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Protein

C-C chemokine receptor type 3

Gene

CCR3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
CD_antigen: CD193
Gene namesi
Name:CCR3
Synonyms:CMKBR3
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 6228Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini63 – 7210CytoplasmicSequence analysis
Transmembranei73 – 9321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini94 – 10714ExtracellularSequence analysisAdd
BLAST
Transmembranei108 – 12922Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini130 – 14617CytoplasmicSequence analysisAdd
BLAST
Transmembranei147 – 17125Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini172 – 20332ExtracellularSequence analysisAdd
BLAST
Transmembranei204 – 22320Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini224 – 23916CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26425Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini265 – 28117ExtracellularSequence analysisAdd
BLAST
Transmembranei282 – 30524Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini306 – 35550CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355C-C chemokine receptor type 3PRO_0000069241Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Modified residuei132 – 1321PhosphotyrosineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000006084.

Chemistry

BindingDBiP56483.

Structurei

3D structure databases

ProteinModelPortaliP56483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP56483.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSLDTVET FGPTSYDDDM GLLCEKADVG ALIAQFVPPL YSLVFMVGLL
60 70 80 90 100
GNVVVVMILI KYRRLRIMTN IYLLNLAISD LLFLFTLPFW IHYVRERNWV
110 120 130 140 150
FSHGMCKVLS GFYHTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG
160 170 180 190 200
VITSIVTWGL AVLAALPEFI FYGTEKLFPK TLCSAIYPQD TVYSWRHFHT
210 220 230 240 250
LKMTILCLAL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL IFVIMAVFFI
260 270 280 290 300
FWTPYNVAIL ISTYQSVLFG LDCERSKHLD LFVLATEVIA YSHCCVNPVI
310 320 330 340 350
YAFVGERFRK YLRHFFHRHV LMHLGKYIPF LPSEKLERTS SVSPSTAEPE

LSIVF
Length:355
Mass (Da):40,806
Last modified:July 15, 1998 - v1
Checksum:iE271F1E694970D9F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801K → E in CAA74107 (PubMed:9454694).Curated
Sequence conflicti202 – 2021K → R in CAA74107 (PubMed:9454694).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017283 Genomic DNA. Translation: AAB70527.1.
Y13776 Genomic DNA. Translation: CAA74107.1.
UniGeneiMmu.10058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017283 Genomic DNA. Translation: AAB70527.1.
Y13776 Genomic DNA. Translation: CAA74107.1.
UniGeneiMmu.10058.

3D structure databases

ProteinModelPortaliP56483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000006084.

Chemistry

BindingDBiP56483.
ChEMBLiCHEMBL5176.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP56483.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and comparison of eleven rhesus macaque chemokine receptors."
    Margulies B.J., Hauer D.A., Clements J.E.
    AIDS Res. Hum. Retroviruses 17:981-986(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The rhesus macaque CCR3 chemokine receptor is a cell entry cofactor for HIV-2, but not for HIV-1."
    Sol N., Treboute C., Gomas E., Ferchal F., Shacklett B., Alizon M.
    Virology 240:213-220(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCCR3_MACMU
AccessioniPrimary (citable) accession number: P56483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.