Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P56484

- CCR8_MOUSE

UniProt

P56484 - CCR8_MOUSE

Protein

C-C chemokine receptor type 8

Gene

Ccr8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for the CCL1/SCY1/TCA-3 chemokine.1 Publication

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. chemokine-mediated signaling pathway Source: GOC
    2. chemotaxis Source: MGI
    3. immune response Source: InterPro
    4. positive regulation of cytosolic calcium ion concentration Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 8
    Short name:
    C-C CKR-8
    Short name:
    CC-CKR-8
    Short name:
    CCR-8
    Alternative name(s):
    CD_antigen: CDw198
    Gene namesi
    Name:Ccr8
    Synonyms:Cmkbr8, Ter1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1201402. Ccr8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 353353C-C chemokine receptor type 8PRO_0000069290Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 181PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP56484.

    PTM databases

    PhosphoSiteiP56484.

    Expressioni

    Tissue specificityi

    Expressed in thymus.1 Publication

    Gene expression databases

    BgeeiP56484.
    CleanExiMM_CCR8.
    GenevestigatoriP56484.

    Structurei

    3D structure databases

    ProteinModelPortaliP56484.
    SMRiP56484. Positions 22-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini62 – 7110CytoplasmicSequence Analysis
    Topological domaini92 – 10514ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini128 – 14417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini170 – 20031ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 23616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 27817ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini303 – 35351CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 6128Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei72 – 9120Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei106 – 12722Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16925Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22020Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 26125Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei279 – 30224Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149415.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP56484.
    KOiK04183.
    OMAiNALCKIM.
    OrthoDBiEOG7B5WW3.
    PhylomeDBiP56484.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR004068. Chemokine_CCR8.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01530. CHEMOKINER8.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56484-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYTMEPNVT MTDYYPDFFT APCDAEFLLR GSMLYLAILY CVLFVLGLLG    50
    NSLVILVLVG CKKLRSITDI YLLNLAASDL LFVLSIPFQT HNLLDQWVFG 100
    TAMCKVVSGL YYIGFFSSMF FITLMSVDRY LAIVHAVYAI KVRTASVGTA 150
    LSLTVWLAAV TATIPLMVFY QVASEDGMLQ CFQFYEEQSL RWKLFTHFEI 200
    NALGLLLPFA ILLFCYVRIL QQLRGCLNHN RTRAIKLVLT VVIVSLLFWV 250
    PFNVALFLTS LHDLHILDGC ATRQRLALAI HVTEVISFTH CCVNPVIYAF 300
    IGEKFKKHLM DVFQKSCSHI FLYLGRQMPV GALERQLSSN QRSSHSSTLD 350
    DIL 353
    Length:353
    Mass (Da):40,045
    Last modified:July 15, 1998 - v1
    Checksum:i31EC4B642CDB9AE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z98206 Genomic DNA. Translation: CAB10896.1.
    Z98205 mRNA. Translation: CAB10895.1.
    AF001277 Genomic DNA. Translation: AAC97598.1.
    CCDSiCCDS23621.1.
    RefSeqiNP_031746.1. NM_007720.2.
    UniGeneiMm.442098.

    Genome annotation databases

    EnsembliENSMUST00000048777; ENSMUSP00000038473; ENSMUSG00000042262.
    GeneIDi12776.
    KEGGimmu:12776.
    UCSCiuc009sca.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z98206 Genomic DNA. Translation: CAB10896.1 .
    Z98205 mRNA. Translation: CAB10895.1 .
    AF001277 Genomic DNA. Translation: AAC97598.1 .
    CCDSi CCDS23621.1.
    RefSeqi NP_031746.1. NM_007720.2.
    UniGenei Mm.442098.

    3D structure databases

    ProteinModelPortali P56484.
    SMRi P56484. Positions 22-314.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL1075278.
    GuidetoPHARMACOLOGYi 65.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P56484.

    Proteomic databases

    PRIDEi P56484.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048777 ; ENSMUSP00000038473 ; ENSMUSG00000042262 .
    GeneIDi 12776.
    KEGGi mmu:12776.
    UCSCi uc009sca.1. mouse.

    Organism-specific databases

    CTDi 1237.
    MGIi MGI:1201402. Ccr8.

    Phylogenomic databases

    eggNOGi NOG149415.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P56484.
    KOi K04183.
    OMAi NALCKIM.
    OrthoDBi EOG7B5WW3.
    PhylomeDBi P56484.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 282166.
    PROi P56484.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56484.
    CleanExi MM_CCR8.
    Genevestigatori P56484.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR004068. Chemokine_CCR8.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01530. CHEMOKINER8.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3."
      Goya I., Gutierrez J., Varona R., Kremer L., Zaballos A., Marquez G.
      J. Immunol. 160:1975-1981(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells."
      Zingoni A., Soto H., Hedrick J.A., Stoppacciaro A., Storlazzi C.T., Sinigaglia F., D'Ambrosio D., O'Garra A., Robinson D., Rocchi M., Santoni A., Zlotnik A., Napolitano M.
      J. Immunol. 161:547-551(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.

    Entry informationi

    Entry nameiCCR8_MOUSE
    AccessioniPrimary (citable) accession number: P56484
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3