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P56484 (CCR8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 8

Short name=C-C CKR-8
Short name=CC-CKR-8
Short name=CCR-8
Alternative name(s):
CD_antigen=CDw198
Gene names
Name:Ccr8
Synonyms:Cmkbr8, Ter1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the CCL1/SCY1/TCA-3 chemokine. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in thymus. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353C-C chemokine receptor type 8
PRO_0000069290

Regions

Topological domain1 – 3333Extracellular Potential
Transmembrane34 – 6128Helical; Name=1; Potential
Topological domain62 – 7110Cytoplasmic Potential
Transmembrane72 – 9120Helical; Name=2; Potential
Topological domain92 – 10514Extracellular Potential
Transmembrane106 – 12722Helical; Name=3; Potential
Topological domain128 – 14417Cytoplasmic Potential
Transmembrane145 – 16925Helical; Name=4; Potential
Topological domain170 – 20031Extracellular Potential
Transmembrane201 – 22020Helical; Name=5; Potential
Topological domain221 – 23616Cytoplasmic Potential
Transmembrane237 – 26125Helical; Name=6; Potential
Topological domain262 – 27817Extracellular Potential
Transmembrane279 – 30224Helical; Name=7; Potential
Topological domain303 – 35351Cytoplasmic Potential

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Disulfide bond104 ↔ 181 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56484 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 31EC4B642CDB9AE5

FASTA35340,045
        10         20         30         40         50         60 
MDYTMEPNVT MTDYYPDFFT APCDAEFLLR GSMLYLAILY CVLFVLGLLG NSLVILVLVG 

        70         80         90        100        110        120 
CKKLRSITDI YLLNLAASDL LFVLSIPFQT HNLLDQWVFG TAMCKVVSGL YYIGFFSSMF 

       130        140        150        160        170        180 
FITLMSVDRY LAIVHAVYAI KVRTASVGTA LSLTVWLAAV TATIPLMVFY QVASEDGMLQ 

       190        200        210        220        230        240 
CFQFYEEQSL RWKLFTHFEI NALGLLLPFA ILLFCYVRIL QQLRGCLNHN RTRAIKLVLT 

       250        260        270        280        290        300 
VVIVSLLFWV PFNVALFLTS LHDLHILDGC ATRQRLALAI HVTEVISFTH CCVNPVIYAF 

       310        320        330        340        350 
IGEKFKKHLM DVFQKSCSHI FLYLGRQMPV GALERQLSSN QRSSHSSTLD DIL 

« Hide

References

[1]"Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3."
Goya I., Gutierrez J., Varona R., Kremer L., Zaballos A., Marquez G.
J. Immunol. 160:1975-1981(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]"The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells."
Zingoni A., Soto H., Hedrick J.A., Stoppacciaro A., Storlazzi C.T., Sinigaglia F., D'Ambrosio D., O'Garra A., Robinson D., Rocchi M., Santoni A., Zlotnik A., Napolitano M.
J. Immunol. 161:547-551(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z98206 Genomic DNA. Translation: CAB10896.1.
Z98205 mRNA. Translation: CAB10895.1.
AF001277 Genomic DNA. Translation: AAC97598.1.
CCDSCCDS23621.1.
RefSeqNP_031746.1. NM_007720.2.
UniGeneMm.442098.

3D structure databases

ProteinModelPortalP56484.
SMRP56484. Positions 22-314.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL1075278.
GuidetoPHARMACOLOGY65.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP56484.

Proteomic databases

PRIDEP56484.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048777; ENSMUSP00000038473; ENSMUSG00000042262.
GeneID12776.
KEGGmmu:12776.
UCSCuc009sca.1. mouse.

Organism-specific databases

CTD1237.
MGIMGI:1201402. Ccr8.

Phylogenomic databases

eggNOGNOG149415.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP56484.
KOK04183.
OMANALCKIM.
OrthoDBEOG7B5WW3.
PhylomeDBP56484.
TreeFamTF330966.

Gene expression databases

BgeeP56484.
CleanExMM_CCR8.
GenevestigatorP56484.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR004068. Chemokine_CCR8.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01530. CHEMOKINER8.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282166.
PROP56484.
SOURCESearch...

Entry information

Entry nameCCR8_MOUSE
AccessionPrimary (citable) accession number: P56484
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries