Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P56481 (GASR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gastrin/cholecystokinin type B receptor

Short name=CCK-B receptor
Short name=CCK-BR
Alternative name(s):
Cholecystokinin-2 receptor
Short name=CCK2-R
Gene names
Name:Cckbr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Gastrin/cholecystokinin type B receptor
PRO_0000069475

Regions

Topological domain1 – 5757Extracellular Potential
Transmembrane58 – 7922Helical; Name=1; Potential
Topological domain80 – 878Cytoplasmic Potential
Transmembrane88 – 10922Helical; Name=2; Potential
Topological domain110 – 13122Extracellular Potential
Transmembrane132 – 15019Helical; Name=3; Potential
Topological domain151 – 17020Cytoplasmic Potential
Transmembrane171 – 18919Helical; Name=4; Potential
Topological domain190 – 21930Extracellular Potential
Transmembrane220 – 24223Helical; Name=5; Potential
Topological domain243 – 33997Cytoplasmic Potential
Transmembrane340 – 36122Helical; Name=6; Potential
Topological domain362 – 37918Extracellular Potential
Transmembrane380 – 40021Helical; Name=7; Potential
Topological domain401 – 45353Cytoplasmic Potential

Amino acid modifications

Lipidation4141S-palmitoyl cysteine By similarity
Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation301N-linked (GlcNAc...) Potential
Glycosylation361N-linked (GlcNAc...) Potential
Disulfide bond127 ↔ 205 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56481 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: DFD21432C323405C

FASTA45349,172
        10         20         30         40         50         60 
MDLLKLNRSL QGPGPGSGSS LCRPGVSLLN SSSAGNLSCE TPRIRGTGTR ELELTIRITL 

        70         80         90        100        110        120 
YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF 

       130        140        150        160        170        180 
IFGTVICKAV SYLMGVSVSV STLNLAAIAL ERYSAICRPL QARVWQTRSH AARVILATWL 

       190        200        210        220        230        240 
LSGLLMVPYP VYTVVQPVGP RILQCMHLWP SERVQQMWSV LLLILLFFIP GVVMAVAYGL 

       250        260        270        280        290        300 
ISRELYLGLR FDGDNDSETQ SRVRNQGGLP GGAAAPGPVH QNGGCRHVTS LTGEDSDGCY 

       310        320        330        340        350        360 
VQLPRSRLEM TTLTTPTTGP GPGPRPNQAK LLAKKRVVRM LLVIVLLFFV CWLPVYSANT 

       370        380        390        400        410        420 
WRAFDGPGAR RALAGAPISF IHLLSYTSAC ANPLVYCFMH RRFRQACLDT CARCCPRPPR 

       430        440        450 
ARPRPLPDED PPTPSIASLS RLSYTTISTL GPG 

« Hide

References

« Hide 'large scale' references
[1]Kopin A.S.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Structure and developmental expression of the mouse CCK-B receptor gene."
Lay J.M., Jenkins C., Friis-Hansen L., Samuelson L.C.
Biochem. Biophys. Res. Commun. 272:837-842(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF019371 mRNA. Translation: AAB71863.1.
AF264178, AF264177 Genomic DNA. Translation: AAG09801.1.
AK028325 mRNA. Translation: BAC25881.1.
CCDSCCDS21651.1.
RefSeqNP_031653.1. NM_007627.4.
UniGeneMm.44513.

3D structure databases

ProteinModelPortalP56481.
SMRP56481. Positions 49-415.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1534414.

Chemistry

BindingDBP56481.
ChEMBLCHEMBL2111334.
GuidetoPHARMACOLOGY77.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP56481.

Proteomic databases

PaxDbP56481.
PRIDEP56481.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033189; ENSMUSP00000033189; ENSMUSG00000030898.
GeneID12426.
KEGGmmu:12426.
UCSCuc009iyd.1. mouse.

Organism-specific databases

CTD887.
MGIMGI:99479. Cckbr.

Phylogenomic databases

eggNOGNOG238659.
HOGENOMHOG000294067.
HOVERGENHBG036927.
InParanoidP56481.
KOK04195.
OMARVRQTWS.
PhylomeDBP56481.
TreeFamTF315303.

Gene expression databases

ArrayExpressP56481.
BgeeP56481.
CleanExMM_CCKBR.
GenevestigatorP56481.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281236.
PROP56481.
SOURCESearch...

Entry information

Entry nameGASR_MOUSE
AccessionPrimary (citable) accession number: P56481
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries