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P56479

- GALR1_MOUSE

UniProt

P56479 - GALR1_MOUSE

Protein

Galanin receptor type 1

Gene

Galr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

    GO - Molecular functioni

    1. galanin receptor activity Source: UniProtKB
    2. neuropeptide binding Source: Ensembl
    3. peptide hormone binding Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. negative regulation of adenylate cyclase activity Source: InterPro
    3. neuropeptide signaling pathway Source: GOC
    4. positive regulation of cytosolic calcium ion concentration Source: InterPro
    5. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galanin receptor type 1
    Short name:
    GAL1-R
    Short name:
    GALR-1
    Gene namesi
    Name:Galr1
    Synonyms:Galnr, Galnr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1096364. Galr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Galanin receptor type 1PRO_0000069464Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi108 ↔ 186PROSITE-ProRule annotation
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Lipidationi319 – 3191S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP56479.

    PTM databases

    PhosphoSiteiP56479.

    Expressioni

    Gene expression databases

    BgeeiP56479.
    CleanExiMM_GALR1.
    GenevestigatoriP56479.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000066381.

    Structurei

    3D structure databases

    ProteinModelPortaliP56479.
    SMRiP56479. Positions 35-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini56 – 7015CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini92 – 10918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 15120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini173 – 19725ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 24729CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 2702ExtracellularSequence Analysis
    Topological domaini292 – 34857CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei110 – 13122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320953.
    GeneTreeiENSGT00620000087530.
    HOGENOMiHOG000230487.
    HOVERGENiHBG101447.
    InParanoidiP56479.
    KOiK04230.
    OMAiPVAYHQG.
    OrthoDBiEOG7327PK.
    PhylomeDBiP56479.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR003906. GAL1_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01418. GALANIN1R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56479-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELAMVNLSE GNGSDPEPPA PESRPLFGIG VENFITLVVF GLIFAMGVLG    50
    NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT 100
    WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR 150
    NALLGVGFIW ALSIAMASPV AYHQRLFHRD SNQTFCWEQW PNKLHKKAYV 200
    VCTFVFGYLL PLLLICFCYA KVLNHLHKKL KNMSKKSEAS KKKTAQTVLV 250
    VVVVFGISWL PHHVVHLWAE FGAFPLTPAS FFFRITAHCL AYSNSSVNPI 300
    IYAFLSENFR KAYKQVFKCH VCDESPRSET KENKSRMDTP PSTNCTHV 348
    Length:348
    Mass (Da):39,114
    Last modified:July 15, 1998 - v1
    Checksum:i6F52D752BAA19F9A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15004 mRNA. Translation: CAA75237.1.
    U90657, U90655, U90656 Genomic DNA. Translation: AAB87748.1.
    CCDSiCCDS29372.1.
    RefSeqiNP_032108.1. NM_008082.2.
    UniGeneiMm.6219.

    Genome annotation databases

    EnsembliENSMUST00000065224; ENSMUSP00000066381; ENSMUSG00000024553.
    GeneIDi14427.
    KEGGimmu:14427.
    UCSCiuc008ftq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15004 mRNA. Translation: CAA75237.1 .
    U90657 , U90655 , U90656 Genomic DNA. Translation: AAB87748.1 .
    CCDSi CCDS29372.1.
    RefSeqi NP_032108.1. NM_008082.2.
    UniGenei Mm.6219.

    3D structure databases

    ProteinModelPortali P56479.
    SMRi P56479. Positions 35-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000066381.

    Chemistry

    GuidetoPHARMACOLOGYi 243.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P56479.

    Proteomic databases

    PRIDEi P56479.

    Protocols and materials databases

    DNASUi 14427.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000065224 ; ENSMUSP00000066381 ; ENSMUSG00000024553 .
    GeneIDi 14427.
    KEGGi mmu:14427.
    UCSCi uc008ftq.1. mouse.

    Organism-specific databases

    CTDi 2587.
    MGIi MGI:1096364. Galr1.

    Phylogenomic databases

    eggNOGi NOG320953.
    GeneTreei ENSGT00620000087530.
    HOGENOMi HOG000230487.
    HOVERGENi HBG101447.
    InParanoidi P56479.
    KOi K04230.
    OMAi PVAYHQG.
    OrthoDBi EOG7327PK.
    PhylomeDBi P56479.
    TreeFami TF315737.

    Miscellaneous databases

    NextBioi 286033.
    PROi P56479.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56479.
    CleanExi MM_GALR1.
    Genevestigatori P56479.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR003906. GAL1_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01418. GALANIN1R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization and functional characterization of the mouse GalR1 galanin receptor."
      Wang S., He C., Maguire M.T., Clemmons A.L., Burrier R.E., Guzzi M.F., Strader C.D., Parker E.M., Bayne M.L.
      FEBS Lett. 411:225-230(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene."
      Jacoby A.S., Webb G.C., Liu M.L., Kofler B., Hort Y.J., Fathi Z., Bottema C.D.K., Shine J., Iismaa T.P.
      Genomics 45:496-508(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.

    Entry informationi

    Entry nameiGALR1_MOUSE
    AccessioniPrimary (citable) accession number: P56479
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3