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Protein

Gastrin/cholecystokinin type B receptor

Gene

Cckbr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

  1. gastrin receptor activity Source: UniProtKB
  2. type B gastrin/cholecystokinin receptor binding Source: MGI

GO - Biological processi

  1. digestive tract development Source: MGI
  2. gastric acid secretion Source: MGI
  3. gland development Source: MGI
  4. positive regulation of cell proliferation Source: UniProtKB
  5. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_188573. Gastrin-CREB signalling pathway via PKC and MAPK.
REACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin/cholecystokinin type B receptor
Short name:
CCK-B receptor
Short name:
CCK-BR
Alternative name(s):
Cholecystokinin-2 receptor
Short name:
CCK2-R
Gene namesi
Name:Cckbr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:99479. Cckbr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularSequence AnalysisAdd
BLAST
Transmembranei58 – 7922Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini80 – 878CytoplasmicSequence Analysis
Transmembranei88 – 10922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini110 – 13122ExtracellularSequence AnalysisAdd
BLAST
Transmembranei132 – 15019Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini151 – 17020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei171 – 18919Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini190 – 21930ExtracellularSequence AnalysisAdd
BLAST
Transmembranei220 – 24223Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini243 – 33997CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei340 – 36122Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini362 – 37918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei380 – 40021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini401 – 45353CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Gastrin/cholecystokinin type B receptorPRO_0000069475Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi127 ↔ 205PROSITE-ProRule annotation
Lipidationi414 – 4141S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP56481.
PRIDEiP56481.

PTM databases

PhosphoSiteiP56481.

Expressioni

Gene expression databases

BgeeiP56481.
CleanExiMM_CCKBR.
ExpressionAtlasiP56481. baseline and differential.
GenevestigatoriP56481.

Interactioni

Protein-protein interaction databases

MINTiMINT-1534414.

Structurei

3D structure databases

ProteinModelPortaliP56481.
SMRiP56481. Positions 49-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238659.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP56481.
KOiK04195.
OMAiWRAFDGP.
PhylomeDBiP56481.
TreeFamiTF315303.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56481-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLLKLNRSL QGPGPGSGSS LCRPGVSLLN SSSAGNLSCE TPRIRGTGTR
60 70 80 90 100
ELELTIRITL YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD
110 120 130 140 150
LLLAVACMPF TLLPNLMGTF IFGTVICKAV SYLMGVSVSV STLNLAAIAL
160 170 180 190 200
ERYSAICRPL QARVWQTRSH AARVILATWL LSGLLMVPYP VYTVVQPVGP
210 220 230 240 250
RILQCMHLWP SERVQQMWSV LLLILLFFIP GVVMAVAYGL ISRELYLGLR
260 270 280 290 300
FDGDNDSETQ SRVRNQGGLP GGAAAPGPVH QNGGCRHVTS LTGEDSDGCY
310 320 330 340 350
VQLPRSRLEM TTLTTPTTGP GPGPRPNQAK LLAKKRVVRM LLVIVLLFFV
360 370 380 390 400
CWLPVYSANT WRAFDGPGAR RALAGAPISF IHLLSYTSAC ANPLVYCFMH
410 420 430 440 450
RRFRQACLDT CARCCPRPPR ARPRPLPDED PPTPSIASLS RLSYTTISTL

GPG
Length:453
Mass (Da):49,172
Last modified:July 15, 1998 - v1
Checksum:iDFD21432C323405C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019371 mRNA. Translation: AAB71863.1.
AF264178, AF264177 Genomic DNA. Translation: AAG09801.1.
AK028325 mRNA. Translation: BAC25881.1.
CCDSiCCDS21651.1.
RefSeqiNP_031653.1. NM_007627.4.
UniGeneiMm.44513.

Genome annotation databases

EnsembliENSMUST00000033189; ENSMUSP00000033189; ENSMUSG00000030898.
GeneIDi12426.
KEGGimmu:12426.
UCSCiuc009iyd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019371 mRNA. Translation: AAB71863.1.
AF264178, AF264177 Genomic DNA. Translation: AAG09801.1.
AK028325 mRNA. Translation: BAC25881.1.
CCDSiCCDS21651.1.
RefSeqiNP_031653.1. NM_007627.4.
UniGeneiMm.44513.

3D structure databases

ProteinModelPortaliP56481.
SMRiP56481. Positions 49-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1534414.

Chemistry

BindingDBiP56481.
ChEMBLiCHEMBL2111334.
GuidetoPHARMACOLOGYi77.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP56481.

Proteomic databases

PaxDbiP56481.
PRIDEiP56481.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033189; ENSMUSP00000033189; ENSMUSG00000030898.
GeneIDi12426.
KEGGimmu:12426.
UCSCiuc009iyd.1. mouse.

Organism-specific databases

CTDi887.
MGIiMGI:99479. Cckbr.

Phylogenomic databases

eggNOGiNOG238659.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP56481.
KOiK04195.
OMAiWRAFDGP.
PhylomeDBiP56481.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiREACT_188573. Gastrin-CREB signalling pathway via PKC and MAPK.
REACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi281236.
PROiP56481.
SOURCEiSearch...

Gene expression databases

BgeeiP56481.
CleanExiMM_CCKBR.
ExpressionAtlasiP56481. baseline and differential.
GenevestigatoriP56481.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Kopin A.S.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structure and developmental expression of the mouse CCK-B receptor gene."
    Lay J.M., Jenkins C., Friis-Hansen L., Samuelson L.C.
    Biochem. Biophys. Res. Commun. 272:837-842(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiGASR_MOUSE
AccessioniPrimary (citable) accession number: P56481
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 4, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.