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P56500

- UCP2_RAT

UniProt

P56500 - UCP2_RAT

Protein

Mitochondrial uncoupling protein 2

Gene

Ucp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat By similarity.By similarity

    GO - Biological processi

    1. aging Source: RGD
    2. cellular response to amino acid starvation Source: RGD
    3. cellular response to glucose stimulus Source: RGD
    4. cellular response to hormone stimulus Source: RGD
    5. cellular response to insulin stimulus Source: RGD
    6. female pregnancy Source: RGD
    7. liver regeneration Source: RGD
    8. mitochondrial transport Source: RGD
    9. negative regulation of apoptotic process Source: RGD
    10. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
    11. positive regulation of cell death Source: RGD
    12. response to fatty acid Source: RGD
    13. response to glucose Source: RGD
    14. response to hypoxia Source: RGD
    15. response to superoxide Source: RGD

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial uncoupling protein 2
    Short name:
    UCP 2
    Alternative name(s):
    Solute carrier family 25 member 8
    Gene namesi
    Name:Ucp2
    Synonyms:Slc25a8
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi3932. Ucp2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: RGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Mitochondrial uncoupling protein 2PRO_0000090667Add
    BLAST

    Proteomic databases

    PaxDbiP56500.
    PRIDEiP56500.

    Expressioni

    Tissue specificityi

    Expressed in a variety of organs, with predominant expression in the heart, lung and spleen.

    Gene expression databases

    GenevestigatoriP56500.

    Interactioni

    Subunit structurei

    Acts as a dimer forming a proton channel.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000024156.

    Structurei

    3D structure databases

    ProteinModelPortaliP56500.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010Mitochondrial matrixSequence Analysis
    Topological domaini33 – 7745Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini101 – 11919Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini137 – 18044Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini198 – 21417Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini235 – 26834Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini292 – 30918Mitochondrial matrixSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3222Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 10023Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 13617Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei181 – 19717Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei215 – 23420Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 29123Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 10696Solcar 1Add
    BLAST
    Repeati114 – 20390Solcar 2Add
    BLAST
    Repeati212 – 29786Solcar 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni276 – 29823Purine nucleotide bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300436.
    GeneTreeiENSGT00750000117384.
    HOGENOMiHOG000165140.
    HOVERGENiHBG009528.
    InParanoidiP56500.
    KOiK15103.
    OMAiSPNIARN.
    OrthoDBiEOG793B7Z.
    PhylomeDBiP56500.
    TreeFamiTF323211.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00784. MTUNCOUPLING.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56500-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGL    50
    ARTAASAQYR GVLGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY 100
    DSVKQFYTKG SEHAGIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA 150
    GGGRRYQSTV EAYKTIAREE GIRGLWKGTS PNVARNAIVN CTELVTYDLI 200
    KDTLLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY 250
    HSAGHCALTM LRKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA 300
    AYESREAPF 309
    Length:309
    Mass (Da):33,377
    Last modified:July 15, 1998 - v1
    Checksum:i3297935CF997AA0E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91V → L in BAA28832. (PubMed:9512646)Curated
    Sequence conflicti268 – 2681A → T in BAA25698. 1 PublicationCurated
    Sequence conflicti268 – 2681A → T in AAH62230. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039033 mRNA. Translation: AAC98733.1.
    AB006613 mRNA. Translation: BAA23383.1.
    AB010743 mRNA. Translation: BAA25698.1.
    AB005143 mRNA. Translation: BAA28832.1.
    BC062230 mRNA. Translation: AAH62230.1.
    RefSeqiNP_062227.2. NM_019354.2.
    XP_006229846.1. XM_006229784.1.
    UniGeneiRn.13333.

    Genome annotation databases

    EnsembliENSRNOT00000024156; ENSRNOP00000024156; ENSRNOG00000017854.
    GeneIDi54315.
    KEGGirno:54315.
    UCSCiRGD:3932. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039033 mRNA. Translation: AAC98733.1 .
    AB006613 mRNA. Translation: BAA23383.1 .
    AB010743 mRNA. Translation: BAA25698.1 .
    AB005143 mRNA. Translation: BAA28832.1 .
    BC062230 mRNA. Translation: AAH62230.1 .
    RefSeqi NP_062227.2. NM_019354.2.
    XP_006229846.1. XM_006229784.1.
    UniGenei Rn.13333.

    3D structure databases

    ProteinModelPortali P56500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000024156.

    Proteomic databases

    PaxDbi P56500.
    PRIDEi P56500.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024156 ; ENSRNOP00000024156 ; ENSRNOG00000017854 .
    GeneIDi 54315.
    KEGGi rno:54315.
    UCSCi RGD:3932. rat.

    Organism-specific databases

    CTDi 7351.
    RGDi 3932. Ucp2.

    Phylogenomic databases

    eggNOGi NOG300436.
    GeneTreei ENSGT00750000117384.
    HOGENOMi HOG000165140.
    HOVERGENi HBG009528.
    InParanoidi P56500.
    KOi K15103.
    OMAi SPNIARN.
    OrthoDBi EOG793B7Z.
    PhylomeDBi P56500.
    TreeFami TF323211.

    Miscellaneous databases

    NextBioi 610992.
    PROi P56500.

    Gene expression databases

    Genevestigatori P56500.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00784. MTUNCOUPLING.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Strobel A., Strosberg A.D., Issad T.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: White adipose tissue.
    2. "Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet."
      Matsuda J., Hosoda K., Itoh H., Son C., Doi K., Tanaka T., Fukunaga Y., Inoue G., Nishimura H., Yoshimasa Y., Yamori Y., Nakao K.
      FEBS Lett. 418:200-204(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brown adipose tissue.
    3. Yamazaki K., Yoshitomi H., Tanaka I.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Spleen.
    4. "Molecular cloning of rat uncoupling protein 2 cDNA and its expression in genetically obese Zucker fatty (fa/fa) rats."
      Hidaka S., Kakuma T., Yoshimatsu H., Yasunaga S., Kurokawa M., Sakata T.
      Biochim. Biophys. Acta 1389:178-186(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.

    Entry informationi

    Entry nameiUCP2_RAT
    AccessioniPrimary (citable) accession number: P56500
    Secondary accession number(s): O70178, O88183, Q6GST1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3