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Protein

Mitochondrial uncoupling protein 3

Gene

Ucp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • cellular response to hormone stimulus Source: RGD
  • fatty acid metabolic process Source: Ensembl
  • mitochondrial transport Source: InterPro
  • response to activity Source: RGD
  • response to cold Source: RGD
  • response to glucocorticoid Source: RGD
  • response to hypoxia Source: HGNC
  • response to insulin Source: RGD
  • response to nutrient Source: RGD
  • response to steroid hormone Source: RGD
  • response to superoxide Source: RGD
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-167826. The fatty acid cycling model.
R-RNO-167827. The proton buffering model.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 3
Short name:
UCP 3
Alternative name(s):
Solute carrier family 25 member 9
Gene namesi
Name:Ucp3
Synonyms:Slc25a9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3933. Ucp3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3222Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei74 – 9623Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei117 – 13317Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei180 – 19617Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei214 – 23320Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei268 – 29023Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Mitochondrial uncoupling protein 3PRO_0000090675Add
BLAST

Proteomic databases

PaxDbiP56499.
PRIDEiP56499.

Expressioni

Gene expression databases

GenevisibleiP56499. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024005.

Structurei

3D structure databases

ProteinModelPortaliP56499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10292Solcar 1Add
BLAST
Repeati111 – 20292Solcar 2Add
BLAST
Repeati211 – 29686Solcar 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni275 – 29723Purine nucleotide bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP56499.
KOiK15103.
OMAiKGTWPNI.
OrthoDBiEOG793B7Z.
PhylomeDBiP56499.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGLQPSEVP PTTVVKFLGA GTAACFADLL TFPLDTAKVR LQIQGENPGV
60 70 80 90 100
QSVQYRGVLG TILTMVRTEG PRSPYSGLVA GLHRQMSFAS IRIGLYDSVK
110 120 130 140 150
QFYTPKGTDH SSVAIRILAG CTTGAMAVTC AQPTDVVKVR FQAMIRLGTG
160 170 180 190 200
GERKYRGTMD AYRTIAREEG VRGLWKGTWP NITRNAIVNC AEMVTYDIIK
210 220 230 240 250
EKLLDSHLFT DNFPCHFVSA FGAGFCATVV ASPVDVVKTR YMNAPPGRYR
260 270 280 290 300
SPLHCMLRMV AQEGPTAFYK GFMPSFLRLG SWNVMMFVTY EQLKRALMKV

QVLRESPF
Length:308
Mass (Da):34,015
Last modified:July 15, 1998 - v1
Checksum:iF86E784530ACC555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006614 mRNA. Translation: BAA23355.1.
U92069 mRNA. Translation: AAB71523.1.
AF035943 mRNA. Translation: AAC05740.1.
AF030163 mRNA. Translation: AAD01891.1.
BC072546 mRNA. Translation: AAH72546.1.
RefSeqiNP_037299.1. NM_013167.2.
UniGeneiRn.9902.

Genome annotation databases

EnsembliENSRNOT00000024005; ENSRNOP00000024005; ENSRNOG00000017716.
GeneIDi25708.
KEGGirno:25708.
UCSCiRGD:3933. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006614 mRNA. Translation: BAA23355.1.
U92069 mRNA. Translation: AAB71523.1.
AF035943 mRNA. Translation: AAC05740.1.
AF030163 mRNA. Translation: AAD01891.1.
BC072546 mRNA. Translation: AAH72546.1.
RefSeqiNP_037299.1. NM_013167.2.
UniGeneiRn.9902.

3D structure databases

ProteinModelPortaliP56499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024005.

Proteomic databases

PaxDbiP56499.
PRIDEiP56499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024005; ENSRNOP00000024005; ENSRNOG00000017716.
GeneIDi25708.
KEGGirno:25708.
UCSCiRGD:3933. rat.

Organism-specific databases

CTDi7352.
RGDi3933. Ucp3.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP56499.
KOiK15103.
OMAiKGTWPNI.
OrthoDBiEOG793B7Z.
PhylomeDBiP56499.
TreeFamiTF323211.

Enzyme and pathway databases

ReactomeiR-RNO-167826. The fatty acid cycling model.
R-RNO-167827. The proton buffering model.

Miscellaneous databases

PROiP56499.

Gene expression databases

GenevisibleiP56499. RN.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet."
    Matsuda J., Hosoda K., Itoh H., Son C., Doi K., Tanaka T., Fukunaga Y., Inoue G., Nishimura H., Yoshimasa Y., Yamori Y., Nakao K.
    FEBS Lett. 418:200-204(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Skeletal muscle.
  2. "Effect of endurance training on mRNA expression of uncoupling proteins 1, 2, and 3 in the rat."
    Boss O., Samec S., Desplanches D., Mayet M.-H., Seydoux J., Muzzin P., Giacobino J.-P.
    FASEB J. 12:335-339(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Skeletal muscle.
  3. "Bidirectional regulation of uncoupling protein-3 and GLUT-4 mRNA in skeletal muscle by cold."
    Lin B.-Z., Coughlin S., Pilch P.F.
    Am. J. Physiol. 275:E386-E391(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Skeletal muscle.
  4. "Lipopolysaccharide treatment increases thermogenesis and induces uncoupling protein-3 gene expression in skeletal muscle."
    Solanes G., Valet P., Lowell B.B.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Skeletal muscle.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiUCP3_RAT
AccessioniPrimary (citable) accession number: P56499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.