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Protein

Endothelin B receptor

Gene

EDNRB

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin B receptor
Short name:
ET-B
Short name:
ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene namesi
Name:EDNRB
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 10175ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12625Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini127 – 13711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 16326Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini164 – 17512ExtracellularSequence AnalysisAdd
BLAST
Transmembranei176 – 19722Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini198 – 21821CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei219 – 24325Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini244 – 27128ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29625Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini297 – 32428CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei325 – 35026Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini351 – 36212ExtracellularSequence AnalysisAdd
BLAST
Transmembranei363 – 38927Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini390 – 44253CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 442416Endothelin B receptorPRO_0000012727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi174 ↔ 255PROSITE-ProRule annotation
Modified residuei305 – 3051PhosphoserineBy similarity
Lipidationi402 – 4021S-palmitoyl cysteineSequence Analysis
Lipidationi403 – 4031S-palmitoyl cysteineSequence Analysis
Lipidationi405 – 4051S-palmitoyl cysteineSequence Analysis
Modified residuei419 – 4191PhosphoserineBy similarity
Modified residuei439 – 4391PhosphotyrosineBy similarity
Modified residuei440 – 4401PhosphoserineBy similarity
Modified residuei441 – 4411PhosphoserineBy similarity
Modified residuei442 – 4421PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007760.

Structurei

3D structure databases

ProteinModelPortaliP56497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278704.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP56497.
KOiK04198.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPPPSLCGR ALVALVLACG LSRIWGEERG FPPDRATPLL QTAEIMTPPT
60 70 80 90 100
KTLWPKGSNA SLARSLAPAE VPKGDRTAGS PPRTISPPPC EGSIEIKETF
110 120 130 140 150
KYINTVVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH
160 170 180 190 200
IIIDIPITVY KLLAEDWPFG VEMCKLVPFI QKASVGITVL SLCALSIDRY
210 220 230 240 250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAVGF DMITIDYKGR
260 270 280 290 300
YLRICLLHPT QKTAFMQFYK TAKDWWLFSF YFCLPLAITA FFYTLMTCEM
310 320 330 340 350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTIY
360 370 380 390 400
DQNDPNRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC
410 420 430 440
LCCWCQSFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS
Length:442
Mass (Da):49,722
Last modified:April 12, 2005 - v3
Checksum:i3E9EE7AE581D7E15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB183285 mRNA. Translation: BAD83850.1.
AF034530 mRNA. Translation: AAC26970.1.
RefSeqiNP_001010943.2. NM_001010943.2.
UniGeneiCfa.3590.

Genome annotation databases

GeneIDi403862.
KEGGicfa:403862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB183285 mRNA. Translation: BAD83850.1.
AF034530 mRNA. Translation: AAC26970.1.
RefSeqiNP_001010943.2. NM_001010943.2.
UniGeneiCfa.3590.

3D structure databases

ProteinModelPortaliP56497.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007760.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403862.
KEGGicfa:403862.

Organism-specific databases

CTDi1910.

Phylogenomic databases

eggNOGiNOG278704.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP56497.
KOiK04198.

Miscellaneous databases

NextBioi20817355.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression analysis of endothelin receptor type B gene in canine atopic dermatitis."
    Tsukui T., Yasuda N., Maeda S., Koyanagi M., Hashimoto R., Masuda K., Ohno K., Sakaguchi M., Tsujimoto H., Iwabuchi S.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Zemke D., Yuzbasiyan-Gurkan V.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-426.

Entry informationi

Entry nameiEDNRB_CANFA
AccessioniPrimary (citable) accession number: P56497
Secondary accession number(s): Q5KSU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 12, 2005
Last modified: June 24, 2015
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.