Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C chemokine receptor type 8

Gene

Ccr8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the CCL1/SCY1/TCA-3 chemokine.1 Publication

GO - Molecular functioni

  • C-C chemokine receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 8
Short name:
C-C CKR-8
Short name:
CC-CKR-8
Short name:
CCR-8
Alternative name(s):
CD_antigen: CDw198
Gene namesi
Name:Ccr8
Synonyms:Cmkbr8, Ter1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1201402 Ccr8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 61Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini62 – 71CytoplasmicSequence analysis10
Transmembranei72 – 91Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini92 – 105ExtracellularSequence analysisAdd BLAST14
Transmembranei106 – 127Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini128 – 144CytoplasmicSequence analysisAdd BLAST17
Transmembranei145 – 169Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini170 – 200ExtracellularSequence analysisAdd BLAST31
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 236CytoplasmicSequence analysisAdd BLAST16
Transmembranei237 – 261Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini262 – 278ExtracellularSequence analysisAdd BLAST17
Transmembranei279 – 302Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini303 – 353CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075278
GuidetoPHARMACOLOGYi65

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692901 – 353C-C chemokine receptor type 8Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP56484
PRIDEiP56484

PTM databases

PhosphoSitePlusiP56484

Expressioni

Tissue specificityi

Expressed in thymus.1 Publication

Gene expression databases

BgeeiENSMUSG00000042262
CleanExiMM_CCR8
ExpressionAtlasiP56484 baseline and differential
GenevisibleiP56484 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038473

Structurei

3D structure databases

ProteinModelPortaliP56484
SMRiP56484
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ9D Eukaryota
ENOG410YUBT LUCA
GeneTreeiENSGT00760000118785
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP56484
KOiK04183
OMAiMFFITLM
OrthoDBiEOG091G0HEN
PhylomeDBiP56484
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR004068 Chemokine_CCR8
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01530 CHEMOKINER8
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P56484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYTMEPNVT MTDYYPDFFT APCDAEFLLR GSMLYLAILY CVLFVLGLLG
60 70 80 90 100
NSLVILVLVG CKKLRSITDI YLLNLAASDL LFVLSIPFQT HNLLDQWVFG
110 120 130 140 150
TAMCKVVSGL YYIGFFSSMF FITLMSVDRY LAIVHAVYAI KVRTASVGTA
160 170 180 190 200
LSLTVWLAAV TATIPLMVFY QVASEDGMLQ CFQFYEEQSL RWKLFTHFEI
210 220 230 240 250
NALGLLLPFA ILLFCYVRIL QQLRGCLNHN RTRAIKLVLT VVIVSLLFWV
260 270 280 290 300
PFNVALFLTS LHDLHILDGC ATRQRLALAI HVTEVISFTH CCVNPVIYAF
310 320 330 340 350
IGEKFKKHLM DVFQKSCSHI FLYLGRQMPV GALERQLSSN QRSSHSSTLD

DIL
Length:353
Mass (Da):40,045
Last modified:July 15, 1998 - v1
Checksum:i31EC4B642CDB9AE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98206 Genomic DNA Translation: CAB10896.1
Z98205 mRNA Translation: CAB10895.1
AF001277 Genomic DNA Translation: AAC97598.1
CCDSiCCDS23621.1
RefSeqiNP_031746.1, NM_007720.2
UniGeneiMm.442098

Genome annotation databases

EnsembliENSMUST00000048777; ENSMUSP00000038473; ENSMUSG00000042262
GeneIDi12776
KEGGimmu:12776
UCSCiuc009sca.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCCR8_MOUSE
AccessioniPrimary (citable) accession number: P56484
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 25, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health