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P56479 (GALR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galanin receptor type 1

Short name=GAL1-R
Short name=GALR-1
Gene names
Name:Galr1
Synonyms:Galnr, Galnr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Galanin receptor type 1
PRO_0000069464

Regions

Topological domain1 – 3434Extracellular Potential
Transmembrane35 – 5521Helical; Name=1; Potential
Topological domain56 – 7015Cytoplasmic Potential
Transmembrane71 – 9121Helical; Name=2; Potential
Topological domain92 – 10918Extracellular Potential
Transmembrane110 – 13122Helical; Name=3; Potential
Topological domain132 – 15120Cytoplasmic Potential
Transmembrane152 – 17221Helical; Name=4; Potential
Topological domain173 – 19725Extracellular Potential
Transmembrane198 – 21821Helical; Name=5; Potential
Topological domain219 – 24729Cytoplasmic Potential
Transmembrane248 – 26821Helical; Name=6; Potential
Topological domain269 – 2702Extracellular Potential
Transmembrane271 – 29121Helical; Name=7; Potential
Topological domain292 – 34857Cytoplasmic Potential

Amino acid modifications

Lipidation3191S-palmitoyl cysteine By similarity
Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation121N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Disulfide bond108 ↔ 186 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56479 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 6F52D752BAA19F9A

FASTA34839,114
        10         20         30         40         50         60 
MELAMVNLSE GNGSDPEPPA PESRPLFGIG VENFITLVVF GLIFAMGVLG NSLVITVLAR 

        70         80         90        100        110        120 
SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT WVLGAFICKF IHYFFTVSML 

       130        140        150        160        170        180 
VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR NALLGVGFIW ALSIAMASPV AYHQRLFHRD 

       190        200        210        220        230        240 
SNQTFCWEQW PNKLHKKAYV VCTFVFGYLL PLLLICFCYA KVLNHLHKKL KNMSKKSEAS 

       250        260        270        280        290        300 
KKKTAQTVLV VVVVFGISWL PHHVVHLWAE FGAFPLTPAS FFFRITAHCL AYSNSSVNPI 

       310        320        330        340 
IYAFLSENFR KAYKQVFKCH VCDESPRSET KENKSRMDTP PSTNCTHV 

« Hide

References

[1]"Genomic organization and functional characterization of the mouse GalR1 galanin receptor."
Wang S., He C., Maguire M.T., Clemmons A.L., Burrier R.E., Guzzi M.F., Strader C.D., Parker E.M., Bayne M.L.
FEBS Lett. 411:225-230(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene."
Jacoby A.S., Webb G.C., Liu M.L., Kofler B., Hort Y.J., Fathi Z., Bottema C.D.K., Shine J., Iismaa T.P.
Genomics 45:496-508(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y15004 mRNA. Translation: CAA75237.1.
U90657, U90655, U90656 Genomic DNA. Translation: AAB87748.1.
CCDSCCDS29372.1.
RefSeqNP_032108.1. NM_008082.2.
UniGeneMm.6219.

3D structure databases

ProteinModelPortalP56479.
SMRP56479. Positions 35-315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000066381.

Chemistry

GuidetoPHARMACOLOGY243.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP56479.

Proteomic databases

PRIDEP56479.

Protocols and materials databases

DNASU14427.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000065224; ENSMUSP00000066381; ENSMUSG00000024553.
GeneID14427.
KEGGmmu:14427.
UCSCuc008ftq.1. mouse.

Organism-specific databases

CTD2587.
MGIMGI:1096364. Galr1.

Phylogenomic databases

eggNOGNOG320953.
GeneTreeENSGT00620000087530.
HOGENOMHOG000230487.
HOVERGENHBG101447.
InParanoidP56479.
KOK04230.
OMAPVAYHQG.
OrthoDBEOG7327PK.
PhylomeDBP56479.
TreeFamTF315737.

Gene expression databases

BgeeP56479.
CleanExMM_GALR1.
GenevestigatorP56479.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286033.
PROP56479.
SOURCESearch...

Entry information

Entry nameGALR1_MOUSE
AccessionPrimary (citable) accession number: P56479
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries