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P56497

- EDNRB_CANFA

UniProt

P56497 - EDNRB_CANFA

Protein

Endothelin B receptor

Gene

EDNRB

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 3 (12 Apr 2005)
      Previous versions | rss
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    Functioni

    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. endothelin receptor activity Source: InterPro

    GO - Biological processi

    1. enteric nervous system development Source: InterPro
    2. regulation of blood pressure Source: InterPro
    3. vasoconstriction Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin B receptor
    Short name:
    ET-B
    Short name:
    ET-BR
    Alternative name(s):
    Endothelin receptor non-selective type
    Gene namesi
    Name:EDNRB
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 442416Endothelin B receptorPRO_0000012727Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi174 ↔ 255PROSITE-ProRule annotation
    Modified residuei305 – 3051PhosphoserineBy similarity
    Lipidationi402 – 4021S-palmitoyl cysteineSequence Analysis
    Lipidationi403 – 4031S-palmitoyl cysteineSequence Analysis
    Lipidationi405 – 4051S-palmitoyl cysteineSequence Analysis
    Modified residuei419 – 4191PhosphoserineBy similarity
    Modified residuei439 – 4391PhosphotyrosineBy similarity
    Modified residuei440 – 4401PhosphoserineBy similarity
    Modified residuei441 – 4411PhosphoserineBy similarity
    Modified residuei442 – 4421PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP56497.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 10175ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 13711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 17512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini198 – 21821CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini244 – 27128ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 32428CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini351 – 36212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini390 – 44253CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei102 – 12625Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 16326Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei176 – 19722Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 24325Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29625Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei325 – 35026Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei363 – 38927Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG278704.
    HOGENOMiHOG000272623.
    HOVERGENiHBG051443.
    InParanoidiP56497.
    KOiK04198.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000499. Endthln_rcpt.
    IPR001112. ETB_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00571. ENDOTHELINBR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56497-1 [UniParc]FASTAAdd to Basket

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    MQPPPSLCGR ALVALVLACG LSRIWGEERG FPPDRATPLL QTAEIMTPPT    50
    KTLWPKGSNA SLARSLAPAE VPKGDRTAGS PPRTISPPPC EGSIEIKETF 100
    KYINTVVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH 150
    IIIDIPITVY KLLAEDWPFG VEMCKLVPFI QKASVGITVL SLCALSIDRY 200
    RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAVGF DMITIDYKGR 250
    YLRICLLHPT QKTAFMQFYK TAKDWWLFSF YFCLPLAITA FFYTLMTCEM 300
    LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTIY 350
    DQNDPNRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC 400
    LCCWCQSFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS 442
    Length:442
    Mass (Da):49,722
    Last modified:April 12, 2005 - v3
    Checksum:i3E9EE7AE581D7E15
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB183285 mRNA. Translation: BAD83850.1.
    AF034530 mRNA. Translation: AAC26970.1.
    RefSeqiNP_001010943.2. NM_001010943.2.
    UniGeneiCfa.3590.

    Genome annotation databases

    GeneIDi403862.
    KEGGicfa:403862.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB183285 mRNA. Translation: BAD83850.1 .
    AF034530 mRNA. Translation: AAC26970.1 .
    RefSeqi NP_001010943.2. NM_001010943.2.
    UniGenei Cfa.3590.

    3D structure databases

    ProteinModelPortali P56497.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403862.
    KEGGi cfa:403862.

    Organism-specific databases

    CTDi 1910.

    Phylogenomic databases

    eggNOGi NOG278704.
    HOGENOMi HOG000272623.
    HOVERGENi HBG051443.
    InParanoidi P56497.
    KOi K04198.

    Miscellaneous databases

    NextBioi 20817355.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000499. Endthln_rcpt.
    IPR001112. ETB_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00571. ENDOTHELINBR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression analysis of endothelin receptor type B gene in canine atopic dermatitis."
      Tsukui T., Yasuda N., Maeda S., Koyanagi M., Hashimoto R., Masuda K., Ohno K., Sakaguchi M., Tsujimoto H., Iwabuchi S.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Zemke D., Yuzbasiyan-Gurkan V.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-426.

    Entry informationi

    Entry nameiEDNRB_CANFA
    AccessioniPrimary (citable) accession number: P56497
    Secondary accession number(s): Q5KSU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 89 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3