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Protein

Mitochondrial uncoupling protein 2

Gene

Ucp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adaptive thermogenesis Source: GO_Central
  • aging Source: RGD
  • cellular response to amino acid starvation Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to hormone stimulus Source: RGD
  • cellular response to insulin stimulus Source: RGD
  • female pregnancy Source: RGD
  • liver regeneration Source: RGD
  • mitochondrial transmembrane transport Source: GO_Central
  • mitochondrial transport Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
  • positive regulation of cell death Source: RGD
  • regulation of mitochondrial membrane potential Source: Ensembl
  • response to cold Source: GO_Central
  • response to fatty acid Source: RGD
  • response to glucose Source: RGD
  • response to hypoxia Source: RGD
  • response to superoxide Source: RGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-167826 The fatty acid cycling model
R-RNO-167827 The proton buffering model

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 2
Short name:
UCP 2
Alternative name(s):
Solute carrier family 25 member 8
Gene namesi
Name:Ucp2
Synonyms:Slc25a8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3932 Ucp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial matrixSequence analysis10
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini33 – 77Mitochondrial intermembraneSequence analysisAdd BLAST45
Transmembranei78 – 100Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini101 – 119Mitochondrial matrixSequence analysisAdd BLAST19
Transmembranei120 – 136Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini137 – 180Mitochondrial intermembraneSequence analysisAdd BLAST44
Transmembranei181 – 197Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini198 – 214Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei215 – 234Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini235 – 268Mitochondrial intermembraneSequence analysisAdd BLAST34
Transmembranei269 – 291Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini292 – 309Mitochondrial matrixSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906671 – 309Mitochondrial uncoupling protein 2Add BLAST309

Proteomic databases

PaxDbiP56500

PTM databases

PhosphoSitePlusiP56500

Expressioni

Tissue specificityi

Expressed in a variety of organs, with predominant expression in the heart, lung and spleen.

Gene expression databases

BgeeiENSRNOG00000017854
GenevisibleiP56500 RN

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024156

Structurei

3D structure databases

ProteinModelPortaliP56500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 106Solcar 1Add BLAST96
Repeati114 – 203Solcar 2Add BLAST90
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni276 – 298Purine nucleotide bindingBy similarityAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165140
HOVERGENiHBG009528
InParanoidiP56500
KOiK15103
OMAiSEHAGIG
OrthoDBiEOG091G0BQ7
PhylomeDBiP56500
TreeFamiTF323211

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002030 Mit_uncoupling_UCP-like
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00784 MTUNCOUPLING
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P56500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGL
60 70 80 90 100
ARTAASAQYR GVLGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY
110 120 130 140 150
DSVKQFYTKG SEHAGIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA
160 170 180 190 200
GGGRRYQSTV EAYKTIAREE GIRGLWKGTS PNVARNAIVN CTELVTYDLI
210 220 230 240 250
KDTLLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY
260 270 280 290 300
HSAGHCALTM LRKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA

AYESREAPF
Length:309
Mass (Da):33,377
Last modified:July 15, 1998 - v1
Checksum:i3297935CF997AA0E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → L in BAA28832 (PubMed:9512646).Curated1
Sequence conflicti268A → T in BAA25698 (Ref. 3) Curated1
Sequence conflicti268A → T in AAH62230 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039033 mRNA Translation: AAC98733.1
AB006613 mRNA Translation: BAA23383.1
AB010743 mRNA Translation: BAA25698.1
AB005143 mRNA Translation: BAA28832.1
BC062230 mRNA Translation: AAH62230.1
RefSeqiNP_062227.2, NM_019354.3
UniGeneiRn.13333

Genome annotation databases

EnsembliENSRNOT00000024156; ENSRNOP00000024156; ENSRNOG00000017854
GeneIDi54315
KEGGirno:54315
UCSCiRGD:3932 rat

Similar proteinsi

Entry informationi

Entry nameiUCP2_RAT
AccessioniPrimary (citable) accession number: P56500
Secondary accession number(s): O70178, O88183, Q6GST1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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