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P56494 (OXYR_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Oxytocin receptor
Short name=OT-R
Gene names
Name:OXTR
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Oxytocin receptor
PRO_0000069999

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 6325Helical; Name=1; Potential
Topological domain64 – 7411Cytoplasmic Potential
Transmembrane75 – 9723Helical; Name=2; Potential
Topological domain98 – 11316Extracellular Potential
Transmembrane114 – 13522Helical; Name=3; Potential
Topological domain136 – 15419Cytoplasmic Potential
Transmembrane155 – 17521Helical; Name=4; Potential
Topological domain176 – 20227Extracellular Potential
Transmembrane203 – 22523Helical; Name=5; Potential
Topological domain226 – 27550Cytoplasmic Potential
Transmembrane276 – 29419Helical; Name=6; Potential
Topological domain295 – 30915Extracellular Potential
Transmembrane310 – 33223Helical; Name=7; Potential
Topological domain333 – 38957Cytoplasmic Potential

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation261N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56494 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: C7EAD8D6F9C51D7B

FASTA38942,914
        10         20         30         40         50         60 
MEGELAANWS TEAVNSSAAP PGAEGNCTAG PPRRNEALAR VEVAVLCLIL FLALSGNACV 

        70         80         90        100        110        120 
LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV 

       130        140        150        160        170        180 
VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV 

       190        200        210        220        230        240 
ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA 

       250        260        270        280        290        300 
AEAPEGAAAG DGGRMALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW 

       310        320        330        340        350        360 
DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS YLKGNRLGET 

       370        380 
STSKKSNSSS FVLSHRSSSQ RSCSQPSTA

« Hide

References

[1]"Cloning and expression of the rhesus monkey oxytocin receptor."
Salvatore C.A., Woyden C.J., Guidotti M.T., Pettibone D.J., Jacobson M.A.
J. Recept. Signal Transduct. 18:15-24(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U82440 mRNA. Translation: AAC52031.1.
RefSeqNP_001038197.1. NM_001044732.1.
UniGeneMmu.3454.

3D structure databases

ProteinModelPortalP56494.
ModBaseSearch...

Protein-protein interaction databases

STRING9544.ENSMMUP00000012694.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMMUT00000013548; ENSMMUP00000012694; ENSMMUG00000009703.
GeneID702048.
KEGGmcc:702048.

Organism-specific databases

CTD5021.

Phylogenomic databases

eggNOGNOG299951.
GeneTreeENSGT00660000095384.
HOGENOMHOG000237331.
HOVERGENHBG105710.
InParanoidP56494.
KOK04229.
OMAGPPRRNE.
OrthoDBEOG4VHK6S.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP56494.
NextBio19961865.

Entry information

Entry nameOXYR_MACMU
AccessionPrimary (citable) accession number: P56494
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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