneTreei ENSGT00750000117384.
HOGENOMi HOG000165140.
HOVERGENi HBG009528.
InParanoidi P56500.
KOi K15103.
OMAi SPNIARN.
OrthoDBi EOG793B7Z.
PhylomeDBi P56500.
TreeFami TF323211.

Miscellaneous databases

NextBioi 610992.
PROi P56500.

Gene expression databases

Genevestigatori P56500.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00784. MTUNCOUPLING.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Strobel A., Strosberg A.D., Issad T.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: White adipose tissue.
  2. "Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet."
    Matsuda J., Hosoda K., Itoh H., Son C., Doi K., Tanaka T., Fukunaga Y., Inoue G., Nishimura H., Yoshimasa Y., Yamori Y., Nakao K.
    FEBS Lett. 418:200-204(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brown adipose tissue.
  3. Yamazaki K., Yoshitomi H., Tanaka I.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spleen.
  4. "Molecular cloning of rat uncoupling protein 2 cDNA and its expression in genetically obese Zucker fatty (fa/fa) rats."
    Hidaka S., Kakuma T., Yoshimatsu H., Yasunaga S., Kurokawa M., Sakata T.
    Biochim. Biophys. Acta 1389:178-186(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiUCP2_RAT
AccessioniPrimary (citable) accession number: P56500
Secondary accession number(s): O70178, O88183, Q6GST1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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