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Protein

Interleukin-7

Gene

Il7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7
Short name:
IL-7
Gene namesi
Name:Il7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2904 Il7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000001562526 – 154Interleukin-7Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 145By similarity
Disulfide bondi58 ↔ 133By similarity
Disulfide bondi71 ↔ 116By similarity
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Three disulfide bonds are present.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP56478
PRIDEiP56478

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016091

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW6Q Eukaryota
ENOG41114MI LUCA
HOGENOMiHOG000036891
HOVERGENiHBG004609
InParanoidiP56478
PhylomeDBiP56478

Family and domain databases

Gene3Di1.20.1250.50, 1 hit
InterProiView protein in InterPro
IPR001181 IL-7
IPR018049 IL-7/IL-9_CS
IPR000226 IL-7/IL-9_fam
IPR038325 IL7_sf
PANTHERiPTHR45542 PTHR45542, 1 hit
PfamiView protein in Pfam
PF01415 IL7, 1 hit
PIRSFiPIRSF001942 IL-7, 1 hit
PRINTSiPR00435 INTERLEUKIN7
SMARTiView protein in SMART
SM00127 IL7, 1 hit
PROSITEiView protein in PROSITE
PS00255 INTERLEUKIN_7_9, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHVSFRYIF GIPPLILVLL PVTSSDCHIK DKDGKAFGSV LMISINQLDK
60 70 80 90 100
MTGTDSDCPN NEPNFFKKHL CDDTKEAAFL NRAARKLRQF LKMNISEEFN
110 120 130 140 150
DHLLRVSDGT QTLVNCTSKE EKTIKEQKKN DPCFLKRLLR EIKTCWNKIL

KGSI
Length:154
Mass (Da):17,709
Last modified:July 15, 1998 - v1
Checksum:i8D9E9E9FD0681741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010464 mRNA Translation: AAB66350.1
UniGeneiRn.10793

Genome annotation databases

UCSCiRGD:2904 rat

Similar proteinsi

Entry informationi

Entry nameiIL7_RAT
AccessioniPrimary (citable) accession number: P56478
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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