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Protein

C-C chemokine receptor type 3

Gene

CCR3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
CD_antigen: CD193
Gene namesi
Name:CCR3
Synonyms:CMKBR3
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 62Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini63 – 72CytoplasmicSequence analysis10
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 107ExtracellularSequence analysisAdd BLAST14
Transmembranei108 – 129Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 171Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini172 – 203ExtracellularSequence analysisAdd BLAST32
Transmembranei204 – 223Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini224 – 239CytoplasmicSequence analysisAdd BLAST16
Transmembranei240 – 264Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini265 – 281ExtracellularSequence analysisAdd BLAST17
Transmembranei282 – 305Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini306 – 355CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692411 – 355C-C chemokine receptor type 3Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Modified residuei132PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000006084.

Chemistry databases

BindingDBiP56483.

Structurei

3D structure databases

ProteinModelPortaliP56483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP56483.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSLDTVET FGPTSYDDDM GLLCEKADVG ALIAQFVPPL YSLVFMVGLL
60 70 80 90 100
GNVVVVMILI KYRRLRIMTN IYLLNLAISD LLFLFTLPFW IHYVRERNWV
110 120 130 140 150
FSHGMCKVLS GFYHTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG
160 170 180 190 200
VITSIVTWGL AVLAALPEFI FYGTEKLFPK TLCSAIYPQD TVYSWRHFHT
210 220 230 240 250
LKMTILCLAL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL IFVIMAVFFI
260 270 280 290 300
FWTPYNVAIL ISTYQSVLFG LDCERSKHLD LFVLATEVIA YSHCCVNPVI
310 320 330 340 350
YAFVGERFRK YLRHFFHRHV LMHLGKYIPF LPSEKLERTS SVSPSTAEPE

LSIVF
Length:355
Mass (Da):40,806
Last modified:July 15, 1998 - v1
Checksum:iE271F1E694970D9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180K → E in CAA74107 (PubMed:9454694).Curated1
Sequence conflicti202K → R in CAA74107 (PubMed:9454694).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017283 Genomic DNA. Translation: AAB70527.1.
Y13776 Genomic DNA. Translation: CAA74107.1.
UniGeneiMmu.10058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017283 Genomic DNA. Translation: AAB70527.1.
Y13776 Genomic DNA. Translation: CAA74107.1.
UniGeneiMmu.10058.

3D structure databases

ProteinModelPortaliP56483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000006084.

Chemistry databases

BindingDBiP56483.
ChEMBLiCHEMBL5176.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP56483.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR3_MACMU
AccessioniPrimary (citable) accession number: P56483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.