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P56484

- CCR8_MOUSE

UniProt

P56484 - CCR8_MOUSE

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Protein

C-C chemokine receptor type 8

Gene

Ccr8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for the CCL1/SCY1/TCA-3 chemokine.1 Publication

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: MGI

GO - Biological processi

  1. chemokine-mediated signaling pathway Source: GOC
  2. chemotaxis Source: MGI
  3. immune response Source: InterPro
  4. positive regulation of cytosolic calcium ion concentration Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 8
Short name:
C-C CKR-8
Short name:
CC-CKR-8
Short name:
CCR-8
Alternative name(s):
CD_antigen: CDw198
Gene namesi
Name:Ccr8
Synonyms:Cmkbr8, Ter1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1201402. Ccr8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
BLAST
Transmembranei34 – 6128Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini62 – 7110CytoplasmicSequence Analysis
Transmembranei72 – 9120Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 10514ExtracellularSequence AnalysisAdd
BLAST
Transmembranei106 – 12722Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini128 – 14417CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16925Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini170 – 20031ExtracellularSequence AnalysisAdd
BLAST
Transmembranei201 – 22020Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 23616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 26125Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini262 – 27817ExtracellularSequence AnalysisAdd
BLAST
Transmembranei279 – 30224Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini303 – 35351CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353C-C chemokine receptor type 8PRO_0000069290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP56484.

PTM databases

PhosphoSiteiP56484.

Expressioni

Tissue specificityi

Expressed in thymus.1 Publication

Gene expression databases

BgeeiP56484.
CleanExiMM_CCR8.
ExpressionAtlasiP56484. baseline.
GenevestigatoriP56484.

Structurei

3D structure databases

ProteinModelPortaliP56484.
SMRiP56484. Positions 1-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149415.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP56484.
KOiK04183.
OMAiNALCKIM.
OrthoDBiEOG7B5WW3.
PhylomeDBiP56484.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR004068. Chemokine_CCR8.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01530. CHEMOKINER8.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56484-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYTMEPNVT MTDYYPDFFT APCDAEFLLR GSMLYLAILY CVLFVLGLLG
60 70 80 90 100
NSLVILVLVG CKKLRSITDI YLLNLAASDL LFVLSIPFQT HNLLDQWVFG
110 120 130 140 150
TAMCKVVSGL YYIGFFSSMF FITLMSVDRY LAIVHAVYAI KVRTASVGTA
160 170 180 190 200
LSLTVWLAAV TATIPLMVFY QVASEDGMLQ CFQFYEEQSL RWKLFTHFEI
210 220 230 240 250
NALGLLLPFA ILLFCYVRIL QQLRGCLNHN RTRAIKLVLT VVIVSLLFWV
260 270 280 290 300
PFNVALFLTS LHDLHILDGC ATRQRLALAI HVTEVISFTH CCVNPVIYAF
310 320 330 340 350
IGEKFKKHLM DVFQKSCSHI FLYLGRQMPV GALERQLSSN QRSSHSSTLD

DIL
Length:353
Mass (Da):40,045
Last modified:July 15, 1998 - v1
Checksum:i31EC4B642CDB9AE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98206 Genomic DNA. Translation: CAB10896.1.
Z98205 mRNA. Translation: CAB10895.1.
AF001277 Genomic DNA. Translation: AAC97598.1.
CCDSiCCDS23621.1.
RefSeqiNP_031746.1. NM_007720.2.
UniGeneiMm.442098.

Genome annotation databases

EnsembliENSMUST00000048777; ENSMUSP00000038473; ENSMUSG00000042262.
GeneIDi12776.
KEGGimmu:12776.
UCSCiuc009sca.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98206 Genomic DNA. Translation: CAB10896.1 .
Z98205 mRNA. Translation: CAB10895.1 .
AF001277 Genomic DNA. Translation: AAC97598.1 .
CCDSi CCDS23621.1.
RefSeqi NP_031746.1. NM_007720.2.
UniGenei Mm.442098.

3D structure databases

ProteinModelPortali P56484.
SMRi P56484. Positions 1-314.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL1075278.
GuidetoPHARMACOLOGYi 65.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P56484.

Proteomic databases

PRIDEi P56484.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048777 ; ENSMUSP00000038473 ; ENSMUSG00000042262 .
GeneIDi 12776.
KEGGi mmu:12776.
UCSCi uc009sca.1. mouse.

Organism-specific databases

CTDi 1237.
MGIi MGI:1201402. Ccr8.

Phylogenomic databases

eggNOGi NOG149415.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P56484.
KOi K04183.
OMAi NALCKIM.
OrthoDBi EOG7B5WW3.
PhylomeDBi P56484.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 282166.
PROi P56484.
SOURCEi Search...

Gene expression databases

Bgeei P56484.
CleanExi MM_CCR8.
ExpressionAtlasi P56484. baseline.
Genevestigatori P56484.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR004068. Chemokine_CCR8.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01530. CHEMOKINER8.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3."
    Goya I., Gutierrez J., Varona R., Kremer L., Zaballos A., Marquez G.
    J. Immunol. 160:1975-1981(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells."
    Zingoni A., Soto H., Hedrick J.A., Stoppacciaro A., Storlazzi C.T., Sinigaglia F., D'Ambrosio D., O'Garra A., Robinson D., Rocchi M., Santoni A., Zlotnik A., Napolitano M.
    J. Immunol. 161:547-551(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.

Entry informationi

Entry nameiCCR8_MOUSE
AccessioniPrimary (citable) accession number: P56484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3