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Protein

Gastrin/cholecystokinin type B receptor

Gene

Cckbr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • digestive tract development Source: MGI
  • gastric acid secretion Source: MGI
  • gland development Source: MGI
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-881907. Gastrin-CREB signalling pathway via PKC and MAPK.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin/cholecystokinin type B receptor
Short name:
CCK-B receptor
Short name:
CCK-BR
Alternative name(s):
Cholecystokinin-2 receptor
Short name:
CCK2-R
Gene namesi
Name:Cckbr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99479. Cckbr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 79Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini80 – 87CytoplasmicSequence analysis8
Transmembranei88 – 109Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini110 – 131ExtracellularSequence analysisAdd BLAST22
Transmembranei132 – 150Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini151 – 170CytoplasmicSequence analysisAdd BLAST20
Transmembranei171 – 189Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini190 – 219ExtracellularSequence analysisAdd BLAST30
Transmembranei220 – 242Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini243 – 339CytoplasmicSequence analysisAdd BLAST97
Transmembranei340 – 361Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini362 – 379ExtracellularSequence analysisAdd BLAST18
Transmembranei380 – 400Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini401 – 453CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2854.
GuidetoPHARMACOLOGYi77.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694751 – 453Gastrin/cholecystokinin type B receptorAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi127 ↔ 205PROSITE-ProRule annotation
Lipidationi414S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP56481.
PRIDEiP56481.

PTM databases

iPTMnetiP56481.
PhosphoSitePlusiP56481.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030898.
CleanExiMM_CCKBR.
ExpressionAtlasiP56481. baseline and differential.
GenevisibleiP56481. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-1534414.
STRINGi10090.ENSMUSP00000033189.

Chemistry databases

BindingDBiP56481.

Structurei

3D structure databases

ProteinModelPortaliP56481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP56481.
KOiK04195.
OMAiQCVHRWP.
OrthoDBiEOG091G084J.
PhylomeDBiP56481.
TreeFamiTF315303.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLKLNRSL QGPGPGSGSS LCRPGVSLLN SSSAGNLSCE TPRIRGTGTR
60 70 80 90 100
ELELTIRITL YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD
110 120 130 140 150
LLLAVACMPF TLLPNLMGTF IFGTVICKAV SYLMGVSVSV STLNLAAIAL
160 170 180 190 200
ERYSAICRPL QARVWQTRSH AARVILATWL LSGLLMVPYP VYTVVQPVGP
210 220 230 240 250
RILQCMHLWP SERVQQMWSV LLLILLFFIP GVVMAVAYGL ISRELYLGLR
260 270 280 290 300
FDGDNDSETQ SRVRNQGGLP GGAAAPGPVH QNGGCRHVTS LTGEDSDGCY
310 320 330 340 350
VQLPRSRLEM TTLTTPTTGP GPGPRPNQAK LLAKKRVVRM LLVIVLLFFV
360 370 380 390 400
CWLPVYSANT WRAFDGPGAR RALAGAPISF IHLLSYTSAC ANPLVYCFMH
410 420 430 440 450
RRFRQACLDT CARCCPRPPR ARPRPLPDED PPTPSIASLS RLSYTTISTL

GPG
Length:453
Mass (Da):49,172
Last modified:July 15, 1998 - v1
Checksum:iDFD21432C323405C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019371 mRNA. Translation: AAB71863.1.
AF264178, AF264177 Genomic DNA. Translation: AAG09801.1.
AK028325 mRNA. Translation: BAC25881.1.
CCDSiCCDS21651.1.
RefSeqiNP_031653.1. NM_007627.5.
UniGeneiMm.44513.

Genome annotation databases

EnsembliENSMUST00000033189; ENSMUSP00000033189; ENSMUSG00000030898.
GeneIDi12426.
KEGGimmu:12426.
UCSCiuc009iyd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019371 mRNA. Translation: AAB71863.1.
AF264178, AF264177 Genomic DNA. Translation: AAG09801.1.
AK028325 mRNA. Translation: BAC25881.1.
CCDSiCCDS21651.1.
RefSeqiNP_031653.1. NM_007627.5.
UniGeneiMm.44513.

3D structure databases

ProteinModelPortaliP56481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1534414.
STRINGi10090.ENSMUSP00000033189.

Chemistry databases

BindingDBiP56481.
ChEMBLiCHEMBL2854.
GuidetoPHARMACOLOGYi77.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP56481.
PhosphoSitePlusiP56481.

Proteomic databases

PaxDbiP56481.
PRIDEiP56481.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033189; ENSMUSP00000033189; ENSMUSG00000030898.
GeneIDi12426.
KEGGimmu:12426.
UCSCiuc009iyd.1. mouse.

Organism-specific databases

CTDi887.
MGIiMGI:99479. Cckbr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP56481.
KOiK04195.
OMAiQCVHRWP.
OrthoDBiEOG091G084J.
PhylomeDBiP56481.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-881907. Gastrin-CREB signalling pathway via PKC and MAPK.

Miscellaneous databases

PROiP56481.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030898.
CleanExiMM_CCKBR.
ExpressionAtlasiP56481. baseline and differential.
GenevisibleiP56481. MM.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGASR_MOUSE
AccessioniPrimary (citable) accession number: P56481
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.