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Protein

C-C chemokine receptor type 8

Gene

Ccr8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the CCL1/SCY1/TCA-3 chemokine.1 Publication

GO - Molecular functioni

  • C-C chemokine receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 8
Short name:
C-C CKR-8
Short name:
CC-CKR-8
Short name:
CCR-8
Alternative name(s):
CD_antigen: CDw198
Gene namesi
Name:Ccr8
Synonyms:Cmkbr8, Ter1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1201402. Ccr8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 61Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini62 – 71CytoplasmicSequence analysis10
Transmembranei72 – 91Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini92 – 105ExtracellularSequence analysisAdd BLAST14
Transmembranei106 – 127Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini128 – 144CytoplasmicSequence analysisAdd BLAST17
Transmembranei145 – 169Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini170 – 200ExtracellularSequence analysisAdd BLAST31
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 236CytoplasmicSequence analysisAdd BLAST16
Transmembranei237 – 261Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini262 – 278ExtracellularSequence analysisAdd BLAST17
Transmembranei279 – 302Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini303 – 353CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075278.
GuidetoPHARMACOLOGYi65.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692901 – 353C-C chemokine receptor type 8Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP56484.
PRIDEiP56484.

PTM databases

PhosphoSitePlusiP56484.

Expressioni

Tissue specificityi

Expressed in thymus.1 Publication

Gene expression databases

BgeeiENSMUSG00000042262.
CleanExiMM_CCR8.
ExpressionAtlasiP56484. baseline and differential.
GenevisibleiP56484. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038473.

Structurei

3D structure databases

ProteinModelPortaliP56484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ9D. Eukaryota.
ENOG410YUBT. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP56484.
KOiK04183.
OMAiMCKIMAG.
OrthoDBiEOG091G0HEN.
PhylomeDBiP56484.
TreeFamiTF330966.

Family and domain databases

InterProiIPR004068. Chemokine_CCR8.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01530. CHEMOKINER8.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYTMEPNVT MTDYYPDFFT APCDAEFLLR GSMLYLAILY CVLFVLGLLG
60 70 80 90 100
NSLVILVLVG CKKLRSITDI YLLNLAASDL LFVLSIPFQT HNLLDQWVFG
110 120 130 140 150
TAMCKVVSGL YYIGFFSSMF FITLMSVDRY LAIVHAVYAI KVRTASVGTA
160 170 180 190 200
LSLTVWLAAV TATIPLMVFY QVASEDGMLQ CFQFYEEQSL RWKLFTHFEI
210 220 230 240 250
NALGLLLPFA ILLFCYVRIL QQLRGCLNHN RTRAIKLVLT VVIVSLLFWV
260 270 280 290 300
PFNVALFLTS LHDLHILDGC ATRQRLALAI HVTEVISFTH CCVNPVIYAF
310 320 330 340 350
IGEKFKKHLM DVFQKSCSHI FLYLGRQMPV GALERQLSSN QRSSHSSTLD

DIL
Length:353
Mass (Da):40,045
Last modified:July 15, 1998 - v1
Checksum:i31EC4B642CDB9AE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98206 Genomic DNA. Translation: CAB10896.1.
Z98205 mRNA. Translation: CAB10895.1.
AF001277 Genomic DNA. Translation: AAC97598.1.
CCDSiCCDS23621.1.
RefSeqiNP_031746.1. NM_007720.2.
UniGeneiMm.442098.

Genome annotation databases

EnsembliENSMUST00000048777; ENSMUSP00000038473; ENSMUSG00000042262.
GeneIDi12776.
KEGGimmu:12776.
UCSCiuc009sca.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98206 Genomic DNA. Translation: CAB10896.1.
Z98205 mRNA. Translation: CAB10895.1.
AF001277 Genomic DNA. Translation: AAC97598.1.
CCDSiCCDS23621.1.
RefSeqiNP_031746.1. NM_007720.2.
UniGeneiMm.442098.

3D structure databases

ProteinModelPortaliP56484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038473.

Chemistry databases

ChEMBLiCHEMBL1075278.
GuidetoPHARMACOLOGYi65.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP56484.

Proteomic databases

PaxDbiP56484.
PRIDEiP56484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048777; ENSMUSP00000038473; ENSMUSG00000042262.
GeneIDi12776.
KEGGimmu:12776.
UCSCiuc009sca.1. mouse.

Organism-specific databases

CTDi1237.
MGIiMGI:1201402. Ccr8.

Phylogenomic databases

eggNOGiENOG410IJ9D. Eukaryota.
ENOG410YUBT. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP56484.
KOiK04183.
OMAiMCKIMAG.
OrthoDBiEOG091G0HEN.
PhylomeDBiP56484.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP56484.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042262.
CleanExiMM_CCR8.
ExpressionAtlasiP56484. baseline and differential.
GenevisibleiP56484. MM.

Family and domain databases

InterProiIPR004068. Chemokine_CCR8.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01530. CHEMOKINER8.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR8_MOUSE
AccessioniPrimary (citable) accession number: P56484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.