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P56481

- GASR_MOUSE

UniProt

P56481 - GASR_MOUSE

Protein

Gastrin/cholecystokinin type B receptor

Gene

Cckbr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system By similarity.By similarity

    GO - Molecular functioni

    1. gastrin receptor activity Source: UniProtKB
    2. protein binding Source: MGI

    GO - Biological processi

    1. digestive tract development Source: MGI
    2. gastric acid secretion Source: MGI
    3. gland development Source: MGI
    4. positive regulation of cell proliferation Source: UniProtKB
    5. positive regulation of cytosolic calcium ion concentration Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_188573. Gastrin-CREB signalling pathway via PKC and MAPK.
    REACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gastrin/cholecystokinin type B receptor
    Short name:
    CCK-B receptor
    Short name:
    CCK-BR
    Alternative name(s):
    Cholecystokinin-2 receptor
    Short name:
    CCK2-R
    Gene namesi
    Name:Cckbr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:99479. Cckbr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: MGI
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453Gastrin/cholecystokinin type B receptorPRO_0000069475Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi127 ↔ 205PROSITE-ProRule annotation
    Lipidationi414 – 4141S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP56481.
    PRIDEiP56481.

    PTM databases

    PhosphoSiteiP56481.

    Expressioni

    Gene expression databases

    ArrayExpressiP56481.
    BgeeiP56481.
    CleanExiMM_CCKBR.
    GenevestigatoriP56481.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1534414.

    Structurei

    3D structure databases

    ProteinModelPortaliP56481.
    SMRiP56481. Positions 49-415.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5757ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini80 – 878CytoplasmicSequence Analysis
    Topological domaini110 – 13122ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini151 – 17020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini190 – 21930ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini243 – 33997CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini362 – 37918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini401 – 45353CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 7922Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei132 – 15019Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei171 – 18919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 24223Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei340 – 36122Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238659.
    HOGENOMiHOG000294067.
    HOVERGENiHBG036927.
    InParanoidiP56481.
    KOiK04195.
    OMAiRVRQTWS.
    PhylomeDBiP56481.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR009126. Cholcskin_rcpt.
    IPR000314. Gastrin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01822. CCYSTOKININR.
    PR00527. GASTRINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56481-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLLKLNRSL QGPGPGSGSS LCRPGVSLLN SSSAGNLSCE TPRIRGTGTR    50
    ELELTIRITL YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD 100
    LLLAVACMPF TLLPNLMGTF IFGTVICKAV SYLMGVSVSV STLNLAAIAL 150
    ERYSAICRPL QARVWQTRSH AARVILATWL LSGLLMVPYP VYTVVQPVGP 200
    RILQCMHLWP SERVQQMWSV LLLILLFFIP GVVMAVAYGL ISRELYLGLR 250
    FDGDNDSETQ SRVRNQGGLP GGAAAPGPVH QNGGCRHVTS LTGEDSDGCY 300
    VQLPRSRLEM TTLTTPTTGP GPGPRPNQAK LLAKKRVVRM LLVIVLLFFV 350
    CWLPVYSANT WRAFDGPGAR RALAGAPISF IHLLSYTSAC ANPLVYCFMH 400
    RRFRQACLDT CARCCPRPPR ARPRPLPDED PPTPSIASLS RLSYTTISTL 450
    GPG 453
    Length:453
    Mass (Da):49,172
    Last modified:July 15, 1998 - v1
    Checksum:iDFD21432C323405C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF019371 mRNA. Translation: AAB71863.1.
    AF264178, AF264177 Genomic DNA. Translation: AAG09801.1.
    AK028325 mRNA. Translation: BAC25881.1.
    CCDSiCCDS21651.1.
    RefSeqiNP_031653.1. NM_007627.4.
    UniGeneiMm.44513.

    Genome annotation databases

    EnsembliENSMUST00000033189; ENSMUSP00000033189; ENSMUSG00000030898.
    GeneIDi12426.
    KEGGimmu:12426.
    UCSCiuc009iyd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF019371 mRNA. Translation: AAB71863.1 .
    AF264178 , AF264177 Genomic DNA. Translation: AAG09801.1 .
    AK028325 mRNA. Translation: BAC25881.1 .
    CCDSi CCDS21651.1.
    RefSeqi NP_031653.1. NM_007627.4.
    UniGenei Mm.44513.

    3D structure databases

    ProteinModelPortali P56481.
    SMRi P56481. Positions 49-415.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1534414.

    Chemistry

    BindingDBi P56481.
    ChEMBLi CHEMBL2111334.
    GuidetoPHARMACOLOGYi 77.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P56481.

    Proteomic databases

    PaxDbi P56481.
    PRIDEi P56481.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033189 ; ENSMUSP00000033189 ; ENSMUSG00000030898 .
    GeneIDi 12426.
    KEGGi mmu:12426.
    UCSCi uc009iyd.1. mouse.

    Organism-specific databases

    CTDi 887.
    MGIi MGI:99479. Cckbr.

    Phylogenomic databases

    eggNOGi NOG238659.
    HOGENOMi HOG000294067.
    HOVERGENi HBG036927.
    InParanoidi P56481.
    KOi K04195.
    OMAi RVRQTWS.
    PhylomeDBi P56481.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_188573. Gastrin-CREB signalling pathway via PKC and MAPK.
    REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 281236.
    PROi P56481.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56481.
    Bgeei P56481.
    CleanExi MM_CCKBR.
    Genevestigatori P56481.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR009126. Cholcskin_rcpt.
    IPR000314. Gastrin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01822. CCYSTOKININR.
    PR00527. GASTRINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kopin A.S.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Structure and developmental expression of the mouse CCK-B receptor gene."
      Lay J.M., Jenkins C., Friis-Hansen L., Samuelson L.C.
      Biochem. Biophys. Res. Commun. 272:837-842(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain.

    Entry informationi

    Entry nameiGASR_MOUSE
    AccessioniPrimary (citable) accession number: P56481
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3