Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P56485 (CXCR7_MOUSE)

Last modified June 16, 2009. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    C-X-C chemokine receptor type 7
      Short name=CXC-R7
      Short name=CXCR-7
Alternative name(s):
    G-protein coupled receptor RDC1 homolog
      Short name=RDC-1
    Chemokine orphan receptor 1
Gene names
Name: Cxcr7
Synonyms: Cmkor1, Rdc1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Receptor for CXCL12/SDF1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in heart, spleen, kidney, astrocytes, and neutrophils.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Hide | Top

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological processG-protein coupled receptor protein signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362C-X-C chemokine receptor type 7
PRO_0000070102

Regions

Topological domain1 – 4747Extracellular Potential
Transmembrane48 – 68211 Potential
Topological domain69 – 8113Cytoplasmic Potential
Transmembrane82 – 102212 Potential
Topological domain103 – 11816Extracellular Potential
Transmembrane119 – 139213 Potential
Topological domain140 – 16223Cytoplasmic Potential
Transmembrane163 – 183214 Potential
Topological domain184 – 21330Extracellular Potential
Transmembrane214 – 234215 Potential
Topological domain235 – 25218Cytoplasmic Potential
Transmembrane253 – 273216 Potential
Topological domain274 – 29623Extracellular Potential
Transmembrane297 – 319237 Potential
Topological domain320 – 36243Cytoplasmic Potential

Amino acid modifications

Glycosylation131N-linked (GlcNAc...) Potential
Glycosylation221N-linked (GlcNAc...) Potential
Disulfide bond117 ↔ 196 By similarity

Experimental info

Sequence conflict971I → T in AAB71343. Ref.1
Sequence conflict1851T → A in AAB71343. Ref.1

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P56485-1 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: 7A0399DED5B73E66

FASTA36241,636
        10         20         30         40         50         60 
MDVHLFDYAE PGNYSDINWP CNSSDCIVVD TVQCPTMPNK NVLLYTLSFI YIFIFVIGMI 

        70         80         90        100        110        120 
ANSVVVWVNI QAKTTGYDTH CYILNLAIAD LWVVITIPVW VVSLVQHNQW PMGELTCKIT 

       130        140        150        160        170        180 
HLIFSINLFG SIFFLACMSV DRYLSITYFT GTSSYKKKMV RRVVCILVWL LAFFVSLPDT 

       190        200        210        220        230        240 
YYLKTVTSAS NNETYCRSFY PEHSIKEWLI GMELVSVILG FAVPFTIIAI FYFLLARAMS 

       250        260        270        280        290        300 
ASGDQEKHSS RKIIFSYVVV FLVCWLPYHF VVLLDIFSIL HYIPFTCQLE NVLFTALHVT 

       310        320        330        340        350        360 
QCLSLVHCCV NPVLYSFINR NYRYELMKAF IFKYSAKTGL TKLIDASRVS ETEYSALEQN 


TK

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Cloning and chromosomal mapping of an orphan chemokine receptor expressed in heart, spleen, kidney, astrocytes, and neutrophils."
Heesen M., Berman M.A., Charest A., Housman D., Gerard C., Dorf M.E.
Immunogenetics 47:364-370(1998) [PubMed: 9510554] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/SvJ.
Tissue: Peritoneal exudate.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Forelimb.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AF000236 mRNA. Translation: AAB71343.1.
AK031100 mRNA. Translation: BAC27252.1.
BC015254 mRNA. Translation: AAH15254.1.
IPIIPI00331263.
RefSeqNP_031748.2.
UniGeneMm.6522

3D structure databases

HSSPHSSP built from PDB template 1DDD based on UniProtKB P34996.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP56485.

Proteomic databases

PRIDEP56485.

Genome annotation databases

EnsemblENSMUSG00000044337. Mus musculus. [Contig view]
GeneID12778.
KEGGmmu:12778.

Organism-specific databases

MGIMGI:109562. Cxcr7.

Phylogenomic databases

HOVERGENP56485.
OMAP56485. INRNYRY.

Gene expression databases

ArrayExpressP56485.
BgeeP56485.
CleanExMM_CXCR7.
GermOnlineENSMUSG00000044337. Mus musculus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR001416. RDC1_rcpt.
[Graphical view]
PANTHERPTHR19264:SF259. RDC1_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00646. RDC1ORPHANR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio282174.
SOURCESearch...

Hide | Top

Entry information

Entry nameCXCR7_MOUSE
AccessionPrimary (citable) accession number: P56485
Secondary accession number(s): Q91WI0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: June 16, 2009
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents