P56484 (CCR8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 8
Short name=C-C CKR-8
Short name=CC-CKR-8
Short name=CCR-8

Alternative name(s):
CD_antigen=CDw198

Gene names

Name:	Ccr8
Synonyms:	Cmkbr8, Ter1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the CCL1/SCY1/TCA-3 chemokine. Ref.1
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in thymus. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	chemotaxis Inferred from direct assay Ref.2. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	C-C chemokine receptor activity Inferred from direct assay Ref.2. Source: MGI protein binding Inferred from physical interaction Ref.2. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	C-C chemokine receptor type 8		PRO_0000069290
Regions
	Topological domain	1 – 33	33	Extracellular Potential
	Transmembrane	34 – 61	28	Helical; Name=1; Potential
	Topological domain	62 – 71	10	Cytoplasmic Potential
	Transmembrane	72 – 91	20	Helical; Name=2; Potential
	Topological domain	92 – 105	14	Extracellular Potential
	Transmembrane	106 – 127	22	Helical; Name=3; Potential
	Topological domain	128 – 144	17	Cytoplasmic Potential
	Transmembrane	145 – 169	25	Helical; Name=4; Potential
	Topological domain	170 – 200	31	Extracellular Potential
	Transmembrane	201 – 220	20	Helical; Name=5; Potential
	Topological domain	221 – 236	16	Cytoplasmic Potential
	Transmembrane	237 – 261	25	Helical; Name=6; Potential
	Topological domain	262 – 278	17	Extracellular Potential
	Transmembrane	279 – 302	24	Helical; Name=7; Potential
	Topological domain	303 – 353	51	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Disulfide bond	104 ↔ 181		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56484 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 31EC4B642CDB9AE5	FASTA	353	40,045
	10 20 30 40 50 60 MDYTMEPNVT MTDYYPDFFT APCDAEFLLR GSMLYLAILY CVLFVLGLLG NSLVILVLVG 70 80 90 100 110 120 CKKLRSITDI YLLNLAASDL LFVLSIPFQT HNLLDQWVFG TAMCKVVSGL YYIGFFSSMF 130 140 150 160 170 180 FITLMSVDRY LAIVHAVYAI KVRTASVGTA LSLTVWLAAV TATIPLMVFY QVASEDGMLQ 190 200 210 220 230 240 CFQFYEEQSL RWKLFTHFEI NALGLLLPFA ILLFCYVRIL QQLRGCLNHN RTRAIKLVLT 250 260 270 280 290 300 VVIVSLLFWV PFNVALFLTS LHDLHILDGC ATRQRLALAI HVTEVISFTH CCVNPVIYAF 310 320 330 340 350 IGEKFKKHLM DVFQKSCSHI FLYLGRQMPV GALERQLSSN QRSSHSSTLD DIL

References

[1]	"Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3." Goya I., Gutierrez J., Varona R., Kremer L., Zaballos A., Marquez G. J. Immunol. 160:1975-1981(1998) [PubMed: 9469461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells." Zingoni A., Soto H., Hedrick J.A., Stoppacciaro A., Storlazzi C.T., Sinigaglia F., D'Ambrosio D., O'Garra A., Robinson D., Rocchi M., Santoni A., Zlotnik A., Napolitano M. J. Immunol. 161:547-551(1998) [PubMed: 9670926] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z98206 Genomic DNA. Translation: CAB10896.1. Z98205 mRNA. Translation: CAB10895.1. AF001277 Genomic DNA. Translation: AAC97598.1.
IPI	IPI00113807.
RefSeq	NP_031746.1. NM_007720.2.
UniGene	Mm.442098.
3D structure databases
ProteinModelPortal	P56484.
SMR	P56484. Positions 13-336.
ModBase	Search...
Protein-protein interaction databases
STRING	P56484.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P56484.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000048777; ENSMUSP00000038473; ENSMUSG00000042262.
GeneID	12776.
KEGG	mmu:12776.
Organism-specific databases
CTD	1237.
MGI	MGI:1201402. Ccr8.
Phylogenomic databases
eggNOG	roNOG08403.
HOGENOM	HBG715940.
HOVERGEN	HBG106917.
InParanoid	P56484.
OMA	GTVMCKV.
OrthoDB	EOG4R23V5.
PhylomeDB	P56484.
Gene expression databases
ArrayExpress	P56484.
Bgee	P56484.
CleanEx	MM_CCR8.
Genevestigator	P56484.
GermOnline	ENSMUSG00000042262. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR004068. Chemokine_CCR8. IPR000355. Chemokine_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
KO	K04183.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01530. CHEMOKINER8. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	282166.
SOURCE	Search...

Entry information

Entry name

CCR8_MOUSE

Accession

Primary (citable) accession number: P56484

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	January 25, 2012
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program