C-C chemokine receptor type 8 - Mus musculus (Mouse)

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P56484 (CCR8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 102. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 8
Short name=C-C CKR-8
Short name=CC-CKR-8
Short name=CCR-8

Alternative name(s):
CD_antigen=CDw198

Gene names

Name:	Ccr8
Synonyms:	Cmkbr8, Ter1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the CCL1/SCY1/TCA-3 chemokine. Ref.1
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in thymus. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from direct assay Ref.2. Source: MGI elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	C-C chemokine receptor activity Inferred from direct assay Ref.2. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 353

353

C-C chemokine receptor type 8

PRO_0000069290

Regions

Topological domain

1 – 33

Extracellular Potential

Transmembrane

34 – 61

Helical; Name=1; Potential

Topological domain

62 – 71

Cytoplasmic Potential

Transmembrane

72 – 91

Helical; Name=2; Potential

Topological domain

92 – 105

Extracellular Potential

Transmembrane

106 – 127

Helical; Name=3; Potential

Topological domain

128 – 144

Cytoplasmic Potential

Transmembrane

145 – 169

Helical; Name=4; Potential

Topological domain

170 – 200

Extracellular Potential

Transmembrane

201 – 220

Helical; Name=5; Potential

Topological domain

221 – 236

Cytoplasmic Potential

Transmembrane

237 – 261

Helical; Name=6; Potential

Topological domain

262 – 278

Extracellular Potential

Transmembrane

279 – 302

Helical; Name=7; Potential

Topological domain

303 – 353

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

104 ↔ 181

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P56484 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 31EC4B642CDB9AE5
Show »

FASTA

353

40,045

        10         20         30         40         50         60 
MDYTMEPNVT MTDYYPDFFT APCDAEFLLR GSMLYLAILY CVLFVLGLLG NSLVILVLVG 

        70         80         90        100        110        120 
CKKLRSITDI YLLNLAASDL LFVLSIPFQT HNLLDQWVFG TAMCKVVSGL YYIGFFSSMF 

       130        140        150        160        170        180 
FITLMSVDRY LAIVHAVYAI KVRTASVGTA LSLTVWLAAV TATIPLMVFY QVASEDGMLQ 

       190        200        210        220        230        240 
CFQFYEEQSL RWKLFTHFEI NALGLLLPFA ILLFCYVRIL QQLRGCLNHN RTRAIKLVLT 

       250        260        270        280        290        300 
VVIVSLLFWV PFNVALFLTS LHDLHILDGC ATRQRLALAI HVTEVISFTH CCVNPVIYAF 

       310        320        330        340        350 
IGEKFKKHLM DVFQKSCSHI FLYLGRQMPV GALERQLSSN QRSSHSSTLD DIL

« Hide

References

[1]	"Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3." Goya I., Gutierrez J., Varona R., Kremer L., Zaballos A., Marquez G. J. Immunol. 160:1975-1981(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells." Zingoni A., Soto H., Hedrick J.A., Stoppacciaro A., Storlazzi C.T., Sinigaglia F., D'Ambrosio D., O'Garra A., Robinson D., Rocchi M., Santoni A., Zlotnik A., Napolitano M. J. Immunol. 161:547-551(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z98206 Genomic DNA. Translation: CAB10896.1. Z98205 mRNA. Translation: CAB10895.1. AF001277 Genomic DNA. Translation: AAC97598.1.
IPI	IPI00113807.
RefSeq	NP_031746.1. NM_007720.2.
UniGene	Mm.442098.
3D structure databases
ProteinModelPortal	P56484.
SMR	P56484. Positions 1-314.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P56484.
Proteomic databases
PRIDE	P56484.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000048777; ENSMUSP00000038473; ENSMUSG00000042262.
GeneID	12776.
KEGG	mmu:12776.
Organism-specific databases
CTD	1237.
MGI	MGI:1201402. Ccr8.
Phylogenomic databases
eggNOG	NOG149415.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	P56484.
KO	K04183.
OMA	EMNILGL.
OrthoDB	EOG4R23V5.
Gene expression databases
ArrayExpress	P56484.
Bgee	P56484.
CleanEx	MM_CCR8.
Genevestigator	P56484.
GermOnline	ENSMUSG00000042262. Mus musculus.
Family and domain databases
InterPro	IPR004068. Chemokine_CCR8. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01530. CHEMOKINER8. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1075278.
NextBio	282166.
SOURCE	Search...

Entry information

Entry name

CCR8_MOUSE

Accession

Primary (citable) accession number: P56484

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents