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Protein

Endothelin B receptor

Gene

EDNRB

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin B receptor
Short name:
ET-B
Short name:
ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene namesi
Name:EDNRB
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 101ExtracellularSequence analysisAdd BLAST75
Transmembranei102 – 126Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini127 – 137CytoplasmicSequence analysisAdd BLAST11
Transmembranei138 – 163Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini164 – 175ExtracellularSequence analysisAdd BLAST12
Transmembranei176 – 197Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini198 – 218CytoplasmicSequence analysisAdd BLAST21
Transmembranei219 – 243Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini244 – 271ExtracellularSequence analysisAdd BLAST28
Transmembranei272 – 296Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini297 – 324CytoplasmicSequence analysisAdd BLAST28
Transmembranei325 – 350Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini351 – 362ExtracellularSequence analysisAdd BLAST12
Transmembranei363 – 389Helical; Name=7Sequence analysisAdd BLAST27
Topological domaini390 – 442CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001272727 – 442Endothelin B receptorAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi174 ↔ 255PROSITE-ProRule annotation
Modified residuei305PhosphoserineBy similarity1
Lipidationi402S-palmitoyl cysteineSequence analysis1
Lipidationi403S-palmitoyl cysteineSequence analysis1
Lipidationi405S-palmitoyl cysteineSequence analysis1
Modified residuei419PhosphoserineBy similarity1
Modified residuei439PhosphotyrosineBy similarity1
Modified residuei440PhosphoserineBy similarity1
Modified residuei441PhosphoserineBy similarity1
Modified residuei442PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP56497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP56497.
KOiK04198.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPPPSLCGR ALVALVLACG LSRIWGEERG FPPDRATPLL QTAEIMTPPT
60 70 80 90 100
KTLWPKGSNA SLARSLAPAE VPKGDRTAGS PPRTISPPPC EGSIEIKETF
110 120 130 140 150
KYINTVVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH
160 170 180 190 200
IIIDIPITVY KLLAEDWPFG VEMCKLVPFI QKASVGITVL SLCALSIDRY
210 220 230 240 250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAVGF DMITIDYKGR
260 270 280 290 300
YLRICLLHPT QKTAFMQFYK TAKDWWLFSF YFCLPLAITA FFYTLMTCEM
310 320 330 340 350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTIY
360 370 380 390 400
DQNDPNRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC
410 420 430 440
LCCWCQSFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS
Length:442
Mass (Da):49,722
Last modified:April 12, 2005 - v3
Checksum:i3E9EE7AE581D7E15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB183285 mRNA. Translation: BAD83850.1.
AF034530 mRNA. Translation: AAC26970.1.
RefSeqiNP_001010943.2. NM_001010943.2.
UniGeneiCfa.3590.

Genome annotation databases

GeneIDi403862.
KEGGicfa:403862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB183285 mRNA. Translation: BAD83850.1.
AF034530 mRNA. Translation: AAC26970.1.
RefSeqiNP_001010943.2. NM_001010943.2.
UniGeneiCfa.3590.

3D structure databases

ProteinModelPortaliP56497.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403862.
KEGGicfa:403862.

Organism-specific databases

CTDi1910.

Phylogenomic databases

HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP56497.
KOiK04198.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDNRB_CANLF
AccessioniPrimary (citable) accession number: P56497
Secondary accession number(s): Q5KSU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 12, 2005
Last modified: June 8, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.