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P56497 (EDNRB_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin B receptor

Short name=ET-B
Short name=ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene names
Name:EDNRB
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 442416Endothelin B receptor
PRO_0000012727

Regions

Topological domain27 – 10175Extracellular Potential
Transmembrane102 – 12625Helical; Name=1; Potential
Topological domain127 – 13711Cytoplasmic Potential
Transmembrane138 – 16326Helical; Name=2; Potential
Topological domain164 – 17512Extracellular Potential
Transmembrane176 – 19722Helical; Name=3; Potential
Topological domain198 – 21821Cytoplasmic Potential
Transmembrane219 – 24325Helical; Name=4; Potential
Topological domain244 – 27128Extracellular Potential
Transmembrane272 – 29625Helical; Name=5; Potential
Topological domain297 – 32428Cytoplasmic Potential
Transmembrane325 – 35026Helical; Name=6; Potential
Topological domain351 – 36212Extracellular Potential
Transmembrane363 – 38927Helical; Name=7; Potential
Topological domain390 – 44253Cytoplasmic Potential

Amino acid modifications

Modified residue3051Phosphoserine By similarity
Modified residue4191Phosphoserine By similarity
Modified residue4391Phosphotyrosine By similarity
Modified residue4401Phosphoserine By similarity
Modified residue4411Phosphoserine By similarity
Modified residue4421Phosphoserine By similarity
Lipidation4021S-palmitoyl cysteine Potential
Lipidation4031S-palmitoyl cysteine Potential
Lipidation4051S-palmitoyl cysteine Potential
Glycosylation591N-linked (GlcNAc...) Potential
Disulfide bond174 ↔ 255 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56497 [UniParc].

Last modified April 12, 2005. Version 3.
Checksum: 3E9EE7AE581D7E15

FASTA44249,722
        10         20         30         40         50         60 
MQPPPSLCGR ALVALVLACG LSRIWGEERG FPPDRATPLL QTAEIMTPPT KTLWPKGSNA 

        70         80         90        100        110        120 
SLARSLAPAE VPKGDRTAGS PPRTISPPPC EGSIEIKETF KYINTVVSCL VFVLGIIGNS 

       130        140        150        160        170        180 
TLLRIIYKNK CMRNGPNILI ASLALGDLLH IIIDIPITVY KLLAEDWPFG VEMCKLVPFI 

       190        200        210        220        230        240 
QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAVGF 

       250        260        270        280        290        300 
DMITIDYKGR YLRICLLHPT QKTAFMQFYK TAKDWWLFSF YFCLPLAITA FFYTLMTCEM 

       310        320        330        340        350        360 
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTIY DQNDPNRCEL 

       370        380        390        400        410        420 
LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQSFEE KQSLEEKQSC 

       430        440 
LKFKANDHGY DNFRSSNKYS SS 

« Hide

References

[1]"Expression analysis of endothelin receptor type B gene in canine atopic dermatitis."
Tsukui T., Yasuda N., Maeda S., Koyanagi M., Hashimoto R., Masuda K., Ohno K., Sakaguchi M., Tsujimoto H., Iwabuchi S.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Zemke D., Yuzbasiyan-Gurkan V.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-426.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB183285 mRNA. Translation: BAD83850.1.
AF034530 mRNA. Translation: AAC26970.1.
RefSeqNP_001010943.2. NM_001010943.2.
UniGeneCfa.3590.

3D structure databases

ProteinModelPortalP56497.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403862.
KEGGcfa:403862.

Organism-specific databases

CTD1910.

Phylogenomic databases

eggNOGNOG278704.
HOGENOMHOG000272623.
HOVERGENHBG051443.
InParanoidP56497.
KOK04198.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817355.

Entry information

Entry nameEDNRB_CANFA
AccessionPrimary (citable) accession number: P56497
Secondary accession number(s): Q5KSU8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 12, 2005
Last modified: April 16, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries