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Protein

Mitochondrial uncoupling protein 2

Gene

Ucp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).By similarity

GO - Biological processi

  1. aging Source: RGD
  2. cellular response to amino acid starvation Source: RGD
  3. cellular response to glucose stimulus Source: RGD
  4. cellular response to hormone stimulus Source: RGD
  5. cellular response to insulin stimulus Source: RGD
  6. female pregnancy Source: RGD
  7. liver regeneration Source: RGD
  8. mitochondrial transport Source: RGD
  9. negative regulation of apoptotic process Source: RGD
  10. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
  11. positive regulation of cell death Source: RGD
  12. regulation of mitochondrial membrane potential Source: Ensembl
  13. response to fatty acid Source: RGD
  14. response to glucose Source: RGD
  15. response to hypoxia Source: RGD
  16. response to superoxide Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_321970. The proton buffering model.
REACT_342800. The fatty acid cycling model.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 2
Short name:
UCP 2
Alternative name(s):
Solute carrier family 25 member 8
Gene namesi
Name:Ucp2
Synonyms:Slc25a8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3932. Ucp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Mitochondrial matrixSequence Analysis
Transmembranei11 – 3222Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini33 – 7745Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei78 – 10023Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini101 – 11919Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei120 – 13617Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 18044Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei181 – 19717Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini198 – 21417Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei215 – 23420Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini235 – 26834Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei269 – 29123Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini292 – 30918Mitochondrial matrixSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Mitochondrial uncoupling protein 2PRO_0000090667Add
BLAST

Proteomic databases

PaxDbiP56500.
PRIDEiP56500.

Expressioni

Tissue specificityi

Expressed in a variety of organs, with predominant expression in the heart, lung and spleen.

Gene expression databases

GenevestigatoriP56500.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024156.

Structurei

3D structure databases

ProteinModelPortaliP56500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10696Solcar 1Add
BLAST
Repeati114 – 20390Solcar 2Add
BLAST
Repeati212 – 29786Solcar 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni276 – 29823Purine nucleotide bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300436.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP56500.
KOiK15103.
OMAiLLKAHLM.
OrthoDBiEOG793B7Z.
PhylomeDBiP56500.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGL
60 70 80 90 100
ARTAASAQYR GVLGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY
110 120 130 140 150
DSVKQFYTKG SEHAGIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA
160 170 180 190 200
GGGRRYQSTV EAYKTIAREE GIRGLWKGTS PNVARNAIVN CTELVTYDLI
210 220 230 240 250
KDTLLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY
260 270 280 290 300
HSAGHCALTM LRKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA

AYESREAPF
Length:309
Mass (Da):33,377
Last modified:July 15, 1998 - v1
Checksum:i3297935CF997AA0E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → L in BAA28832 (PubMed:9512646).Curated
Sequence conflicti268 – 2681A → T in BAA25698 (Ref. 3) Curated
Sequence conflicti268 – 2681A → T in AAH62230 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039033 mRNA. Translation: AAC98733.1.
AB006613 mRNA. Translation: BAA23383.1.
AB010743 mRNA. Translation: BAA25698.1.
AB005143 mRNA. Translation: BAA28832.1.
BC062230 mRNA. Translation: AAH62230.1.
RefSeqiNP_062227.2. NM_019354.3.
UniGeneiRn.13333.

Genome annotation databases

EnsembliENSRNOT00000024156; ENSRNOP00000024156; ENSRNOG00000017854.
GeneIDi54315.
KEGGirno:54315.
UCSCiRGD:3932. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039033 mRNA. Translation: AAC98733.1.
AB006613 mRNA. Translation: BAA23383.1.
AB010743 mRNA. Translation: BAA25698.1.
AB005143 mRNA. Translation: BAA28832.1.
BC062230 mRNA. Translation: AAH62230.1.
RefSeqiNP_062227.2. NM_019354.3.
UniGeneiRn.13333.

3D structure databases

ProteinModelPortaliP56500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024156.

Proteomic databases

PaxDbiP56500.
PRIDEiP56500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024156; ENSRNOP00000024156; ENSRNOG00000017854.
GeneIDi54315.
KEGGirno:54315.
UCSCiRGD:3932. rat.

Organism-specific databases

CTDi7351.
RGDi3932. Ucp2.

Phylogenomic databases

eggNOGiNOG300436.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP56500.
KOiK15103.
OMAiLLKAHLM.
OrthoDBiEOG793B7Z.
PhylomeDBiP56500.
TreeFamiTF323211.

Enzyme and pathway databases

ReactomeiREACT_321970. The proton buffering model.
REACT_342800. The fatty acid cycling model.

Miscellaneous databases

NextBioi610992.
PROiP56500.

Gene expression databases

GenevestigatoriP56500.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Strobel A., Strosberg A.D., Issad T.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: White adipose tissue.
  2. "Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet."
    Matsuda J., Hosoda K., Itoh H., Son C., Doi K., Tanaka T., Fukunaga Y., Inoue G., Nishimura H., Yoshimasa Y., Yamori Y., Nakao K.
    FEBS Lett. 418:200-204(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brown adipose tissue.
  3. Yamazaki K., Yoshitomi H., Tanaka I.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spleen.
  4. "Molecular cloning of rat uncoupling protein 2 cDNA and its expression in genetically obese Zucker fatty (fa/fa) rats."
    Hidaka S., Kakuma T., Yoshimatsu H., Yasunaga S., Kurokawa M., Sakata T.
    Biochim. Biophys. Acta 1389:178-186(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiUCP2_RAT
AccessioniPrimary (citable) accession number: P56500
Secondary accession number(s): O70178, O88183, Q6GST1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 1, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.