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Protein

Galanin receptor type 1

Gene

Galr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

  1. galanin receptor activity Source: UniProtKB
  2. neuropeptide binding Source: Ensembl
  3. peptide hormone binding Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. negative regulation of adenylate cyclase activity Source: InterPro
  3. neuropeptide signaling pathway Source: GOC
  4. positive regulation of cortisol secretion Source: MGI
  5. positive regulation of cytosolic calcium ion concentration Source: InterPro
  6. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_235286. Peptide ligand-binding receptors.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 1
Short name:
GAL1-R
Short name:
GALR-1
Gene namesi
Name:Galr1
Synonyms:Galnr, Galnr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1096364. Galr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
BLAST
Transmembranei35 – 5521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini56 – 7015CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 10918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei110 – 13122Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini132 – 15120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei152 – 17221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini173 – 19725ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 24729CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 2702ExtracellularSequence Analysis
Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 34857CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Galanin receptor type 1PRO_0000069464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi108 ↔ 186PROSITE-ProRule annotation
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Lipidationi319 – 3191S-palmitoyl cysteineBy similarity

Post-translational modificationi

Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP56479.

PTM databases

PhosphoSiteiP56479.

Expressioni

Gene expression databases

BgeeiP56479.
CleanExiMM_GALR1.
GenevestigatoriP56479.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066381.

Structurei

3D structure databases

ProteinModelPortaliP56479.
SMRiP56479. Positions 35-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiP56479.
KOiK04230.
OMAiPVAYHQG.
OrthoDBiEOG7327PK.
PhylomeDBiP56479.
TreeFamiTF315737.

Family and domain databases

InterProiIPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56479-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELAMVNLSE GNGSDPEPPA PESRPLFGIG VENFITLVVF GLIFAMGVLG
60 70 80 90 100
NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT
110 120 130 140 150
WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR
160 170 180 190 200
NALLGVGFIW ALSIAMASPV AYHQRLFHRD SNQTFCWEQW PNKLHKKAYV
210 220 230 240 250
VCTFVFGYLL PLLLICFCYA KVLNHLHKKL KNMSKKSEAS KKKTAQTVLV
260 270 280 290 300
VVVVFGISWL PHHVVHLWAE FGAFPLTPAS FFFRITAHCL AYSNSSVNPI
310 320 330 340
IYAFLSENFR KAYKQVFKCH VCDESPRSET KENKSRMDTP PSTNCTHV
Length:348
Mass (Da):39,114
Last modified:July 15, 1998 - v1
Checksum:i6F52D752BAA19F9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15004 mRNA. Translation: CAA75237.1.
U90657, U90655, U90656 Genomic DNA. Translation: AAB87748.1.
CCDSiCCDS29372.1.
RefSeqiNP_032108.1. NM_008082.2.
UniGeneiMm.6219.

Genome annotation databases

EnsembliENSMUST00000065224; ENSMUSP00000066381; ENSMUSG00000024553.
GeneIDi14427.
KEGGimmu:14427.
UCSCiuc008ftq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15004 mRNA. Translation: CAA75237.1.
U90657, U90655, U90656 Genomic DNA. Translation: AAB87748.1.
CCDSiCCDS29372.1.
RefSeqiNP_032108.1. NM_008082.2.
UniGeneiMm.6219.

3D structure databases

ProteinModelPortaliP56479.
SMRiP56479. Positions 35-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066381.

Chemistry

GuidetoPHARMACOLOGYi243.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP56479.

Proteomic databases

PRIDEiP56479.

Protocols and materials databases

DNASUi14427.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065224; ENSMUSP00000066381; ENSMUSG00000024553.
GeneIDi14427.
KEGGimmu:14427.
UCSCiuc008ftq.1. mouse.

Organism-specific databases

CTDi2587.
MGIiMGI:1096364. Galr1.

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiP56479.
KOiK04230.
OMAiPVAYHQG.
OrthoDBiEOG7327PK.
PhylomeDBiP56479.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiREACT_235286. Peptide ligand-binding receptors.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi286033.
PROiP56479.
SOURCEiSearch...

Gene expression databases

BgeeiP56479.
CleanExiMM_GALR1.
GenevestigatoriP56479.

Family and domain databases

InterProiIPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic organization and functional characterization of the mouse GalR1 galanin receptor."
    Wang S., He C., Maguire M.T., Clemmons A.L., Burrier R.E., Guzzi M.F., Strader C.D., Parker E.M., Bayne M.L.
    FEBS Lett. 411:225-230(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene."
    Jacoby A.S., Webb G.C., Liu M.L., Kofler B., Hort Y.J., Fathi Z., Bottema C.D.K., Shine J., Iismaa T.P.
    Genomics 45:496-508(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.

Entry informationi

Entry nameiGALR1_MOUSE
AccessioniPrimary (citable) accession number: P56479
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 4, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.