Reviewed, UniProtKB/Swiss-Prot P56479 (GALR1_MOUSE)

Names and origin

Protein names

Recommended name:
    Galanin receptor type 1
Alternative name(s):
    GAL1-R
    GALR1

Gene names

Name:	Galr1
Synonyms:	Galnr, Galnr1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	galanin receptor activity Traceable author statement. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Galanin receptor type 1		PRO_0000069464
Regions
	Topological domain	1 – 34	34	Extracellular Potential
	Transmembrane	35 – 55	21	1 Potential
	Topological domain	56 – 70	15	Cytoplasmic Potential
	Transmembrane	71 – 91	21	2 Potential
	Topological domain	92 – 109	18	Extracellular Potential
	Transmembrane	110 – 131	22	3 Potential
	Topological domain	132 – 151	20	Cytoplasmic Potential
	Transmembrane	152 – 172	21	4 Potential
	Topological domain	173 – 197	25	Extracellular Potential
	Transmembrane	198 – 218	21	5 Potential
	Topological domain	219 – 247	29	Cytoplasmic Potential
	Transmembrane	248 – 268	21	6 Potential
	Topological domain	269 – 270	2	Extracellular Potential
	Transmembrane	271 – 291	21	7 Potential
	Topological domain	292 – 348	57	Cytoplasmic Potential
Amino acid modifications
	Lipidation	319	1	S-palmitoyl cysteine By similarity
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
	Glycosylation	182	1	N-linked (GlcNAc...) Potential
	Disulfide bond	108 ↔ 186		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56479-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 6F52D752BAA19F9A	FASTA	348	39,114
	10 20 30 40 50 60 MELAMVNLSE GNGSDPEPPA PESRPLFGIG VENFITLVVF GLIFAMGVLG NSLVITVLAR 70 80 90 100 110 120 SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT WVLGAFICKF IHYFFTVSML 130 140 150 160 170 180 VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR NALLGVGFIW ALSIAMASPV AYHQRLFHRD 190 200 210 220 230 240 SNQTFCWEQW PNKLHKKAYV VCTFVFGYLL PLLLICFCYA KVLNHLHKKL KNMSKKSEAS 250 260 270 280 290 300 KKKTAQTVLV VVVVFGISWL PHHVVHLWAE FGAFPLTPAS FFFRITAHCL AYSNSSVNPI 310 320 330 340 IYAFLSENFR KAYKQVFKCH VCDESPRSET KENKSRMDTP PSTNCTHV

References

[1]	"Genomic organization and functional characterization of the mouse GalR1 galanin receptor." Wang S., He C., Maguire M.T., Clemmons A.L., Burrier R.E., Guzzi M.F., Strader C.D., Parker E.M., Bayne M.L. FEBS Lett. 411:225-230(1997) [PubMed: 9271210] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene." Jacoby A.S., Webb G.C., Liu M.L., Kofler B., Hort Y.J., Fathi Z., Bottema C.D.K., Shine J., Iismaa T.P. Genomics 45:496-508(1997) [PubMed: 9367674] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y15004 mRNA. Translation: CAA75237.1. U90657, U90655, U90656 Genomic DNA. Translation: AAB87748.1.
IPI	IPI00113788.
RefSeq	NP_032108.1.
UniGene	Mm.6219
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P56479.
Genome annotation databases
Ensembl	ENSMUSG00000024553. Mus musculus. [Contig view]
GeneID	14427.
KEGG	mmu:14427.
Organism-specific databases
MGI	MGI:1096364. Galr1.
Phylogenomic databases
HOGENOM	P56479.
HOVERGEN	P56479.
OMA	P56479. FFFRITA.
Gene expression databases
ArrayExpress	P56479.
Bgee	P56479.
CleanEx	MM_GALR1.
GermOnline	ENSMUSG00000024553. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR000405. Galanin_rcpt. IPR003906. Galnin_1_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19264:SF236. Galnin_1_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01418. GALANIN1R. PR00663. GALANINR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	286033.
SOURCE	Search...

Entry information

Entry name

GALR1_MOUSE

Accession

Primary (citable) accession number: P56479

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)