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Protein

Oxytocin receptor

Gene

OXTR

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin receptor
Short name:
OT-R
Gene namesi
Name:OXTR
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 6325Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 7411CytoplasmicSequence analysisAdd
BLAST
Transmembranei75 – 9723Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini98 – 11316ExtracellularSequence analysisAdd
BLAST
Transmembranei114 – 13522Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini136 – 15419CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini176 – 20227ExtracellularSequence analysisAdd
BLAST
Transmembranei203 – 22523Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini226 – 27550CytoplasmicSequence analysisAdd
BLAST
Transmembranei276 – 29419Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini295 – 30915ExtracellularSequence analysisAdd
BLAST
Transmembranei310 – 33223Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini333 – 38957CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Oxytocin receptorPRO_0000069999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis
Disulfide bondi112 ↔ 187PROSITE-ProRule annotation
Modified residuei366 – 3661PhosphoserineBy similarity
Modified residuei368 – 3681PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012694.

Chemistry

BindingDBiP56494.

Structurei

3D structure databases

ProteinModelPortaliP56494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP56494.
KOiK04229.
OMAiCCSASYL.
OrthoDBiEOG091G0DB6.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF19. PTHR24241:SF19. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGELAANWS TEAVNSSAAP PGAEGNCTAG PPRRNEALAR VEVAVLCLIL
60 70 80 90 100
FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD
110 120 130 140 150
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR
160 170 180 190 200
RTDRLAVLAT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY
210 220 230 240 250
ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AEAPEGAAAG
260 270 280 290 300
DGGRMALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW
310 320 330 340 350
DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS
360 370 380
YLKGNRLGET STSKKSNSSS FVLSHRSSSQ RSCSQPSTA
Length:389
Mass (Da):42,914
Last modified:July 15, 1998 - v1
Checksum:iC7EAD8D6F9C51D7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82440 mRNA. Translation: AAC52031.1.
RefSeqiNP_001038197.1. NM_001044732.1.
UniGeneiMmu.3454.

Genome annotation databases

EnsembliENSMMUT00000013548; ENSMMUP00000012694; ENSMMUG00000009703.
GeneIDi702048.
KEGGimcc:702048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82440 mRNA. Translation: AAC52031.1.
RefSeqiNP_001038197.1. NM_001044732.1.
UniGeneiMmu.3454.

3D structure databases

ProteinModelPortaliP56494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012694.

Chemistry

BindingDBiP56494.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000013548; ENSMMUP00000012694; ENSMMUG00000009703.
GeneIDi702048.
KEGGimcc:702048.

Organism-specific databases

CTDi5021.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP56494.
KOiK04229.
OMAiCCSASYL.
OrthoDBiEOG091G0DB6.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF19. PTHR24241:SF19. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOXYR_MACMU
AccessioniPrimary (citable) accession number: P56494
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.