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P56497

- EDNRB_CANFA

UniProt

P56497 - EDNRB_CANFA

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Protein
Endothelin B receptor
Gene
EDNRB
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. endothelin receptor activity Source: InterPro

GO - Biological processi

  1. enteric nervous system development Source: InterPro
  2. regulation of blood pressure Source: InterPro
  3. vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin B receptor
Short name:
ET-B
Short name:
ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene namesi
Name:EDNRB
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 10175Extracellular Reviewed prediction
Add
BLAST
Transmembranei102 – 12625Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini127 – 13711Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei138 – 16326Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini164 – 17512Extracellular Reviewed prediction
Add
BLAST
Transmembranei176 – 19722Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini198 – 21821Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei219 – 24325Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini244 – 27128Extracellular Reviewed prediction
Add
BLAST
Transmembranei272 – 29625Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini297 – 32428Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei325 – 35026Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini351 – 36212Extracellular Reviewed prediction
Add
BLAST
Transmembranei363 – 38927Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini390 – 44253Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 442416Endothelin B receptor
PRO_0000012727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi174 ↔ 255 By similarity
Modified residuei305 – 3051Phosphoserine By similarity
Lipidationi402 – 4021S-palmitoyl cysteine Reviewed prediction
Lipidationi403 – 4031S-palmitoyl cysteine Reviewed prediction
Lipidationi405 – 4051S-palmitoyl cysteine Reviewed prediction
Modified residuei419 – 4191Phosphoserine By similarity
Modified residuei439 – 4391Phosphotyrosine By similarity
Modified residuei440 – 4401Phosphoserine By similarity
Modified residuei441 – 4411Phosphoserine By similarity
Modified residuei442 – 4421Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP56497.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278704.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP56497.
KOiK04198.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56497-1 [UniParc]FASTAAdd to Basket

« Hide

MQPPPSLCGR ALVALVLACG LSRIWGEERG FPPDRATPLL QTAEIMTPPT    50
KTLWPKGSNA SLARSLAPAE VPKGDRTAGS PPRTISPPPC EGSIEIKETF 100
KYINTVVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH 150
IIIDIPITVY KLLAEDWPFG VEMCKLVPFI QKASVGITVL SLCALSIDRY 200
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAVGF DMITIDYKGR 250
YLRICLLHPT QKTAFMQFYK TAKDWWLFSF YFCLPLAITA FFYTLMTCEM 300
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTIY 350
DQNDPNRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC 400
LCCWCQSFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS 442
Length:442
Mass (Da):49,722
Last modified:April 12, 2005 - v3
Checksum:i3E9EE7AE581D7E15
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB183285 mRNA. Translation: BAD83850.1.
AF034530 mRNA. Translation: AAC26970.1.
RefSeqiNP_001010943.2. NM_001010943.2.
UniGeneiCfa.3590.

Genome annotation databases

GeneIDi403862.
KEGGicfa:403862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB183285 mRNA. Translation: BAD83850.1 .
AF034530 mRNA. Translation: AAC26970.1 .
RefSeqi NP_001010943.2. NM_001010943.2.
UniGenei Cfa.3590.

3D structure databases

ProteinModelPortali P56497.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403862.
KEGGi cfa:403862.

Organism-specific databases

CTDi 1910.

Phylogenomic databases

eggNOGi NOG278704.
HOGENOMi HOG000272623.
HOVERGENi HBG051443.
InParanoidi P56497.
KOi K04198.

Miscellaneous databases

NextBioi 20817355.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression analysis of endothelin receptor type B gene in canine atopic dermatitis."
    Tsukui T., Yasuda N., Maeda S., Koyanagi M., Hashimoto R., Masuda K., Ohno K., Sakaguchi M., Tsujimoto H., Iwabuchi S.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Zemke D., Yuzbasiyan-Gurkan V.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-426.

Entry informationi

Entry nameiEDNRB_CANFA
AccessioniPrimary (citable) accession number: P56497
Secondary accession number(s): Q5KSU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 12, 2005
Last modified: April 16, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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