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P56479

- GALR1_MOUSE

UniProt

P56479 - GALR1_MOUSE

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Protein

Galanin receptor type 1

Gene
Galr1, Galnr, Galnr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

  1. galanin receptor activity Source: MGI
  2. neuropeptide binding Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. negative regulation of adenylate cyclase activity Source: InterPro
  3. neuropeptide signaling pathway Source: GOC
  4. positive regulation of cytosolic calcium ion concentration Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 1
Short name:
GAL1-R
Short name:
GALR-1
Gene namesi
Name:Galr1
Synonyms:Galnr, Galnr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1096364. Galr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Extracellular Reviewed predictionAdd
BLAST
Transmembranei35 – 5521Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini56 – 7015Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei71 – 9121Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini92 – 10918Extracellular Reviewed predictionAdd
BLAST
Transmembranei110 – 13122Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini132 – 15120Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei152 – 17221Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini173 – 19725Extracellular Reviewed predictionAdd
BLAST
Transmembranei198 – 21821Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini219 – 24729Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei248 – 26821Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini269 – 2702Extracellular Reviewed prediction
Transmembranei271 – 29121Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini292 – 34857Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Galanin receptor type 1PRO_0000069464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12 – 121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi108 ↔ 186 By similarity
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction
Lipidationi319 – 3191S-palmitoyl cysteine By similarity

Post-translational modificationi

Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP56479.

PTM databases

PhosphoSiteiP56479.

Expressioni

Gene expression databases

BgeeiP56479.
CleanExiMM_GALR1.
GenevestigatoriP56479.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066381.

Structurei

3D structure databases

ProteinModelPortaliP56479.
SMRiP56479. Positions 35-315.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00620000087530.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiP56479.
KOiK04230.
OMAiPVAYHQG.
OrthoDBiEOG7327PK.
PhylomeDBiP56479.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56479-1 [UniParc]FASTAAdd to Basket

« Hide

MELAMVNLSE GNGSDPEPPA PESRPLFGIG VENFITLVVF GLIFAMGVLG    50
NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT 100
WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR 150
NALLGVGFIW ALSIAMASPV AYHQRLFHRD SNQTFCWEQW PNKLHKKAYV 200
VCTFVFGYLL PLLLICFCYA KVLNHLHKKL KNMSKKSEAS KKKTAQTVLV 250
VVVVFGISWL PHHVVHLWAE FGAFPLTPAS FFFRITAHCL AYSNSSVNPI 300
IYAFLSENFR KAYKQVFKCH VCDESPRSET KENKSRMDTP PSTNCTHV 348
Length:348
Mass (Da):39,114
Last modified:July 15, 1998 - v1
Checksum:i6F52D752BAA19F9A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15004 mRNA. Translation: CAA75237.1.
U90657, U90655, U90656 Genomic DNA. Translation: AAB87748.1.
CCDSiCCDS29372.1.
RefSeqiNP_032108.1. NM_008082.2.
UniGeneiMm.6219.

Genome annotation databases

EnsembliENSMUST00000065224; ENSMUSP00000066381; ENSMUSG00000024553.
GeneIDi14427.
KEGGimmu:14427.
UCSCiuc008ftq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15004 mRNA. Translation: CAA75237.1 .
U90657 , U90655 , U90656 Genomic DNA. Translation: AAB87748.1 .
CCDSi CCDS29372.1.
RefSeqi NP_032108.1. NM_008082.2.
UniGenei Mm.6219.

3D structure databases

ProteinModelPortali P56479.
SMRi P56479. Positions 35-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000066381.

Chemistry

GuidetoPHARMACOLOGYi 243.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P56479.

Proteomic databases

PRIDEi P56479.

Protocols and materials databases

DNASUi 14427.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065224 ; ENSMUSP00000066381 ; ENSMUSG00000024553 .
GeneIDi 14427.
KEGGi mmu:14427.
UCSCi uc008ftq.1. mouse.

Organism-specific databases

CTDi 2587.
MGIi MGI:1096364. Galr1.

Phylogenomic databases

eggNOGi NOG320953.
GeneTreei ENSGT00620000087530.
HOGENOMi HOG000230487.
HOVERGENi HBG101447.
InParanoidi P56479.
KOi K04230.
OMAi PVAYHQG.
OrthoDBi EOG7327PK.
PhylomeDBi P56479.
TreeFami TF315737.

Miscellaneous databases

NextBioi 286033.
PROi P56479.
SOURCEi Search...

Gene expression databases

Bgeei P56479.
CleanExi MM_GALR1.
Genevestigatori P56479.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic organization and functional characterization of the mouse GalR1 galanin receptor."
    Wang S., He C., Maguire M.T., Clemmons A.L., Burrier R.E., Guzzi M.F., Strader C.D., Parker E.M., Bayne M.L.
    FEBS Lett. 411:225-230(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene."
    Jacoby A.S., Webb G.C., Liu M.L., Kofler B., Hort Y.J., Fathi Z., Bottema C.D.K., Shine J., Iismaa T.P.
    Genomics 45:496-508(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.

Entry informationi

Entry nameiGALR1_MOUSE
AccessioniPrimary (citable) accession number: P56479
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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